Journal of Cell Communication and Signaling最新文献

{"title":"The small molecule peptide ANXA114-26 inhibits ovarian cancer cell proliferation and reverses cisplatin resistance by binding to the formyl peptide receptors receptor","authors":"Nana Li,&nbsp;Peihua Yan,&nbsp;Ling Guo,&nbsp;Huiyan Wang,&nbsp;Baohong Cui,&nbsp;Lichen Teng,&nbsp;Yajuan Su","doi":"10.1002/ccs3.12058","DOIUrl":"https://doi.org/10.1002/ccs3.12058","url":null,"abstract":"<p>Chemo-resistance in ovarian cancer is currently a major obstacle to the treatment and recovery of ovarian cancer. Therefore, identifying factors associated with chemo-resistance in ovarian cancer may reverse chemo-sensitization. Using isobaric tags for relative and absolute quantitation (ITRAQ) technology, we found a small molecule peptide with annexin 1 (ANXA1) as a precursor protein. Then, we explored the effects and mechanisms of this small molecule peptide on the proliferation, apoptosis, and drug resistance of ovarian cancer resistant cells through CCK-8, EdU cell proliferation assay, Annexin V-FITC/PI assay, Western blot,qRT-PCR. ANXA114-26 was highly expressed in the serums of sensitive patients. ANXA114-26 promoted apoptosis of ovarian cancer cells and increased the sensitization of ovarian cancer cells to cisplatin. The ANXA114-26 and ANXA1 competitively bind formyl peptide receptors (FPR). ANXA114-26 decreased multidrug resistance-associated protein 1 (MRP1) expression in ovarian cancer cells through the FPR/Cyclin D1/NF-ĸBp65 pathway. We found a peptide derived named ANXA114-26 in the serum of ovarian cancer patients. It can reduce ovarian cancer cell proliferation and reduce MRP1 expression through the FPR/Cyclin D1/NF-ĸBp65 pathway.</p>","PeriodicalId":15226,"journal":{"name":"Journal of Cell Communication and Signaling","volume":"19 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccs3.12058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The case of Connective Tissue Growth Factor and the pit of misleading and improper nomenclatures","authors":"Bernard Perbal","doi":"10.1002/ccs3.12062","DOIUrl":"https://doi.org/10.1002/ccs3.12062","url":null,"abstract":"<p>\u0000 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15226,"journal":{"name":"Journal of Cell Communication and Signaling","volume":"19 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccs3.12062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142860049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytokine expression and cytokine-mediated cell–cell communication during skeletal muscle regeneration revealed by integrative analysis of single-cell RNA sequencing data","authors":"Pallob Barai,&nbsp;Jie Chen","doi":"10.1002/ccs3.12055","DOIUrl":"10.1002/ccs3.12055","url":null,"abstract":"<p>Skeletal muscles undergo self-repair upon injury, owing to the resident muscle stem cells and their extensive communication with the microenvironment of injured muscles. Cytokines play a critical role in orchestrating intercell communication to ensure successful regeneration. Immune cells as well as other types of cells in the injury site, including muscle stem cells, are known to secret cytokines. However, the extent to which various cell types express distinct cytokines and how the secreted cytokines are involved in intercell communication during regeneration are largely unknown. Here we integrated 15 publicly available single-cell RNA-sequencing (scRNA-seq) datasets of mouse skeletal muscles at early regeneration timepoints (0, 2, 5, and 7 days after injury). The resulting dataset was analyzed for the expression of 393 annotated mouse cytokines. We found widespread and dynamic cytokine expression by all cell types in the regenerating muscle. Interrogating the integrated dataset using CellChat revealed extensive, bidirectional cell–cell communications during regeneration. Our findings provide a comprehensive view of cytokine signaling in the regenerating muscle, which can guide future studies of ligand-receptor signaling and cell–cell interaction to achieve new mechanistic insights into the regulation of muscle regeneration.</p>","PeriodicalId":15226,"journal":{"name":"Journal of Cell Communication and Signaling","volume":"18 4","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis and diagnosis prediction of lung adenocarcinoma outcome based on a novel model anchored in circadian clock-related genes","authors":"Bernard Perbal","doi":"10.1002/ccs3.12053","DOIUrl":"10.1002/ccs3.12053","url":null,"abstract":"<div>\u0000 <section>\u0000 <p>The transition of JCCS from Springer to Wiley was rich in future prospects and was confirmed by the Journal reorganization launched in 2019. However, in spite of my recently renewed demand, the “B&amp;B” section of the Journal (Bits and Bytes not be confused with Bed and Breakfast, albeit…) did not fit into the Wiley Publishing categories and had to be dropped, to the great disappointment of many authors and our readership. This Editorial will fill the gap by discussing new published aspects on the topic of the connections existing between circadian cellular signaling and cancer prognosis, with the identification of eight genetically significant clock-related genes in lung cancer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15226,"journal":{"name":"Journal of Cell Communication and Signaling","volume":"18 4","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 12th international workshop on the CCN family of genes in pictures","authors":"Annick Perbal","doi":"10.1002/ccs3.12051","DOIUrl":"10.1002/ccs3.12051","url":null,"abstract":"&lt;p&gt;From June 20th to June 23rd, the 12th International workshop on the CCN Family of Genes has been held at the &lt;b&gt;Scandic Holmenkollen Park Hotel, OSLO–Norway&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Organizers&lt;/b&gt;&lt;/p&gt;&lt;p&gt;Professor Håvard Attramadal and Dr. Vivi T. Monsen, Oslo University Hospital&lt;/p&gt;&lt;p&gt;&lt;b&gt;Co-organizers&lt;/b&gt;&lt;/p&gt;&lt;p&gt;Professor Bernard Perbal and Annick Perbal, International CCN Society, Nice France&lt;/p&gt;&lt;p&gt;The workshop has been scientifically and socially very successful.&lt;/p&gt;&lt;p&gt;Since the previous meeting held in Nice in 2022, it has been opened to different fields.&lt;/p&gt;&lt;p&gt;This year, Dr. Katia Scotlandi from Bologna, Italy, has been selected to be the 9&lt;sup&gt;th&lt;/sup&gt; ICCNS Awardee.&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;Dr. Katia Scotlandi has long been committed to advancing research and scientific interest in the field of IGF and insulin system. Her scientific group has demonstrated the importance of the related signaling pathway in sarcomas, particularly in the Ewing sarcoma and participated in the development of rationale strategies to inhibit IGF1R-mediated signaling at preclinical level. She has also highlighted the role of the insulin receptor in the rapid development of resistance to antibodies targeting IGF1R. More recently, she has introduced the concept that the RNA-binding protein IGF2BP3 may regulate the cell sensitivity to anti-IGF1R agents. In addition she has significantly contributed hard to the identification of novel biomarkers of risk and prognosis, including CCN3, as well as of new therapeutic targets for these tumors. More recently, she has developed a platform for sequencing and establishment of complex preclinical models to accelerate our understanding of bone sarcomas.&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Listing of the ICCNS awardees&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Program&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;T&lt;/b&gt;&lt;b&gt;hursday, June 20&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;9:00 Registration begins&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;10:30–11:30 Business meeting for the JCCS Editorial Board.&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;11:45–13:00 Lunch&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Workshop Opening&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Session I&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;ECM Proteins in Cell Communication and Signaling&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Chairs: Brahim Chaqour and Vivi T. Monsen&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;14:40–15:10 Coffee Break&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;18:30 Welcome reception and Dinner with Live Music at Scandic Holmenkollen Park Hotel&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Session II&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Vascular Development and Pathophysiology&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Chairs: Lester Lau and Håvard Attramadal&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;9:50–10:20 Coffee Break&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Session III&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Mechanisms of Diseases: Fibrosis and The Matrix&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Chairs: George Bou-Gharios and Satoshi Kubota&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Lunch 12:10–13:30&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Boat Trip on the Oslo Fjord with dinner&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Saturday, June 22&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Session IV&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Tissue Development and Homeostasis&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Chairs: Blandine Poulet and Bernard Perbal&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;9:45–10:15 Coffee ","PeriodicalId":15226,"journal":{"name":"Journal of Cell Communication and Signaling","volume":"18 4","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging role of IRE1α in vascular diseases","authors":"Jia Shi,&nbsp;Fan He,&nbsp;Xiaogang Du","doi":"10.1002/ccs3.12056","DOIUrl":"10.1002/ccs3.12056","url":null,"abstract":"<p>A mounting body of evidence suggests that the endoplasmic reticulum stress and the unfolded protein response are involved in the underlying mechanisms responsible for vascular diseases. Inositol-requiring protein 1α (IRE1α), the most ancient branch among the UPR-related signaling pathways, can possess both serine/threonine kinase and endoribonuclease (RNase) activity and can perform physiological and pathological functions. The IRE1α-signaling pathway plays a critical role in the pathology of various vascular diseases. In this review, we provide a general overview of the physiological function of IRE1α and its pathophysiological role in vascular diseases.</p>","PeriodicalId":15226,"journal":{"name":"Journal of Cell Communication and Signaling","volume":"18 4","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the dual role of endoplasmic reticulum stress in urological cancers: Implications for tumor progression and cell death interactions","authors":"Najma Farahani,&nbsp;Mina Alimohammadi,&nbsp;Mehdi Raei,&nbsp;Noushin Nabavi,&nbsp;Amir Reza Aref,&nbsp;Kiavash Hushmandi,&nbsp;Salman Daneshi,&nbsp;Alireza Razzaghi,&nbsp;Afshin Taheriazam,&nbsp;Mehrdad Hashemi","doi":"10.1002/ccs3.12054","DOIUrl":"10.1002/ccs3.12054","url":null,"abstract":"<p>The endoplasmic reticulum (ER) is crucial for maintaining calcium balance, lipid biosynthesis, and protein folding. Disruptions in ER homeostasis, often due to the accumulation of misfolded or unfolded proteins, lead to ER stress, which plays a significant role in various diseases, especially cancer. Urological cancers, which account for high male mortality worldwide, pose a persistent challenge due to their incurability and tendency to develop drug resistance. Among the numerous dysregulated biological mechanisms, ER stress is a key factor in the progression and treatment response of these cancers. This review highlights the dual role of aberrant ER stress activation in urologic cancers, affecting both tumor growth and therapeutic outcomes. While ER stress can support tumor growth through pro-survival autophagy, it primarily inhibits cancer progression via apoptosis and pro-death autophagy. Interestingly, ER stress can paradoxically aid cancer progression through mechanisms such as exosome-mediated immune evasion. Additionally, the review examines how pharmacological interventions, particularly with phytochemicals, can stimulate ER stress-mediated tumor suppression. Key regulators, including PERK, IRE1α, and ATF6, are discussed for their roles in upregulating CHOP levels and triggering apoptosis. In conclusion, a deeper understanding of ER stress in urological cancers not only clarifies the complex interactions between cellular stress and cancer progression but also provides new opportunities for innovative therapeutic strategies.</p>","PeriodicalId":15226,"journal":{"name":"Journal of Cell Communication and Signaling","volume":"18 4","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “LncRNA HOTTIP promotes LPS-induced lung epithelial cell injury by recruiting DNMT1 to epigenetically regulate SP-C”","authors":"","doi":"10.1002/ccs3.12042","DOIUrl":"10.1002/ccs3.12042","url":null,"abstract":"<p>Li, S., Li, S., Gao, Z. and Liu, Y. (2024), LncRNA HOTTIP promotes LPS-induced lung epithelial cell injury by recruiting DNMT1 to epigenetically regulate SP-C. <i>J. Cell Commun. Signal</i>, 18: e12020. https://doi.org/10.1002/ccs3.12020.</p><p>In the originally published article, the funding number was omitted. The correct sentence is:</p><p>The research was sponsored by the Scientific Research Project of Heilongjiang Health Commission (No. 2020-332).</p><p>We apologize for this error.</p>","PeriodicalId":15226,"journal":{"name":"Journal of Cell Communication and Signaling","volume":"18 4","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role for the PIP2-binding protein myristoylated alanine-rich C-kinase substrate in vascular tissue: A novel therapeutic target for cardiovascular disease","authors":"Anthony P. Albert,&nbsp;Kazi S. Jahan,&nbsp;Harry Z. E. Greenberg,&nbsp;Yousif A. Shamsaldeen","doi":"10.1002/ccs3.12052","DOIUrl":"10.1002/ccs3.12052","url":null,"abstract":"<p>In vascular smooth muscle cells (VSMCs) and vascular endothelial cells (VECs), phosphatidylinositol 4,5-bisphosphate (PIP₂) acts as a substrate for phospholipase C (PLC)- and phosphoinositol 3-kinase (PI3K)-mediated signaling pathways and an unmodified ligand at ion channels and other macromolecules, which are key processes in the regulation of cell physiological and pathological phenotypes. It is envisaged that these distinct roles of PIP₂ are achieved by PIP₂-binding proteins, which act as PIP₂ buffers to produce discrete pools of PIP₂ that permits targeted release within the cell. This review discusses evidence for the expression, cell distribution, and role of myristoylated alanine-rich C-kinase substrate (MARCKS), a PIP₂-binding protein, in cellular signaling and function of VSMCs. The review indicates the possibilities for MARCKS as a therapeutic target for vascular disease involving dysfunctional cell proliferation and migration, endothelial barrier permeability, and vascular contractility such as atherosclerosis, systemic and pulmonary hypertension, and sepsis.</p>","PeriodicalId":15226,"journal":{"name":"Journal of Cell Communication and Signaling","volume":"18 4","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tert-butyl hydroperoxide induces trabecular meshwork cells injury through ferroptotic cell death","authors":"Xuejing Yan,&nbsp;Qian Liu,&nbsp;Shen Wu,&nbsp;Xiaowei Fan,&nbsp;Yufei Teng,&nbsp;Ningli Wang,&nbsp;Jingxue Zhang","doi":"10.1002/ccs3.12050","DOIUrl":"https://doi.org/10.1002/ccs3.12050","url":null,"abstract":"<p>Trabecular meshwork (TM) tissue has a crucial role in regulating aqueous humor circulation in the eye, thus maintaining normal intraocular pressure (IOP). TM dysfunction causes IOP elevation, which leads to glaucoma. To investigate biological changes in TM tissue in patients with glaucoma, we analyzed the mRNA expression microarray dataset, GSE27276. Gene ontology analysis indicated that redox microenvironment imbalance is among the main changes of TM tissue in patients with glaucoma. Subsequently, we induced oxidative stress in TM cells using the tert-butyl hydroperoxide (tBHP) treatment, to generate in vivo and in vitro models, and conducted mRNA sequencing to identify genes with critical roles in maintaining the redox microenvironment balance. We found that the tBHP caused TM dysfunction in vivo, characterized by aqueous humor circulation resistance, IOP elevation, and TM cell death. Further, Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that ferroptosis signaling was enriched in tBHP-treated TM cells. Consistently, in vitro analyses showed that levels of reactive oxygen species, ferric ion, and malondialdehyde were increased after the tBHP treatment, indicating TM cell ferroptosis. Furthermore, inhibiting ferroptosis alleviated tBHP-induced TM cell injury. This study provides new insights suggesting that inhibition of ferroptosis has potential as a treatment for glaucoma.</p>","PeriodicalId":15226,"journal":{"name":"Journal of Cell Communication and Signaling","volume":"18 3","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccs3.12050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142273204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}