Journal of Central Nervous System Disease最新文献

{"title":"Correlation of Cognition With Disability and Physical Performance in Patients With Relapsing-Remitting MS.","authors":"Marko Luostarinen, Anne M Portaankorva, Pirjo Urpilainen, Saara Takala, Mika Venojärvi","doi":"10.1177/11795735251349716","DOIUrl":"10.1177/11795735251349716","url":null,"abstract":"<p><strong>Background: </strong>Cognitive impairment is common in patients with multiple sclerosis (MS). Physical activity is clearly linked to cognitive performance, and several studies have shown the importance of regular cognition testing, but such testing is still not routinely performed in clinical practice.</p><p><strong>Objective: </strong>This study aimed to investigate the association between cognition, disability, and physical performance in relapsing-remitting MS (RRMS) patients.</p><p><strong>Methods: </strong>A total of 41 patients with RRMS with an Expanded Disability Status Scale (EDSS) level of 0-5.5 and 20 healthy controls completed the MS Functional Composite (MSFC) test and the Symbol Digit Modality Test (SDMT). Six-Minute Walk (6MW) was evaluated for all participants, and they used an accelerometer for seven days.</p><p><strong>Results: </strong>A significant correlation was found between cognition and disability level measured by the MSFC (MSFC/SDMT, r = 0.668, <i>P</i> = .001) and between disability and 6MW (EDSS/6MW, r = -0.516, <i>P</i> = .001; MSFC/6MW, r = 0.348, <i>P</i> = .028) in the patients' group. Cognition results (SDMT) were statistically significantly weaker in patients with EDSS >2.5 vs EDSS ≤2.5 or control group. Total daily activity (MVPS) correlated with cognition as measured by the SDMT in the control group but not in the patients' group. In the EDSShigh group, better results on the 6MW test were associated with better cognition results as measured by the SDMT (r = 0.505, <i>P</i> = .039).</p><p><strong>Conclusion: </strong>There was a clear association between disability, 6MW and cognition. Better results on the 6MW predicted better cognition and disability.Clinical trial registration number: NCT04115930.</p>","PeriodicalId":15218,"journal":{"name":"Journal of Central Nervous System Disease","volume":"17 ","pages":"11795735251349716"},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lumbar Intraspinal Calcium Pyrophosphate Deposition: A Comprehensive Case Study.","authors":"Juan M López-Navarro, Diego A Sandoval-Lopez, Pavle Popovic, Vasileios Karantzoulis, Zeid Bittar, Edgar Santos, Farzam Vazifehdan","doi":"10.1177/11795735251347335","DOIUrl":"10.1177/11795735251347335","url":null,"abstract":"<p><strong>Introduction: </strong>Calcium pyrophosphate deposition (CPPD) disease is characterized by calcium pyrophosphate crystals in hyaline and fibrocartilage. Chondrocalcinosis, a radiographic hallmark for CPPD, becomes more prevalent with age. Although CPPD mainly targets peripheral joints, spinal involvement, affecting intervertebral discs and spinal ligaments, is less common but significant, seen in 24.3% of hospitalized patients with CPPD disease. This report describes a rare case of spinal CPPD causing spinal canal stenosis in the lumbar region.</p><p><strong>Case description: </strong>A 79-year-old woman with a 3-year history of low back pain presented with severe left-sided pain and mobility impairment. Initial examination showed lumbar tenderness and normal muscle strength. Computed tomography (CT) and magnetic resonance imaging scans revealed a calcified extradural mass occupying the anterior portion of the lumbar spinal canal, most likely associated with the posterior longitudinal ligament. The patient underwent L3-L5 hemilaminectomies and dorsal spondylodesis, removing a whitish intraspinal mass. Histopathology confirmed CPPD. Post-surgery, the patient experienced initial pain relief but required emergency surgery due to complications. Over the next year, her mobility and pain improved significantly.</p><p><strong>Discussion: </strong>Spinal CPPD manifests with varied clinical presentations, complicating diagnosis. Imaging reveals calcifications ranging from deposits to mass-like lesions causing compression. CT provides detailed visualization of characteristic calcifications, aiding in diagnosis, while histopathology remains the gold standard. Multidisciplinary collaboration is vital for accurate diagnosis and optimal management.</p>","PeriodicalId":15218,"journal":{"name":"Journal of Central Nervous System Disease","volume":"17 ","pages":"11795735251347335"},"PeriodicalIF":2.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor Response to: Is Transcranial Direct Current Stimulation Really Beneficial for Frontotemporal Dementia? (Published 12-18-2024).","authors":"Donna C Tippett, Kyriaki Neophytou, Yuan Tao, Jessica Gallegos, Christopher Morrow, Chiadi U Onyike, Kyrana Tsapkini","doi":"10.1177/11795735251339997","DOIUrl":"10.1177/11795735251339997","url":null,"abstract":"","PeriodicalId":15218,"journal":{"name":"Journal of Central Nervous System Disease","volume":"17 ","pages":"11795735251339997"},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The EEG is Not Suitable for Diagnosing Delirium, But Can Exclude Epileptic Activity as a Cause.","authors":"Josef Finsterer, Joao Gama Marques","doi":"10.1177/11795735251344418","DOIUrl":"10.1177/11795735251344418","url":null,"abstract":"","PeriodicalId":15218,"journal":{"name":"Journal of Central Nervous System Disease","volume":"17 ","pages":"11795735251344418"},"PeriodicalIF":2.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of a Rehabilitation Treatment Using Action Observation Therapy Enhanced by Muscle Synergy-Derived Electrical Stimulation (OTHELLO) in Post-Stroke Patients: A RCT Study Protocol.","authors":"Monia Cabinio, Tiziana Lencioni, Arturo Nuara, Federica Rossetto, Valeria Blasi, Gaia Bailo, Rebecca Cardini, Rita Bertoni, Alessandro Viganò, Mariangela Bianco, Angela Comanducci, Pietro Avanzini, Maurizio Ferrarin, Luca Fornia, Francesca Baglio","doi":"10.1177/11795735251331511","DOIUrl":"https://doi.org/10.1177/11795735251331511","url":null,"abstract":"<p><p><b>Background:</b> Action Observation Therapy (AOT) and Neuromuscular Electrical Stimulation (NMES) are widely adopted techniques for upper-limb rehabilitation in post-stroke patients. Although AOT and NMES are individually effective, studies investigating a potential synergistic effect on enhancing rehabilitative outcomes are lacking. <b>Objectives:</b> This study aims at comparing the effect of AOT and NMES applied together (AOT-NMES) on muscle synergies with respect to either AOT alone or a Motor Neutral Observation treatment alone (MNO, involving neither AOT nor NMES) on motor function recovery of upper limb. <b>Design:</b> Randomized Controlled Trial (RCT) with n = 60 post-stroke patients with resulting upper limb disability, randomly allocated (1:1:1 ratio) in three interventional arms: AOT-NMES (n = 20), AOT (n = 20) and MNO (n = 20). <b>Methods and Analyses:</b> All rehabilitation treatments will consist of n°15 60 min-long rehabilitative sessions. Primary outcome measure will be upper limb motor function, assessed using the Fugl-Meyer Assessment scale for upper limb (FM-UL), collected at the baseline (T0), post-intervention (T1) and at follow-up (T2, 6-months after T1). Other outcome measures will be collected through a multidimensional evaluation including assessing stroke-associated quality of life, neurophysiological data, biomechanical and MRI measures. The innovative protocol will also be evaluated for usability and safety. <b>Discussion:</b> We expect to determine the efficacy, usability and safety of the AOT-NMES rehabilitation approach for the recovery of upper limb motor function in post-stroke patients. The obtained results will also help reveal the neural underpinnings of motor recovery, as assessed by neurophysiological data, biomechanical and MRI measures.</p>","PeriodicalId":15218,"journal":{"name":"Journal of Central Nervous System Disease","volume":"17 ","pages":"11795735251331511"},"PeriodicalIF":2.6,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraneoplastic Tumefactive Demyelination With Underlying Anaplastic Thyroid Cancer: A Case Report and Review of the Literature.","authors":"Chaloulos-Iakovidis Panagiotis, Arsany Hakim, Stork Lidia, Stadelmann-Nessler Christine, Kollár Attila, Chan Andrew, De Beukelaer Sophie, Salmen Anke, Hoepner Robert, Helly Hammer","doi":"10.1177/11795735251340051","DOIUrl":"https://doi.org/10.1177/11795735251340051","url":null,"abstract":"<p><p>We present a case of paraneoplastic tumefactive demyelination in a 55-year-old female with an underlying anaplastic thyroid carcinoma (ATC), alongside a review of the literature on all cases of tumefactive demyelination associated with non-CNS neoplasia. In the presented case the patient developed a right-sided subacute sensorimotor hemiparesis. The initial cerebral MRI revealed a bilateral frontoparietal tumefactive mass lesion with marked gadolinium uptake and mass effect. Cerebrospinal fluid revealed CSF-specific oligoclonal bands type III, with negative cell count, protein and pathogen testing. Brain biopsy indicated demyelination and T-cell infiltrates and foamy macrophages. A body CT revealed an anaplastic thyroid carcinoma. Despite steroids, plasma exchange, rituximab, and cancer treatment, the patient died due to clinical fluctuation and cancer progression. In addition to our case 9 cases of tumefactive demyelinating have been reported in patients with newly diagnosed extracranial neoplasia, most commonly seminoma germ cell tumour (7/10). 8/10 (80%) of patients were male, with mean age at diagnosis was 52.9 years 95% C.I. [43.8, 62.0]. 5/10 patients presented with sensorimotor hemiparesis and/or confusion/neurocognitive deficits. 4/10 with visual deficits and 2/10 with aphasia. In all cases neoplasia was diagnosed simultaneously or after neurological manifestations. All cases presented initially as solitary lesions. A malignancy specific-treatment as well as steroid treatment in different regiments were applied. In addition in 2/10 plasmapheresis was implemented and 1/10 patients received intravenous immunoglobulins. In the majority of cases including the presented case partial neurological improvement was documented whereas malignancy usually progressed. To our knowledge, this is the first report of paraneoplastic tumefactive demyelination associated with an ATC highlighting the importance of a thorough workup in these patients. This is the first reported case of paraneoplastic tumefactive demyelination associated with ATC, underscoring the necessity of a comprehensive diagnostic approach in similar patients.</p>","PeriodicalId":15218,"journal":{"name":"Journal of Central Nervous System Disease","volume":"17 ","pages":"11795735251340051"},"PeriodicalIF":2.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aseptic Pleocytosis Can Only be Classified as a Phenotypic Manifestation of MNGIE After Exclusion of all Differential Causes.","authors":"Zahra Al-Sahlawi, Noor Abdulla Redha, Hasan Hasan","doi":"10.1177/11795735251330595","DOIUrl":"https://doi.org/10.1177/11795735251330595","url":null,"abstract":"","PeriodicalId":15218,"journal":{"name":"Journal of Central Nervous System Disease","volume":"17 ","pages":"11795735251330595"},"PeriodicalIF":2.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Snapshots on Stroke Prevention and Control and More Proactive National Strategies Against It in China.","authors":"Bin Jiang","doi":"10.1177/11795735251337605","DOIUrl":"https://doi.org/10.1177/11795735251337605","url":null,"abstract":"<p><strong>Background and purpose: </strong>Stroke has become a major public health problem. This paper aims to briefly review the current epidemiological characteristics, preliminary achievements, and national action strategies related to stroke prevention and control in China.</p><p><strong>Methods: </strong>English and Chinese literature were searched on stroke epidemiological characteristics and more proactive strategies for its prevention and control in China. Potential papers related to this topic were identified from PubMed, Medline, Embase, Cochrane Library, Wanfang Database, SINOMED, and China National Knowledge Infrastructure databases, as well as the annual reports and websites of the People's Daily, the State Council, and the National Health Commission of the People's Republic of China.</p><p><strong>Results: </strong>Stroke has been ranked among the top three causes of death in China, and has become a public health problem endangering people's health. High rates of incidence, mortality, and disability bring a heavy burden to stroke patients, families, and society. With China's economic development, urbanization, and population aging, the prevalence and incidence of stroke are still rising. Although some progress has been made in specialized stroke prevention and treatment in China, there is still much room for improvement. Curbing increasing stroke due to increased prevalence and suboptimal control of risk factors and unhealthy lifestyles is no longer just the efforts of medical service institutions. It still requires a more proactive national strategy and general mobilization of the whole people. Increased prevalence of stroke, survivors' unfavorable outcomes, and suboptimal rehabilitation also need specialized stroke care and the perfect Hierarchical Medical System within the regional medical consortium in China.</p><p><strong>Conclusions: </strong>The current situation of stroke prevention and treatment is still very serious in China. In the future, the stroke prevention and treatment model will change from passive stroke treatment and risk factor control to a more proactive prevention model of health factor management.</p>","PeriodicalId":15218,"journal":{"name":"Journal of Central Nervous System Disease","volume":"17 ","pages":"11795735251337605"},"PeriodicalIF":2.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiomics from Alzheimer's Brains and Mesenchymal Stem Cell-Derived Extracellular Vesicles Identifies Therapeutic Potential of Specific Subpopulations to Target Mitochondrial Proteostasis.","authors":"Morteza Abyadeh, Alaattin Kaya","doi":"10.1177/11795735251336302","DOIUrl":"https://doi.org/10.1177/11795735251336302","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) is characterized by complex molecular alterations that complicate its pathogenesis and contribute to the lack of effective treatments. Mesenchymal stem cell-derived extracellular vesicles (EVs) have shown promise in AD models, but results across different EV subpopulations remain inconsistent.</p><p><strong>Objectives: </strong>This study investigates proteomic and transcriptomic data from publicly available postmortem AD brain datasets to identify molecular changes at both the gene and protein levels. These findings are then compared with the proteomes of various EV subpopulations, differing in size and distribution, to determine the most promising subtype for compensating molecular degeneration in AD.</p><p><strong>Design: </strong>We conducted a comprehensive analysis of 788 brain samples, including 481 AD cases and 307 healthy controls, examining protein and mRNA levels to uncover AD-associated molecular changes. These findings were then compared with the proteomes of different EV subpopulations to identify potential therapeutic candidates.</p><p><strong>Methods: </strong>A multi-omics approach was employed, integrating proteomic and transcriptomic data analysis, miRNA and transcription factor profiling, protein-protein network construction, hub gene identification, and enrichment analyses. This approach aimed to explore molecular changes in AD brains and pinpoint the most relevant EV subpopulations for therapeutic intervention.</p><p><strong>Results: </strong>We identified common alterations in the cAMP signaling pathway and coagulation cascade at both the protein and mRNA levels. Distinct changes in energy metabolism were observed at the protein level but not at the mRNA level. A specific EV subtype, characterized by a broader size distribution obtained through high-speed centrifugation, was identified as capable of compensating for dysregulated mitochondrial proteostasis in AD brains. Network biology analyses further highlighted potential regulators of key therapeutic proteins within this EV subtype.</p><p><strong>Conclusion: </strong>This study underscores the critical role of proteomic alterations in AD and identifies a promising EV subpopulation, enriched with proteins targeting mitochondrial proteostasis, as a potential therapeutic strategy for AD.</p>","PeriodicalId":15218,"journal":{"name":"Journal of Central Nervous System Disease","volume":"17 ","pages":"11795735251336302"},"PeriodicalIF":2.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unleashing the potential: 40 Hz multisensory stimulation therapy for cognitive impairment.","authors":"Xiao Chen, Zhongyue Lv, Guomin Xie, Cui Zhao, Yan Zhou, Fan Fu, Jiayi Li, Xiaoling Zhang, Feiteng Qi, Yifei Xu, Yifu Chen","doi":"10.1177/11795735251328029","DOIUrl":"10.1177/11795735251328029","url":null,"abstract":"<p><p>Cognitive impairment encompasses a spectrum of disorders marked by acquired deficits in cognitive function, potentially leading to diminished daily functioning and work capacity, often accompanied by psychiatric and behavioral disturbances. Alzheimer's disease (AD) and Post-stroke cognitive impairment (PSCI) are significant causes of cognitive decline. With the global population getting older, AD and PSCI are becoming major health concerns, underscoring the critical necessity for successful treatment options. In recent years, various non-invasive biophysical stimulation techniques, including ultrasound, light, electric, and magnetic stimulation, have been developed for the treatment of central nervous system diseases. Preliminary clinical studies have demonstrated the feasibility and safety of these techniques. This review discuss the impact of 40 Hz multisensory stimulation on cerebral function, behavioral outcomes, and disease progression in both animal models and individuals exhibiting cognitive deficits, such as AD and PSCI. Furthermore, it summarizes the potential neural pathways involved in this therapeutic modality by synthesizing evidence from a variety of studies within the field. Subsequently, it evaluates the existing constraints of this technique and underscores the potential advantages of 40 Hz multisensory stimulation therapy for individuals with cognitive deficits, with the goal of enhancing the management and care of AD and PSCI.</p>","PeriodicalId":15218,"journal":{"name":"Journal of Central Nervous System Disease","volume":"17 ","pages":"11795735251328029"},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}