Journal of Cardiovascular and Thoracic Research最新文献

{"title":"Reduction of maximal false lumen area ratio by interactive cannulation perfusion in DeBakey type I acute aortic dissection repair.","authors":"Qin Jiang, Shanshan Lin, Xiaoxiao Gou, Tao Yu, Keli Huang, Shengshou Hu","doi":"10.34172/jcvtr.025.33215","DOIUrl":"10.34172/jcvtr.025.33215","url":null,"abstract":"<p><strong>Introduction: </strong>Acknowledging lacking of recognition on postoperative aortic remodeling by intraoperative transition of cannulation perfusion mode during the open repair surgery of DeBakey type I acute aortic dissection (AAD), this study aims to investigate the effect of interactive cannulation strategy on the maximum false lumen area (MFLA) ratio.</p><p><strong>Methods: </strong>A total of 321 AAD patients were retrospectively reviewed from March 2017 to March 2023, of which 166 patients receiving peripheral cannulation (PC, right axillary and femoral artery) and 155 patients receiving peripheral-to-centric cannulation (PCC, transition from right axillary and femoral artery to one branch of the tetrafurcated graft). The primary outcome was postoperative MFLA ratio in descending thoracic aorta. Secondary outcomes were postoperative inflammation response and anaerobic metabolism, hepatorenal dysfunction, and the ostium condition of branch artery of abdominal aorta involved by false lumen.</p><p><strong>Results: </strong>There was a lower postoperative MFLA ratio in PCC group than that in PC group, respectively (0.36±0.11 vs. 0.44±0.13, <i>P</i><0.001). The abdominal branch arteries involved by false lumen was also deceased in PCC group. There was also a lower serum inflammation response (24 hours, hr-CRP: 111.8±14.1mg/L vs. 116.8±15.0mg/L, <i>P</i>=0.002; IL-6: 104.4±49.9pg/ml vs. 124.0±50.1pg/ml, <i>P</i><0.001), anaerobic metabolism (8 hours, lactate: 8.3±1.5mmol/L vs. 8.8±1.6mmol/L, <i>P</i>=0.002), impaired liver function (15.5% vs. 39.8%, <i>P</i><0.001) and need for renal replacement therapy (10.3% vs. 20.5%, <i>P</i>=0.012) in PCC group than those in PC group.</p><p><strong>Conclusion: </strong>Interactive cannulation with prompt transition from peripheral artery to centric perfusion during surgical repair of AAD was associated with the reduction of MFLA and hepatorenal dysfunction.</p>","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"17 2","pages":"121-127"},"PeriodicalIF":0.7,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of neutrophil gelatinase-associated lipocalin (NGAL) levels as a biomarker for the early diagnosis of heart failure patients without of kidney disease.","authors":"Anahita Asadolahi Mashhadian, Hashem Nayeri, Ziba Rezvani Sichani","doi":"10.34172/jcvtr.025.33007","DOIUrl":"10.34172/jcvtr.025.33007","url":null,"abstract":"<p><strong>Introduction: </strong>Neutrophil Gelatinase-Associated Lipocalin (NGAL) is a specific early diagnostic biomarker for acute kidney injury and has shown high diagnostic value across various types of injuries with different etiologies. However, its role in heart failure (HF) diagnosis remains under investigation. This study aims to assess NGAL levels as a potential biomarker for the early detection of HF in patients without of kidney disease.</p><p><strong>Methods: </strong>A total of 118 participants were enrolled from Shahid Ashrafi and Saei Khomeini Hospitals, including 59 patients with HF and 59 healthy controls. The patients was 48 years, while the healthy controls had an average age of 46 years. The patient group was diagnosed with heart failure with reduced ejection fraction (HFREF, EF<40%) and had no history of kidney disease. After providing written informed consent, they were enrolled in the study: (code IR.IAU. FALA.REC.1397.024). Blood samples were collected from all participants to measure BUN (Blood Urea Nitrogen), creatinine, cardiac troponin I (CTNI), C-reactive protein (CRP), NGAL, and white blood cell (WBC) count.</p><p><strong>Results: </strong>The results revealed significantly higher serum levels of NGAL, CRP, CTNI, CR, and BUN in the patient group compared to healthy controls. A significant relationship was found between these biomarkers and the incidence of HF in individuals without prior kidney disease (<i>P</i> value<0.001).</p><p><strong>Conclusion: </strong>In conclusion, NGAL can be used to accurately predict the presence of HF without a history of kidney disease of cases, suggesting its potential as an early diagnostic tool for HF in such patients.</p>","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"17 2","pages":"91-96"},"PeriodicalIF":0.7,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An integrated bioinformatics approach for identification of key modulators and biomarkers involved in atrial fibrillation.","authors":"Summan Thahiem, Ayesha Ishtiaq, Faisal Iftekhar, Muhammad Ishtiaq Jan, Iram Murtaza","doi":"10.34172/jcvtr.025.33347","DOIUrl":"10.34172/jcvtr.025.33347","url":null,"abstract":"<p><strong>Introduction: </strong>Atrial fibrillation (AFib) is a sustained form of cardiac arrythmia that occurs due to sympathetic overdrive, neurohumoral and electrophysiological changes. Sympatho-renal modulatory approach via miRNA-based therapeutics is likely to be an important treatment option for AFib. The study was aimed to unravel the common miRNAs as therapeutic targets involved in sympatho- renovascular axis to combat AFib.</p><p><strong>Methods: </strong>We employed the bioinformatics approach to discover differentially expressed genes (DEGs) from microarray gene expression datasets GSE41177 and GSE79768 of AFib patients. Concomitantly, genes associated with sympathetic cardio-renal axis, from Genetic Testing Registry (GTR) of National Center for Biotechnology Information (NCBI) were also analyzed. Overlapping miRNAs that target the maximum number of genes across all three pathological conditions perpetuating AFib were shortlisted. To confirm the reliability of the identified miRNAs, differential expression analysis was performed on miRNA expression profiles GSE190898, GSE68475, GSE70887 and GSE28954 derived from AFib patient samples.</p><p><strong>Results: </strong>ShinyGO analysis revealed enrichment in beta-adrenergic signaling, calcium signaling, as well as G protein-coupled receptor (GPCR) signaling involved in post synaptic membrane potential. The intersection of top 10 modules in miRNA-mRNA network revealed hub miRNAs having highest node degree, maximum neighborhood component (MNC), and maximal clique centrality (MCC) scores. Differential expression analysis revealed hub miRNAs identified through integrated approach were found to be significantly dysregulated in AFib patients.</p><p><strong>Conclusion: </strong>This integrated approach identified 6 hub miRNAs, 4 reported (miR-101-3p, miR-23-3p, miR-27-3p, miR-25-3p) and 2 novel (miR-32-5p, miR-92-3p) miRNAs that might act as putative biomarkers for AFib.</p>","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"17 2","pages":"109-120"},"PeriodicalIF":0.7,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of isolated coronary artery bypass graft on moderate functional mitral regurgitation.","authors":"Hakimeh Sadeghian, Babak Oloomi, Seyed Hossein Ahmadi Tafti, Akbar Shafiee, Arash Jalali, Mohammad Amin Masoumi","doi":"10.34172/jcvtr.025.33277","DOIUrl":"10.34172/jcvtr.025.33277","url":null,"abstract":"<p><strong>Introduction: </strong>The natural course and clinical significance of moderate mitral regurgitation (MR) in patients undergoing isolated coronary artery bypass graft (CABG) surgery are still debated. This study aimed to determine the course of moderate functional MR after CABG.</p><p><strong>Methods: </strong>In this registry-based cohort, patients who underwent isolated elective CABG at Tehran Heart Center between 2010 and 2017 were included. Transthoracic echocardiography was performed at baseline before CABG and after 12 months of follow-up. The outcomes of interest were both improvement and progression of MR during the study.</p><p><strong>Results: </strong>Among 291 patients with moderate functional MR, the mean age was 66.1±9.6 years, and 204 (70.1%) were males. Most of the study population had extensive coronary disease (240 patients; 82.5% with thee-vessel disease). Moreover, 101 patients (34.7%) had suffered a prior myocardial infarction. The mean LVEF before CABG was 42.0±9.9 and 145 patients (49.8%) had an LVEF≤40% prior to surgery.The median follow-up duration was 10.1 months (9.0-11.2). Only four patients had improvements in MR at follow-up. Eleven patients (3.8%) in the study population showed worsening MR after isolated CABG. In this group of patients, mean LVEF dropped from 44.1±10.9 at baseline to 41.8±11.5 during follow-up Due to the low number of cases with regression and progression, an analysis of predictors of MR change was not performed.</p><p><strong>Conclusion: </strong>This study showed that in patients with moderate functional MR, isolated CABG did not result in significant changes in the degree of MR.</p>","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"17 2","pages":"133-138"},"PeriodicalIF":0.7,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is peres formula reliable for determination of proper position of central venous catheter tip in Iranian population?","authors":"Maryam Ghanbari Garekani, Amirhossein Poopak, Hamidreza Pouraliakbar, Arash Barghi, Razieh Omidvar, Ziae Totonchi","doi":"10.34172/jcvtr.025.33436","DOIUrl":"10.34172/jcvtr.025.33436","url":null,"abstract":"<p><strong>Introduction: </strong>Accurate positioning of central venous catheter (CVC) tips is essential to minimize complications such as arrhythmias, thrombosis, or cardiac tamponade.</p><p><strong>Methods: </strong>This study evaluated the reliability of the Peres formula, which estimates CVC tip placement based on patient height, within an Iranian population. A cross-sectional analysis of 100 patients undergoing cardiac surgery revealed that the Peres formula often resulted in incorrect CVC positioning, necessitating radiographic confirmation and post-insertion adjustments.</p><p><strong>Results: </strong>The mean deviation of CVC tip placement from the ideal position near the carina was 5.13±0.78 cm. Correlation analysis highlighted significant associations between the deviation and demographic factors, including height and body mass index (BMI), suggesting the need for population-specific adjustments to the Peres formula.</p><p><strong>Conclusion: </strong>These findings underscore the importance of tailored approaches to CVC placement to account for anatomical and physiological differences, emphasizing the need for modified guidelines for the Iranian population to enhance safety and accuracy in clinical practice due to the fact that Peres formula is not suitable for Iranian population.</p>","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"17 2","pages":"97-101"},"PeriodicalIF":0.7,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and surgical outcomes following cardiac myxoma resection.","authors":"Nootan Hadiya, Madhur Kumar, Rimy Parshad, Poorna Chandar, Anubhav Gupta","doi":"10.34172/jcvtr.025.33237","DOIUrl":"10.34172/jcvtr.025.33237","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiac myxomas are the most common primary cardiac neoplasm (30-50%) with clinical incident of 0.5/ million population. Tranthoracic echocardiography remains the investigation of choice. Surgical excision is curative. The present study aims to analyze demographic and clinical characteristics as well as surgical outcomes in terms of mortality and recurrence of cardiac myxoma.</p><p><strong>Methods: </strong>Thirty patients of cardiac myxoma who met the inclusion criteria during study period study period, January-2018 to April-2024 were included. Data was analyzed for demographic characteristics, echocardiographic findings of myxoma and associated valve lesion, associated valve surgery and survival outcome.</p><p><strong>Results: </strong>Of all subjects, 83.33% presented with dyspnea. Majority of myxoma, 76.67% were attached to interatrial septum. Overall survival at 1- and 3- year was 91.23%. Recurrence free survival at 1-, 3- years and end of this study were 100%, 84.71% and 84.71% respectively. Myxomas with valvular incompetence are rare entity and there is paucity of data and evidences recommending concomitant valve intervention in such cases. There were no immediate peri-operative deaths, however, in contrast to other studies; surgical site infection was the most common post operative complication. Overall survival at 1- and 3- year was 91.23%. Recurrence free survival at 1-, 3- years and end of this study were 100%, 84.71% and 84.71% respectively. Recurrence occurred in first- and third-year following surgery.</p><p><strong>Conclusion: </strong>Study highlights decent outcomes following cardiac myxoma resection. Case specific concomitant valve intervention spiral the success of surgery.</p>","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"17 1","pages":"35-39"},"PeriodicalIF":1.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between serum uric acid levels and the cardiometabolic phenotype among healthcare workers of Tabriz University of Medical Sciences.","authors":"Mohammadhossein Somi, Negin Frounchi, Seyed Sina Zakavi, Alireza Ostadrahimi, Neda Gilani, Elnaz Faramarzi, Sarvin Sanaie","doi":"10.34172/jcvtr.32902","DOIUrl":"10.34172/jcvtr.32902","url":null,"abstract":"<p><strong>Introduction: </strong>It is unclear whether hyperuricemia can be considered as an independent risk factor or just as a marker to represent the correlation between uric acid levels and other risk factors of MetS. In this work, we intend to study the correlation between serum uric acid (SUA) and the cardiometabolic phenotype among Tabriz University of Medical Science healthcare workers.</p><p><strong>Methods: </strong>In this cross-sectional study, anthropometric measurements, serum fasting blood sugar (FBS), triglyceride (TG), cholesterol, high-density lipoprotein (HDL), liver enzymes, blood urea nitrogen (BUN), SUA, creatinine (Cr), and blood pressures of 1,451 healthcare workers were evaluated. MetS was diagnosed based on ATP III. We classified the participants into four cardiometabolic phenotypes: metabolically-healthy lean (MHL), metabolically-unhealthy lean (MUHL), metabolically-healthy obese (MHO), and metabolically-unhealthy obese (MUHO).</p><p><strong>Results: </strong>MHL (26.6%) and MHO (65.8 %) had the highest prevalence rates in the first and second SUA categories, respectively (<i>P</i>≤0.001). Compared to the lowest SUA category, the odds of MHO and MUHO increased by 3.13 (95% CI 2.21-4.44) and 5.50 (95%CI 3.53-8.57) in the highest category, respectively. This trend was not observed regarding the association between MUHL and the SUA classification.</p><p><strong>Conclusion: </strong>We propose using the easily-measured SUA level as a marker for early diagnosis of at-risk MUHL and MHO individuals to administer proper interventions. Further prospective studies are needed to identify the effects of SUA on the progression of MetS in various body-size subgroups.</p>","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"17 1","pages":"40-48"},"PeriodicalIF":1.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relation of giant right atrial mass and thrombocytopenia; Recovery with surgery.","authors":"Roghayeh Pourkia, Sadegh Sedaghat, Hamid Reza Vafaei, Seyed Sina Taheri Otaghsare","doi":"10.34172/jcvtr.025.32978","DOIUrl":"10.34172/jcvtr.025.32978","url":null,"abstract":"<p><p>As we know, cardiac myxoma is one of the most primary cardiac masses but laboratory findings in this type of tumor is non-specific and the diagnosis is by imaging. In this case we have reported a 61 year old man came to the emergency ward of hospital with history of recent onset dyspnea and The Laboratory finding indicates polycythemia with thrombocytopenia. Ultrasonography of abdomen and bone marrow aspiration and biopsy revealed no significant diagnosis but on echocardiography a large sized mass was detected in right atrium. After cardiologist and cardiac surgeon consultation the plan was to surgical Excision and after that the thrombocytopenia has been resolved. In this case report we want to write about a rare correlation between cardiac myxoma and thrombocytopenia and show that early diagnosis and treatment of the disease can help and totally cure complaints of patient.</p>","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"17 1","pages":"70-73"},"PeriodicalIF":1.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Nigella sativa on VCAM-1 and ICAM-1: A systematic review of preclinical and clinical studies.","authors":"Zeinab Faghfoori, Zeinab Javadivala, Aida Malek Mahdavi","doi":"10.34172/jcvtr.025.33343","DOIUrl":"10.34172/jcvtr.025.33343","url":null,"abstract":"<p><p>The objective of present review was to assess all studies about effect of <i>Nigella sativa</i> (<i>N. sativa</i>) on vascular cell and intercellular adhesion molecules-1 (VCAM-1 and ICAM-1) under different situations. Search was performed until May 2024 using Scopus, PubMed, Web of Science, and Google Scholar databases without any restriction and alert services were utilized following the primary search. The references cited in related papers were also evaluated. Nineteen studies including human (n=4), animal (n=11), and <i>in vitro</i> (n=4) were eligible. All <i>in vitro</i> and majority of animal researches were indicative of the favorable effects of <i>N. sativa</i> and thymoquinone in attenuating VCAM-1 and ICAM-1 levels; however, three animal studies did not show any significant effect. Results of clinical trials were conflicting. In two clinical trials, supplementation with <i>N. sativa</i> oil and <i>N. sativa</i> powder led to significant reduction in VCAM-1 levels in coronary artery disease (CAD) and Hashimoto's thyroiditis patients, whereas no significant change occurred according to the other clinical trial involving subjects with the risk factor for cardiovascular disease (CVD). Furthermore, significant reduction in ICAM-1 levels occurred after <i>N. sativa</i> oil consumption in two clinical trials involving type 2 diabetic and CAD patients, whilst no significant change was noticed in subjects with the risk factor for CVD and Hashimoto's thyroiditis patients. <i>N. sativa</i> seems beneficial in attenuating VCAM-1 and ICAM-1 levels under different situations; however, additional long-term controlled clinical trials are needed for making concise conclusions about the effect of <i>N. sativa</i> on endothelial dysfunction related biomarkers.</p>","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"17 1","pages":"12-19"},"PeriodicalIF":1.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline characteristics and seven-year follow-up of patients with coronary slow flow: A cohort study in northeastern Iran.","authors":"Farima Farsi, Negar Morovatdar, Ali Eshraghi","doi":"10.34172/jcvtr.33167","DOIUrl":"10.34172/jcvtr.33167","url":null,"abstract":"<p><strong>Introduction: </strong>An angiographic finding known as \"coronary slow flow phenomenon\" (CSFP) occurs when there is no discernible stenosis but the contrast flow is slower than usual. Although the prognosis for the majority of CSFP cases is favorable, frequent angina significantly lowers their quality of life. Therefore, this study aimed to explore the potential contributing risk factors and prognostic implications of CSFP on long-term cardiovascular outcomes.</p><p><strong>Methods: </strong>This retrospective, cohort study was conducted between years 2014-2022 and included a total of 65 CSFP patients and 65 controls with normal coronary flow, as evidenced by coronary angiography. These two groups were examined in terms of future cardiovascular consequences due to this phenomenon, baseline demographic characteristics, and laboratory findings. A <i>P</i> value<0.05 was considered significant.</p><p><strong>Results: </strong>In this study 130 people including 73 men and 57 women, who because of the typical chest pain and at least a noninvasive test took angiography, were explored. The median triglyceride (200.80±48.51 vs 131.79±34.22, <i>P</i><0.001), total cholesterol (189.46±10.84 vs 103.43±8.13, <i>P</i><0.001), and low-density lipoprotein (153.28±34.28 vs 103.34±19.70, <i>P</i>=0.01) were significantly higher in the affected people. During clinical follow-up, a higher number of major adverse cardiac events (8.97±2.95 vs 4.52±2.12, <i>P</i><0.001) was observed in the CSFP cases. Moreover, a one-unit increase in body mass index raised the probability of adverse cardiac events by 0.912 in CSFP cases.</p><p><strong>Conclusion: </strong>Our research indicated that individuals with CSFP were more likely to develop cardiac events including unstable angina. Furthermore, obesity and dyslipidemia could provoke this phenomenon.</p>","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"17 1","pages":"20-26"},"PeriodicalIF":1.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}