Polymorphism of rs599839 in the PSRC1 gene is associated with coronary artery disease in an Iranian population

IF 1.2 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Golnaz Houshmand, Mohammad Javad Alemzadeh-Ansari, Saeideh Mazloumzadeh, Niloofar Naderi, Maryam Pourirahim, Katayoun Heshmatzad, Majid Maleki, Samira Kalayinia
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Abstract

Introduction: Coronary artery disease (CAD) is the leading health complication worldwide because of its high prevalence and mortality. The association between CAD susceptibility and the rs599839 (C/T) polymorphism in the human proline and serine-rich coiled-coil (PSRC1) was reported in a genome-wide association study. To validate this association, we performed this case-control study to genotype the 1p13.3 (rs599839) locus in a sample of the Iranian population with CAD (stenosis≥70% in≥1 coronary artery). Methods: We performed an association analysis with PCR and Sanger sequencing of rs599839 (C/T) polymorphism and CAD risk in 280 CAD patients and 287 healthy controls defined as a coronary calcium score of zero and no noncalcified plaques in coronary computed tomography angiography. SPSS, version 16.0, was applied for statistical analysis. Results: The rs599839 (C/T) locus showed a significant association with CAD (P value<0.001). TT and CT genotypes were associated with CAD (P value<0.001). Furthermore, the dominant status (TT+CT vs. CC) was associated with an increased risk of CAD (OR, 9.14; 95% CI, 3.77 to 22.15; and P value<0.001). Conclusion: The study findings indicate strong evidence for rs599839 (C/T) association with CAD risk.
伊朗人群中PSRC1基因rs599839多态性与冠状动脉疾病相关
导语:冠状动脉疾病(CAD)是世界范围内主要的健康并发症,因为它的高患病率和死亡率。一项全基因组关联研究报道了CAD易感性与人类富含脯氨酸和丝氨酸的卷曲线圈(PSRC1)的rs599839 (C/T)多态性之间的关联。为了验证这种关联,我们对伊朗冠心病患者(≥1条冠状动脉狭窄≥70%)进行了病例对照研究,对1p13.3 (rs599839)基因座进行了分型。方法:我们对280名冠心病患者和287名健康对照进行了PCR和Sanger测序,分析了rs599839 (C/T)多态性与冠心病风险的相关性,这些健康对照被定义为冠状动脉ct血管造影中冠状动脉钙评分为零且无非钙化斑块。采用SPSS 16.0软件进行统计分析。结果:rs599839 (C/T)位点与CAD有显著相关性(P值<0.001)。TT和CT基因型与CAD相关(P值<0.001)。此外,优势地位(TT+CT vs. CC)与CAD风险增加相关(OR, 9.14;95% CI, 3.77 ~ 22.15;P值<0.001)。结论:研究结果有力地证明rs599839 (C/T)与冠心病风险相关。
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来源期刊
Journal of Cardiovascular and Thoracic Research
Journal of Cardiovascular and Thoracic Research CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
2.00
自引率
0.00%
发文量
22
审稿时长
7 weeks
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