Journal of Cardiovascular and Thoracic Research最新文献

{"title":"Concerns regarding NGAL as a biomarker for heart failure without kidney disease.","authors":"Çağrı Zorlu, Sefa Erdi Ömür","doi":"10.34172/jcvtr.026.33669","DOIUrl":"10.34172/jcvtr.026.33669","url":null,"abstract":"","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"18 1","pages":"69-70"},"PeriodicalIF":1.4,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13294611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of left ventricular strain measurements and native T1 and T2 mapping on cardiac magnetic resonance imaging in evaluating early left ventricle myocardial derangement in patients with high normal blood pressure.","authors":"Rishabh Khurana, Priya Jagia, Vineeta Ojha, Sanjeev Kumar, Ambuj Roy, Maroof Ahmed Khan, Niraj Nirmal Pandey","doi":"10.34172/jcvtr.026.33467","DOIUrl":"10.34172/jcvtr.026.33467","url":null,"abstract":"<p><strong>Introduction: </strong>The study sought to evaluate changes in left ventricular (LV) strain and native T1/T2 mapping characteristics on cardiac magnetic resonance imaging (CMR) in patients with high-normal blood pressure (HNBP).</p><p><strong>Methods: </strong>A prospective case-control study including 25 cases having HNBP and 25 age- and sex-matched healthy controls was conducted. LV strain was evaluated on CMR using feature tracking and 2-dimensional and 3-dimensional longitudinal, circumferential and radial strain values were calculated. Native T1/T2 mapping values were also calculated.</p><p><strong>Results: </strong>Subclinical impairment of LV mechanics was evident in the form of deranged LV strain parameters in cases with HNBP compared to controls. The two-dimensional global radial (25.34±3.06 vs. 28.52±5.69; <i>P</i>=0.0323), global circumferential (-16.05±1.31 vs. -17.27±2.23; <i>P</i>=0.0241) and global longitudinal strain (-16.33±2.24 vs. -16.49±7.25); <i>P</i>=0.0193) and three-dimensional global circumferential strain (-13.94±10.81 vs. -17.84±2.78; <i>P</i>=0.0133) values were significantly impaired in cases compared to controls. No significant difference was observed in the native T1/T2 mapping parameters.</p><p><strong>Conclusion: </strong>LV strain parameters are significantly deranged in patients with HNBP, compared to healthy controls, in the absence of other morphological changes or interstitial fibrosis. Impaired LV strain parameters can serve as a new marker for detection of subclinical myocardial dysfunction in patients with HNBP having preserved chamber function.</p>","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"18 1","pages":"55-61"},"PeriodicalIF":1.4,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13309326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing mitral transcatheter edge-to-edge repair and surgical intervention in mitral regurgitation: A meta-analysis.","authors":"Emídio Mata, Barbara Lage Garcia, Margarida Castro, Mariana Tinoco, Luísa Pinheiro, João Português, Francisco Ferreira, Lucy Calvo, Sílvia Ribeiro, António Lourenço","doi":"10.34172/jcvtr.026.33487","DOIUrl":"10.34172/jcvtr.026.33487","url":null,"abstract":"<p><p>Surgery remains the standard treatment for severe mitral valve regurgitation (MR), but growing evidence highlights the potential role of mitral valve percutaneous edge-to-edge repair (M-TEER). This meta-analysis aims to compare 12-month all-cause mortality between M-TEER and surgical intervention (SMVI). A systematic search (October 2024) of PubMed, Cochrane, Scopus, and Web of Science identified randomized control trials (RCTs) and propensity-matched observational studies comparing 12-month all-cause mortality in MR patients treated with M-TEER or SMVI. An inverse variance random-effects meta-analysis assessed outcomes using risk ratios (RR) and 95% confidence intervals (CI). Two RCTs (MATTERHORN and EVEREST II) and three observational studies totaling 1,782 patients, were included in the final analysis. A non-significant trend of higher mortality at 30 days was observed in the SMVI group (RR: 0.72; CI: 0.26-2.00), along with higher complication rates mainly due to bleeding. At 12 months follow-up, SMVI was associated with a significantly lower risk of all-cause mortality (RR: 1.41; CI: 1.11-1.81), while the M-TEER group had more patients with MR grade 3 or higher (RR: 4.05; CI: 1.54-10.67), with a non-significant trend of higher rate of MR reintervention (RR 2.51; CI 0.83-7.66) at 12 months. Based on current evidence, M-TEER should continue to be reserved for patients with prohibitive high surgical risk. While propensity-matched cohorts were pooled for the study estimates, the limited available data from randomized trials, combined with heterogeneity in patient populations, particularly regarding MR etiology, underscores the need for further studies.</p>","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"18 1","pages":"4-14"},"PeriodicalIF":1.4,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13309324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RNA therapeutics: A promising therapy for future cardiology.","authors":"Samad Ghaffari, Taher Entezari-Maleki","doi":"10.34172/jcvtr.026.33867","DOIUrl":"10.34172/jcvtr.026.33867","url":null,"abstract":"","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"18 1","pages":"1-3"},"PeriodicalIF":1.4,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13287957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148317320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACE/ACE2 axis in cardiovascular disease and COVID-19: Molecular insights and therapeutic perspectives.","authors":"Sony Peter, Thiruchenduran Mohana, Dhanavel Anandhi, Vishwanathan Sathya Priya, Romi Keerikkattil Sleeba, Harisree Panikkaveedu Haridas, Midhun Thazhissery Mohanan, Swathi Thoduvayil, Sinha Mathew, Dhanya Muraleedharan Santhamma, Dinesh Roy Divakaran","doi":"10.34172/jcvtr.026.33335","DOIUrl":"10.34172/jcvtr.026.33335","url":null,"abstract":"<p><p>The renin-angiotensin system (RAS) plays a central role in regulating blood pressure and cardiovascular health. Angiotensin-converting enzyme (ACE) facilitates the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor that contributes to hypertension and heart failure. Conversely, ACE2 converts angiotensin II into angiotensin-(1-7), a vasodilator with protective cardiovascular effects. An imbalance between ACE and ACE2 activities has been increasingly associated with the progression of cardiovascular diseases and complications related to COVID-19. This review analyzed 100 relevant studies published up to May 2024, identified through a comprehensive literature search on PubMed and Scopus. The findings highlighted that dysregulation of the ACE/ACE2 axis exacerbates cardiovascular dysfunction. The interaction of SARS-CoV-2 with ACE2 reduces its protective function, intensifying inflammatory responses and leading to complications such as lung injury and heart failure. Additionally, genetic polymorphisms in ACE and ACE2 influence individual susceptibility and severity of COVID-19. Promising therapeutic strategies, including ACE2-based peptides and angiotensin II receptor modulators, are under investigation but require further clinical validation. Targeting the ACE/ACE2 axis could provide effective treatment options for cardiovascular disease and COVID-19-related complications, warranting further in-depth research.</p>","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"18 1","pages":"15-25"},"PeriodicalIF":1.4,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13309327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ruptured mitral valve aneurysm in a patient with immunodeficiency and chronic renal failure.","authors":"Mustafa Kamil Yemis, Saadet Guven, Ozgur Can Usta, Ahmet Oz, Turgut Karabag","doi":"10.34172/jcvtr.026.33214","DOIUrl":"10.34172/jcvtr.026.33214","url":null,"abstract":"<p><p>Mitral valve aneurysm; defined as a bulge of the mitral valve leaflet toward the left atrium is a rare abnormality whose pathophysiology is poorly understood. The weakened aneurysmal wall may rupture and may cause severe mitral regurgitation and life-threatining conditions. In this case report we present a case of mitral anterior leaflet aneurysm rupture in a patient with immun deficiency and chronic renal failure.</p>","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"18 1","pages":"66-68"},"PeriodicalIF":1.4,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13309331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated asprosin levels in epicardial adipose tissue: Implications for coronary artery disease.","authors":"Hossein Shateri, Babak Manafi, Amir Hossein Yazdi, Sayed Mostafa Hosseini","doi":"10.34172/jcvtr.026.33554","DOIUrl":"10.34172/jcvtr.026.33554","url":null,"abstract":"<p><strong>Introduction: </strong>This study investigates the role of the adipokine asprosin in coronary artery disease (CAD) by comparing its levels in epicardial adipose tissue (EAT) and serum between individuals with and without CAD. Asprosin is known to be involved in conditions such as insulin resistance and obesity, both of which are risk factors for CAD.</p><p><strong>Methods: </strong>The study included 25 CAD patients and 25 non-CAD patients undergoing open-heart surgery for valve issues. EAT samples were collected during surgery, and the mRNA levels of the FBN-1 gene were measured using qRT-PCR, while the protein levels of asprosin in both EAT and serum were determined using the ELISA method.</p><p><strong>Results: </strong>The results showed that the mRNA level of FBN-1 in the EAT of CAD patients was significantly higher than that in the control group (<i>P</i><0.001). Additionally, asprosin protein levels were significantly elevated in both the EAT (<i>P</i><0.003) and serum (<i>P</i><0.027) of CAD patients compared to non-CAD individuals.</p><p><strong>Conclusion: </strong>These findings suggest that asprosin may play a critical role in the pathogenesis of CAD, particularly through its increased presence in EAT and serum. The study highlights the potential of asprosin as a biomarker for CAD, though further research is needed to fully understand its mechanisms in the progression of the disease.</p>","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"18 1","pages":"32-37"},"PeriodicalIF":1.4,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13309332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mid-term outcomes associated with thoracic endovascular aortic repair and differences in outcomes for thoracic aortic aneurysms versus type B aortic dissections.","authors":"Taiwo Dodo-Williams, Daniel Willie-Permor, Shima Rahgozar, Isaac Naazie, Kevin Yei, Mahmoud B Malas","doi":"10.34172/jcvtr.026.33435","DOIUrl":"10.34172/jcvtr.026.33435","url":null,"abstract":"<p><strong>Introduction: </strong>Thoracic endovascular aortic repair (TEVAR) has become the preferred treatment modality of thoracic aortic pathologies. Since survival outcomes are influenced by disease acuity and pathology, we aim to compare mid-term outcomes of TEVAR in the management of thoracic aortic aneurysms (TAA) vs. Stanford type-B aortic dissections (TBAD).</p><p><strong>Methods: </strong>Patients undergoing TEVAR (2010-2019) in the Vascular Quality Initiative-Medicare-linked database were included in this analysis. Patients were divided into two groups: TAA and TBAD. Postoperative outcomes included 30-day mortality, stroke, myocardial infarction (MI), and spinal cord ischemia (SCI). Mid-term outcomes included 1 and 2-year all-cause mortality, reintervention and rupture.</p><p><strong>Results: </strong>Of the 2105 patients undergoing TEVAR in this analysis, 1,492 (70.9%) had TAA while 613 (29.1%) had TBAD. The TBAD group had a significantly lower 30-day mortality (aOR:0.67,95%Cl:0.46-0.98,<i>P</i>=0.037), lower 1-year mortality (aHR:0.72,95%CI:0.57-0.90, <i>P</i>=0.004) and also at 2 years (aHR:0.79,95%CI:0.65-0.95, <i>P</i>=0.013). Within 1 year, patients with TBAD had a significantly higher incidence of aneurysm related reintervention (18.8% vs. 12.9%, <i>P</i>=0.003). This finding persisted at 2 years (24.9% vs. 19.7%, <i>P</i><0.001). There was no significant difference in rupture between groups at 2 years (4.1% vs. 3.4%, <i>P</i>=0.40).</p><p><strong>Conclusion: </strong>In this large multi-institutional study, patients undergoing TEVAR for TBAD had significantly lower postoperative mortality but a higher risk of reintervention at one and two years compared to patients with TAA. Additionally, both groups demonstrated a similar risk of rupture at both 1 and 2 years post-TEVAR. The rate of post-TEVAR rupture in both groups underscore the need for careful follow-up and reintervention as needed to maintain the integrity of the repair.</p>","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"18 1","pages":"38-45"},"PeriodicalIF":1.4,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13309325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring cardiovascular risk in subclinical hypothyroidism: The impact of TSHR gene expression and systemic biomarkers.","authors":"Manjusha Kottola, Desigamani Kanniyappan, Damodaran Boopathi, Jeyapal Vidhyadharan, Vishnu Manjerikattil Govindan, Vineetha Vijayan, Joby Paruthiparayil Jose, Jisha Anjali Madhavan Pillai, Rajitha Puthiya Purayil, Swathi Thoduvayil, Midhun Thazhissery Mohanan, Dinesh Roy Divakaran","doi":"10.34172/jcvtr.026.33666","DOIUrl":"10.34172/jcvtr.026.33666","url":null,"abstract":"<p><strong>Introduction: </strong>Subclinical hypothyroidism (SCH), defined by elevated thyroid-stimulating hormone (TSH) with normal thyroid hormone levels, affects approximately 3-8% of the population. Growing evidence indicates that thyroid-stimulating hormone receptor (TSHR) expression in cardiovascular tissues, together with systemic inflammation (IL-6) and oxidative stress (3-nitrotyrosine), may contribute to cardiovascular dysfunction in SCH. This study aimed to evaluate the association between TSHR gene expression and systemic biomarkers-hormonal, inflammatory, and oxidative-and to assess their predictive value for cardiovascular risk in SCH patients.</p><p><strong>Methods: </strong>A case-control design was adopted involving 150 SCH subjects and 150 age- and sex-matched healthy controls. Demographic and clinical data were collected using structured interviews. Fasting blood samples were analyzed for TSH (CLIA), IL-6, and 3-nitrotyrosine (ELISA), while TSHR gene expression was quantified using real-time PCR with GAPDH as an internal control. Statistical analyses were performed using Stata version 17.0.</p><p><strong>Results: </strong>Compared with controls, SCH patients showed significantly higher levels of TSH, IL-6, 3-nitrotyrosine, and TSHR gene expression (<i>P</i><0.05). Receiver operating characteristic (ROC) analysis revealed high diagnostic accuracy for these parameters. Although univariate analysis associated TSHR dysregulation with SCH, multivariate regression identified TSH as the only independent predictor of disease status. Oxidative stress demonstrated a significant positive association with TSHR expression, whereas IL-6 showed no independent influence.</p><p><strong>Conclusion: </strong>SCH is characterized by elevated hormonal, oxidative, and inflammatory markers, with oxidative stress contributing to TSHR upregulation. TSH remains the strongest independent predictor, underscoring the hormonal-oxidative interaction in cardiovascular risk among SCH patients.</p>","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"18 1","pages":"46-54"},"PeriodicalIF":1.4,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13309705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of spectral CT in coil embolization treatment of bronchial artery aneurysm: A case report.","authors":"Shanshan Zhang, Tao Hu, Langzhou Fu, Longyu Duan","doi":"10.34172/jcvtr.026.33417","DOIUrl":"10.34172/jcvtr.026.33417","url":null,"abstract":"<p><p>We report a case of a bronchial artery aneurysm accompanied by a bronchial artery to pulmonary artery fistula in which only coil embolization was performed. Post-embolization, the majority of patients face significant metal artifacts from stents or coils during routine CT scans, which can compromise the visibility of the images. In this case, we conducted a spectral CT scan with metal artifact reduction technology postoperatively to clearly visualize the coils and accurately evaluate the treatment's effectiveness.</p>","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"18 1","pages":"62-65"},"PeriodicalIF":1.4,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13380537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}