Journal of Cardiac Failure最新文献

{"title":"Into the Fick of It: Cardiac Output Assessment in Patients With Left Ventricular Assist Devices.","authors":"Cole J Buchanan, Brian Brian A Houston, Mark N Belkin","doi":"10.1016/j.cardfail.2026.08.024","DOIUrl":"10.1016/j.cardfail.2026.08.024","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Determinants of Health and Heart Failure Outcomes: Nuance and Complexity.","authors":"Megan Thomas Hebdon, Khadijah Breathett","doi":"10.1016/j.cardfail.2026.08.027","DOIUrl":"10.1016/j.cardfail.2026.08.027","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recovering Differently: Rethinking Primary Graft Dysfunction and Recovery Trajectory Across a Diversifying Donor Pool.","authors":"Lauren East, Nitheesha Ganta, Shelley Hall, Aditi Nayak","doi":"10.1016/j.cardfail.2026.08.026","DOIUrl":"10.1016/j.cardfail.2026.08.026","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When the Gradient Falls, Do Symptoms Follow? Understanding the impact of Myosin Inhibitors on Patient Reported Outcomes.","authors":"Meaghan O'Hara, Christopher Sciamanna, Gene H Kim, Nikhil Narang","doi":"10.1016/j.cardfail.2026.08.025","DOIUrl":"10.1016/j.cardfail.2026.08.025","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body Composition in Heart Failure: A Phenotype-Informed Framework for Assessment and Management.","authors":"Camilla C S VAN DER Hoef, Jozine M Ter Maaten, Laura M G Meems, Thomas M Gorter, Jasper Tromp, Dirk J VAN Veldhuisen, Adriaan A Voors","doi":"10.1016/j.cardfail.2026.08.018","DOIUrl":"10.1016/j.cardfail.2026.08.018","url":null,"abstract":"<p><p>Body mass index (BMI) and waist-based anthropometric indices are widely used to estimate adiposity and cardiometabolic risk. Yet in established heart failure (HF), modestly higher BMI is associated with improved survival, while waist-based measures show a linear association with worse outcomes. This apparent discrepancy suggests that the biological interpretation of BMI and body composition changes once HF develops. In HF, BMI reflects the composite of adipose tissue, fluid accumulation, and skeletal muscle wasting, whereas waist-based indices reflect primarily central adiposity. In this narrative review, we explore the challenges of body-composition interpretation in HF and propose a conceptual, phenotype-informed framework for body-composition assessment and management. Within this framework, BMI may mask biologically distinct, yet clinically relevant phenotypes, as defined by adiposity, congestion, and skeletal-muscle integrity. By integrating these interacting components, the framework highlights that similar BMI values may represent biologically distinct phenotypes with different risk profiles and potential management implications. Across BMI categories, preserved muscle mass and limited congestion are associated with more favorable outcomes, whereas central adiposity, congestion, and muscle wasting identify higher-risk states. This conceptual framework provides a foundation for future research and may ultimately inform more individualized body-composition assessment, risk stratification, and management of patients with HF.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Dipeptidyl Peptidase 3 Levels, an Antagonist of Angiotensin-(1-7), in Acute Heart Failure: Insights From the Pragmatic Urinary Sodium-based treatment algoritHm in Acute Heart Failure (PUSH-AHF) trial.","authors":"Stijn Legtenberg, Karine Santos, Iris E Beldhuis, Oliver Hartmann, Lara E E C Zonneveld, Peter VAN DER Meer, Jan A Krikken, Wybe Nieuwland, Dirk J VAN Veldhuisen, Adriaan A Voors, Kevin Damman, Jozine M Ter Maaten","doi":"10.1016/j.cardfail.2026.08.019","DOIUrl":"10.1016/j.cardfail.2026.08.019","url":null,"abstract":"<p><strong>Background: </strong>Angiotensin-(1-7) promotes vasodilation and counteracts angiotensin II in the vasculature and kidneys, whereas dipeptidyl peptidase 3 (DPP3) inactivates angiotensin-(1-7) . Although circulating DPP3 (cDPP3) has been studied in chronic heart failure (HF), data in acute HF are limited. We evaluated cDPP3 levels and their association with clinical characteristics, decongestive response, and outcomes in acute HF.</p><p><strong>Methods: </strong>We analyzed patients enrolled in the randomized Pragmatic Urinary Sodium-based treatment algoritHm in Acute Heart Failure (PUSH-AHF) trial comparing natriuresis-guided diuretic therapy with standard of care in acute HF. cDPP3 levels were measured at baseline; at 24, 48 and 72 hours; and at discharge. Associations between cDPP3 levels, clinical characteristics, 24-hour natriuresis, and the combined endpoint of 180-day all-cause mortality or HF hospitalization were assessed. We also evaluated whether diuretic treatment strategy modified these associations.</p><p><strong>Results: </strong>Baseline cDPP3 was available in 287 of 310 patients (93%; mean age 73 ± 12 years, 43% female) with a median concentration of 39 (26-62) ng/mL. cDPP3 decreased significantly within 24 hours (-17%, P < .01) and stabilized thereafter. Both the lowest and highest quartiles were associated with lower estimated glomerular filtration rate, greater urea, and greater N-terminal pro B-type natriuretic peptide levels (all P < .03). In greater cDPP3 quartiles, natriuresis-guided diuretic therapy resulted in greater 24-hour natriuresis and diuresis compared with standard of care; however, no significant treatment-cDPP3 interaction was observed. cDPP3 levels did not modify the treatment effect on the overall neutral combined endpoint.</p><p><strong>Conclusions: </strong>Greater cDPP3 concentrations are associated with impaired kidney function and reduced diuretic response in acute HF. Natriuresis-guided therapy improved decongestion across cDPP3 strata. Further studies should clarify the clinical role of cDPP3 in acute HF.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epicardial Adipose Tissue Attenuation and Persistent Left Ventricular Dysfunction in Heart Failure With Reduced Ejection Fraction (RECOVER-EAT).","authors":"Shaun Khanna, Nicholas McLellan, Sheran Vasanthakumar, Cheng Hwee Soh, Aditya Bhat, Andrew Lin, Damini Dey, Sriram Rao, Stephen J Nicholls, Clare Arnott, Nitesh Nerlekar","doi":"10.1016/j.cardfail.2026.08.020","DOIUrl":"10.1016/j.cardfail.2026.08.020","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-Term Mechanical Circulatory Support Before Heart Transplantation and Early Outcomes: Insights From the International Primary Graft Dysfunction Consortium","authors":"MERCEDES RIVAS-LASARTE MD, PhD,&nbsp;EDUARD RODENAS-ALESINA MD,&nbsp;YASBANOO MOAYEDI MD, MHSc,&nbsp;LAUREN K. TRUBY MD, MS,&nbsp;FARID FOROUTAN PhD,&nbsp;ERIK HENRICKSEN PharmD,&nbsp;MARISA SIGNORILE MMath,&nbsp;NITISH K. DHINGRA MD,&nbsp;LAURA HASTENTEUFEL MD,&nbsp;CHUN-PO S. FAN PhD,&nbsp;JOAN GUZMAN-BOFARULL MD,&nbsp;MARTA FARRERO-TORRES MD, PhD,&nbsp;KIRAN K. KHUSH MD, MAS,&nbsp;DAVID COUTO-MALLON MD, PhD,&nbsp;ROXANA MOAYEDIFAR MD,&nbsp;GENE KIM MD,&nbsp;MARIA GENEROSA CRESPO-LEIRO MD, PhD,&nbsp;SHARON CHIH MBBS, PhD,&nbsp;ADAM D. DEVORE MD,&nbsp;KOJI TAKEDA MD, PhD,&nbsp;SHELLEY A. HALL MD","doi":"10.1016/j.cardfail.2026.06.022","DOIUrl":"10.1016/j.cardfail.2026.06.022","url":null,"abstract":"<div><h3>Background</h3><div>Heart transplantation (HT) remains the gold-standard therapy for selected patients with advanced heart failure. Increasing recipient complexity and donor organ scarcity have led to the increased use of short-term mechanical circulatory support (ST-MCS) as a bridge to HT. The prognostic impact of ST-MCS on primary graft dysfunction (PGD) and other early outcomes remains limited.</div></div><div><h3>Methods</h3><div>We analyzed data from the Primary Graft Dysfunction Consortium, a retrospective registry including 3800 adult HTs at 14 centers in the United States, Canada, and Europe between 2010 and 2020. Primary outcomes were severe PGD (according to International Society for Heart and Lung Transplantation criteria) and 1-year mortality. Multivariable logistic regression and Cox models were used, with multiple imputation for missingness.</div></div><div><h3>Results</h3><div>Overall, 669 patients (17.6%) received pre-HT ST-MCS. Among them, 16.9% were supported with extracorporeal membrane oxygenation (ECMO), 60.4% with an intra-aortic balloon pump, 9.1% with a percutaneous left ventricular assist device, 9.1% with surgical ventricular assist devices, and 4.5% with other devices. ST-MCS use increased over time and varied by region, with the intra-aortic balloon pump predominating in the United States and ECMO more frequently used in Canada and Europe. Overall, ST-MCS was not associated with severe PGD after adjustment; however, ECMO was independently associated with greater PGD risk (adjusted odds ratio 3.28, 95% confidence interval 1.90−5.66). One-year mortality was 11.0% and did not differ significantly according to ST-MCS use after multivariable adjustment.</div></div><div><h3>Conclusions</h3><div>In this large contemporary multinational cohort, pretransplant ST-MCS use has increased, with geographic heterogeneity observed. Although ECMO is associated with a greater risk of severe PGD, ST-MCS does not independently increase 1-year mortality after HT, supporting its use as a bridge in high-risk patients.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 9","pages":"Pages 1529-1539"},"PeriodicalIF":9.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The First 90 Days: Reframing Sex Equity in Simultaneous Heart-Kidney Transplantation","authors":"SILVI SHAH MD, MS,&nbsp;TIMOTHY GONG MD","doi":"10.1016/j.cardfail.2026.07.011","DOIUrl":"10.1016/j.cardfail.2026.07.011","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 9","pages":"Pages 1581-1583"},"PeriodicalIF":9.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Future of Donor Heart Preservation","authors":"SAMEER K. SINGH MD,&nbsp;KOJI TAKEDA MD, PhD","doi":"10.1016/j.cardfail.2026.06.026","DOIUrl":"10.1016/j.cardfail.2026.06.026","url":null,"abstract":"<div><div>In recent years, the field of donor heart preservation has rapidly expanded to incorporate several new technologies aimed at increasing the available donor pool. Traditional ice cold storage, although effective, allows for limited preservation time and also subjects the organ to cold-induced injury. Controlled hypothermia systems improve temperature stability and reduce cold injury, while normothermic ex vivo perfusion platforms enable continuous metabolic support while also incorporating functional assessment, allowing for the utilization of extended-criteria and donation after circulatory death donors. Hypothermic oxygenated perfusion represents a hybrid approach combining the benefit of hypothermia with continuous oxygen delivery, allowing for enhanced preservation and extended preservation times. Emerging techniques such as rapid recovery and intermediate-temperature (10°C) storage further aim to enhance myocardial protection while offering to reduce costs and logistical complexities. Altogether, these technologies represent various strategies that have the potential to expand donor utilization, improve graft preservation, and increase access to heart transplantation.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 9","pages":"Pages 1605-1610"},"PeriodicalIF":9.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}