Journal of Cardiac Failure最新文献

{"title":"Performance of Clinical Scoring Systems in the Diagnosis of Transthyretin Amyloid Cardiomyopathy in a Diverse Patient Cohort","authors":"Garred S. Greenberg MD ,&nbsp;Chinwendu Onuegbu MD ,&nbsp;Carlos Espiche MD ,&nbsp;Andrea Scotti MD ,&nbsp;Paul Ippolito MD ,&nbsp;Henry Dwaah MD ,&nbsp;Jake Gilman MS ,&nbsp;James Tauras MD ,&nbsp;Aldo L. Schenone MD ,&nbsp;Piotr J. Slomka PhD ,&nbsp;Michelle M. Kittleson MD, PhD ,&nbsp;Marcelo F. Di Carli MD ,&nbsp;Mario J. Garcia MD ,&nbsp;Mark Travin MD ,&nbsp;Leandro Slipczuk MD, PhD","doi":"10.1016/j.cardfail.2024.11.016","DOIUrl":"10.1016/j.cardfail.2024.11.016","url":null,"abstract":"<div><h3>Background</h3><div>Two diagnostic clinical scoring systems, the ATTR-CM Score and the T-AMYLO Score, have been proposed but not validated in diverse populations despite Black race being an important risk factor for transthyretin amyloid cardiomyopathy (ATTR-CM). The aim of this study was to evaluate their performance in diagnosing ATTR-CM in a diverse patient cohort.</div></div><div><h3>Methods</h3><div>This retrospective single-center study analyzed patients who underwent a 99mTc-pyrophosphate single-photon emission computed tomography scan (Tc-PYP) for workup of suspected ATTR-CM. ATTR-CM was considered present in those exhibiting Perugini scores of 2 or 3, confirmed by myocardial radiotracer uptake via single-photon emission computed tomography. The diagnostic performance of a multivariate regression model and the two scoring systems was tested against Tc-PYP as the gold standard.</div></div><div><h3>Results</h3><div>Our cohort included 476 patients, of which 308 (65%) were non-Hispanic Black, 93 (20%) were Hispanic, and 215 (45%) were female. A total of 164 (34%) had a positive Tc-PYP result. Age ≥74 years, male sex, history of carpal tunnel, left ventricular ejection fraction &lt;55%, posterior wall thickness over 12 mm, and relative wall thickness over 0.57 were independent predictors of positive Tc-PYP results in our cohort, and hemoglobin level &lt;10 mg/dL, glomerular filtration rate &lt;30 mL/min/1.73 m², and coronary artery disease were independent predictors of negative Tc-PYP. The multivariate model had an area under the curve (AUC) of 0.92 (95% CI 0.90–0.95). The ATTR-CM Score (AUC, 0.86; 95% CI 0.83–0.90) had better diagnostic accuracy than the T-AMYLO Score (AUC, 0.75; 95% CI 0.71–0.80; <em>P</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>Two simple clinical scoring systems, derived to identify patients at high risk of having ATTR-CM necessitating further diagnostic evaluation, showed good predictive accuracy in our diverse patient cohort. The ATTR-CM Score was superior to the T-AMYLO Score in our cohort.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 8","pages":"Pages 1139-1148"},"PeriodicalIF":8.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JCF in Case You Missed it! ISHLT 2025","authors":"ELENA M. DONALD MD ,&nbsp;ALEXANDER HAJDUCZOK MD ,&nbsp;UL WEENA MD ,&nbsp;JASON FEINMAN ,&nbsp;ERSILIA M. DEFILIPPIS MD","doi":"10.1016/j.cardfail.2025.05.004","DOIUrl":"10.1016/j.cardfail.2025.05.004","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 8","pages":"Pages 1345-1348"},"PeriodicalIF":8.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium-glucose Cotransporter-2 Inhibitor Initiation and Incident Dementia in Heart Failure With Diabetes: A Population-based Cohort Study.","authors":"Che-Yuan Wu, Abhinav Sharma, Jodi D Edwards, Peter P Liu, C Fangyun Wu, Sho Podolsky, Moira K Kapral, Krista L Lanctôt, Bradley J Macintosh, Hugo Cogo-Moreira, Baiju R Shah, Walter Swardfager","doi":"10.1016/j.cardfail.2025.05.022","DOIUrl":"https://doi.org/10.1016/j.cardfail.2025.05.022","url":null,"abstract":"<p><strong>Background: </strong>Heart failure often coexists with important dementia-risk factors, such as diabetes, atrial fibrillation and hypertension. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have been associated with a lower dementia risk in general diabetes populations, but evidence is limited, specifically in heart failure with comorbid diabetes.</p><p><strong>Objective: </strong>To investigate the association of SGLT2 inhibitors with incident dementia in people with heart failure and diabetes.</p><p><strong>Methods: </strong>This target trial emulation cohort study used linkable administrative databases from Ontario, Canada. New users of SGLT2 inhibitors or dipeptidyl peptidase-4 (DPP4) inhibitors aged ≥ 66 years with diabetes and heart failure (July 2016-December 2020) entered this cohort. A 180-day lag time was implemented to mitigate reverse causality. The primary analysis used an intention-to-treat exposure definition. Cause-specific hazard ratios (HRs), with death as a competing risk, were estimated by using Cox models with propensity-score fine stratification weights. Weighted incidence-rate differences (IRDs) per 1000 person-years were also estimated.</p><p><strong>Results: </strong>Among 4402 SGLT2 inhibitor and 6319 DPP4 inhibitor new users, over a median follow-up of 3.95 years from treatment initiation, SGLT2 inhibitor vs DPP4 inhibitor initiation was associated with lower dementia risk (HR 0.73, 95% confidence interval [CI] 0.60-0.87; IRD -8.1, 95% CI -12.7 to -3.5). The secondary as-treated analysis showed greater risk reduction (HR 0.53, 95% CI 0.39-0.70; IRD -14.2, 95% CI -20.1 to -8.4) than the primary intention-to-treat analysis.</p><p><strong>Conclusions: </strong>SGLT2 inhibitor initiation was associated with dementia risk reduction in heart failure and diabetes, a population at a high risk of developing dementia.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Heart Failure Society of America-Developed Educational Module Improves Clinician Comfort With Initiation and Optimization of Guideline-Directed Medical Therapy.","authors":"Brittany Chapman, Nancy M Albert, Alex Zajichek, Eva Steinel, David Baran, Lars G Svensson, Leslie Cho, Samir Kapadia, Jessica Hohman, Richard Rothman, Jerry D Estep, Gabriel Pavlic, Amanda Vest, Randall C Starling, Trejeeve Martyn","doi":"10.1016/j.cardfail.2025.06.012","DOIUrl":"10.1016/j.cardfail.2025.06.012","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Top 17 Things I Wish I'd Known at the End of My Training.","authors":"Peter M Eckman","doi":"10.1016/j.cardfail.2025.06.011","DOIUrl":"10.1016/j.cardfail.2025.06.011","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Indian Expert Consensus on Patient-Profile-Based Implementation of Guideline-Directed Medical Therapy in the Management of Heart Failure With Reduced Ejection Fraction: APPROACH-HF.","authors":"Chandrashekhar K Ponde, Jagdish C Mohan, Abraham Oomman, A Sreenivas Kumar, Prakash K Hazra, Uday M Jadhav","doi":"10.1016/j.cardfail.2025.07.001","DOIUrl":"10.1016/j.cardfail.2025.07.001","url":null,"abstract":"<p><p>Heart failure with reduced ejection fraction (HFrEF) is a significant contributor to impaired quality of life, hospitalizations and mortality, globally as well as in India. Early and rapid initiation of the 4 pillars of guideline-directed medical therapy (GDMT) has been shown to significantly improve the morbidity and mortality rates associated with HFrEF. However, despite robust clinical evidence and proven benefits, GDMT is significantly underused in clinical practice. Lack of simplified, yet patient-profile-tailored treatment protocols, concerns regarding the safety or tolerability of medications, and therapeutic inertia commonly contribute to underuse. An Indian expert consensus was developed by using the modified Delphi technique to address the GDMT underuse. This expert consensus provides guidance on the use of GDMT based on the patient profiles encountered commonly in clinical practice with the objective of aiding optimal GDMT use and, thereby, improving the clinical outcomes in patients with HFrEF.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Literacy and Physical Function Among Older Black and Hispanic Individuals With Heart Failure.","authors":"Shabatun J Islam, Sergio Teruya, Denise Fine, Natalia Sabogal, Sergylensky Fils, Ikram Ullah, Anya Sanchorawala, Edward Miller, Cesia Gallegos, Cinthia DE Freitas, Damian Kurian, Natalia Ionescu, Ivrose Janvier, Farbod Raiszadeh, Emelia J Benjamin, Jared W Magnani, Mathew S Maurer, Frederick L Ruberg","doi":"10.1016/j.cardfail.2025.06.010","DOIUrl":"10.1016/j.cardfail.2025.06.010","url":null,"abstract":"<p><strong>Background: </strong>Insufficient health literacy negatively impacts outcomes for heart failure (HF). Older adults with HF face significant barriers, including prevalence of multiple comorbidities, frailty and deficits in physical function, which can impact HF outcomes. Examination of the association between health literacy and physical function remains limited in older adults with HF. We investigated the cross-sectional associations of health literacy and physical function in a cohort of older self-identified Black and Hispanic patients with HF.</p><p><strong>Methods and results: </strong>The Screening for Cardiac Amyloidosis with Nuclear Imaging in Minority Populations (SCAN-MP) study recruited participants (age ≥ 60 years) of self-identified Black race or Hispanic ethnicity in New York City, Boston and New Haven. We measured health literacy by using the Newest Vital Sign, and we measured physical function by using the 6-minute walk duration (6MWD) and the Short Physical Performance Battery test (SPPB). Linear regression models evaluated the association between participants' health-literacy levels and physical function, as defined by continuous measures of 6MWD and SPPB. Only 12.7% of the cohort (n = 433) had adequate health literacy. After adjusting for age, sex, number of comorbidities, and neighborhood social vulnerability, those with adequate (compared to limited) health literacy demonstrated better performance on the 6MWD (β = 37.5 m, 95% CI [1.49, 73.5]; P = 0.04) and SPPB (β = 1.18 (0.41, 1.95); P = 0.002).</p><p><strong>Conclusion: </strong>Older Black or Hispanic participants with HF have an extremely high prevalence of limited health literacy, which is associated with poor physical function. Interventions targeting health literacy may represent an avenue to improve HF outcomes for patients with minoritized backgrounds.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Levosimendan for the Treatment of Pulmonary Hypertension due to Heart Failure With Preserved Ejection Fraction: Rationale and Design of the LEVEL Trial.","authors":"Hidenori Yaku, Daniel Burkhoff, Barry A Borlaug, Anuradha Lala, Javed Butler, Stuart Rich, Sanjiv J Shah","doi":"10.1016/j.cardfail.2025.06.009","DOIUrl":"10.1016/j.cardfail.2025.06.009","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary hypertension due to heart failure with preserved ejection fraction (PH-HFpEF) represents a major unmet therapeutic need; several multicenter randomized clinical trials have demonstrated lack of benefit when using conventional pulmonary vasodilators. Recent data suggest that levosimendan, through its unique mechanism as a combined Ca²⁺ sensitizer and K⁺-ATP channel activator, may offer benefits in PH-HFpEF by targeting excessive sympathetic activation and splanchnic vasoconstriction.</p><p><strong>Methods: </strong>The LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF (LEVEL) trial is a multicenter, phase-3, randomized, double-blind, placebo-controlled study evaluating oral levosimendan vs placebo in 230 patients with PH-HFpEF. Participants will receive either levosimendan (initially 2 mg/day, uptitrated to 3 mg/day) or matching placebo for 12 weeks. The primary endpoint is the change in 6-minute walk distance from baseline to week 12. Secondary endpoints include changes in the Kansas City Cardiomyopathy Questionnaire overall summary score, clinical worsening events, N-terminal pro-B-type natriuretic peptide levels, and New York Heart Association functional class.</p><p><strong>Conclusions: </strong>LEVEL is the first phase-3 trial to investigate whether oral levosimendan can improve exercise capacity in patients with PH-HFpEF. The results may establish a new therapeutic approach and enhance understanding of the role of splanchnic vasoconstriction in PH-HFpEF pathophysiology.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Focus: Understanding Muscle Wasting in Heart Failure: An Explanation of Consolidating Concepts from the Recent International Expert Consensus on Sarcopenia: Implications for Heart Failure Management.","authors":"Spencer Carter, Jennifer T Thibodeau","doi":"10.1016/j.cardfail.2025.06.008","DOIUrl":"10.1016/j.cardfail.2025.06.008","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving Training Paradigms: The Critical Need for Advanced Heart Failure in the Contemporary CICU.","authors":"Soumya Banna, Alexander Thomas, Sarah Abou Alaiwi, Sanjana Garimella, Ethan Fraser","doi":"10.1016/j.cardfail.2025.05.016","DOIUrl":"10.1016/j.cardfail.2025.05.016","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}