Journal of Cardiac Failure最新文献

{"title":"Iron Deficiency and Exercise Capacity in Patients With LVADs","authors":"WILLIAM HERRIK NIELSEN MD , KIRAN K. MIRZA MD, PhD , AEVAR O. ÚLFARSSON MD , OSCAR BRAUN MD, PhD , GRUNDE GJESDAL MD, PhD , KASPER ROSSING MD, DMSc , FINN GUSTAFSSON MD, PhD","doi":"10.1016/j.cardfail.2024.12.008","DOIUrl":"10.1016/j.cardfail.2024.12.008","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 6","pages":"Pages 957-960"},"PeriodicalIF":6.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applying the Principle of Discernment to Academic Medicine: The Mid-Careerist View","authors":"Emer Joyce MB, BCh, PhD , Robert J. Mentz MD , Anuradha Lala MD","doi":"10.1016/j.cardfail.2025.05.007","DOIUrl":"10.1016/j.cardfail.2025.05.007","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 6","pages":"Pages 879-880"},"PeriodicalIF":6.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144238306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Natriuretic Response Prediction Equation Using a Race-free Estimated Glomerular Filtration Rate Equation.","authors":"Zachary L Cox, Veena S Rao, Jesse O Wrenn, Sean P Collins, Jeffrey M Testani, Juan B Ivey-Miranda","doi":"10.1016/j.cardfail.2025.05.013","DOIUrl":"10.1016/j.cardfail.2025.05.013","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for Undiagnosed Heart Failure: A Viewpoint.","authors":"João Pedro Ferreira, Faiez Zannad","doi":"10.1016/j.cardfail.2025.04.016","DOIUrl":"10.1016/j.cardfail.2025.04.016","url":null,"abstract":"<p><p>The syndrome of heart failure (HF) is characterized by a triad of (1) signs and symptoms, (2) cardiac alterations, and (3) natriuretic peptide elevation. Patients who exhibit alterations of cardiac structure or function without overt signs or symptoms of HF are staged as having \"pre-HF.\" However, many people with undiagnosed HF walk little and do not exercise; thus, they may be classified as having asymptomatic \"pre-HF\" simply because they never exercise enough to feel breathless. Moreover, many patients have comorbidities such as chronic obstructive pulmonary disease or obesity and the physical limitations may be attributed to the comorbidities rather than to HF. Such comorbidities may also influence natriuretic peptide measurements. The potential implications of an HF misdiagnosis are that many patients may remain undertreated. This is illustrated with data from the HOMAGE (Heart Omics in AGEing) study, which included asymptomatic people with mild natriuretic peptide elevation. When comparing patient characteristics, HOMAGE participants were similar to those of ALDO-DHF (Effect of Spironolactone on Diastolic Function and Exercise Capacity in Patients with Heart Failure with Preserved Ejection Fraction) who were classified as symptomatic patients with HF. Given the confluence of HF with several cardiac-renal and metabolic conditions, we propose a simplified, pragmatic, and inclusive approach for early HF diagnosis and treatment.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual Natriuretic and Diuretic Response in Acute Heart Failure: Insights from the PUSH-AHF Pharmacologic Substudy.","authors":"Iris E Beldhuis, Jozine M Termaaten, Peter VAN DER Meer, Jenifer E Coster, Lukas Baumhove, Jan A Krikken, Wybe Nieuwland, Dirk J VAN Veldhuisen, Adriaan A Voors, Kevin Damman","doi":"10.1016/j.cardfail.2025.04.015","DOIUrl":"10.1016/j.cardfail.2025.04.015","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Serially Measured Circulating Biomarker Patterns and Pulmonary Artery Pressures Measured by Invasive Hemodynamic Monitoring.","authors":"Mylène Barry-Loncq DE Jong, Youssra Allach, Sabrina Abou Kamar, Pascal R D Clephas, Hans-Peter Brunner-LA Rocca, M Louis Handoko, Vokko P VAN Halm, Wouter E M Kok, Folkert W Asselbergs, Roland R J VAN Kimmenade, Saskia L M A Beeres, Michiel Rienstra, Mariusz K Szymanski, Rudolf A DE Boer, Isabella Kardys, Jasper J Brugts","doi":"10.1016/j.cardfail.2025.04.014","DOIUrl":"10.1016/j.cardfail.2025.04.014","url":null,"abstract":"<p><strong>Background: </strong>Invasive hemodynamic monitoring devices provide relevant insights into the hemodynamic status of heart failure (HF) patients. Additionally, circulating biomarkers have been advocated as additives in HF management by offering prognostic information and therapeutic targets. However, limited data exist correlating serially measured biomarkers to hemodynamic pressures provided by invasive sensors. This study aims to investigate the association between serial biomarker patterns and pulmonary artery (PA) pressure dynamics in HF patients.</p><p><strong>Methods and results: </strong>This study is a substudy of MONITOR-HF (Remote Haemodynamic Monitoring of Pulmonary Artery Pressures in Patients With Chronic Heart Failure) (NTR7673), a prospective investigator-initiated multicenter randomized clinical trial conducted in chronic HF (CHF) patients. Blood samples were collected at baseline and 3, 6, and 12 months of follow-up, and 92 proteins (OLINK CV-III panel) were measured. The primary endpoint was the average mean PA pressure (mPAP) during the week preceding blood sample collection, in patients who received an invasive PA pressure sensor. Linear mixed models were used to evaluate the association between serial biomarker levels and mPAP, adjusting for sex and age, and correcting for multiple testing. This study included 165 patients who had a median age of 68 years (interquartile range, 61-75 years) and were predominantly male (78%). Fifteen biomarkers were significantly associated with the 7-day average mPAP, with 13 biomarkers maintaining consistent associations across different lag times. The strongest associations were found between mPAP and N-terminal pro-B-type natriuretic peptide, pulmonary surfactant protein D, insulin-like growth factor binding protein 7, and matrix metalloproteinase-2.</p><p><strong>Conclusions: </strong>We found a consistent association between invasive hemodynamic pressures and 13 serially measured blood biomarkers in chronic HF patients. These results could deepen the understanding and therapy guidance of congestive HF.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Survival Outcomes With Cardiac Contractility Modulation: Methodological Validation Using Cardiac Resynchronization Therapy Data.","authors":"Andrew J Sauer, Ryan Hass, Gary Cranke, Daniel Burkhoff, Ishu Rao","doi":"10.1016/j.cardfail.2025.04.013","DOIUrl":"10.1016/j.cardfail.2025.04.013","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remote Optimization of Guideline-Directed Medical Therapy Using Home Monitoring in Heart Failure: The GOALS-HF Study.","authors":"Syed Kazim Rizvi, Ritika Dhruve, Neil Keshvani, Nicholas Hendren, Davinder S Chadha, Sthanu Ramakrishnan, Abhishek Nandekar, Udayan Dasgupta, Matthew W Segar, Muthiah Vaduganathan, Javed Butler, Charit Bhograj, Ambarish Pandey, Stephen J Greene","doi":"10.1016/j.cardfail.2025.05.005","DOIUrl":"10.1016/j.cardfail.2025.05.005","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mineralocorticoid Receptor Antagonists and Aldosterone Synthase Inhibitors: Agent Comparison With Implications for Clinical Practice and Trial Design.","authors":"João Pedro Ferreira, Pedro Marques, Ana Rita Leite, João Sérgio Neves, Faiez Zannad, Bertram Pitt","doi":"10.1016/j.cardfail.2025.05.002","DOIUrl":"10.1016/j.cardfail.2025.05.002","url":null,"abstract":"<p><p>Steroidal (s) and nonsteroidal (ns) mineralocorticoid receptor antagonists (MRAs) and aldosterone synthase inhibitors (ASis) are either available for clinical use or are being tested in clinical trials in cardiovascular, kidney and metabolic (CKM) conditions. All agents block the actions of aldosterone, but they present important differences in terms of modes of action, pharmacokinetics and dynamics and side-effect profiles. Such differences may have clinical implications. To ascertain such potential differences, we performed a description and indirect comparison of MRA and ASi trial results in hypertension, chronic kidney disease and heart failure. Whenever possible, we used data from head-to-head comparisons. We then used this information to provide clinical guidance and to suggest how to improve clinical trials in the future. Notably, by performing more head-to-head comparison trials and trials with dual or triple combination therapies with sodium glucose co-transporter 2 inhibitors (SGLT2is) and/or oral glucagon-like peptide 1 receptor agonists (GLP1ras). In short, this article focuses on the similarities and potential differences among MRAs, nsMRAs and ASis, with implications for both clinical use and clinical trial design.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uptitration of Sacubitril/Valsartan in Acute Heart Failure: Insight from the PREMIER Study.","authors":"Shunichi Doi, Atsushi Tanaka, Keisuke Kida, Takumi Imai, Yusuke Ueda, Yukiko Nakano, Yoshihisa Kizaki, Daiju Fukuda, Yuya Matsue, Yoshihiro J Akashi, Koichi Node","doi":"10.1016/j.cardfail.2025.05.001","DOIUrl":"10.1016/j.cardfail.2025.05.001","url":null,"abstract":"<p><strong>Aims: </strong>This study investigated the effect of uptitration of sacubitril/valsartan (Sac/Val) compared with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (ACEIs/ARBs) on N-terminal pro-B-type natriuretic peptide (NT-proBNP) level within current guideline-directed medical therapy in acute heart failure (AHF).</p><p><strong>Methods and results: </strong>This was the secondary analysis in the Program Angiotensin-Neprilysin Inhibition in Admitted Patients with Worsening Heart Failure (PREMIER) study. AHF patients were allocated to switch to Sac/Val or ACEIs/ARBs, and the Sac/Val group was divided into Sac/Val with or without uptitration group (Sac/Val >24/26 mg or ≤24/26 mg twice daily at week 8). The primary endpoint was the proportional change in geometric means of NT-proBNP levels at week 8. A total of 376 patients were included, consistent with the primary analysis in PREMIER. The percent changes in the NT-proBNP level were -51% (Sac/Val with uptitration), -39% (Sac/Val without uptitration), and -32% (ACEIs/ARBs). Their group ratios adjusted for baseline characteristics were 0.72 (Sac/Val with uptitration vs. ACEIs/ARBs, 95% confidence interval [CI], 0.59 to 0.89; P = .002) and 0.93 (Sac/Val without uptitration vs. ACEIs/ARBs, 95% CI, 0.76 to 1.13; P = .47). However, the Sac/Val without uptitration group yielded a greater NT-proBNP reduction than the ACEI/ARB group (adjusted ratio of change 0.72, 95% CI, 0.55 to 0.94; P = .016) in the subgroup of reduced ejection fraction. There were no adverse events associated with Sac/Val uptitration.</p><p><strong>Conclusions: </strong>Uptitration of Sac/Val therapy yielded a greater NT-proBNP level reduction in AHF patients, but Sac/Val therapy without uptitration also reduced NT-proBNP levels in a subgroup with reduced ejection fraction compared with ACEI/ARB therapy.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}