{"title":"At the Heart of Transition: A Journey in Gratitude","authors":"Kevin S. Shah MD, FACC, FHFSA","doi":"10.1016/j.cardfail.2024.11.014","DOIUrl":"10.1016/j.cardfail.2024.11.014","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 4","pages":"Pages 715-716"},"PeriodicalIF":6.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael Gao, Hannah Every, Jehanzeb Kayani, Anuradha Lala
{"title":"A Call to Focus on Prevention in Heart Failure: Heart Failure Risk Patterns and Profiles in the National Health and Nutrition Examination Survey Using PREVENT-HF.","authors":"Michael Gao, Hannah Every, Jehanzeb Kayani, Anuradha Lala","doi":"10.1016/j.cardfail.2025.03.011","DOIUrl":"10.1016/j.cardfail.2025.03.011","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elena M Donald, Alberto Pinsino, Nona Jiang, Joanna Eichler, Logan Cho, Mansi Shah, Shruti Bidani, Michelle M Kittleson, Palak Shah, Gabriel Sayer, Nir Uriel, Kiran K Khush, Rebecca Cogswell, Ersilia M Defilippis
{"title":"Sex-Based Differences in Early and Late Kidney Outcomes After Heart Transplantation.","authors":"Elena M Donald, Alberto Pinsino, Nona Jiang, Joanna Eichler, Logan Cho, Mansi Shah, Shruti Bidani, Michelle M Kittleson, Palak Shah, Gabriel Sayer, Nir Uriel, Kiran K Khush, Rebecca Cogswell, Ersilia M Defilippis","doi":"10.1016/j.cardfail.2025.03.006","DOIUrl":"10.1016/j.cardfail.2025.03.006","url":null,"abstract":"<p><strong>Background: </strong>The development of kidney disease after heart transplantation (HT) has been well described and is associated with increased post-HT mortality. Limited data have evaluated sex-based differences in kidney outcomes post-HT.</p><p><strong>Methods: </strong>Adults (≥ 18 years old) in the United Network for Organ Sharing registry who underwent HT between 2010 and 2022 were included. Multiorgan transplants were excluded as were patients who required dialysis pre-HT. Baseline characteristics were compared by sex. Outcomes included early kidney failure (need for post-operative dialysis) and late kidney failure (chronic dialysis or kidney transplantation). Multivariable logistic regression was used to determine whether sex predicted development of early kidney failure, and multivariable Cox regression was used to determine whether sex predicted late kidney failure. Outcomes were also compared before and after the 2018 heart-allocation system change.</p><p><strong>Results: </strong>We included 30,414 HT recipients (n = 8223, 27.0% female); 3535 patients (n = 891, 25% female) developed early kidney failure post-HT. After adjusting for multiple clinical factors, sex was not found to be a significant predictor of early kidney failure post-HT (OR 0.93, 95% CI 0.83-1.04; P = 0.2). Following implementation of the 2018 allocation system, rates of early renal failure increased significantly in both men (10% to 14%; P < 0.001) and women (9% to 13%; P < 0.001), but the effect was similar by sex (P-interaction: > 0.9). Over a median follow-up of 5 years (IQR 2.4-8.0), there were no differences in time to late kidney failure by sex (log rank P = 0.4). After adjustment for various clinical and demographic factors, there was no difference in risk of late kidney failure by sex (aHR 1.11, 95% CI 0.96-1.27; P = 0.2).</p><p><strong>Conclusions: </strong>Although sex did not predict the development of early or late kidney failure after HT, future studies are needed to determine sex-specific risk factors for kidney failure and potential preventive strategies.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jacob Abraham, Mark Anderson, Scott Silvestry, Edward G Soltesz, Masahiro Ono, Kanika Mody, Fardad Esmailian, Arman Kilic, Rupinder Bharmi, Rothy Chhim, Roberta Bogaev-Chapman, Gundars J Katlaps, Ismael Salas DE Armas, Mani A Daneshmand, David J Kaczorowski, Duc Thinh Pham, Danny Ramzy, David D'Alessandro
{"title":"Outcomes of Surgically Implanted Impella Microaxial Flow Pumps in Heart Failure-Related Cardiogenic Shock.","authors":"Jacob Abraham, Mark Anderson, Scott Silvestry, Edward G Soltesz, Masahiro Ono, Kanika Mody, Fardad Esmailian, Arman Kilic, Rupinder Bharmi, Rothy Chhim, Roberta Bogaev-Chapman, Gundars J Katlaps, Ismael Salas DE Armas, Mani A Daneshmand, David J Kaczorowski, Duc Thinh Pham, Danny Ramzy, David D'Alessandro","doi":"10.1016/j.cardfail.2025.03.008","DOIUrl":"10.1016/j.cardfail.2025.03.008","url":null,"abstract":"<p><strong>Background: </strong>Patients with cardiogenic shock (CS) are increasingly treated with high-profile microaxial flow pumps (Impella 5.5), but little is known about the indications and outcomes of this support strategy in patients with CS due to heart failure (HF-CS).</p><p><strong>Objectives: </strong>We sought to describe the clinical features and outcomes of patients with HF-CS treated with Impella 5.5.</p><p><strong>Methods: </strong>We analyzed data from a prospective, multicenter observational study of patients with CS who had been implanted with an Impella 5.5. Adverse events, in-hospital survival rates and 6- and 12-month survival rates were analyzed in the total cohort and between patients treated with Impella 5.5 alone or with multiple temporary mechanical circulatory support (tMCS) devices. Outcomes were stratified based on native heart survival (NHS) and heart-replacement therapy (HRT).</p><p><strong>Results: </strong>Of the 804 patients with CS who received Impella 5.5, 444 had HF-CS. Prior to Impella 5.5 placement, 214 (48.1%) had received other tMCS devices. The duration of Impella support was 21.1 ± 20.1 days (median: 15; IQR: 8, 26 days). Survival to discharge was 75.0% for the total cohort, 86.5% for those receiving Impella 5.5 alone, and 65.0% for those receiving multiple tMCS devices. The need for renal-replacement therapy and thrombocytopenia requiring transfusions was more common in those receiving multiple tMCS devices. Among patients with NHS, 6- and 12-month survival rates were 71.3% and 64.4%, respectively, while patients receiving HRT had survival rates > 93%.</p><p><strong>Conclusions: </strong>Patients with HF-CS treated with Impella 5.5 had overall favorable in-hospital, 6-month and 12-month survival, both as a bridge to NHS as HRT.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Satoshi Shoji, Nicole Solomon, Karen Chiswell, Senthil Selvaraj, Michel G Khouri, Sabra C Lewsey, Lori Baylor, Marianna Bruno, Gregg C Fonarow, Stephen J Greene
{"title":"Hospital-Level Variation and Predictive Model for Diagnosis of Transthyretin Amyloid Cardiomyopathy Among Patients Hospitalized Due to Heart Failure.","authors":"Satoshi Shoji, Nicole Solomon, Karen Chiswell, Senthil Selvaraj, Michel G Khouri, Sabra C Lewsey, Lori Baylor, Marianna Bruno, Gregg C Fonarow, Stephen J Greene","doi":"10.1016/j.cardfail.2025.03.013","DOIUrl":"10.1016/j.cardfail.2025.03.013","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ilan Richter, Justin Fried, Kevin Clerkin, Jayant Raikhelkar, Dor Lotan, Boaz Elad, Gabriel Sayer, Nir Uriel
{"title":"Increasing Access: Reducing Referral Delay in Patients With Ambulatory Advanced HF.","authors":"Ilan Richter, Justin Fried, Kevin Clerkin, Jayant Raikhelkar, Dor Lotan, Boaz Elad, Gabriel Sayer, Nir Uriel","doi":"10.1016/j.cardfail.2025.03.015","DOIUrl":"10.1016/j.cardfail.2025.03.015","url":null,"abstract":"<p><strong>Background: </strong>Referral to advanced heart failure care (AHFC) is advocated to ensure favorable outcomes, and it has been shown to improve prognosis and quality of life in patients at advanced stages of disease. Nevertheless, it may occur later than desired; the rate of eligible patients referred in a timely manner is unknown. We sought to describe the current state of referral for AHFC, highlight potential factors leading to delayed referral and discuss strategies to increase access to AHFC.</p><p><strong>Methods and results: </strong>We performed electronic searches on Pubmed, EMBASE, Web of Science, and The Cochrane Library to identify studies describing referral patterns to advanced heart failure, patient and provider characteristics associated with increased or decreased referral, settings of care, and associated clinical outcomes. We then discuss possible reasons for referral delay, as well as potential avenues for research and directed intervention to reduce delay and improve patients' outcomes.</p><p><strong>Conclusion: </strong>A referral delay currently exists for AHFC, driven by multiple factors, among them providers' misconceptions about the benefits of AHFC and the appropriate timing of referral, a lack of specialized providers, insufficient and unequal access to care across demographics, and patients' lack of awareness. Efforts to reduce these and other root causes are needed to improve referral rates and optimize outcomes for patients with HF.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adam D Devore, Jiecheng Xie, Leigh Etters, Efren Rael, Sandi Wibowo, Chen Hao, Maulik Majmudar, Adrian F Hernandez, Gregg C Fonarow, Akshay S Desai
{"title":"A Digital Platform to Optimize Guideline-Directed Heart Failure Therapy: Rationale and Design of the AIM-POWER Trial.","authors":"Adam D Devore, Jiecheng Xie, Leigh Etters, Efren Rael, Sandi Wibowo, Chen Hao, Maulik Majmudar, Adrian F Hernandez, Gregg C Fonarow, Akshay S Desai","doi":"10.1016/j.cardfail.2025.02.018","DOIUrl":"10.1016/j.cardfail.2025.02.018","url":null,"abstract":"<p><strong>Background: </strong>Patients with heart failure (HF) remain at high risk for hospitalization and death, in part, due to underuse of available HF pharmacological therapy. Digital interventions may facilitate rapid initiation and titration of HF pharmacological therapy, but they have not been systematically evaluated in adequately powered, randomized, control trials. In the AIM-POWER study, we evaluated the safety and efficacy of the BiovitalsHF DTx decision-support platform as a strategy to guide optimal initiation and titration of pharmacological therapy in patients with HF with reduced ejection fraction (HFrEF).</p><p><strong>Methods and results: </strong>We enrolled 122 participants with symptomatic HFrEF (left ventricular ejection fraction ≤ 40%) who had not yet been optimized on HF pharmacological therapy. Participants were randomized 1:1 in an open-label fashion to management; they were supported by BiovitalsHF or usual care. Using wearable home-based monitors and digital scales, the BiovitalsHF platform assembled data regarding patients' status and formulated suggestions regarding initiation and titration of HF pharmacological therapy per published guidelines. These recommendations were provided to site clinicians, but final decisions about prescribing and titration were left to the sites. The primary outcome was the between-group difference in the change in an HF optimal medical therapy score from baseline-90 days.</p><p><strong>Conclusion: </strong>The results of the AIM-POWER study will provide important insights into digital interventions for HF management and will evaluate the effectiveness of BiovitalsHF in improving the use and dosing of pharmacological therapy for participants with HFrEF.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"2023 Update of the Japanese Heart Failure Society Scientific Statement on BNP and NT-proBNP Levels in Heart Failure Practice.","authors":"Masatoshi Minamisawa, Toshihisa Anzai, Takayuki Inomata, Koichiro Kinugawa, Yasushi Sakata, Naoki Sato, Hiroyuki Tsutsui, Kazuhiro Yamamoto, Michihiro Yoshimura, Yoshihiko Saito, Koichiro Kuwahara","doi":"10.1016/j.cardfail.2025.03.005","DOIUrl":"10.1016/j.cardfail.2025.03.005","url":null,"abstract":"<p><p>This revised 2023 statement on blood brain (B-type) natriuretic peptide (BNP) and N-terminal prohormone of brain (B-type) natriuretic peptide (NT-proBNP) represents an expert consensus that aims to enhance efficient referral from general practitioners or non-cardiovascular specialists, providing a comprehensive, up-to-date perspective on BNP and NT-proBNP in the diagnosis and management of heart failure, with a focus on the following two major modifications: (1) Changes regarding cutoff values for BNP and NT-proBNP (criteria for heart failure diagnosis and referral criteria to cardiovascular specialists); and (2) Content related to heart failure management using BNP and NT-proBNP (BNP-guided therapy).</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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