SHANTANU P. SENGUPTA MD, DNB, PhD, FACC, FASE , ABRAHAM OOMMAN MD, DM, DNB , HARIKRISHNAN SIVADASANPILLAI MD, DM, DNB , UDAY JADHAV MD, FACC , RAGHURAMAN BAGIRATH MD, DM , SUNDAR T MS, FRCS, FCCP , SANJAY MITTAL MD, DM , JAIGOPAL P.B. MD, DM, FACC , VIJAY CHOPRA MD, DM , This article was published on behalf of the Heart Failure Association of India.
{"title":"Guideline-Directed Medical Therapy in Heart Failure in a Developing Country: a Real-World Physician Survey From India","authors":"SHANTANU P. SENGUPTA MD, DNB, PhD, FACC, FASE , ABRAHAM OOMMAN MD, DM, DNB , HARIKRISHNAN SIVADASANPILLAI MD, DM, DNB , UDAY JADHAV MD, FACC , RAGHURAMAN BAGIRATH MD, DM , SUNDAR T MS, FRCS, FCCP , SANJAY MITTAL MD, DM , JAIGOPAL P.B. MD, DM, FACC , VIJAY CHOPRA MD, DM , This article was published on behalf of the Heart Failure Association of India.","doi":"10.1016/j.cardfail.2025.03.020","DOIUrl":"10.1016/j.cardfail.2025.03.020","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 8","pages":"Pages 1370-1373"},"PeriodicalIF":8.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
YEAHWA HONG MD, PhD , NICHOLAS R. HESS MD , LUKE A. ZIEGLER BA , ANDER DORKEN-GALLASTEGI MD , NIDHI IYANNA MPH , MOHAMED ABDULLAH MD, PhD , EDWARD T. HORN PharmD , MICHAEL A. MATHIER MD , MARY E. KEEBLER MD , GAVIN W. HICKEY MD , DAVID J. KACZOROWSKI MD
{"title":"Right Ventricular Mass Oversizing Is Associated With Improved Post-transplant Survival in Heart Transplant Recipients With Elevated Transpulmonary Gradient","authors":"YEAHWA HONG MD, PhD , NICHOLAS R. HESS MD , LUKE A. ZIEGLER BA , ANDER DORKEN-GALLASTEGI MD , NIDHI IYANNA MPH , MOHAMED ABDULLAH MD, PhD , EDWARD T. HORN PharmD , MICHAEL A. MATHIER MD , MARY E. KEEBLER MD , GAVIN W. HICKEY MD , DAVID J. KACZOROWSKI MD","doi":"10.1016/j.cardfail.2024.09.018","DOIUrl":"10.1016/j.cardfail.2024.09.018","url":null,"abstract":"<div><h3>Background</h3><div>This study evaluates the effects of pre-transplant transpulmonary gradient (TPG) and donor right ventricular mass (RVM) on outcomes following heart transplantation.</div></div><div><h3>Methods</h3><div>UNOS registry was queried to analyze adult recipients who underwent primary isolated heart transplantation from 1/1/2010 to 12/31/2018. The recipients were dichotomized into 2 groups based on their TPG at the time of transplantation, < 12 and ≥ 12 mmHg. The outcomes included 5-year survival and post-transplant complications. Propensity score-matching was performed. Subanalysis was performed to evaluate the effects of donor-recipient RVM matching, where a ratio < 0.85 was classified as undersized, 0.85–1.15 as size-matched, and > 1.15 as oversized.</div></div><div><h3>Results</h3><div>We analyzed 17,898 isolated heart transplant recipients, and 5129 (28.7%) recipients had TPG ≥ 12 mmHg at the time of transplantation. The recipients with TPG ≥ 12 mmHg experienced significantly lower 5-year survival rates (78.4% vs 81.2%; <em>P</em> < 0.001) compared to the recipients with TPG < 12 mmHg, and this finding persisted in the propensity score-matched comparison. The recipients with TPG ≥ 12 mmHg experienced a higher rate of post-transplant dialysis and a longer duration of hospitalization. Oversizing the donor RVM considerably improved the 5-year survival among the recipients with TPG ≥ 12 mmHg, comparable to those with TPG < 12 mmHg.</div></div><div><h3>Conclusion</h3><div>Elevated pre-transplant TPG is associated with significantly reduced post-transplant survival. However, oversizing the donor RVM is associated with improved survival rates in recipients with elevated TPG, resulting in improved survival that is comparable to that of recipients with normal TPG. Therefore, careful risk stratification and donor matching among recipients with elevated TPG is essential to improve outcomes in this vulnerable population.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 8","pages":"Pages 1152-1163"},"PeriodicalIF":8.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
STEPHEN J. GREENE MD , HANNA K. GAGGIN MD, MPH , LORI D. BASH PhD, MPH , DOMINIK LAUTSCH MD , YAN SONG PhD , MO ZHOU PhD , JAMES SIGNOROVITCH PhD , ANDRA S. STEVENSON PhD , ROBERT O. BLAUSTEIN MD, PhD , JAVED BUTLER MD, MPH, MBA
{"title":"Cardiologist-Reported Reasons for Not Titrating Guideline-Directed Medical Therapy for Heart Failure with Reduced Ejection Fraction","authors":"STEPHEN J. GREENE MD , HANNA K. GAGGIN MD, MPH , LORI D. BASH PhD, MPH , DOMINIK LAUTSCH MD , YAN SONG PhD , MO ZHOU PhD , JAMES SIGNOROVITCH PhD , ANDRA S. STEVENSON PhD , ROBERT O. BLAUSTEIN MD, PhD , JAVED BUTLER MD, MPH, MBA","doi":"10.1016/j.cardfail.2025.04.010","DOIUrl":"10.1016/j.cardfail.2025.04.010","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 8","pages":"Pages 1365-1369"},"PeriodicalIF":8.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JEPPE KOFOED PETERSEN MB , CHRISTIAN SELMER MD, PhD , SØREN LUND KRISTENSEN MD, PhD , RASMUS RØRTH MD, PhD , ADELINA YAFASOVA MD , LUCAS GROVE BAGER VEJLSTRUP MD , SAM AIYAD ALI MD , MORTEN SCHOU MD, DMSc , LARS KØBER MD, DMSc , EMIL LOLDRUP FOSBØL MD, PhD , LAUGE ØSTERGAARD MD, PhD
{"title":"Prognostic Impact of Thyroid Function in Patients With Incident Heart Failure: A Nationwide Study","authors":"JEPPE KOFOED PETERSEN MB , CHRISTIAN SELMER MD, PhD , SØREN LUND KRISTENSEN MD, PhD , RASMUS RØRTH MD, PhD , ADELINA YAFASOVA MD , LUCAS GROVE BAGER VEJLSTRUP MD , SAM AIYAD ALI MD , MORTEN SCHOU MD, DMSc , LARS KØBER MD, DMSc , EMIL LOLDRUP FOSBØL MD, PhD , LAUGE ØSTERGAARD MD, PhD","doi":"10.1016/j.cardfail.2024.11.010","DOIUrl":"10.1016/j.cardfail.2024.11.010","url":null,"abstract":"<div><h3>Background</h3><div>There is a paucity of data on the prognostic impact of thyroid dysfunction in patients with heart failure (HF). We aimed to examine the association between these 2 conditions in a nationwide cohort of patients with HF.</div></div><div><h3>Methods</h3><div>This Danish cohort study evaluated the thyroid function of patients diagnosed with first-time HF from 2000–2021. Patients were categorized according to laboratory-based thyroid-function values (euthyroid, overt/subclinical hypothyroidism or hyperthyroidism) recorded within 1 year before the HF diagnoses. The primary outcome was a composite of mortality and hospitalization due to HF, examined using the cumulative incidence function. Cox proportional hazard analysis adjusted for major comorbidities was performed to investigate differences in outcomes among groups.</div></div><div><h3>Results</h3><div>Of the 58,067 individuals included in this study (43.9% female, median age 75.7 years [p25–p75:66.4–83.5]), 54,319 (93.6%) were euthyroid, 1669 (2.9%) had subclinical hypothyroidism, 239 (0.4%) had overt hypothyroidism, 1633 (2.8%) had subclinical hyperthyroidism, and 207 (0.4%) had overt hyperthyroidism. Compared with euthyroid patients, the adjusted 1-year HR of the composite outcome was 1.11 (95% CI, 1.02–1.20) in patients with subclinical hypothyroidism, 1.24 (95% CI, 1.02–1.51) in patients with overt hypothyroidism, 1.06 (95% CI, 0.98–1.15) in patients with subclinical hyperthyroidism, and 1.27 (95% CI, 1.00–1.60) in patients with overt hyperthyroidism. This positive association was driven mainly by the increased mortality rates.</div></div><div><h3>Conclusion</h3><div>In patients with incident HF, the presence of both hypo- and hyperthyroidism up to 1 year prior to HF diagnosis was associated with increased risk of the composite of mortality and hospitalization for HF. Our results demonstrate a high-risk group of patients in need of increased clinical awareness.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 8","pages":"Pages 1118-1126"},"PeriodicalIF":8.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACOB ABRAHAM MD , AMARINDER S. BINDRA MD , MARAT FUDIM MD, MHS , PUJAN P. PATEL MD , NIRAV Y. RAVAL MD , DMITRY YARANOV MD , FARES YARED MD , SETH J. WILKS PhD , STEFANIE BUSGANG MPH , PHILIP B. ADAMSON MD
{"title":"Real-World Analysis of Health Care Utilization With Baroreflex Activation Therapy for Heart Failure","authors":"JACOB ABRAHAM MD , AMARINDER S. BINDRA MD , MARAT FUDIM MD, MHS , PUJAN P. PATEL MD , NIRAV Y. RAVAL MD , DMITRY YARANOV MD , FARES YARED MD , SETH J. WILKS PhD , STEFANIE BUSGANG MPH , PHILIP B. ADAMSON MD","doi":"10.1016/j.cardfail.2025.02.003","DOIUrl":"10.1016/j.cardfail.2025.02.003","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 8","pages":"Pages 1349-1353"},"PeriodicalIF":8.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JOZINE M. TER MAATEN M.D., Ph.D. , RANDALL C. STARLING M.D., M.Ph.
{"title":"Insights From Around the World: the 2025 Japanese Heart Failure Guidelines","authors":"JOZINE M. TER MAATEN M.D., Ph.D. , RANDALL C. STARLING M.D., M.Ph.","doi":"10.1016/j.cardfail.2025.06.003","DOIUrl":"10.1016/j.cardfail.2025.06.003","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 8","pages":"Pages 1323-1325"},"PeriodicalIF":8.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JOBAN VAISHNAV MD , KEVIN M. ALEXANDER MD, FACC, FHFSA
{"title":"Improving ATTR-CM Detection: Targeting Populations With the Greatest Need","authors":"JOBAN VAISHNAV MD , KEVIN M. ALEXANDER MD, FACC, FHFSA","doi":"10.1016/j.cardfail.2025.04.017","DOIUrl":"10.1016/j.cardfail.2025.04.017","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 8","pages":"Pages 1149-1151"},"PeriodicalIF":8.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}