Journal of Cardiac Failure最新文献

{"title":"Health Literacy and Physical Function among Older Black and Hispanic Individuals with Heart Failure.","authors":"Shabatun J Islam, Sergio Teruya, Denise Fine, Natalia Sabogal, Sergylensky Fils, Ikram Ullah, Anya Sanchorawala, Edward Miller, Cesia Gallegos, Cinthia de Freitas, Damian Kurian, Natalia Ionescu, Ivrose Janvier, Farbod Raiszadeh, Emelia J Benjamin, Jared W Magnani, Mathew S Maurer, Frederick L Ruberg","doi":"10.1016/j.cardfail.2025.06.010","DOIUrl":"https://doi.org/10.1016/j.cardfail.2025.06.010","url":null,"abstract":"<p><strong>Background: </strong>Inadequate health literacy negatively impacts outcomes for heart failure (HF). Older adults with HF face significant barriers including prevalence of multiple comorbidities, frailty, and deficits in physical function, which can impact HF outcomes. Examination of the association between health literacy and physical function remains limited in older adults with HF. We investigated the cross-sectional associations of health literacy and physical function in a cohort of older self-identified Black and Hispanic patients with HF.</p><p><strong>Methods & results: </strong>The Screening for Cardiac Amyloidosis with Nuclear Imaging in Minority Population (SCAN-MP) study recruited participants (age >60 years) of self-identified Black race or Hispanic ethnicity in New York City, Boston, and New Haven. We measured health literacy using the Newest Vital Sign and physical function using the 6-minute walk duration (6MWD) and the Short Physical Performance Battery test (SPPB). Linear regression models evaluated the association between participants' health literacy levels and physical function as defined by continuous measures of 6MWD and SPPB. Only 12.7% of the cohort (n=433) had adequate health literacy. After adjusting for age, sex, number of comorbidities, and neighborhood social vulnerability, those with adequate (compared to limited) health literacy, demonstrated better performance on the 6MWD (β=37.5 m, 95% CI [1.49, 73.5], p=0.04) and SPPB (β=1.18 (0.41, 1.95), p=0.002).</p><p><strong>Conclusion: </strong>Older Black or Hispanic participants with HF have extremely high prevalence of limited health literacy, which is associated with poor physical function. Interventions targeting health literacy may represent an avenue to improve HF outcomes for patients with minoritized backgrounds.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Levosimendan for the Treatment of Pulmonary Hypertension due to Heart Failure with Preserved Ejection Fraction: Rationale and Design of the LEVEL Trial: Rationale and Design of LEVEL.","authors":"Hidenori Yaku, Daniel Burkhoff, Barry A Borlaug, Anuradha Lala, Javed Butler, Stuart Rich, Sanjiv J Shah","doi":"10.1016/j.cardfail.2025.06.009","DOIUrl":"https://doi.org/10.1016/j.cardfail.2025.06.009","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary hypertension due to heart failure with preserved ejection fraction (PH-HFpEF) represents a major unmet therapeutic need, with several multicenter randomized clinical trials demonstrating lack of benefit with conventional pulmonary vasodilators. Recent data suggest that levosimendan, through its unique mechanism as a combined Ca²⁺ sensitizer and K⁺-ATP channel activator, may offer benefits in PH-HFpEF by targeting excessive sympathetic activation and splanchnic vasoconstriction.</p><p><strong>Methods: </strong>The LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF (LEVEL) trial is a multicenter, phase 3, randomized, double-blind, placebo-controlled study evaluating oral levosimendan versus placebo in 230 patients with PH-HFpEF. Participants receive either levosimendan (initially 2 mg/day, up-titrated to 3 mg/day) or matching placebo for 12 weeks. The primary endpoint is change in 6-minute walk distance from baseline to Week 12. Secondary endpoints include the changes in Kansas City Cardiomyopathy Questionnaire overall summary score, clinical worsening events, N-terminal pro-B-type natriuretic peptide levels, and New York Heart Association functional class.</p><p><strong>Conclusions: </strong>LEVEL is the first phase 3 trial to investigate whether oral levosimendan can improve exercise capacity in patients with PH-HFpEF. The results may establish a new therapeutic approach and enhance understanding of the role of splanchnic vasoconstriction in PH-HFpEF pathophysiology.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Focus: Understanding Muscle Wasting in Heart Failure. An explanation of \"Consolidating Concepts from Recent International Expert Consensus on Sarcopenia: Implications for Heart Failure Management\".","authors":"Spencer Carter, Jennifer T Thibodeau","doi":"10.1016/j.cardfail.2025.06.008","DOIUrl":"https://doi.org/10.1016/j.cardfail.2025.06.008","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving training paradigms: The critical need for advanced heart failure in the contemporary CICU.","authors":"Soumya Banna, Alexander Thomas, Sarah Abou Alaiwi, Sanjana Garimella, Ethan Fraser","doi":"10.1016/j.cardfail.2025.05.016","DOIUrl":"https://doi.org/10.1016/j.cardfail.2025.05.016","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Equip, engage, empower: Considerations for effective values elicitation in the LVAD population.","authors":"Rebecca S Steinberg, Rashonda A Carlisle, Catherine Shelton, Shelley A Hall, Aditi Nayak","doi":"10.1016/j.cardfail.2025.06.007","DOIUrl":"https://doi.org/10.1016/j.cardfail.2025.06.007","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Albuminuria, Kidney Function and Heart Failure Risk in Type 2 Diabetes: Participant-level pooled analysis from CANVAS Program and CREDENCE trial.","authors":"T Ha Jeffrey, Fletcher Robert, Arnott Clare, Jun Min, S Kotwal Sradha, Perkovic Vlado, V Badve Sunil, L Neuen Brendon","doi":"10.1016/j.cardfail.2025.05.021","DOIUrl":"https://doi.org/10.1016/j.cardfail.2025.05.021","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Don't Count Them Out: Recruitment Strategies for Older Adults With Heart Failure","authors":"LYNDSAY DEGROOT PhD, RN, CNE ,&nbsp;HAILEY MILLER PhD, RN ,&nbsp;NOELLE V. PAVLOVIC PhD, RN ,&nbsp;MARTHA N. ABSHIRE SAYLOR PhD, RN","doi":"10.1016/j.cardfail.2024.12.013","DOIUrl":"10.1016/j.cardfail.2024.12.013","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 7","pages":"Pages 1072-1075"},"PeriodicalIF":6.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconsidering the Clinical Integration of Lipoprotein(a) in Heart Failure Risk Models","authors":"XIA HE MM ,&nbsp;YADI LI MD ,&nbsp;XINMIN DENG MD","doi":"10.1016/j.cardfail.2025.04.009","DOIUrl":"10.1016/j.cardfail.2025.04.009","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 7","pages":"Pages 1096-1097"},"PeriodicalIF":6.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary Artery Calcium for Risk Stratification of Heart Failure Mortality: The Coronary Artery Calcium Consortium","authors":"OMAR MHAIMEED MD ,&nbsp;ZEINA A. DARDARI MS ,&nbsp;MICHAEL KHORSANDI MD ,&nbsp;OMAR DZAYE MD, MPH ,&nbsp;KAVITA SHARMA MD ,&nbsp;KHURRAM NASIR MD, MPH, MSc ,&nbsp;DANIEL S. BERMAN MD ,&nbsp;MATTHEW J. BUDOFF MD ,&nbsp;LESLEE J. SHAW PhD ,&nbsp;JOHN A. RUMBERGER MD, PhD ,&nbsp;MICHAEL D. MIEDEMA MD MPH ,&nbsp;MICHAEL J. BLAHA MD MPH","doi":"10.1016/j.cardfail.2024.10.437","DOIUrl":"10.1016/j.cardfail.2024.10.437","url":null,"abstract":"<div><h3>Background</h3><div>There is increasing interest in predicting heart failure (HF), a major cause of morbidity and mortality with a significant financial burden. The role of coronary artery calcium (CAC), an accessible and inexpensive test, in predicting long-term HF mortality among asymptomatic adults remains unknown. We aimed to determine whether CAC burden is associated with HF-related mortality in the CAC Consortium.</div></div><div><h3>Methods and Results</h3><div>The study included 66,636 primary prevention patients from the CAC Consortium. Multivariable competing risks regression was used to assess the association between CAC and HF-related mortality adjusting for demographics and traditional risk factors. The mean age was 54.4 years, 67% male, 89% White, and 55% had a CAC of &gt;0. We observed 260 HF-related mortality events during a median follow up of 12.5 years; 75.3% occurred among those with a baseline CAC score of &gt;100. Compared with a CAC of 0, there was a stepwise higher risk (<em>P</em> &lt; .005) of HF mortality for a CAC of 1–100 (subdistribution hazard ratio [SHR] 2.27, 95% CI 1.3–3.99), 100–400 (SHR 3.68, 95% CI 2.1–6.43), and &gt;400 (SHR 7.05, 95% CI 4.05–12.29). This increasing risk of HF mortality across higher CAC scores persisted across age groups, sex, and in the intermediate and high-risk groups as calculated by the pooled cohort equation and Predicting Risk of cardiovascular disease EVENTs (PREVENT) equation.</div></div><div><h3>Conclusions</h3><div>A higher CAC is associated with an increasing incidence of long-term HF-related mortality in the primary prevention population, particularly intermediate and high-risk patients. Early preventive approaches in patients with high CAC must focus on preventing HF and atherosclerotic cardiovascular disease with lifestyle changes and medications.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 7","pages":"Pages 1005-1015"},"PeriodicalIF":6.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter Left Ventricular Restoration System: Ancora Heart Inc","authors":"YOGITA ROCHLANI MD,&nbsp;ENKLAJD MARSELA MD,&nbsp;ULRICH P. JORDE MD","doi":"10.1016/j.cardfail.2025.02.004","DOIUrl":"10.1016/j.cardfail.2025.02.004","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 7","pages":"Pages 1093-1095"},"PeriodicalIF":6.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}