Journal of Cardiac Failure最新文献

{"title":"Balancing fat loss and muscle loss in the quest to reduce obesity in patients with heart failure.","authors":"Sheldon E Litwin","doi":"10.1016/j.cardfail.2025.01.004","DOIUrl":"https://doi.org/10.1016/j.cardfail.2025.01.004","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implantable Cardioverter-Defibrillators and Cardiovascular Resynchronization Therapy with Left Ventricular Assist Devices: A MOMENTUM 3 Trial Analysis.","authors":"Gabriel Sayer, Mustafa M Ahmed, Mandeep R Mehra, Igor Gosev, Himabindu Vidula, Adam D DeVore, Douglas A Horstmanshof, Joseph C Cleveland, Garrick C Stewart, Mark S Slaughter, Karol Mudy, Aijia Wang, Nir Uriel","doi":"10.1016/j.cardfail.2024.12.011","DOIUrl":"https://doi.org/10.1016/j.cardfail.2024.12.011","url":null,"abstract":"<p><strong>Background: </strong>The benefit of implantable cardioverter-defibrillators (ICD) and cardiovascular resynchronization therapy (CRT-D) in patients supported with a HeartMate 3 left ventricular assist device (LVAD) remains uncertain.</p><p><strong>Methods: </strong>An analysis of the MOMENTUM 3 randomized clinical trial and the first 1000 patients in the Continued Access Protocol trial. Patients were divided into three groups based on the presence of ICD and/or CRT-D: No device (n=153, 11%), ICD only (n=699, 50.4%), CRT-D (n=535, 38.6%). We assessed the association of ICD or CRT-D with overall mortality, ventricular arrhythmias (VA), rehospitalization rates, quality of life and six-minute walk test distance at 2-years of follow-up.</p><p><strong>Results: </strong>Patients with ICD or CRT-D had similar survival to those without (HR 1.3, 95% CI 0.8-2.1, p=0.36) with no differences in rehospitalizations, quality-of-life or six-minute walk test distance. VA occurred more frequently in patients with ICD or CRT-D (HR 2.4, 95% CI 1.3-4.3, p=0.006). Compared to ICD alone, patients with CRT-D demonstrated similar survival (HR 1.1, 95% CI 0.9-1.5, p=0.36), however, had increased rates of VA (HR 1.3, 95% CI 1.0-1.7, p=0.03). There were no differences in rate of rehospitalization between those with ICD or CRT-D and those without (p=0.19) or between those with ICD and those with CRT-D (p=0.32). A propensity-matched sensitivity analysis confirmed these findings.</p><p><strong>Conclusions: </strong>In this post-hoc analysis of the MOMENTUM 3 trial, the presence of ICD or CRT-D at the time of HM3 LVAD implantation was associated with an increased incidence of VA but was not associated with survival, quality of life or functional capacity.</p><p><strong>Trial registration: </strong>Momentum 3 portfolio, NCT02224755 (Pivotal) and NCT02892955 (CAP).</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Don't Count Them Out: Recruitment Strategies for Older Adults with Heart Failure.","authors":"Lyndsay DeGroot, Hailey Miller, Noelle Pavlovic, Martha Abshire Saylor","doi":"10.1016/j.cardfail.2024.12.013","DOIUrl":"https://doi.org/10.1016/j.cardfail.2024.12.013","url":null,"abstract":"<p><p>None.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recovery of Left Ventricular Ejection Fraction in Patients with Anthracycline-Induced Cardiomyopathy- A Contemporary Cohort Study.","authors":"Osnat Itzhaki Ben Zadok, Panagiotis Simitsis, Anju Nohria","doi":"10.1016/j.cardfail.2024.12.012","DOIUrl":"https://doi.org/10.1016/j.cardfail.2024.12.012","url":null,"abstract":"<p><strong>Background: </strong>Data on left ventricular ejection fraction (LVEF) recovery in patients with anthracycline-induced cardiomyopathy (AIC) are limited.</p><p><strong>Objectives: </strong>To evaluate LVEF recovery rate, its predictors and association with cardiovascular outcomes in a contemporary and diverse AIC cohort.</p><p><strong>Methods: </strong>This retrospective study analyzed patients diagnosed with AIC from 2010-2023 at two U.S. university-hospitals and an affiliated cancer-center. LVEF recovery, defined as ≥10% improvement in LVEF to a value ≥50% within 3 years of AIC detection, was assessed using Cox proportional-hazards accounting for competing risks. The association between LVEF recovery and the composite of heart failure (HF) hospitalizations, mechanical circulatory support, heart-transplantation or cardiovascular death was assessed using Cox regression analysis with LVEF recovery as a time-dependent factor.</p><p><strong>Results: </strong>Among 167 patients with AIC (median age 67 (Q1, Q3: 53, 74) years, 53% female), majority had lymphoma (55%) or breast cancer (23%). The median time from first anthracycline exposure to AIC detection was 631 (219, 3569) days and the median LVEF was 38 (29, 45)%. At the detection of AIC, 69% had symptomatic HF. LVEF recovered in 38% (n=63) at a median of 349 (137, 691) days from AIC detection. Age≥60 years at anthracycline exposure, non-white race, diabetes mellitus, longer interval between anthracycline exposure and AIC detection and LV dilation were associated with a lower likelihood of recovery, while statin use and AIC detection after 2022 were associated with a higher likelihood of recovery. LVEF recovery was not associated with cardiovascular outcomes.</p><p><strong>Conclusion: </strong>In this contemporary and diverse AIC cohort, 38% achieved LVEF recovery. Routine screening for AIC and statin therapy may improve recovery rates.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes after Heart Transplantation among Non-Native English-Speaking Recipients.","authors":"Fabian Vargas, Jaya Batra, Carolina Lemos, Ella Magun, Ruben A Salazar, Christy N Taylor, Elena M Donald, Elissa Driggin, Matthew Regan, Robin McArthur-Murphy, Heidi Lumish, Daniella Concha, Alice Chung, Stephanie Golob, Farhana Latif, Kevin J Clerkin, Koji Takeda, Gabriel Sayer, Nir Uriel, Ersilia M DeFilippis","doi":"10.1016/j.cardfail.2024.12.010","DOIUrl":"https://doi.org/10.1016/j.cardfail.2024.12.010","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Effective communication and understanding are imperative for heart transplant (HT) recipients who require lifelong adherence to treatment plans and medications. Whether non-native English speaking (NNES) recipients have inferior outcomes compared to native English-speaking recipients (NES) has not been studied post-HT.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We reviewed adult HT recipients at Columbia University Irving Medical Center from January 2005 through December 2022 with primary language determined by chart review. Baseline characteristics and patient level zip codes which were used to derive socioeconomic status (SES) index using data from the Agency for Healthcare Research and Quality (AHRQ) were included. Mortality at 1-year and 5-year was compared between NNES and NES. Survival curves were estimated by the Kaplan-Meir method and log-rank testing was used to compare survival between groups. Secondary outcomes including hospitalization, hospitalization for infection, and rejection at 1-year, as well as rejection and CAV at 5-years were analyzed using cumulative incidence functions with Gray's testing to detect outcome differences between groups. Multivariable Cox proportional hazard models were constructed to determine if there was an association between NNES and primary and secondary outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Of 1,066 HT recipients, 103 (10%) were NNES. NNES recipients were more likely to identify as non-White, have Medicaid as the primary payer, and have lower educational attainment. On average, NNES recipients resided in zip codes with higher levels of unemployment, lower educational attainment, and lower household incomes. Overall, NNES had lower median AHRQ SES indices (51 vs 55, p&lt;0.001). After adjustment for clinical factors including socioeconomic status, race/ethnicity, and education level, mortality at 1- and 5-years for NNES and NES recipients were not significantly different although there was a trend towards improved survival in the NNES group (1-year adjusted hazard ratio (HR) 0.24, 95% CI 0.06-1.01, p=0.05; 5-year adjusted HR 0.48, 95% CI 0.22-1.03, p=0.06). Similarly, there were no differences in need for re-hospitalization, infection requiring hospitalization, and rejection at 1 year.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;There were no significant differences in outcomes at 1 year and 5 years post-HT among NNES and NES. Availability of interpreter services and educational resources in multiple languages are paramount to maintaining effective communication and equitable outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Lay summary: &lt;/strong&gt;Although the population of individuals living with heart failure in the United States is incredibly diverse, little is known about whether non-Native English speakers (NNES) fare differently after heart transplantation. In this study of over 1000 heart transplant recipients, we found that although NNES patients were more likely to be non-White, had lower education status ","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Critical Time for Tafamidis in the Real World - Will the Data Support its First Mover Advantage?","authors":"Paloma Remior-Perez, Sumeet Singh Mitter","doi":"10.1016/j.cardfail.2025.01.003","DOIUrl":"10.1016/j.cardfail.2025.01.003","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Inflammation to Inspiration and Innovation: A New Perspective on the Utility of Anti-inflammatory Therapies for Acute Heart Failure.","authors":"Michael Sobieraj, Kannu Bansal, Katherine Aa Clark","doi":"10.1016/j.cardfail.2025.01.002","DOIUrl":"https://doi.org/10.1016/j.cardfail.2025.01.002","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sense the Wave Coming?","authors":"Kathleen L Morris, Ashwin Ravichandran","doi":"10.1016/j.cardfail.2025.01.001","DOIUrl":"https://doi.org/10.1016/j.cardfail.2025.01.001","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Inflammatory Score and Incident Heart Failure in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study.","authors":"Christine M Park, Lauren Balkan, Joanna B Ringel, James Shikany, Robin Bostick, Suzanne E Judd, Chanel Jonas, Pankaj Arora, Todd M Brown, Raegan Durant, Scott Hummel, Elizabeth A Jackson, Madeline R Sterling, Ryan Demmer, Melana Yuzefpolskaya, Emily B Levitan, Monika M Safford, Parag Goyal","doi":"10.1016/j.cardfail.2024.12.009","DOIUrl":"https://doi.org/10.1016/j.cardfail.2024.12.009","url":null,"abstract":"<p><strong>Background: </strong>Inflammation plays a key role in the development of heart failure (HF), and diet is a known modifiable factor that modulates systemic inflammation. The dietary inflammatory score (DIS) is a tool to quantify the inflammatory components of diet. We sought to determine whether the DIS is associated with incident HF events.</p><p><strong>Methods: </strong>We examined a total of 17,975 participants without HF at baseline within the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. The main exposure variable was DIS quartile, which was derived from the Food Frequency Questionnaire obtained at baseline study enrollment. The main outcome was incident HF event, defined as HF hospitalization or death. To examine the association between DIS and incident HF events, we conducted Cox proportional hazard regression modeling, adjusting for total energy intake, sociodemographic factors, and pro-inflammatory lifestyle behaviors.</p><p><strong>Results: </strong>The sample mean age was 64 + 9.2 years, 55.8% were female, and 32.3% were Black. Over a median follow-up of 11.1 years, we observed 900 incident HF events, including 752 hospitalizations and 148 HF deaths. In an adjusted model, the highest DIS quartile (Q4) was associated with incident HF (HR 1.26 95% CI 1.03-1.54). Of note, these findings remained even after adjusting for comorbid conditions and physiologic parameters. In an age-stratified analysis, the association was only present among those aged < 65 years (Q4: HR 1.65 95% CI 1.08-2.51). Moreover, the association was present for HFrEF (Q4: HR 1.44 95% CI 1.07-1.94), but not HFpEF.</p><p><strong>Conclusion: </strong>The highest DIS quartile was associated with incident HF events. These findings indicate the potential value of specific dietary pattern to prevent HF.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron Deficiency and Exercise Capacity in LVAD Patients.","authors":"William Herrik Nielsen, Kiran K Mirza, Aevar O Úlfarsson, Oscar Braun, Grunde Gjesdal, Kasper Rossing, Finn Gustafsson","doi":"10.1016/j.cardfail.2024.12.008","DOIUrl":"https://doi.org/10.1016/j.cardfail.2024.12.008","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}