COLETTE DEJONG MD , MATTHEW S. DURSTENFELD MD, MAS , JONATHAN D. DAVIS MD , CHRISTINA S. WANG PharmD , JUSTIN C. CHEN MD , DHRUV S. KAZI MD, MSc MS , MATTHEW D. HICKEY MD , JANET GROCHOWSKI PharmD , WAYNE T. STEWARD PhD, MPH , ELISE D. RILEY PhD, MPH , LUCAS S. ZIER MD , NILOUFAR MOREAU PharmD , MARK D. HUFFMAN MD, MPH , ALEXANDER T. SANDHU MD, MS , PAUL A. HEIDENREICH MD, MS , ANUBHA AGARWAL MD, MSc , PRISCILLA Y. HSUE MD
{"title":"Prototyping and Manufacturing of Customized Over-Encapsulated Polypills for Heart Failure With Reduced Ejection Fraction in a Safety-Net Health Care System","authors":"COLETTE DEJONG MD , MATTHEW S. DURSTENFELD MD, MAS , JONATHAN D. DAVIS MD , CHRISTINA S. WANG PharmD , JUSTIN C. CHEN MD , DHRUV S. KAZI MD, MSc MS , MATTHEW D. HICKEY MD , JANET GROCHOWSKI PharmD , WAYNE T. STEWARD PhD, MPH , ELISE D. RILEY PhD, MPH , LUCAS S. ZIER MD , NILOUFAR MOREAU PharmD , MARK D. HUFFMAN MD, MPH , ALEXANDER T. SANDHU MD, MS , PAUL A. HEIDENREICH MD, MS , ANUBHA AGARWAL MD, MSc , PRISCILLA Y. HSUE MD","doi":"10.1016/j.cardfail.2025.01.030","DOIUrl":"10.1016/j.cardfail.2025.01.030","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 5","pages":"Pages 868-871"},"PeriodicalIF":6.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SONG LI MD , ARJUN BAHL MD , BOYANGZI K. LI MD, PhD , MANREET K. KANWAR MD , BORUI LI MPH , SHASHANK S. SINHA MD, MSc , JAIME HERNANDEZ-MONTFORT MD , QIUYUE KONG MPH , PAAVNI SANGAL MPH , ROBERT W. YEH MD, MSc , DANIEL BURKHOFF MD, PhD , CLAUDIUS MAHR DO , NAVIN K. KAPUR MD
{"title":"Practice Variation in Temporary Mechanical Circulatory Support for Cardiogenic Shock","authors":"SONG LI MD , ARJUN BAHL MD , BOYANGZI K. LI MD, PhD , MANREET K. KANWAR MD , BORUI LI MPH , SHASHANK S. SINHA MD, MSc , JAIME HERNANDEZ-MONTFORT MD , QIUYUE KONG MPH , PAAVNI SANGAL MPH , ROBERT W. YEH MD, MSc , DANIEL BURKHOFF MD, PhD , CLAUDIUS MAHR DO , NAVIN K. KAPUR MD","doi":"10.1016/j.cardfail.2024.10.447","DOIUrl":"10.1016/j.cardfail.2024.10.447","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 5","pages":"Pages 858-862"},"PeriodicalIF":6.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transformation and Beauty After Breaking","authors":"Anuradha Lala MD , Robert J. Mentz MD","doi":"10.1016/j.cardfail.2025.04.002","DOIUrl":"10.1016/j.cardfail.2025.04.002","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 5","pages":"Pages 759-760"},"PeriodicalIF":6.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
KONSTANTINOS SIDERIS MD , MINGYUAN ZHANG MS , PETER WOHLFAHRT MD, PhD , ALFONSO F. SIU MD , JINCHENG SHEN PhD , SPENCER CARTER MD , CHRISTOS P. KYRIAKOPOULOS MD , IOSIF TALEB MD , OMAR WEVER-PINZON MD , KEVIN SHAH MD , CRAIG H. SELZMAN MD , CARLOS RODRIGUEZ-CORREA MD , CHRIS KAPELIOS MD , LINA BRINKER MD , RAMI ALHARETHI MD , RACHEL HESS MD , STAVROS G. DRAKOS MD, PhD , BENJAMIN A. STEINBERG MD , JAMES C. FANG MD , ABDALLAH G. KFOURY MD , JOSEF STEHLIK MD, MPH
{"title":"Integration of Patient Reported Quality-of-life Data into Risk Assessment in Heart Failure","authors":"KONSTANTINOS SIDERIS MD , MINGYUAN ZHANG MS , PETER WOHLFAHRT MD, PhD , ALFONSO F. SIU MD , JINCHENG SHEN PhD , SPENCER CARTER MD , CHRISTOS P. KYRIAKOPOULOS MD , IOSIF TALEB MD , OMAR WEVER-PINZON MD , KEVIN SHAH MD , CRAIG H. SELZMAN MD , CARLOS RODRIGUEZ-CORREA MD , CHRIS KAPELIOS MD , LINA BRINKER MD , RAMI ALHARETHI MD , RACHEL HESS MD , STAVROS G. DRAKOS MD, PhD , BENJAMIN A. STEINBERG MD , JAMES C. FANG MD , ABDALLAH G. KFOURY MD , JOSEF STEHLIK MD, MPH","doi":"10.1016/j.cardfail.2024.08.053","DOIUrl":"10.1016/j.cardfail.2024.08.053","url":null,"abstract":"<div><h3>Background</h3><div>Optimal management of outpatients with heart failure (HF) requires serially updating the estimates of their risk for adverse clinical outcomes to guide treatment. Patient-reported outcomes (PROs) are becoming increasingly used in clinical care. The purpose of this study was to determine whether the inclusion of PROs can improve the risk prediction for HF hospitalization and death in ambulatory patients with HF.</div></div><div><h3>Methods and Results</h3><div>We included consecutive patients with HF with reduced ejection fraction (HFrEF) and HF with preserved EF (HFpEF) seen in a HF clinic between 2015 and 2019 who completed PROs as part of routine care. Cox regression with a least absolute shrinkage and selection operator regularization and gradient boosting machine analyses were used to estimate risk for a combined outcome of HF hospitalization, heart transplant, left ventricular assist device implantation, or death. The performance of the prediction models was evaluated with the time-dependent concordance index <span><math><mrow><mo>(</mo><msub><mi>C</mi><mi>τ</mi></msub><mo>)</mo></mrow></math></span>. Among 1165 patients with HFrEF (mean age 59.1 ± 16.1, 68% male), the median follow-up was 487 days. Among 456 patients with HFpEF (mean age 64.2 ± 16.0 years, 55% male) the median follow-up was 494 days. Gradient boosting regression that included PROs had the best prediction performance – <span><math><msub><mi>C</mi><mi>τ</mi></msub></math></span> 0.73 for patients with HFrEF and 0.74 in patients with HFpEF, and showed very good stratification of risk by time to event analysis by quintile of risk. The Kansas City Cardiomyopathy Questionnaire overall summary score, visual analogue scale and Patient Reported Outcomes Measurement Information System dimensions of satisfaction with social roles and physical function had high variable importance measure in the models.</div></div><div><h3>Conclusions</h3><div>PROs improve risk prediction in both HFrEF and HFpEF, independent of traditional clinical factors. Routine assessment of PROs and leveraging the comprehensive data in the electronic health record in routine clinical care could help more accurately assess risk and support the intensification of treatment in patients with HF.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 5","pages":"Pages 761-770"},"PeriodicalIF":6.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ANDREW J. SAUER MD , CHARLES F. SHERROD MD , KENSEY L. GOSCH MS , SUZANNE V. ARNOLD MD, MHA , MATTHEW REANEY PhD, MSc , YUE ZHONG PhD , JENNY LAM MD, PhD , KATHLEEN W. WYRWICH PhD , JOHN A. SPERTUS MD, MPH
{"title":"The Psychometric Performance of the Kansas City Cardiomyopathy Questionnaire-12 in Symptomatic Obstructive Hypertrophic Cardiomyopathy","authors":"ANDREW J. SAUER MD , CHARLES F. SHERROD MD , KENSEY L. GOSCH MS , SUZANNE V. ARNOLD MD, MHA , MATTHEW REANEY PhD, MSc , YUE ZHONG PhD , JENNY LAM MD, PhD , KATHLEEN W. WYRWICH PhD , JOHN A. SPERTUS MD, MPH","doi":"10.1016/j.cardfail.2024.09.010","DOIUrl":"10.1016/j.cardfail.2024.09.010","url":null,"abstract":"<div><h3>Background</h3><div>A primary goal of treating patients with obstructive hypertrophic cardiomyopathy (oHCM) is to improve their symptoms, function and quality of life. Although the psychometric properties of the 23-item Kansas City Cardiomyopathy Questionnaire (KCCQ-23) have been described in oHCM, they have not been assessed for the shorter 12-item version (KCCQ-12), which is used increasingly in clinical practice.</div></div><div><h3>Methods and Results</h3><div>Using data from the EXPLORER-HCM trial, the psychometric properties of the KCCQ-12 were evaluated. The KCCQ-12 domain and summary scores had moderate correlations with the most relevant clinical (New York Heart Association class, exercise duration, peak oxygen consumption) and patient-reported measures (EQ-5D-5L visual analog scale, Work Productivity and Activity Impairment [WPAI] questionnaire, and Hypertrophic Cardiomyopathy Symptom Questionnaire [HCMSQ]). KCCQ-12 domain scores had strong internal consistency, and test-retest reliability, demonstrated significant and proportional changes with differing magnitudes of clinical change (assessed by the patients’ global impressions of change and the patients’ impressions of severity), and they demonstrated close equivalence to the KCCQ-23 scores.</div></div><div><h3>Conclusions</h3><div>The KCCQ-12 demonstrated good psychometric performance for patients with oHCM, comparable to that of the KCCQ-23, supporting its use in clinical practice to care for patients with oHCM.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 5","pages":"Pages 813-820"},"PeriodicalIF":6.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
MOLLY K. SILKOWSKI DO , RYAN J. TEDFORD MD , JAVED BUTLER MD , BRIAN A. HOUSTON MD
{"title":"PCWL: A Compelling Hemodynamic Metric in Advancing HFpEF Diagnosis","authors":"MOLLY K. SILKOWSKI DO , RYAN J. TEDFORD MD , JAVED BUTLER MD , BRIAN A. HOUSTON MD","doi":"10.1016/j.cardfail.2025.02.005","DOIUrl":"10.1016/j.cardfail.2025.02.005","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 5","pages":"Pages 845-847"},"PeriodicalIF":6.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ELENA M. DONALD MD , ALEXANDER G. HAJDUCZOK MD , RACHEL GOODMAN MD , SHAZLI KHAN MD , DANIEL BURKHOFF MD, PhD , ADITI NAYAK MD
{"title":"Innovate and Translate: Highlights From Technology and Heart Failure Therapeutics, 2025, in Boston","authors":"ELENA M. DONALD MD , ALEXANDER G. HAJDUCZOK MD , RACHEL GOODMAN MD , SHAZLI KHAN MD , DANIEL BURKHOFF MD, PhD , ADITI NAYAK MD","doi":"10.1016/j.cardfail.2025.02.012","DOIUrl":"10.1016/j.cardfail.2025.02.012","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 5","pages":"Pages 848-852"},"PeriodicalIF":6.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
MARIA GAMERO MD , ESTEFANIA OLIVEROS SOLES MD, MSc , YEVGENIY BRAILOVSKY DO, MSc
{"title":"Is Simpler Better? The Psychometric Performance of the Kansas City Cardiomyopathy Questionnaire-12 in Symptomatic Obstructive Cardiomyopathy","authors":"MARIA GAMERO MD , ESTEFANIA OLIVEROS SOLES MD, MSc , YEVGENIY BRAILOVSKY DO, MSc","doi":"10.1016/j.cardfail.2025.03.007","DOIUrl":"10.1016/j.cardfail.2025.03.007","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 5","pages":"Pages 821-823"},"PeriodicalIF":6.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}