Journal of Cardiac Failure最新文献

{"title":"Epidermal Metabolomic Changes Following Left Ventricular Assist Device Implantation in Patients with Advanced Heart Failure.","authors":"Abena Adwetewa-Badu, Trisha Mukerjee, Benjamin A Sweigart, James D Baleja, Noah T Abdelmalek, Samuel Potash, Tatiana Mendez, Addy Alt-Holland, Gordon S Huggins, Didjana Celkupa, Amanda R Vest","doi":"10.1016/j.cardfail.2025.08.006","DOIUrl":"https://doi.org/10.1016/j.cardfail.2025.08.006","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Outcomes of Tirzepatide and Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Type 2 Diabetes.","authors":"Takefumi Kishimori, Takao Kato, Atsuyuki Wada, Akira Tani, Ryosuke Yamaji, Jumpei Koike, Yoshihiro Iwasaki, Takehiro Matsumoto, Takafumi Yagi, Masaharu Okada","doi":"10.1016/j.cardfail.2025.07.026","DOIUrl":"https://doi.org/10.1016/j.cardfail.2025.07.026","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving Natural History of Left Ventricular Ejection Fraction Recovery and Relapse in Heart Failure with Reduced Ejection Fraction.","authors":"Nandan Kodur, Paul Gunsalus, Alex Milinovich, Jarrod E Dalton, W H Wilson Tang","doi":"10.1016/j.cardfail.2025.08.007","DOIUrl":"https://doi.org/10.1016/j.cardfail.2025.08.007","url":null,"abstract":"<p><strong>Background: </strong>Patients with heart failure (HF) with reduced left ventricular ejection fraction (HFrEF; LVEF) may achieve recovery of LVEF. The trends in achieving LVEF recovery across time and the risk and clinical predictors of subsequent relapse remain understudied. The purpose of this study is to describe the contemporary natural history of LVEF recovery and relapse in HFrEF.</p><p><strong>Methods: </strong>In this retrospective cohort study, a HFrEF cohort (LVEF ≤40%; N=42,329) and LVEF recovery cohort (HFrEF with improvement in LVEF to ≥50%; N=10,877) were followed longitudinally to assess LVEF recovery and relapse, respectively, including in an analysis that stratified patients based on three distinct guideline-directed medical therapy (GDMT) eras.</p><p><strong>Results: </strong>Coinciding with advances in GDMT, the probability of achieving LVEF recovery increased greatly across GDMT eras, with an estimated median time to recovery in the 2009-2015, 2016-2020, and 2021-2024 eras of 7 years (95% CI, 6.7-7.3), 3.9 years (95% CI, 3.7-4.0), and 1.8 years (95% CI, 1.7-1.9), respectively (P<0.005). In the 2021-2024 era, an estimated 71.8% (95% CI, 69.4-74.2) of patients achieved LVEF recovery within 3 years. Nevertheless, the probability of sustaining LVEF recovery did not improve across GDMT eras, with an estimated 46.2% (95% CI, 44.9-47.4) of patients experiencing LVEF relapse within 5 years. Higher area deprivation index was independently associated with lower probability of LVEF recovery and higher risk of LVEF relapse.</p><p><strong>Conclusions: </strong>Patients with HFrEF are more likely to achieve LVEF recovery in the current era of GDMT compared with prior eras, but are not less likely to experience LVEF relapse. Socioeconomic status independently influences prognosis beyond biological factors.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Mild and Moderate Aortic Stenosis in Acute Heart Failure: Insights From RELAX-AHF-2.","authors":"Constantijn S Venema, Marco Metra, Laura Staal, Iris E Beldhuis, Gad Cotter, Beth A Davison, G Michael Felker, Gerasimos Filippatos, Barry H Greenberg, Peter S Pang, Piotr Ponikowski, Claudio Gimpelewicz, Erik Lipsic, Adriaan A Voors, John R Teerlink, Joanna J Wykrzykowska","doi":"10.1016/j.cardfail.2025.07.017","DOIUrl":"10.1016/j.cardfail.2025.07.017","url":null,"abstract":"<p><strong>Background: </strong>Aortic stenosis leads to increased afterload, which may be detrimental in a failing left ventricle and has been associated with an increased risk of hospitalizations due to heart failure and mortality in chronic heart failure. The prevalence and impact of aortic stenosis in acute heart failure are less well described. This post hoc analysis aimed to evaluate the prevalence and prognostic impact of aortic stenosis in a large cohort of patients hospitalized due to acute heart failure.</p><p><strong>Methods and results: </strong>All patients from the Relaxin in Acute Heart Failure 2 (RELAX-AHF-2) trial with data available on aortic stenosis severity were included in the present analysis (n = 6241). Patients with severe aortic stenosis were ineligible for RELAX-AHF-2. Baseline characteristics, in-hospital outcomes and 180-day clinical outcomes were compared between patients with and without aortic stenosis. Mild or moderate aortic stenosis was present in 454 (7.3%) patients. Patients with aortic stenosis were older, more commonly female, had more comorbidities, and had higher left ventricular ejection fractions compared to patients without aortic stenosis. Mild or moderate aortic stenosis was associated with a higher risk of cardiovascular mortality or readmission for heart or renal failure (unadjusted hazard ratio (HR) 1.32, 95% CI 1.11-1.57). This association was maintained when adjusting for age and sex, but not after comprehensive multivariable adjustment (adjusted HR 1.04, 95% CI 0.82-1.32).</p><p><strong>Conclusion: </strong>The presence of mild or moderate aortic stenosis reflects an increased risk profile in patients with acute heart failure, but it is not an independent predictor of poor clinical outcomes.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JCS/JHFS 2025 Guideline on Diagnosis and Treatment of Heart Failure.","authors":"Takeshi Kitai, Shun Kohsaka, Takao Kato, Eri Kato, Kimi Sato, Kanako Teramoto, Hidenori Yaku, Eiichi Akiyama, Masahiko Ando, Chisato Izumi, Tomomi Ide, Yu-Ki Iwasaki, Yohei Ohno, Takahiro Okumura, Neiko Ozasa, Shuichiro Kaji, Takeshi Kashimura, Hiroaki Kitaoka, Yoshiharu Kinugasa, Shintaro Kinugawa, Koichi Toda, Toshiyuki Nagai, Makiko Nakamura, Shungo Hikoso, Masatoshi Minamisawa, Satoru Wakasa, Yuta Anchi, Shogo Oishi, Akiko Okada, Masaru Obokata, Nobuyuki Kagiyama, Naoko P Kato, Takashi Kohno, Takuma Sato, Yasuyuki Shiraishi, Yodo Tamaki, Yuichi Tamura, Kazuya Nagao, Yuji Nagatomo, Naoko Nakamura, Kotaro Nochioka, Akihiro Nomura, Seitaro Nomura, Yu Horiuchi, Atsushi Mizuno, Ryosuke Murai, Takayuki Inomata, Koichiro Kuwahara, Yasushi Sakata, Hiroyuki Tsutsui, Koichiro Kinugawa","doi":"10.1016/j.cardfail.2025.07.008","DOIUrl":"10.1016/j.cardfail.2025.07.008","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Where's the Remote? Failure to Report Clinical Workflows in Heart Failure Remote Monitoring Studies","authors":"ELISE L. SHALOWITZ MS ,&nbsp;PARDEEP S. JHUND MBChB MSc, PhD ,&nbsp;MITCHELL A. PSOTKA MD, PhD ,&nbsp;ABHINAV SHARMA MD, PhD ,&nbsp;MATTHEW G. DIMOND ,&nbsp;TREJEEVE MARTYN MD ,&nbsp;RICHARD NKULIKIYINKA MD ,&nbsp;MONA FIUZAT PharmD ,&nbsp;DAVID P. KAO MD","doi":"10.1016/j.cardfail.2024.11.012","DOIUrl":"10.1016/j.cardfail.2024.11.012","url":null,"abstract":"<div><h3>Background</h3><div>Remote patient monitoring (RPM) clinical trials have reported mixed results in improving outcomes for patients with chronic heart failure (HF). The impact of clinical workflows that could impact RPM effectiveness is often overlooked. We sought to characterize workflows and response protocols that could impact outcomes in studies of noninvasive RPM in HF.</div></div><div><h3>Methods</h3><div>We reviewed studies (1999–2024) assessing noninvasive RPM interventions for adults with HF. We collected 24 aspects of workflows describing education, physiologic and symptomatic data collection, transmission and review, clinical escalation protocols, and response time. We attempted to perform a meta-analysis to identify associations between workflow components and outcomes of death and hospitalization.</div></div><div><h3>Results</h3><div>We identified 63 studies (57.1% randomized controlled, 23.8% pilot/feasibility, 19.1% other) comprising 16,699 subjects. Despite a large number of studies and subjects, workflow reporting was insufficient to perform our intended meta-analysis regarding key workflow components. RPM clinical workflows were diverse in configuration, with high variability in component description ranging from always reported to never reported. Specifics of monitoring devices and related training were well reported as expected based on most trial hypotheses. However, elements of clinical data response such as frequency of data review, clinical escalation criteria, and provider response time were often underreported or not reported at all (48%, 24%, and 97%, respectively), hindering study replication and evidence-based implementation.</div></div><div><h3>Conclusions</h3><div>Clinical workflows are poorly described in noninvasive RPM studies, preventing systematic assessment, device comparison, and replication. A standardized approach to reporting HF RPM workflows is vital to evaluate effectiveness and guide evidence-based clinical implementation.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 9","pages":"Pages 1420-1429"},"PeriodicalIF":8.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JCF in Case you Missed it! ESC Heart Failure Congress 2025","authors":"Nicola Melarkey MD ,&nbsp;Jozine M. ter Maaten MD, PhD ,&nbsp;Patricia Campbell MD ,&nbsp;Niels Grote Beverborg MD, PhD","doi":"10.1016/j.cardfail.2025.05.014","DOIUrl":"10.1016/j.cardfail.2025.05.014","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 9","pages":"Pages 1476-1479"},"PeriodicalIF":8.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not One-Size-Fits-All: Clinical Conundrum of Cardiac Allograft Vasculopathy Assessment and Prevention","authors":"INDRANEE RAJAPREYAR MD,&nbsp;MICHAEL S. KIERNAN MD, MS","doi":"10.1016/j.cardfail.2025.07.004","DOIUrl":"10.1016/j.cardfail.2025.07.004","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 9","pages":"Pages 1417-1419"},"PeriodicalIF":8.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celebrate 30 Years of HFSA at ASM 2025 – Reunite, Reflect, and Reimagine the Future of Heart Failure","authors":"","doi":"10.1016/j.cardfail.2025.08.001","DOIUrl":"10.1016/j.cardfail.2025.08.001","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 9","pages":"Pages 1493-1495"},"PeriodicalIF":8.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2023 Update of the Japanese Heart Failure Society Scientific Statement on BNP and NT-proBNP Levels in Heart Failure Practice","authors":"MASATOSHI MINAMISAWA MD, PhD ,&nbsp;TOSHIHISA ANZAI MD, PhD ,&nbsp;TAKAYUKI INOMATA MD, PhD ,&nbsp;KOICHIRO KINUGAWA MD, PhD ,&nbsp;YASUSHI SAKATA MD, PhD ,&nbsp;NAOKI SATO MD, PhD ,&nbsp;HIROYUKI TSUTSUI MD, PhD ,&nbsp;KAZUHIRO YAMAMOTO MD, PhD ,&nbsp;MICHIHIRO YOSHIMURA MD, PhD ,&nbsp;YOSHIHIKO SAITO MD, PhD ,&nbsp;KOICHIRO KUWAHARA MD, PhD","doi":"10.1016/j.cardfail.2025.03.005","DOIUrl":"10.1016/j.cardfail.2025.03.005","url":null,"abstract":"<div><div>This revised 2023 statement on blood brain (B-type) natriuretic peptide (BNP) and N-terminal prohormone of brain (B-type) natriuretic peptide (NT-proBNP) represents an expert consensus that aims to enhance efficient referral from general practitioners or non-cardiovascular specialists, providing a comprehensive, up-to-date perspective on BNP and NT-proBNP in the diagnosis and management of heart failure, with a focus on the following two major modifications: (1) Changes regarding cutoff values for BNP and NT-proBNP (criteria for heart failure diagnosis and referral criteria to cardiovascular specialists); and (2) Content related to heart failure management using BNP and NT-proBNP (BNP-guided therapy).</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 9","pages":"Pages 1453-1459"},"PeriodicalIF":8.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}