Journal of Cardiac Failure最新文献

{"title":"Impact of Atrial Fibrillation on Hemodynamics, Oxygen Consumption, and Its Fick Determinants in Patients With Heart Failure With Preserved Ejection Fraction","authors":"STEPHEN J. FOULKES PhD,&nbsp;SARA MOURA-FERREIRA MD,&nbsp;MAURICIO MILANI MD, PhD,&nbsp;YOURI BEKHUIS MD,&nbsp;MAARTEN FALTER MD,&nbsp;BORIS DELPIRE MD,&nbsp;RIK PAUWELS MD,&nbsp;SARAH STROOBANTS MD,&nbsp;SIDDHARTH JOGANI MD,&nbsp;SIMON VANHENTENRIJK MD, PharmD, MSc,&nbsp;SIBEL ALTINTAS MD,&nbsp;RUTA JASAITYTE MD, PhD,&nbsp;JAN STASSEN MD, PhD,&nbsp;LIEVEN HERBOTS MD, PhD,&nbsp;GUIDO CLAESSEN MD, PhD,&nbsp;MARK J. HAYKOWSKY PhD,&nbsp;JAN VERWERFT MD, PhD","doi":"10.1016/j.cardfail.2025.12.007","DOIUrl":"10.1016/j.cardfail.2025.12.007","url":null,"abstract":"<div><h3>Objective</h3><div>Atrial fibrillation (AF) is a common comorbidity in patients with heart failure with preserved ejection fraction (HFpEF) that contributes to increased morbidity and mortality. We sought to evaluate the impact of AF on key HFpEF features, including exercise tolerance (peak oxygen uptake, VO₂peak) hemodynamic responses, and peripheral oxygen extraction (a-vO₂diff).</div></div><div><h3>Methods</h3><div>Patients referred to a multidsciplinary clinic for evaluation of unexplained dyspnea and diagnosed with HFpEF after a comprehensive clinical and hemodynamic evaluation were stratified on the basis of whether they were in persistent/permanent AF (AF_Persist; n = 86), paroxysmal AF (AF_Parox; n = 328), or sinus rhythm (SR; n = 274). Cardiopulmonary exercise testing with simultaneous echocardiography was applied to assess the VO₂peak, a-vO₂diff, and exercise hemodynamics. Groups were compared using analysis of covariance with adjustment for age, sex, body mass index, and the presence of hypertension and diabetes.</div></div><div><h3>Results</h3><div>Compared with patients in SR or with AF_Parox, patients with HFpEF and AF_Persist had a lower VO₂peak (1.3−2.4 mL/kg/min lower, <em>P</em> &lt; .001). This coincided with lower peak exercise cardiac output (CO, 0.6−1.2 L/min lower), secondary to a lesser stroke volume (14−17 mL lower, <em>P</em> &lt; .001), and a smaller left ventricular end-diastolic volume (15−18 mL lower, <em>P</em> &lt; .001) that tended to decrease during exercise. In contrast, there was no impact of AF status on peak exercise a-vO₂diff, mean pulmonary artery pressure or the mean pulmonary artery pressure/CO slope.</div></div><div><h3>Conclusions</h3><div>Patients with HFpEF and AF_Persist have a lower VO₂peak secondary to decreased CO, SV, and reduced end-diastolic volume reserve. Rhythm control strategies may therefore be pivotal in optimizing exercise performance and clinical outcomes in patients with HFpEF and AF.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 10","pages":"Pages 1715-1726"},"PeriodicalIF":9.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No Patient With Heart Failure Left Behind: Making Guideline-Directed Medical Therapy a Reality for All","authors":"GRANT YOUNG,&nbsp;JUAN CARLOS BATLLE MD,&nbsp;KATHERINE A.A. CLARK MD, MBA, FACC","doi":"10.1016/j.cardfail.2026.03.004","DOIUrl":"10.1016/j.cardfail.2026.03.004","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 10","pages":"Pages 1701-1703"},"PeriodicalIF":9.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Tale of Two Medicares: The Medicare Advantage Experience for Patients with Heart Failure","authors":"CATHERINE G. DERINGTON PHARMD, MS,&nbsp;KAREN E. JOYNT MADDOX MD, MPH,&nbsp;LARRY A. ALLEN MD, MHS","doi":"10.1016/j.cardfail.2026.03.005","DOIUrl":"10.1016/j.cardfail.2026.03.005","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 10","pages":"Pages 1712-1714"},"PeriodicalIF":9.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147457730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Care for Patients With Heart Failure in the Czech Republic: Progress Achieved and Future Goals","authors":"MARKÉTA HEGAROVÁ MD, PhD,&nbsp;LENKA HOŠKOVÁ MD, PhD,&nbsp;IVAN MÁLEK MD, PhD,&nbsp;IVAN NETUKA MD, PhD,&nbsp;JAN KREJČÍ MD, PhD,&nbsp;PETR FILA MD, PhD,&nbsp;JOSEF STEHLIK MD, MPH,&nbsp;VOJTĚCH MELENOVSKÝ MD, PhD","doi":"10.1016/j.cardfail.2026.05.018","DOIUrl":"10.1016/j.cardfail.2026.05.018","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 10","pages":"Pages 1849-1852"},"PeriodicalIF":9.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148224751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifetime Achievement Award Spotlight","authors":"Gregg C. Fonarow MD, FACC, FAHA, FHFSA","doi":"10.1016/j.cardfail.2026.09.004","DOIUrl":"10.1016/j.cardfail.2026.09.004","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 10","pages":"Pages 1856-1858"},"PeriodicalIF":9.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149175064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanded Results From a Dedicated Guideline-Directed Medical Therapy Clinic","authors":"LAURA P. COHEN M.D., M.P.P.,&nbsp;CHARLOTTE PAQUETTE B.A.,&nbsp;MICHELLE VASSILOPOULOS R.N.,&nbsp;ASHLEY TRINGALE A.G.A.C.N.P.-B.C.,&nbsp;KATHRYN E. SHEPPARD P.A.,&nbsp;CHRISTINE KO Pharm.D.,&nbsp;LANA TSAO M.D.,&nbsp;SAFIA CHATUR M.D.,&nbsp;CLAIRE LIN B.A.,&nbsp;AFERDITA SPAHILLARI M.D.,&nbsp;YUXI LIU M.S.,&nbsp;JAMES L. JANUZZI Jr. M.D.","doi":"10.1016/j.cardfail.2025.09.019","DOIUrl":"10.1016/j.cardfail.2025.09.019","url":null,"abstract":"<div><h3>Background</h3><div>Implementation of guideline-directed medical therapy (GDMT) for heart failure (HF) care in general cardiology environments is suboptimal. A dedicated GDMT clinic was expanded to include individuals with HF across the full spectrum of left ventricular ejection fraction (LVEF).</div></div><div><h3>Methods</h3><div>Referred individuals were seen by advanced-practice providers until maximally tolerated therapy was achieved. Achievement of optimal GDMT was evaluated and compared to that of patients with usual care, matched in a 1:2 fashion. Key prognostic HF indicators were assessed.</div></div><div><h3>Results</h3><div>The mean (SD) age of 92 GDMT-eligible clinic participants was 66.5 (15.4) years; 25 (27.2%) were female; and 18 (19.6%) had LVEF ≥ 50%. From baseline to follow-up visit (12.9 weeks), the number of patients eligible for optimal GDMT with LVEF &lt; 50% increased from 12.0%–91.3% (<em>P</em> &lt; 0.001); among eligible individuals with LVEF ≥ 50%, optimal GDMT increased from 5.6%–77.8% (<em>P</em> = 0.001). There was an increase in the proportion of optimal GDMT at ≥ 50% target dosage (1.1%–50.0%) and at target dosage (0.0%–30.4%). These changes were substantially greater than in the matched cohort of usual-care patients. Among GDMT patients, significant improvements were observed in symptoms, NT-proBNP levels and important echocardiographic measurements. Both Kansas City Cardiomyopathy Questionnaire Overall and Clinical Summary Scores significantly increased by 8 points (<em>P</em> = 0.01), and 6-minute walk distance increased by 37 meters (<em>P</em> = 0.03). GDMT administration was safe and well tolerated.</div></div><div><h3>Conclusions</h3><div>Successful implementation of GDMT in a dedicated clinic embedded in a general cardiology practice was well tolerated and effective in improving key outcomes across the entire spectrum of LVEF.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 10","pages":"Pages 1689-1700"},"PeriodicalIF":9.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Contractility Modulation for Patients With Heart Failure and Preserved Ejection Fraction: The AIM HIGHer Study","authors":"JAVED BUTLER MD, MPH, MBA,&nbsp;ISHU RAO MD,&nbsp;ANDREW J. SAUER MD,&nbsp;STEFAN D. ANKER MD, PhD,&nbsp;Francesco Fioretti MD,&nbsp;DANIEL BURKHOFF MD,&nbsp;GERASIMOS FILIPPATOS MD, DrHC, FESC, FHFA, FHFSA,&nbsp;CAROLYN S.P. LAM MBBS, PhD, FRCP, MS, FACC, FAMS, FESC,&nbsp;GREGG W. STONE MD, FACC, MSCAI,&nbsp;OUSSAMA WAZNI MD, MBA","doi":"10.1016/j.cardfail.2026.02.050","DOIUrl":"10.1016/j.cardfail.2026.02.050","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 10","pages":"Pages 1833-1837"},"PeriodicalIF":9.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Amyloidosis Epidemiologic Paradox: Therapeutic Advances Amid Increasing Mortality","authors":"JENNA BILODEAU-GANDRE MD,&nbsp;PAMELA FIELDS APRN,&nbsp;CECELIA HERNANDEZ MSN-CNE, BSN,&nbsp;MELISSA A. LYLE MD","doi":"10.1016/j.cardfail.2026.02.038","DOIUrl":"10.1016/j.cardfail.2026.02.038","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 10","pages":"Pages 1778-1780"},"PeriodicalIF":9.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147457787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JCF in Case You Missed It! Summary of American College of Cardiology (ACC) 2026","authors":"DIANA DE OLIVEIRA-GOMES MD,&nbsp;ALEXANDER HAJDUCZOK MD,&nbsp;ANURADHA LALA MD","doi":"10.1016/j.cardfail.2026.04.014","DOIUrl":"10.1016/j.cardfail.2026.04.014","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 10","pages":"Pages 1816-1820"},"PeriodicalIF":9.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When the Right Ventricle Becomes the Teacher: Lessons From Acute Right Heart Failure","authors":"ALEXANDRA MIHAI MD","doi":"10.1016/j.cardfail.2026.07.013","DOIUrl":"10.1016/j.cardfail.2026.07.013","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 10","pages":"Pages 1853-1855"},"PeriodicalIF":9.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148603360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}