Journal of Cardiac Failure最新文献

{"title":"JCF In case you missed it! AAHFN 2025 Annual Meeting.","authors":"Laura Peters, Stephanie Barnes, Marie Galvao, Kismet Rasmusson, Meg Fraser","doi":"10.1016/j.cardfail.2025.06.006","DOIUrl":"https://doi.org/10.1016/j.cardfail.2025.06.006","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disruptions in Sleep Health and Independent Associations with Psychological Distress in Close Family Members of Cardiac Arrest Survivors: A Prospective Study","authors":"ISABELLA M. TINCHER BA ,&nbsp;DANIELLE A. ROJAS MS ,&nbsp;MINA YUAN BA ,&nbsp;SABINE ABUKHADRA BS ,&nbsp;CHRISTINE E. DEFORGE PhD, RN, CCRN ,&nbsp;S. JUSTIN THOMAS PhD ,&nbsp;KRISTIN FLANARY MA ,&nbsp;DAICHI SHIMBO MD ,&nbsp;NOUR MAKAREM PhD, FAHA ,&nbsp;BERNARD P. CHANG MD, PhD ,&nbsp;SACHIN AGARWAL MD, MPH","doi":"10.1016/j.cardfail.2024.10.007","DOIUrl":"10.1016/j.cardfail.2024.10.007","url":null,"abstract":"<div><h3>Background</h3><div>While recent guidelines have noted the deleterious effects of poor sleep on cardiovascular health, the upstream impact of cardiac arrest–induced psychological distress on sleep health metrics among families of cardiac arrest survivors remains unknown.</div></div><div><h3>Methods</h3><div>Sleep health of close family members of consecutive patients with cardiac arrest admitted to an academic center (August 16, 2021–June 28, 2023) was self-reported using the Pittsburgh Sleep Quality Index (PSQI). The baseline PSQI, focused on sleep in the month before cardiac arrest, was administered during hospitalization and repeated 1 month after cardiac arrest alongside the Patient Health Questionnaire-8 (PHQ-8) to assess depression severity. Multivariable linear regressions analyzed associations between total PHQ-8 scores and changes in global PSQI scores between baseline and 1 month, with higher scores indicating deterioration. A prioritization exercise explored potential interventions categorized into the family's information and well-being needs to reduce psychological distress.</div></div><div><h3>Results</h3><div>In our sample of 102 close family members (mean age 52 ± 15 years, 70% female, 21% Black, 33% Hispanic), mean global PSQI scores showed a significant decline between baseline and 1 month after cardiac arrest (6.2 ± 3.8 vs. 7.4 ± 4.1; <em>P</em> &lt; .01). This deterioration was notable for sleep quality, duration, and daytime dysfunction. Higher PHQ-8 scores were significantly associated with higher change in PSQI scores after adjusting for family members’ age, sex, race/ethnicity, prior psychiatric history, and patient's discharge disposition (B = 0.4 [95% CI 0.24–0.48]; <em>P</em> &lt; .01, β = 0.5). Most families expressed a higher priority for information-based interventions over well-being needs to help alleviate psychological distress during the first month following cardiac arrest (76% vs. 34%, <em>P</em> &lt; .01).</div></div><div><h3>Conclusions</h3><div>A significant sleep health decline was observed among close family members of cardiac arrest survivors during the acute period, with psychological distress associated with this disruption. Understanding these temporal associations will help guide the development of targeted interventions to support families during this uncertain time.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 7","pages":"Pages 1018-1029"},"PeriodicalIF":6.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Testing Practices and Pathological Assessments in Patients With End-stage Heart Failure Undergoing Heart Transplantation and Left Ventricular Assist Device Use","authors":"ELIZABETH SILVER ,&nbsp;ALESSIA ARGIRO MD ,&nbsp;SARAH S. MURRAY PhD, MS ,&nbsp;LAUREN KORTY MS ,&nbsp;GRACE LIN MD, PhD ,&nbsp;VICTOR PRETORIUS MBchB ,&nbsp;MARCUS A. UREY MD ,&nbsp;KIMBERLY N. HONG MD, MHSA ,&nbsp;ERIC D. ADLER MD ,&nbsp;QUAN M. BUI MD","doi":"10.1016/j.cardfail.2024.09.015","DOIUrl":"10.1016/j.cardfail.2024.09.015","url":null,"abstract":"<div><h3>Background</h3><div>Genetic cardiomyopathies (CMs) are increasingly recognized as causes of end-stage heart failure (ESHF). Identification of a genetic etiology in ESHF has important prognostic and family implications. However, genetic testing practices are understudied in patients with ESHF.</div></div><div><h3>Methods</h3><div>This single-center, retrospective study included consecutive patients with ESHF who underwent heart transplantation (HT) or left ventricular assist device (LVAD) implantation between 2018 and 2023. Data, including genetic testing and pathology reports, were collected from the electronic medical records. Analyses of demographic and clinical characteristics were stratified by genetic-testing completion and the presence of clinically actionable variants. Logistic regression was performed to evaluate for associations between histology findings and genetic variants.</div></div><div><h3>Results</h3><div>A total of 529 adult patients (mean age 57 years) were included in the study and were predominantly male (79%, 422/529) and non-white (61%, 322/529). Genetic testing was performed in 54% (196/360) of patients with either nonischemic or mixed CMs. A clinically actionable result was identified in 36% (70/196) of patients, of whom only 43% (30/70) had genetic counselor referrals. The most common genetic variants were <em>TTN</em> (32%, 24/75), <em>MYBPC3</em> (13%, 10/75) and <em>TTR</em> (11%, 8/75). Clinically actionable variants were identified in patients with known heart failure precipitators such as alcohol use. In multivariable analysis, the presence of interstitial fibrosis, specifically diffuse, on pathology was significantly associated with a clinically actionable variant (aOR 2.29, 95% CI [1.08–4.86]; <em>P</em> = 0.03).</div></div><div><h3>Conclusion</h3><div>Patients with ESHF and with nonischemic or mixed CM who were undergoing advanced therapies had low uptakes of genetic services, including testing and counselors, despite high burdens of genetic disease. Pathology findings such as interstitial fibrosis may provide insight into genetic etiology. The underuse of services suggests a need for implementation strategies to improve uptake.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 7","pages":"Pages 1039-1047"},"PeriodicalIF":6.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The HFSA Clinic Database: A National Resource to Advance Heart Failure Care","authors":"","doi":"10.1016/j.cardfail.2025.06.005","DOIUrl":"10.1016/j.cardfail.2025.06.005","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 7","pages":"Pages 1099-1100"},"PeriodicalIF":6.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Stressed Blood Volume With Endovascular Ablation of the Right Greater Splanchnic Nerve in Heart Failure With Preserved Ejection Fraction: The REBALANCE-HF Trial","authors":"HUSAM M. SALAH MD ,&nbsp;MARAT FUDIM MD, MHS ,&nbsp;BARRY A. BORLAUG MD ,&nbsp;SHELDON E. LITWIN MD ,&nbsp;MATTHEW STARK ,&nbsp;SANJIV J. SHAH MD ,&nbsp;DANIEL BURKHOFF MD, PhD","doi":"10.1016/j.cardfail.2025.01.016","DOIUrl":"10.1016/j.cardfail.2025.01.016","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 7","pages":"Pages 1081-1084"},"PeriodicalIF":6.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of GLP-1 Receptor Agonists in Patients With Heart Failure and Mildly Reduced or Preserved Ejection Fraction: A Systematic Review and Meta-Analysis","authors":"SAAD AHMED WAQAS MBBS ,&nbsp;MUHAMMAD UMER SOHAIL MBBS ,&nbsp;MUHAMMAD SAAD MBBS ,&nbsp;ABDUL MANNAN KHAN MINHAS MD ,&nbsp;STEPHEN J. GREENE MD ,&nbsp;MARAT FUDIM MD, MHS ,&nbsp;GREGG C. FONAROW MD, MHS ,&nbsp;DMITRY ABRAMOV MD ,&nbsp;MUHAMMAD SHAHZEB KHAN MD, MSc ,&nbsp;RAHEEL AHMED MRCP","doi":"10.1016/j.cardfail.2025.01.022","DOIUrl":"10.1016/j.cardfail.2025.01.022","url":null,"abstract":"<div><h3>Background</h3><div>Heart failure (HF) with mildly reduced or preserved ejection fraction (HFpEF) accounts for over half of cases of HF, with obesity playing a key role. Residual risk remains high despite available therapies. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have shown potential cardiometabolic benefits, but their role in HFpEF remains unclear.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis of randomized controlled trials evaluating GLP-1RAs in HFpEF were conducted. Studies evaluating GLP-1RA in combination with glucose-dependent insulinotropic polypeptide (GIP) were also included. The analyzed outcomes included cardiovascular (CV) death, worsening HF events and their composite. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled by using a random-effects model.</div></div><div><h3>Results</h3><div>Six randomized controlled trials involving 8788 patients were included. GLP-1RAs significantly reduced the composite outcome of CV death or worsening HF events (HR: 0.68 [0.51–0.89]; <em>P</em> = 0.006, I² = 47%) as well as worsening HF events alone (HR: 0.56 [0.38–0.82]; <em>P</em> = 0.003, I² = 51%). No significant reduction was observed for CV death alone (HR: 0.86 [0.67–1.12]; <em>P</em> = 0.27, I² = 0%).</div></div><div><h3>Conclusion</h3><div>GLP-1RAs reduce worsening HF events and the composite of CV death or worsening HF in HFpEF, particularly in patients with obesity or diabetes. These findings support their role as a promising therapy requiring further HFpEF-focused trials.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 7","pages":"Pages 1076-1080"},"PeriodicalIF":6.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor by He et al","authors":"ADITHYA K. YADALAM MD, MSc,&nbsp;ARSHED A. QUYYUMI MD","doi":"10.1016/j.cardfail.2025.05.003","DOIUrl":"10.1016/j.cardfail.2025.05.003","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 7","pages":"Page 1098"},"PeriodicalIF":6.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Testing in Advanced Heart Failure: Is it Ever Too Late?","authors":"NOSHEEN REZA MD, MS","doi":"10.1016/j.cardfail.2025.05.009","DOIUrl":"10.1016/j.cardfail.2025.05.009","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 7","pages":"Pages 1048-1050"},"PeriodicalIF":6.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLP-1 Receptor Agonist in Nonobese Patients with Type 2 Diabetes Mellitus and Heart Failure with Preserved Ejection Fraction","authors":"SUMANTH KHADKE MD ,&nbsp;ASHISH KUMAR MD ,&nbsp;AMMAR BHATTI DO ,&nbsp;SOURBHA S. DANI MD, MSc ,&nbsp;SADEER AL-KINDI MD ,&nbsp;KHURRAM NASIR MD ,&nbsp;SALIM S. VIRANI MD, PhD ,&nbsp;JAGRITI UPADHYAY MD ,&nbsp;DINAMARIE C. GARCIA-BANIGAN MD ,&nbsp;SONU ABRAHAM MD ,&nbsp;RAYA HUSAMI MD ,&nbsp;YIXIN KONG PhD ,&nbsp;SHERIF LABIB MD ,&nbsp;DAVID VENESY MD ,&nbsp;SACHIN SHAH MD ,&nbsp;DANIEL LENIHAN MD ,&nbsp;MUTHIAH VADUGANATHAN MD ,&nbsp;ANITA DESWAL MD, MPH ,&nbsp;GREGG C. FONAROW MD ,&nbsp;JAVED BUTLER MD ,&nbsp;SARJU GANATRA MD","doi":"10.1016/j.cardfail.2024.10.448","DOIUrl":"10.1016/j.cardfail.2024.10.448","url":null,"abstract":"<div><h3>Background</h3><div>Glucagon-like peptide-1 receptor agonists (GLP-1RAs) promote weight loss and improve heart failure-related symptoms, quality of life, and functional capacity in patients with obesity and heart failure with preserved ejection fraction (HFpEF). However, their clinical effectiveness in nonobese patients with diabetes and HFpEF is understudied.</div></div><div><h3>Methods</h3><div>The TriNetX research network was used to identify adult patients (≥18 years) with type 2 diabetes mellitus (T2DM), heart failure with preserved ejection fraction (left ventricular ejection fraction ≥45%), elevated brain natriuretic peptide (≥ 150 pg/mL) or N-terminal pro-B-type natriuretic peptide(≥ 450 pg/mL) and a body mass index (BMI) &lt;30 kg/m2 on or before August 31, 2022. Patients were divided into two groups based on GLP-1RA use. After propensity score matching, Cox proportional hazard ratios (HRs) were used to compare outcomes over a 12-month follow-up period.</div></div><div><h3>Results</h3><div>The study included 84,990 patients (n= 42,495 per group, mean age 64 years, 49% females, 65% white). Patients on GLP-1RAs were associated with lower incidence of heart failure exacerbation events (HR 0.60, 95% CI 0.58-0.62, p&lt;0.001) and all-cause emergency room visits or hospitalizations (HR, 0.67, 95% CI 0.66–0.69; <em>P</em> &lt; .001) compared with those not on GLP-1RAs. Other outcomes, including acute myocardial infarction, atrial fibrillation, ischemic stroke, pulmonary hypertension, C-reactive protein ≥ 5 mg/L, acute kidney injury, and the need for renal replacement therapy, were also significantly less frequent in the GLP-1RA group. These associated benefits persisted even among patients on a sodium-glucose cotransporter-2 inhibitor (SGLT2i).</div></div><div><h3>Conclusion</h3><div>GLP-1RA use is associated with improved cardiovascular outcomes in nonobese patients with T2DM and HFpEF and has an associated incremental benefit even among patients on SGLT2i.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 7","pages":"Pages 989-1001"},"PeriodicalIF":6.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reprieve System for the Treatment of Patients With Acute Decompensated Heart Failure","authors":"JUAN B. IVEY-MIRANDA MD ,&nbsp;VEENA S. RAO PhD ,&nbsp;TAMAZ SHABURISHVILI MD ,&nbsp;IVLITA VERULAVA MD ,&nbsp;NINA KHABEISHVILI MD ,&nbsp;MARK C. PETRIE MD ,&nbsp;JAVED BUTLER MD, MPH, MBA ,&nbsp;JULIO NUNEZ MD, PhD ,&nbsp;JAN BIEGUS MD, PhD ,&nbsp;PIOTR PONIKOWSKI MD, PhD ,&nbsp;KEVIN DAMMAN MD, PhD ,&nbsp;SEAN P. COLLINS MD ,&nbsp;JEFFREY M. TESTANI MD, MTR ,&nbsp;ZACHARY L. COX PharmD","doi":"10.1016/j.cardfail.2025.02.002","DOIUrl":"10.1016/j.cardfail.2025.02.002","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 7","pages":"Pages 1085-1089"},"PeriodicalIF":6.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}