Journal of Cardiac Failure最新文献

{"title":"Long-term Changes in Body Composition and Exercise Capacity Following Calorie Restriction and Exercise Training in Older Patients with Obesity and Heart Failure With Preserved Ejection Fraction","authors":"BHARATHI UPADHYA MD ,&nbsp;PETER H. BRUBAKER PhD ,&nbsp;BARBARA J. NICKLAS PhD ,&nbsp;DENISE K. HOUSTON PhD ,&nbsp;MARK J. HAYKOWSKY PhD ,&nbsp;DALANE W. KITZMAN MD","doi":"10.1016/j.cardfail.2024.06.007","DOIUrl":"10.1016/j.cardfail.2024.06.007","url":null,"abstract":"<div><h3>Background</h3><div>Obesity combined with heart failure with preserved ejection fraction (HFpEF) is the dominant form of HF among older persons. In a randomized trial, we previously showed that a 5-month calorie restriction (CR) program, with or without aerobic exercise training (AT), resulted in significant weight and fat loss and improved exercise capacity. However, little is known regarding the long-term effects of these outcomes after a short-term (5-month) intervention of CR with or without AT in older patients with obesity and HFpEF.</div></div><div><h3>Methods</h3><div>Sixteen participants from either the CR or CR+AT who experienced significant weight loss ≥ 2 kg were reexamined after a long-term follow-up endpoint (28.0 ± 10.8 months) without intervention. The follow-up assessment included body weight and composition via dual-energy X-ray absorptiometry and exhaustive cardiopulmonary treadmill exercise testing.</div></div><div><h3>Results</h3><div>Compared to the 5-month time-point intervention endpoint, at the long-term follow-up endpoint, mean body weight increased +5.2 ± 4.0 kg (90.7 ± 11.2 kg vs 95.9 ± 11.9; <em>P</em> &lt; 0.001) due to increased fat mass (38.9 ± 9.3 vs 43.8 ± 9.8; <em>P</em> &lt; 0.001) with no change in lean mass (49.6 ± 7.1 vs 49.9±7.6; <em>P</em> = 0.67), resulting in worse body composition (decreased lean-to-fat mass). Change in total mass was strongly and significantly correlated with change in fat mass (r = 0.75; <em>P</em> &lt; 0.001), whereas there appeared to be a weaker correlation with change in lean mass (r = 0.50; <em>P</em> = 0.051). Additionally, from the end of the 5-month time-point intervention endpoint to the long-term follow-up endpoint, there were large, significant decreases in VO₂peak (-2.2 ± 2.1 mL/kg/min; <em>P</em> = 0.003) and exercise time (-2.4 ± 2.6 min; <em>P</em> = 0.006). There appeared to be an inverse correlation between the change in VO₂peak and the change in fat mass (r = -0.52; <em>P</em> = 0.062).</div></div><div><h3>Conclusion</h3><div>Although CR and CR+AT in older patients with obesity and HFpEF can improve body composition and exercise capacity significantly, these positive changes diminish considerably during long-term follow-up endpoints, and regained weight is predominantly adipose, resulting in worsened overall body composition compared to baseline. This suggests a need for long-term adherence strategies to prevent weight regain and maintain improvements in body composition and exercise capacity following CR in older patients with obesity and HFpEF.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 3","pages":"Pages 497-507"},"PeriodicalIF":6.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Analytical Methods for Composite End Points in Clinical Trials: Insights from the Vericiguat Global Study in Subjects with Heart Failure With Reduced Ejection Fraction Trial","authors":"CYNTHIA M. WESTERHOUT PhD ,&nbsp;SARAH RATHWELL MSc ,&nbsp;KEVIN J. ANSTROM PhD ,&nbsp;ADRIAN F. HERNANDEZ MD, MHS ,&nbsp;PIOTR PONIKOWSKI MD ,&nbsp;JUSTIN A. EZEKOWITZ MBBCh, MSc ,&nbsp;ADRIAAN A. VOORS MD, PhD ,&nbsp;G. MICHAEL FELKER MD, MHS ,&nbsp;JEFFREY A. BAKAL PhD, PStat ,&nbsp;ROBERT O. BLAUSTEIN MD, PhD ,&nbsp;RICHARD NKULIKIYINKA MD ,&nbsp;CHRISTOPHER M. O'CONNOR MD ,&nbsp;PAUL W. ARMSTRONG MD ,&nbsp;VICTORIA Study Group","doi":"10.1016/j.cardfail.2024.08.038","DOIUrl":"10.1016/j.cardfail.2024.08.038","url":null,"abstract":"<div><h3>Background</h3><div>In VICTORIA (Vericiguat Global Study in Subjects with Heart Failure with Reduced Ejection Fraction), participants with heart failure (HF) and reduced ejection fraction, vericiguat decreased the primary composite outcome (time to first HF hospitalization [HFH] or cardiovascular death [CVD]) (897 events) compared with placebo (972 events) (hazard ratio, 0.90; 95% confidence interval [CI], 0.82–0.98; <em>P</em> = .02). In this prespecified secondary analysis, we applied the weighted composite end point (WCE) and the win ratio (WR) methods to provide complementary assessments of treatment effect.</div></div><div><h3>Methods and Results</h3><div>The WCE method estimated the mean HFH-adjusted survival based on prespecified weights from a Delphi panel of the VICTORIA executive committee and national leaders: mild (weight per event, 0.39), moderate (0.5), or severe (0.67) HFH, and CVD (1.0). The unmatched WR was estimated for the descending hierarchy of CVD, then recurrent HFH. The WCE used all 3412 primary clinical events: 875 severe HFH (vericiguat, 416/ placebo, 459), 1614 moderate HFH (767/847), 68 mild HFH (38/30), and 855 CVD (414/441). Improved HFH-adjusted survival occurred with vericiguat (mean 78.2% vs 75.6%, difference 2.4%, 95% CI, 1.7%–3.2%, <em>P</em> &lt; .0001). Based on a comparison of 6,375,624 pairs, the WR of 1.13 (95% CI 1.03–1.24, <em>P</em> = .01) also indicated improved clinical outcomes with vericiguat.</div></div><div><h3>Conclusions</h3><div>The results of the WCE and WR methods were consistent with the primary analysis of the time to first HFH or CVD. Although both WCE and WR assessed recurrent events, the WCE allowed inclusion of all recurrent events, insights on the severity of HFH events, and an absolute measure of the participant–treatment experience. This approach complements conventional assessment, better informing consumers of new therapeutics and future trial designs.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 3","pages":"Pages 551-558"},"PeriodicalIF":6.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FINEARTS Restoration: Revisiting the Role of Steroidal Mineralocorticoid Receptor Antagonists in Heart Failure with Mildly Reduced or Preserved Ejection Fraction Following FINEARTS-HF","authors":"RICKY D. TURGEON BSc(Pharm), ACPR, PharmD ,&nbsp;CRAIG J. BEAVERS PharmD","doi":"10.1016/j.cardfail.2024.09.011","DOIUrl":"10.1016/j.cardfail.2024.09.011","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 3","pages":"Pages 603-605"},"PeriodicalIF":6.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142377849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Centered Research Design to Increase Representativeness of Diverse Populations in Clinical Trials","authors":"TRACY Y. WANG MD, MHS, MSc","doi":"10.1016/j.cardfail.2024.10.438","DOIUrl":"10.1016/j.cardfail.2024.10.438","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 3","pages":"Pages 579-581"},"PeriodicalIF":6.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of Palliative Care into Heart Failure Care: Consensus-Based Recommendations from the Heart Failure Society of America","authors":"SARAH CHUZI MD, MSc ,&nbsp;MARTHA ABSHIRE SAYLOR PhD, RN ,&nbsp;LARRY A. ALLEN MD ,&nbsp;AKSHAY S. DESAI MD, MPH ,&nbsp;SHELLI FEDER PhD, APRN, FNP-C ,&nbsp;NATHAN E. GOLDSTEIN MD ,&nbsp;HUNTER GRONINGER MD ,&nbsp;JAMES N. KIRKPATRICK MD ,&nbsp;JAMES A. TULSKY MD ,&nbsp;JILL M. STEINER MD, MS ,&nbsp;NATASHA LEVER MSN, ACNP-BC ,&nbsp;ELDRIN LEWIS MD, MPH ,&nbsp;JOSEPH G. ROGERS MD ,&nbsp;HAIDER J. WARRAICH MD","doi":"10.1016/j.cardfail.2024.10.435","DOIUrl":"10.1016/j.cardfail.2024.10.435","url":null,"abstract":"<div><div>Heart failure (HF) is characterized by significant symptoms, compromised quality of life, frequent hospital admissions, and high mortality rates; palliative care (PC) is, therefore, highly relevant for patients with HF and their clinicians. Multiple guidelines and consensus statements recommend the provision of PC alongside HF management. However, few resources exist to guide the integration of PC into HF care, for both primary PC (provided by HF clinicians in the course of HF care) and specialty PC (provided by PC specialists). Through this consensus statement, the Heart Failure Society of America aims to provide a contemporary, practical guide for clinicians and institutions about how PC should be operationalized in the context of comprehensive HF care. Key components of high-quality, integrated HF-PC are described, with a focus on clinical and operational considerations for providing primary and specialty PC, quality measurement and value demonstration, reimbursement and incentive concerns, and the provision of hospice care.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 3","pages":"Pages 559-573"},"PeriodicalIF":6.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HF Seminar HFSA Society Page","authors":"","doi":"10.1016/j.cardfail.2025.02.008","DOIUrl":"10.1016/j.cardfail.2025.02.008","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 3","pages":"Pages 606-607"},"PeriodicalIF":6.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143600596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Ventricular Unloading Using Intra-aortic Entrainment Pumping Before Reperfusion Reduces Post-AMI Infarct Size","authors":"MARAT FUDIM MD, MHS ,&nbsp;FILIP KONECNY DVM, PhD ,&nbsp;JASON J. HEURING PhD ,&nbsp;CHRISTOPHER A. DURST PhD ,&nbsp;ERIC S. FAIN MD ,&nbsp;MANESH R. PATEL MD","doi":"10.1016/j.cardfail.2024.07.022","DOIUrl":"10.1016/j.cardfail.2024.07.022","url":null,"abstract":"<div><h3>Background</h3><div>Anterior myocardial infarction standard of care prioritizes swift coronary reperfusion. Recent studies show left ventricular (LV) unloading with transvalvular axial flow pumps for 30 minutes before reperfusion (vs immediate reperfusion) decreases 28-day infarct size. Intra-aortic entrainment pumping, using hardware located away from the heart to provide support throughout the cardiac cycle, decreases effective systemic vascular resistance and augments visceral blood flow and pressure, and may reproduce this benefit with a decreased risk. This study characterized the hemodynamic effects of unloading before and during reperfusion using intra-aortic entrainment pumping and investigated whether unloading decreased anterior myocardial infarction scar size.</div></div><div><h3>Methods and Results</h3><div>Yorkshire swine were subjected to 90 minutes of left anterior descending artery balloon occlusion and randomly assigned to immediate reperfusion (<em>n</em> = 6) vs 30 minutes unloading before reperfusion followed by 120 minutes of further unloading (<em>n</em> = 7). Unloading was achieved using percutaneous entrainment pumping in the descending aorta. The anterior myocardial infarction model matches that used in recent transvalvular pumping studies. Mortality before randomization was 22%. After randomization, mortality was 36% for immediate reperfusion and 0% for unloading. Unloading showed immediate hemodynamic benefit that increased through reperfusion and continued support, leading to distinct differences in cardiac function between groups after 30 minutes of reperfusion. Unloading increased stroke volume and cardiac efficiency at this timepoint relative to preocclusion baseline and reduced 28-day LV scar size by 37%–45%.</div></div><div><h3>Conclusions</h3><div>We present the first preclinical data showing extracardiac LV unloading before coronary reperfusion using intra-aortic entrainment pumping decreases 28-day infarct size. Extracardiac unloading to decrease LV scar size may provide an alternative to transvalvular pumping with potential advantages, including reduced risk.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 3","pages":"Pages 538-548"},"PeriodicalIF":6.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“OK to Discharge to the Street”: Housing Insecurity and Heart Failure Outcomes","authors":"THOMAS M. CASCINO MD, MSc,&nbsp;MONICA COLVIN MD","doi":"10.1016/j.cardfail.2025.01.005","DOIUrl":"10.1016/j.cardfail.2025.01.005","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 3","pages":"Pages 521-524"},"PeriodicalIF":6.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Double-Blind Reviews With Increases in Women as First Authors: An Initial Report From the Journal of Cardiac Failure","authors":"ERSILIA M. DEFILIPPIS MD ,&nbsp;ELENA DONALD MD ,&nbsp;LOGAN CHO MD ,&nbsp;ANDREW SAUER MD ,&nbsp;JENNIFER MANING MD ,&nbsp;VANESSA BLUMER MD ,&nbsp;ALEXANDER HAJDUCZOK MD ,&nbsp;QUENTIN YOUMANS MD ,&nbsp;MARTHA GULATI MD ,&nbsp;MEREDITH T. HURT MPS ,&nbsp;ALAYNA HUMPHREY ,&nbsp;NOSHEEN REZA MD ,&nbsp;ROBERT MENTZ MD ,&nbsp;ANURADHA LALA MD","doi":"10.1016/j.cardfail.2024.09.004","DOIUrl":"10.1016/j.cardfail.2024.09.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Women continue to remain under-represented in academic publishing in the field of cardiology. Some evidence suggests that double-blind peer reviews may mitigate the impact of gender bias. In July 2021, the <em>Journal of Cardiac Failure</em> implemented a process for the conduct of double-blind reviews after previously using single-blind reviews, with the aim of improving author diversity. The purpose of the current study was to examine the association between changes in authorship characteristics and implementation of double-blind reviews.</div></div><div><h3>Methods</h3><div>Manuscripts were stratified into 3 Eras: March–September 2021 (Era 1: prior to double-blind reviews); March–September 2022 (Era 2); and March–September 2023 (Era 3). All article types except invited editorials were included. Data were abstracted, including names, genders, ranks, and disciplines of the first and senior authors.</div></div><div><h3>Results</h3><div>A total of 310 manuscripts were included in the analysis. The proportion of women first authors increased from 24% in Era 1 to 34% in Era 2 to 39% in Era 3, while the percentage of women authors serving in a senior authorship role remained fairly stable over time–around 21%–22%. Even after adjusting for region, article type, first-author discipline, and last-author gender, there was an increase in female first authors over time (<em>P</em> = 0.015). Manuscripts with a female senior author were significantly more likely to have a female first author.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that double-blind peer review may contribute to increased gender diversity of first authors and may highlight areas for future improvement by the <em>Journal</em> and academic publishing in general.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 3","pages":"Pages 592-597"},"PeriodicalIF":6.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Life's Essential 8 With Incident Heart Failure and Its Prognosis","authors":"YANPING LI PhD ,&nbsp;XUAN-MAI T. NGUYEN MD PhD ,&nbsp;TIMOTHY TREU MPH ,&nbsp;DONG D. WANG ScD ,&nbsp;YUK-LAM HO MPH ,&nbsp;SERENA C. HOUGHTON PhD ,&nbsp;BRIAN CHAREST MPH ,&nbsp;RUIFENG LI PhD ,&nbsp;DANIEL POSNER PhD ,&nbsp;MARY PYATT MPH ,&nbsp;MARYAM RAHAFROOZ PhD ,&nbsp;SRIDHARAN RAGHAVAN MD ,&nbsp;DAVID R. GAGNON PhD ,&nbsp;STACEY B. WHITBOURNE PhD ,&nbsp;JOHN MICHAEL GAZIANO MD ,&nbsp;LUC DJOUSSE MD ,&nbsp;JACOB JOSEPH MD ,&nbsp;PETER W.F. WILSON MD ,&nbsp;KELLY CHO PhD ,&nbsp;Million Veteran Program","doi":"10.1016/j.cardfail.2025.01.014","DOIUrl":"10.1016/j.cardfail.2025.01.014","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"31 3","pages":"Pages 598-602"},"PeriodicalIF":6.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}