Performance of Clinical Scoring Systems in the Diagnosis of Transthyretin Amyloid Cardiomyopathy in a Diverse Patient Cohort.

IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Garred S Greenberg, Chinwendu Onuegbu, Carlos Espiche, Andrea Scotti, Paul Ippolito, Henry Dwaah, Jake Gilman, James Tauras, Aldo L Schenone, Piotr J Slomka, Michelle M Kittleson, Marcelo F Di Carli, Mario J Garcia, Mark Travin, Leandro Slipczuk
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引用次数: 0

Abstract

Background: Two diagnostic clinical scoring systems, the ATTR-CM Score and the T-AMYLO Score, have been proposed but not validated in diverse populations, despite Black race being an important risk factor for transthyretin amyloid cardiomyopathy (ATTR-CM). The aim of this study was to evaluate their performance in diagnosing ATTR-CM in a diverse patient cohort.

Methods: This retrospective single-center study analyzed patients who underwent a 99mTc-pyrophosphate single photon emission computed tomography scan (Tc-PYP) for workup of suspected ATTR-CM. ATTR-CM was considered present in those exhibiting Perugini scores of 2 or 3, confirmed by myocardial radiotracer uptake via single photon emission computed tomography. The diagnostic performance of a multivariate regression model and the two scoring systems was tested against Tc-PYP as the gold standard.

Results: Our cohort included 476 patients, of which 308 (65%) were non-Hispanic Black, 93 (20%) were Hispanic, and 215 (45%) were female. A total of 164 (34%) had a positive Tc-PYP. Age ≥74 years, male sex, history of carpal tunnel, LVEF <55%, posterior wall thickness over 12mm, and relative wall thickness over 0.57 were independent predictors of positive Tc-PYP in our cohort, and hemoglobin <10 mg/dL, glomerular filtration rate <30 ml/min/1.73m2, and coronary artery disease were independent predictors of negative Tc-PYP. The multivariate model had an area under the curve (AUC) of 0.92 (95% CI, 0.90-0.95). The ATTR-CM Score (AUC, 0.86; 95% CI, 0.83-0.90) had better diagnostic accuracy than the T-AMYLO Score (AUC, 0.75; 95% CI, 0.71-0.80) (P < 0.001).

Conclusions: Two simple clinical scoring systems, derived to identify patients at high risk of having ATTR-CM necessitating further diagnostic evaluation, showed good predictive accuracy in our diverse patient cohort. The ATTR-CM Score was superior to the T-AMYLO Score in our cohort.

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来源期刊
Journal of Cardiac Failure
Journal of Cardiac Failure 医学-心血管系统
CiteScore
7.80
自引率
8.30%
发文量
653
审稿时长
21 days
期刊介绍: Journal of Cardiac Failure publishes original, peer-reviewed communications of scientific excellence and review articles on clinical research, basic human studies, animal studies, and bench research with potential clinical applications to heart failure - pathogenesis, etiology, epidemiology, pathophysiological mechanisms, assessment, prevention, and treatment.
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