Journal of Behavioral and Brain Science最新文献

{"title":"Fluvoxamine reverses estrogen-dependent decline in voluntary activities and decreased amygdala levels of serotonin in ovariectomized rats","authors":"Yukiko Ishibashi, N. Izumo, K. Iwata, Tomomi Morikawa, T. Kameyama, Yasuo Watanabe, T. Manabe, Hideo Matsuzaki","doi":"10.20821/JBS.46.0_5","DOIUrl":"https://doi.org/10.20821/JBS.46.0_5","url":null,"abstract":"Studies suggest that increased expression of brain-derived neurotrophic factor (BDNF) could mediate the antidepressant effects of drugs. We analyzed the effects of fluvoxamine on locomotor activities, serotonin levels in the amygdala, and hippocampal expression of BDNF mRNA in ovariectomized (OVX) rats. Female Wistar rats (8 weeks, 180–200 g) were divided into four groups: sham; OVX; OVX with estrogen; and OVX with fluvoxamine. Six weeks after ovariectomy, rats were assessed according to spontaneous locomotor activity, forced-swimming test (FST), and microdialyses experiments. Body and uterine weight of OVX rats 6 weeks after surgery were significantly increased and decreased, respectively, compared with those of the sham group, but these changes were returned to sham-group levels upon chronic administration of estrogen and fluvoxamine. More potent decreases in voluntary activities were observed in OVX rats compared with rats in the sham group, but were increased markedly upon administration of estrogen and fluvoxamine. In the FST, immobility time and beat counts were increased and decreased significantly by ovariectomy compared with those of the sham group, respectively, but estrogen and fluvoxamine treatment reversed these changes significantly. More potent decreases in serotonin release in the amygdala were observed in OVX rats compared with those of sham rats, but were reversed upon estrogen Journal of Brain Science, June 30, 2016,Vol.46 7 replacement. Similar recovery was observed in OVX rats upon fluvoxamine treatment. These data suggest that, in OVX rats, chronic administration of fluvoxamine can recover estrogen-dependent changes in behaviors, decreased serotonin release in the amygdala, and reduced expression of BDNF mRNA. Key wards: Amygdala, Serotonin, Estrogen, Fluvoxamine, OVX; Abbreviations BDNF, brain-derived neurotrophic factor; ER, endoplasmic reticulum; OVX, ovariectmized; RT-PCR, reverse transcription-polymerase chain reaction; SSRI, selective serotonin reuptake inhibitor; XBP-1, X-box binding protein-1; mRNA, messenger ribonucleic acid Introduction The female hormone estrogen has an important role in bone physiology (reviewed in [15, 16]). Moreover, there is a close relationship between estrogen and memory, learning, and emotion in the brain (reviewed in [16]). Also, it has been reported that replenishment with estrogen can improve recognition, learning and memory (reviewed in [3, 5, 14]). We reported that, in female rats 6 weeks after their ovaries had been removed, depression-like symptoms (as manifested by decreases in spontaneous locomotor activities and serotonin levels in the amygdala) could be observed [9]. Depression is a complex disorder brought about by genetic and environmental conditions. Depression involves brain abnormalities as well as dysfunction of the endocrine system, inflammation, altered glucose metabolism and, in some cases, coronary artery disease [8, 18]. Selective serotonin reuptake inhibitors (SSRIs) ","PeriodicalId":15186,"journal":{"name":"Journal of Behavioral and Brain Science","volume":"24 1","pages":"5-19"},"PeriodicalIF":0.0,"publicationDate":"2016-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78425594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microglial activation in healthy adult Japanese subjects: apositron emission tomography study","authors":"M. Ikuma, Y. Ouchi, Kyoko Nakaizumi, Masamichi Yokokura, K. Takebayashi, Katsuaki Suzuki, N. Mori","doi":"10.20821/JBS.46.0_55","DOIUrl":"https://doi.org/10.20821/JBS.46.0_55","url":null,"abstract":"Background: Accumulating evidence suggests that microglia cells contribute to the normal brain homeostasis in addition to working as immune-competent cells in pathological processes associated with neurodegeneration or neuroinflammation. Microglial activation can be measured in vivo using 11C-(R)-PK11195 and positron emission tomography (PET). The aim of the study was to determine possible relationships between microglial activation and age as well as cognitive functioning in healthy Journal of Brain Science, June 30, 2016,Vol.46 56 subjects. Methods: Fifty-five healthy subjects (male/female = 35/20, age range 18-84 years) underwent a PET measurement with 11C-(R)-PK11195 and T1-weighted magnetic resonance imaging (MRI). A subset of young male subjects (age range 21-40 years) were assessed their intelligence quotient (IQ) using the third edition of Wechsler adult intelligence scale within the same day. The binding potentials of 11C-(R)-PK11195 in selected brain regions were estimated by a modified simplified reference tissue model in each of subjects. Results: Bindings of 11C-(R)-PK11195 in the cerebral cortices and subcortical regions significantly and positively correlated with age of subjects. When each sex was separately analyzed, the significant positive correlation was observed in male, but not female, subjects. In a subset of young male subjects, there was a negative correlation between the IQ scores and regional 11C-(R)-PK11195 bindings in cortical and subcortical regions. Conclusion: Results suggest that microglial activation in the brain might be associated with not only normal aging but also cognitive functioning in the youth.","PeriodicalId":15186,"journal":{"name":"Journal of Behavioral and Brain Science","volume":"47 1","pages":"55-69"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86703227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of unbalanced large head on neurodevelopment in infancy: a longitudinal birth cohort study","authors":"R. Oshima, K. Tsuchiya, N. Mori, N. Takei","doi":"10.20821/JBS.46.0_34","DOIUrl":"https://doi.org/10.20821/JBS.46.0_34","url":null,"abstract":"","PeriodicalId":15186,"journal":{"name":"Journal of Behavioral and Brain Science","volume":"27 1","pages":"34-54"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83532990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placenta-derived hypo-serotonin situations in the developing forebrain inhibits dopaminergic fiber development, resulting in ADHD","authors":"Kohji Sato","doi":"10.20821/JBS.46.0_20","DOIUrl":"https://doi.org/10.20821/JBS.46.0_20","url":null,"abstract":"","PeriodicalId":15186,"journal":{"name":"Journal of Behavioral and Brain Science","volume":"101 1","pages":"20-33"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73329844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Physical Stress Does Not Interact with Epstein-Barr Virus (EBV)-Encoded Dutpase to Alter the Sickness Response.","authors":"Taryn G Aubrecht,&nbsp;Zachary M Weil,&nbsp;Bachir Abi Salloum,&nbsp;Maria Eugenia Ariza,&nbsp;Marshall Williams,&nbsp;Brenda Reader,&nbsp;Ronald Glaser,&nbsp;John Sheridan,&nbsp;Randy J Nelson","doi":"10.4236/jbbs.2015.511049","DOIUrl":"https://doi.org/10.4236/jbbs.2015.511049","url":null,"abstract":"<p><p>Most adult humans have been infected with Epstein-Barr virus (EBV), which is thought to contribute to the development of chronic fatigue syndrome. Stress is known to influence the immune system and can exacerbate the sickness response. Although a role for psychological stress in the sickness response, particularly in combination with EBV-encoded deoxyuridine triphosphate nucleotidohydrolase (dUTPase) has been established, and the role of physical stressors in these interactions remains unspecified. In this study, we seek to determine the interaction of chronic physical (swim) stress and EBV-encoded dUTPase injection. We hypothesize that a chronic physical stressor will exacerbate the sickness response following EBV-encoded dUTPase injection. To test this hypothesis mice receive daily injections of EBV-encoded dUTPase or vehicle and are subjected to 15 min of swim stress each day for 14 days or left unmanipulated. On the final evening of injections mice undergo behavioral testing. EBV-encoded dUTPase injection alone produces some sickness behaviors. The physical swimming stress does not alter the sickness response.</p>","PeriodicalId":15186,"journal":{"name":"Journal of Behavioral and Brain Science","volume":"5 11","pages":"513-523"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34481287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and characterization of a novel splice variant of disrupted in schizophrenia 1 (Disc1)","authors":"Y. Miyatake, S. Matsuzaki, M. Taniguchi, Hironori Takamura, Kohei Yamada, T. Hattori, T. Kameyama, T. Manabe, M. Tohyama, T. Katayama","doi":"10.20821/JBS.45.0_5","DOIUrl":"https://doi.org/10.20821/JBS.45.0_5","url":null,"abstract":"","PeriodicalId":15186,"journal":{"name":"Journal of Behavioral and Brain Science","volume":"1 1","pages":"5-34"},"PeriodicalIF":0.0,"publicationDate":"2015-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83043752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The pathogenesis and clinical features of cerebrovascular disease in diabetes mellitus","authors":"Jinlong Cheng, Bolin Chen","doi":"10.20821/JBS.45.0_45","DOIUrl":"https://doi.org/10.20821/JBS.45.0_45","url":null,"abstract":"45 Review The pathogenesis and clinical features of cerebrovascular disease in diabetes mellitus Jinlong Cheng1, Bolin Chen2,* 1. Department of Internal medicine , Tianjin MingJin metabolic disease hospital, Tianjin 300381,China 2. Department of Physiology and Pathophysiology, Tianjin Medical University Tianjin 300070, China * Correspondence to Bolin Chen E-mail: econversation@163.com Received:2015-02-01 Accepted:2015-03-01 Abstract Cerebrovascular disease is a kind of complications in diabetes mellitus which is induced by suger, fat and protein metabolic disorder. These series of nutrient metabolic disorder can lead to intracranial large blood vessels and microvascular lesions. About 20-40 percent of type 2 diabetes patients will suffer from cerebrovascular diseases which become the main causes of death in diabetic patients [1]. Recently many kinds of pathogenesis have been found by researchers about cerebrovascular diseases in diabetes mellitus such as hyperglycemia, insulin resistance [2], endothelial cell dysfunction [3], abnormal lipids metabolism and so on. The major clinical manifestations of diabetic cerebrovascular diseases are asymptomatic cerebral atherosclerosis, stroke, cerebral small vessel diseases and acute cerebral vascular diseases. This article will introduce the Japan Brain Science Society","PeriodicalId":15186,"journal":{"name":"Journal of Behavioral and Brain Science","volume":"24 1","pages":"45-56"},"PeriodicalIF":0.0,"publicationDate":"2015-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90699027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To alleviate the mental stress of the hospital staff by the use of Morita therapy","authors":"Yandong Wang, Yan Wu, Xuelong Jin","doi":"10.20821/JBS.45.0_35","DOIUrl":"https://doi.org/10.20821/JBS.45.0_35","url":null,"abstract":"35 Research and Report To alleviate the mental stress of the hospital staff by the use of Morita therapy Yandong Wang1, Yan Wu2,Xuelong Jin3* 1. Tianjin Nankai hospital, Tianjin 300100, china 2. Nankai University, Tianjin 300071, China 3. Tianjin MingJin metabolic disease hospital, Tianjin 300381,China * Correspondence to Xuelong Jin E-mail: sentianxinli@163.com Received:2015-1-10 Accepted:2015-2-10","PeriodicalId":15186,"journal":{"name":"Journal of Behavioral and Brain Science","volume":"111 1","pages":"35-44"},"PeriodicalIF":0.0,"publicationDate":"2015-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73701453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial Progenitor Cells : implications for radiation-induced brain injury","authors":"Q. Liu, Xuelong Jin","doi":"10.20821/JBS.44.0_42","DOIUrl":"https://doi.org/10.20821/JBS.44.0_42","url":null,"abstract":"Radiation therapy, the most commonly used for the treatment of brain tumors, has been shown to be of major significance in tumor control and survival rate of brain tumor patients. About 200,000 patients with brain tumor are treated with either partial large field or whole brain radiation every year in China. The use of radiation therapy for treatment of brain tumors, however, may lead to devastating functional deficits in brain several months to years after treatment. An initial brain pathology resulting from exposure to radiation appears to be the dysfunction or disruption of the blood-brain barrier (BBB) and edema formation, which resulted from loss of tight junction (TJ) proteins and BBB components pericytes and astrocyte end-feet. Both of these scenarios lead to apoptosis of endothelial and neural cells and neuroinflammation in and around capillaries, which may progress into a variety of neurological impairments. It’s been found that Bone-marrow-derived EPCs (endothelial progenitor cells) play an integral role in the regulation and protection of the endothelium, as well as new vessel formation. It can incorporate into injured vessels and become mature endothelial cells during re-endothelialization and neovascularization processes, so the transplantation of EPCs into ischemic tissues provide a novel therapeutic option for radiation-induced brain injury. The efficacy of EPCs repairing disrupted BBB can be evaluated from the changes of expression of S100B, VEGF and EBA. is a non-invasive method that can be used to track labeled transplanted cells which can show the exact trace of EPCs in the region of brain injury. This review discusses the therapeutic potential radiation-induced brain injury.","PeriodicalId":15186,"journal":{"name":"Journal of Behavioral and Brain Science","volume":"78 1","pages":"42-62"},"PeriodicalIF":0.0,"publicationDate":"2014-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88454511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yokukansan increases serum Brain-derived neurotrophic factor (BDNF) levels in Gunn rat","authors":"M. Furuya, T. Miyaoka, S. Hashioka, R. Wake, K. Tsuchie, J. Horiguchi","doi":"10.20821/JBS.44.0_34","DOIUrl":"https://doi.org/10.20821/JBS.44.0_34","url":null,"abstract":"Brain-derived neurotrophic factor (BDNF) is expressed at high levels in the hippocampal dentate gyrus (DG), and decreased levels of BDNF have been implicated in the pathophysiology of schizophrenia (SCZ). We have previously reported that yokukansan (YKS), which is a traditional Japanese medicine, is effective for SCZ and promotes neurogenesis in the DG of Gunn rats, an animal model of SCZ. In this study, we investigated the effect of YKS on serum BDNF levels in Gunn rats. The results showed that YKS increased serum BDNF in this model, which may suggest that BDNF expression in the DG leads to increased neurogenesis. Our findings may help to explain the efficacy of YKS in treating SCZ.","PeriodicalId":15186,"journal":{"name":"Journal of Behavioral and Brain Science","volume":"20 1","pages":"34-41"},"PeriodicalIF":0.0,"publicationDate":"2014-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75382779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}