The pathogenesis and clinical features of cerebrovascular disease in diabetes mellitus

45 Review The pathogenesis and clinical features of cerebrovascular disease in diabetes mellitus Jinlong Cheng1, Bolin Chen2,* 1. Department of Internal medicine , Tianjin MingJin metabolic disease hospital, Tianjin 300381,China 2. Department of Physiology and Pathophysiology, Tianjin Medical University Tianjin 300070, China * Correspondence to Bolin Chen E-mail: econversation@163.com Received:2015-02-01 Accepted:2015-03-01 Abstract Cerebrovascular disease is a kind of complications in diabetes mellitus which is induced by suger, fat and protein metabolic disorder. These series of nutrient metabolic disorder can lead to intracranial large blood vessels and microvascular lesions. About 20-40 percent of type 2 diabetes patients will suffer from cerebrovascular diseases which become the main causes of death in diabetic patients [1]. Recently many kinds of pathogenesis have been found by researchers about cerebrovascular diseases in diabetes mellitus such as hyperglycemia, insulin resistance [2], endothelial cell dysfunction [3], abnormal lipids metabolism and so on. The major clinical manifestations of diabetic cerebrovascular diseases are asymptomatic cerebral atherosclerosis, stroke, cerebral small vessel diseases and acute cerebral vascular diseases. This article will introduce the Japan Brain Science Society