慢性身体压力不会与eb病毒(EBV)编码的Dutpase相互作用以改变疾病反应。

Journal of Behavioral and Brain Science Pub Date : 2015-10-01 Epub Date: 2015-10-27 DOI:10.4236/jbbs.2015.511049
Taryn G Aubrecht, Zachary M Weil, Bachir Abi Salloum, Maria Eugenia Ariza, Marshall Williams, Brenda Reader, Ronald Glaser, John Sheridan, Randy J Nelson
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引用次数: 4

摘要

大多数成年人都感染了eb病毒(EBV),这种病毒被认为会导致慢性疲劳综合征。众所周知,压力会影响免疫系统,并可能加剧疾病反应。虽然心理应激在疾病反应中的作用,特别是与ebv编码的脱氧尿苷三磷酸核苷酸水解酶(dUTPase)的结合已经确定,但物理应激源在这些相互作用中的作用仍未明确。在这项研究中,我们试图确定慢性物理(游泳)应激和ebv编码dUTPase注射的相互作用。我们假设慢性身体应激源会加剧ebv编码dUTPase注射后的疾病反应。为了验证这一假设,小鼠每天接受ebv编码dUTPase或载体的注射,并在14天内每天进行15分钟的游泳应激或不进行操作。在注射的最后一个晚上,小鼠进行行为测试。单独注射ebv编码dUTPase会产生一些疾病行为。身体上的游泳压力不会改变疾病反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Chronic Physical Stress Does Not Interact with Epstein-Barr Virus (EBV)-Encoded Dutpase to Alter the Sickness Response.

Chronic Physical Stress Does Not Interact with Epstein-Barr Virus (EBV)-Encoded Dutpase to Alter the Sickness Response.

Chronic Physical Stress Does Not Interact with Epstein-Barr Virus (EBV)-Encoded Dutpase to Alter the Sickness Response.

Chronic Physical Stress Does Not Interact with Epstein-Barr Virus (EBV)-Encoded Dutpase to Alter the Sickness Response.

Most adult humans have been infected with Epstein-Barr virus (EBV), which is thought to contribute to the development of chronic fatigue syndrome. Stress is known to influence the immune system and can exacerbate the sickness response. Although a role for psychological stress in the sickness response, particularly in combination with EBV-encoded deoxyuridine triphosphate nucleotidohydrolase (dUTPase) has been established, and the role of physical stressors in these interactions remains unspecified. In this study, we seek to determine the interaction of chronic physical (swim) stress and EBV-encoded dUTPase injection. We hypothesize that a chronic physical stressor will exacerbate the sickness response following EBV-encoded dUTPase injection. To test this hypothesis mice receive daily injections of EBV-encoded dUTPase or vehicle and are subjected to 15 min of swim stress each day for 14 days or left unmanipulated. On the final evening of injections mice undergo behavioral testing. EBV-encoded dUTPase injection alone produces some sickness behaviors. The physical swimming stress does not alter the sickness response.

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