Journal of Artificial Organs最新文献_第8页

Introduction of ex vivo perfusion of extended-criteria donor hearts in a single center in Asia. 在亚洲的一个中心引入扩展标准供体心脏体外灌注。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-03-01 Epub Date: 2024-05-23 DOI: 10.1007/s10047-024-01447-x

Oswald Joseph On Jing Lee, Inderjeet Bhatia, Sylvia Ho Yan Wan, Katherine Yue Yan Fan, Michael Ka Lam Wong, Timmy Wing Kuk Au, Cally Ka Lai Ho

{"title":"Introduction of ex vivo perfusion of extended-criteria donor hearts in a single center in Asia.","authors":"Oswald Joseph On Jing Lee, Inderjeet Bhatia, Sylvia Ho Yan Wan, Katherine Yue Yan Fan, Michael Ka Lam Wong, Timmy Wing Kuk Au, Cally Ka Lai Ho","doi":"10.1007/s10047-024-01447-x","DOIUrl":"10.1007/s10047-024-01447-x","url":null,"abstract":"The shortage of organs for heart transplantation has created a need to explore the use of extended-criteria organs. We report the preliminary use of normothermic TransMedics Organ Care System-an ex vivo approach to preserve extended-criteria brain-dead donor hearts. This System maintains a normal temperature, provides continuous perfusion and oxygenation, reduces ischemic time, and enables additional viability assessment options. In a retrospective single-centre study conducted from April 2020 to March 2023, four extended criteria brain-dead donor hearts were perfused and monitored using the Organ Care System. Suitability for transplantation was assessed based on stable or decreasing lactate levels, along with appropriate perfusion parameters. The Organ Care for use of the Organ Care System were coronary artery disease, left ventricular hypertrophy, high-dose inotrope use in the donor, a downtime exceeding 20 min, and a left ventricular ejection fraction of 40-50%. Three out of the four donor hearts were transplanted, while one was discarded due to rising lactate concentration. The three recipients had a higher surgical risk profile for heart transplant. All showed normal cardiac function and no primary graft dysfunction postoperatively. At 2-3 years post-transplant, all recipients have a ventricular function of > 60%, with only one showing evidence of mild rejection. The Organ Care System enables the successful transplantation of marginal donor organs in high-risk recipients, showcasing the feasibility of recruiting donors with extended criteria. This technique is safe and promising, expanding the donor pool and addressing the organ shortage in heart transplantation in Hong Kong.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":"69-77"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Difference in coagulation systems of large animal species used in cardiovascular research: a systematic review. 心血管研究中使用的大型动物物种凝血系统的差异：系统综述。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-03-01 Epub Date: 2024-05-20 DOI: 10.1007/s10047-024-01446-y

Louis Staelens, Tom Langenaeken, Filip Rega, Bart Meuris

{"title":"Difference in coagulation systems of large animal species used in cardiovascular research: a systematic review.","authors":"Louis Staelens, Tom Langenaeken, Filip Rega, Bart Meuris","doi":"10.1007/s10047-024-01446-y","DOIUrl":"10.1007/s10047-024-01446-y","url":null,"abstract":"Preclinical testing using animal models is indispensable in cardiovascular research. However, the translation to clinical practice of these animal models is questionable since it is not always clear how representative they are. This systematic review intends to summarize the interspecies differences in the coagulation profile of animal models used in cardiovascular research. It aims to guide future research in choosing the optimal animal species. A literature search of PubMed, Embase, Web of Science (Core Collection) and Cochrane Library was performed using a search string that was well defined and not modified during the study. An overview of the search terms used in each database can be found in the appendix. Articles describing coagulation systems in large animals were included. We identified 30 eligible studies of which 15 were included. Compared to humans, sheep demonstrated a less active external pathway of coagulation. Sheep had a higher platelet count but the platelet activatability and response to biomaterials were lower. Both sheep and pigs displayed no big differences in the internal coagulation system compared to humans. Pigs showed results very similar to those of humans, with the exception of a higher platelet count and stronger platelet aggregation in pigs. Coagulation profiles of different species used for preclinical testing show strong variation. Adequate knowledge of these differences is key in the selection of the appropriate species for preclinical cardiovascular research. Future thrombogenicity research should compare sheep to pig in an identical experimental setup.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":"1-14"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of anisotropic pore structure and dense selective layer of capillary membranes for long-term ECMO by cross-sectional ion-milling method. 利用横截面离子研磨法表征用于长期 ECMO 的毛细管膜的各向异性孔隙结构和致密选择层。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-03-01 Epub Date: 2024-08-20 DOI: 10.1007/s10047-024-01461-z

Makoto Fukuda, Kazunori Sadano, Tomoki Maeda, Eri Murata, Naoyuki Miyashita, Tsutomu Tanaka, Tomohiro Mori, Akane Saito, Kiyotaka Sakai

{"title":"Characterization of anisotropic pore structure and dense selective layer of capillary membranes for long-term ECMO by cross-sectional ion-milling method.","authors":"Makoto Fukuda, Kazunori Sadano, Tomoki Maeda, Eri Murata, Naoyuki Miyashita, Tsutomu Tanaka, Tomohiro Mori, Akane Saito, Kiyotaka Sakai","doi":"10.1007/s10047-024-01461-z","DOIUrl":"10.1007/s10047-024-01461-z","url":null,"abstract":"Since the COVID-19 pandemic of 2020-2023, extracorporeal membrane oxygenator (ECMO) has attracted considerable attention worldwide. It is expected that ECMO with long-term durability is put into practical use in order to prepare for next emerging infectious diseases and to facilitate manufacturing for novel medical devices. Polypropylene (PP) and polymethylpentene (PMP) capillary membranes are currently the mainstream for gas exchange membrane for ECMO. ECMO support days for COVID-19-related acute hypoxemic respiratory failure have been reported to be on average for 14 or 24 days. It is necessary to improve opposing functions such that promoting the permeation of oxygen and carbon dioxide and inhibiting the permeation of water vapor or plasma to develop sufficient durability for long-term use. For this purpose, accurately controlling the anisotropy of the pore structure of the entire cross section and functions of capillary membrane is significant. In this study, we focused on the cross-sectional ion-milling (CSIM) method, to precisely clarify the pore structure of the entire cross section of capillary membrane for ECMO, because there is less physical stress on the porous structure applied during the preparation of cross-sectional samples of porous capillary membranes. We attempted to observe the cross sections of commercially available PMP membranes using the CSIM method. As a result, we succeeded in fabricating fine-scale flat cross-sectional samples of PMP capillary membranes. The pore structures and the degree of anisotropy of the cross sections are quantitatively clarified. The achievements and the approaches of this study are being applied to the development of next-generation gas exchange membranes.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":"50-60"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationships among hemolysis indicators and neuron-specific-enolase in patients undergoing veno-arterial extracorporeal membrane oxygenation. 静脉-动脉体外膜氧合患者溶血指标与神经元特异性烯醇化酶之间的关系。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-03-01 Epub Date: 2024-07-10 DOI: 10.1007/s10047-024-01454-y

Ryo Okubo, Tomonori Shirasaka, Ryohei Ushioda, Masahiko Narita, Shingo Kunioka, Yuta Kikuchi, Masahiro Tsutsui, Nobuya Motoyoshi, Hiroyuki Kamiya

{"title":"Relationships among hemolysis indicators and neuron-specific-enolase in patients undergoing veno-arterial extracorporeal membrane oxygenation.","authors":"Ryo Okubo, Tomonori Shirasaka, Ryohei Ushioda, Masahiko Narita, Shingo Kunioka, Yuta Kikuchi, Masahiro Tsutsui, Nobuya Motoyoshi, Hiroyuki Kamiya","doi":"10.1007/s10047-024-01454-y","DOIUrl":"10.1007/s10047-024-01454-y","url":null,"abstract":"Neuron-specific-enolase is used as a marker of neurological prognosis after cardiopulmonary resuscitation. It is also present in red blood cells and platelets. It is not known whether hemolysis increases the values of neuron-specific-enolase enough to clinically affect its interpretation in critically ill patients who are to be introduced to veno-arterial extracorporeal oxygenation. In this study, we examined the relationships among neuron-specific-enolase and hemolysis indicators such as free hemoglobin and lactate dehydrogenase after the introduction of veno-arterial extracorporeal oxygenation. Of the 91 patients who underwent veno-arterial extracorporeal membrane oxygenation in our hospital from January 1, 2018, to February 24, 2021, 68 patients survived for more than 24 h. Of these, 14 patients who were categorized into the better cerebral performance categories (1-3) and 19 patients who were categorized into the poor neurological prognosis category (4) were included. After the introduction of veno-arterial extracorporeal membrane oxygenation, neuron-specific-enolase was markedly higher in the poor neurological prognosis group than in the good neurological prognosis group (41.6 vs. 92.0, p = 0.04). A significant positive correlation was revealed between neuron-specific-enolase and free hemoglobin in the good neurological prognosis group (rs = 0.643, p = 0.0131). A similar relationship was observed for lactate dehydrogenase and neuron-specific-enolase in both the conscious (rs = 0.737, p = 0.00263) and non-conscious groups (rs = 0.544, p = 0.0176). When neuron-specific-enolase is used as a marker for neuroprognostic evaluation, an abnormally high value is likely to indicate the lack of consciousness, whereas a lower elevation should be interpreted with caution, taking into account the effects of hemolysis.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":"43-49"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Left ventricular assist devices: yesterday, today, and tomorrow. 左心室辅助装置：昨天、今天和明天。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2024-12-01 Epub Date: 2024-03-07 DOI: 10.1007/s10047-024-01436-0

Athanasios Tsiouris, Mark S Slaughter, Ashok Kumar Coimbatore Jeyakumar, Adam N Protos

引用次数: 0

Utilizing a long sheath to minimize atheroma manipulation (minimal manipulation approach) during Zone 1 and 2 thoracic endovascular aortic repair with a shaggy aorta. 在 1 区和 2 区胸腔内血管主动脉修补术中，利用长鞘管尽量减少对粥样斑块的操作（最小操作法）。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2024-12-01 Epub Date: 2024-03-21 DOI: 10.1007/s10047-024-01440-4

Hidetake Kawajiri, Takuma Kobayashi, Kaichiro Manabe, Keiichi Kanda, Satoshi Numata

引用次数: 0

Successful management of HeartMate 3 in a patient with arrhythmogenic right ventricular cardiomyopathy. 成功治疗一名心律失常性右室心肌病患者的 HeartMate 3。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2024-12-01 Epub Date: 2024-02-24 DOI: 10.1007/s10047-024-01434-2

Makiko Nakamura, Teruhiko Imamura, Yuki Hida, Toshihide Izumida, Masaki Nakagaito, Saori Nagura, Toshio Doi, Kazuaki Fukahara, Koichiro Kinugawa

引用次数: 0

The outcomes of a standardized protocol for extracorporeal mechanical circulatory support selection-left ventricular challenge protocol. 体外机械循环支持选择标准化方案-左心室挑战方案的成果。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2024-12-01 Epub Date: 2024-01-08 DOI: 10.1007/s10047-023-01427-7

Naoki Tadokoro, Tetsuya Koyamoto, Kohei Tonai, Yuki Yoshida, Koudai Hirahsima, Satoshi Kainuma, Naonori Kawamoto, Kimito Minami, Hiroshi Nishioka, Tsukamoto Yasumasa, Tomoyuki Fujita, Satsuki Fukushima

{"title":"The outcomes of a standardized protocol for extracorporeal mechanical circulatory support selection-left ventricular challenge protocol.","authors":"Naoki Tadokoro, Tetsuya Koyamoto, Kohei Tonai, Yuki Yoshida, Koudai Hirahsima, Satoshi Kainuma, Naonori Kawamoto, Kimito Minami, Hiroshi Nishioka, Tsukamoto Yasumasa, Tomoyuki Fujita, Satsuki Fukushima","doi":"10.1007/s10047-023-01427-7","DOIUrl":"10.1007/s10047-023-01427-7","url":null,"abstract":"There are no criteria for surgical mechanical circulatory system (MCS) selection for acute heart failure. Since 2021, we have utilized cardiopulmonary bypass system to assess patients' heart and lung condition to inform surgical MCS selection. we aimed to retrospectively analyze the outcomes of treatments administered using our protocol. We analyzed the data of 19 patients who underwent surgical MCS implantation. We compared patients' characteristics across the biventricular-assist device (BiVAD), central Y-Y extracorporeal membrane oxygenation (ECMO), central ECMO, and left VAD (LVAD) systems. Patients' diagnoses included fulminant myocarditis (47.4%), dilated cardiomyopathy (21.1%), acute myocardial infarction (15.8%), infarction from aortic dissection (5.3%), doxorubicin-related cardiomyopathy (5.3%), and tachycardia-induced myocarditis (5.3%). Eight patients (42.1%) underwent LVAD implantation, 1 (5.2%) underwent central ECMO, 4 (21.1%) underwent BiVAD implantation, and 6 (31.6%) underwent central Y-Y ECMO. 48 h after surgery, both the pulmonary arterial and right atrial pressures were effectively controlled, with median values being 19.0 mmHg and 9.0 mmHg, respectively. No patients transitioned from LVAD to BiVAD in the delayed period. Cerebrovascular events occurred in 21.1%. Successful weaning was achieved in 11 patients (57.9%), and 5 patients (26.3%) were converted to durable LVAD. Two-year cumulative survival was 84.2%. Our protocol showed good results for device selection in patients with heart failure, and device selection according to this protocol enabled good control of the pulmonary and systemic circulations.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":"358-367"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139377672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of macrophage aggregates prepared by rotation culture and their response to polymeric materials. 旋转培养法制备的巨噬细胞聚集体的特征及其对聚合物材料的反应

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2024-12-01 Epub Date: 2024-01-09 DOI: 10.1007/s10047-023-01428-6

Shota Toda, Yoshihide Hashimoto, Naoko Nakamura, Masahiro Yamada, Ryusuke Nakaoka, Wataru Nomura, Masaya Yamamoto, Tsuyoshi Kimura, Akio Kishida

{"title":"Characteristics of macrophage aggregates prepared by rotation culture and their response to polymeric materials.","authors":"Shota Toda, Yoshihide Hashimoto, Naoko Nakamura, Masahiro Yamada, Ryusuke Nakaoka, Wataru Nomura, Masaya Yamamoto, Tsuyoshi Kimura, Akio Kishida","doi":"10.1007/s10047-023-01428-6","DOIUrl":"10.1007/s10047-023-01428-6","url":null,"abstract":"Understanding the interaction between macrophages and biomaterials is important for the creation of new biomaterials and the development of technologies to control macrophage function. Since macrophages are strongly adhesive, caution is required when performing in vitro evaluations. Similarly, when THP-1 cells, macrophage precursor cells, are differentiated into macrophages using phorbol-12-myristate-13-acetate (PMA), it becomes difficult to detach them from the adherent substrate, which has been a problem on investigation of immunological responses to biomaterials. In this study, the interaction of THP-1 cell-differentiated macrophages with biomaterials was analyzed based on a new method of seeding THP-1 cells. THP-1 cells were cultured in static and rotation culture without and with PMA. In undifferentiated THP-1 cells, there was no change in cellular function between static and rotation cultures. In rotation culture with PMA, THP-1 cells differentiated and formed macrophage aggregates. IL-1β and MRC1 expression in macrophage aggregates was examined after differentiation and M1/M2 polarization. Macrophage aggregates in rotation culture tended to be polarized toward M2 macrophages compared with those in static culture. In the evaluation of the responses of macrophage aggregates to several kinds of polymeric materials, macrophage aggregates showed different changes in MRC1 expression over time at 30, 50, and 70 rpm. Rotation speed of 30 rpm was considered most appropriate condition in that it gave stable results with the same trend as obtained with static culture. The use of macrophage aggregates obtained by rotational culture is expected to provide new insights into the evaluation of inflammatory properties of biomaterials.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":"410-418"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11582132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139402939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of bleeding events in real-world Japanese registry for Percutaneous Ventricular Assist Device. 日本经皮心室辅助装置真实世界登记中的出血事件发生率。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2024-12-01 Epub Date: 2024-02-24 DOI: 10.1007/s10047-023-01429-5

Takashi Nishimura, Koichi Toda, Junya Ako, Atsushi Hirayama, Koichiro Kinugawa, Yoshio Kobayashi, Minoru Ono, Naoki Sato, Takahiro Shindo, Akira Shiose, Morimasa Takayama, Satoshi Yasukochi, Yoshiki Sawa

{"title":"Prevalence of bleeding events in real-world Japanese registry for Percutaneous Ventricular Assist Device.","authors":"Takashi Nishimura, Koichi Toda, Junya Ako, Atsushi Hirayama, Koichiro Kinugawa, Yoshio Kobayashi, Minoru Ono, Naoki Sato, Takahiro Shindo, Akira Shiose, Morimasa Takayama, Satoshi Yasukochi, Yoshiki Sawa","doi":"10.1007/s10047-023-01429-5","DOIUrl":"10.1007/s10047-023-01429-5","url":null,"abstract":"Purpose: Bleeding complication is a critical risk factor for outcomes of acute heart failure patients requiring mechanical circulatory support (MCS), including percutaneous catheter-type heart pumps (Impella). The Japanese registry for Percutaneous Ventricular Assist Device (J-PVAD) is an ongoing, large-scale, real-world registry to characterize Japanese patients requiring Impella. Here we analyzed bleeding complication profiles in patients who received Impella.Methods: All consecutive Japanese patients who received Impella from October 2017 to January 2020 were enrolled. The 30-day survival and bleeding complications were analyzed.Results: A total of 1344 patients were included: 653 patients received Impella alone, 685 patients received a combination of veno-arterial extracorporeal membrane oxygenation and Impella (ECPELLA), and 6 patients had failed Impella delivery. Overall 30-day survival was 67.0%, with Impella alone at 81.9% and ECPELLA at 52.7%. Overall bleeding/hematoma adverse events with a relation or not-excluded relation to Impella was 6.92%. Among them, the rates of hematoma and bleeding from medical device access sites were 1.41% and 4.09%, respectively. There was no difference between etiologies for these events.Conclusion: This study represents the first 3-year survival and the safety profile focused on bleeding adverse events from the J-PVAD registry. The results show that the real-world frequency of bleeding adverse events for patients who received Impella was an expected range from previous reports, and future real-world studies should aim to expand this data set to improve outcomes and adverse events.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":"375-384"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139939972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0