Journal of applied physiology最新文献

{"title":"Last Word on Viewpoint: Technological advances in elite sport: Where does one draw the line?","authors":"Borja Muniz-Pardos, Kenenisa Bekele, Carlos Mayo, Yannis Pitsiladis","doi":"10.1152/japplphysiol.00505.2024","DOIUrl":"https://doi.org/10.1152/japplphysiol.00505.2024","url":null,"abstract":"","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use visual biofeedback during your workout just like any other method.","authors":"Stephane Perrey","doi":"10.1152/japplphysiol.00297.2024","DOIUrl":"https://doi.org/10.1152/japplphysiol.00297.2024","url":null,"abstract":"","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of preterm birth on the pattern of altitude acclimatization at rest and during moderate-intensity exercise across three days at 3,375 m.","authors":"Benjamin J Narang, Giorgio Manferdelli, Grégoire P Millet, Tadej Debevec","doi":"10.1152/japplphysiol.00291.2024","DOIUrl":"10.1152/japplphysiol.00291.2024","url":null,"abstract":"<p><p>Preterm birth elicits long-lasting physiological effects in various organ systems, potentially modulating exercise and environmental stress responses. To establish whether prematurely-born adults respond uniquely during early high-altitude acclimatization at rest and during exercise, 17 healthy adults born preterm (gestational age < 32 wk) and 17 term-born, age- and aerobic-capacity-matched, control participants completed a three-day high-altitude sojourn (3,375 m). Oxygen uptake, pulmonary ventilation, and hemodynamic responses, as well as pulse oxygen saturation, brain tissue saturation index (TSI), and skeletal muscle TSI, were measured daily at rest and during moderate-intensity steady-state exercise bouts. In general, the prematurely-born group displayed comparable acclimatization responses at rest, with similar ventilation and cardiac output observed between groups throughout. Resting brain TSI was, however, higher in the preterm group upon arrival at high altitude (72 ± 7% vs. 68 ± 3%; <i>d</i> = 1.20). Absolute exercising oxygen uptake was lower in the preterm participants (<i>P</i> = 0.047), with this group displaying lower exercising cardiac output underpinned by reduced stroke volume (both <i>P</i> = 0.035). Nevertheless, exercising minute ventilation (V̇e) did not differ between groups (<i>P</i> = 0.237) while brain TSI (70 ± 6% vs. 66 ± 3%; <i>d</i> = 1.35) and pulse oxygen saturation (85 ± 3% vs. 82 ± 5%; <i>d</i> = 1.52) were higher with prematurity upon arrival to high altitude. These findings suggest that healthy prematurely-born adults exhibit comparable early acclimatization patterns to their term-born counterparts and better maintain cerebral oxygenation at rest. Together, these data suggest that prematurely-born adults should not be discouraged from high-altitude sojourns involving physical activity.<b>NEW & NOTEWORTHY</b> The acclimatization pattern across three days at 3,375 m, at rest and during moderate-intensity exercise, was similar between healthy adults born prematurely and their term-born counterparts. Preterm adults free from respiratory complications were found to better maintain brain tissue and capillary oxygen saturation at high altitudes, whereas the term-born group experienced larger altitude-induced reductions. Despite apparent cardiac limitations, preterm individuals tolerated exercise similarly to their term-born peers. These findings underscore the notion that preterm birth per se does not predispose healthy adults to decreased altitude tolerance during exercise.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel technical equipment: do these devices keep their promise?","authors":"Christoph Triska, Astrid Mathy","doi":"10.1152/japplphysiol.00424.2024","DOIUrl":"10.1152/japplphysiol.00424.2024","url":null,"abstract":"","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic cerebral autoregulation during repeated handgrip exercise: comparisons with spontaneous rest and sit-stand maneuvers.","authors":"Wenxing Qin, Marina Fukuie, Daisuke Hoshi, Shoya Mori, Tsubasa Tomoto, Jun Sugawara, Takashi Tarumi","doi":"10.1152/japplphysiol.00217.2024","DOIUrl":"10.1152/japplphysiol.00217.2024","url":null,"abstract":"<p><p>Induced arterial pressure oscillation may improve the assessment of dynamic cerebral autoregulation (dCA) with transfer function analysis (TFA). This study investigated dCA during repeated handgrip exercise (RHE) compared with spontaneous rest and sit-stand maneuvers (SSM), often used in cerebrovascular research. After a 5-min rest, 20 healthy young adults (10 women and 10 men) underwent 5 min of RHE (30% maximal voluntary contraction) and SSM at 0.05 Hz and 0.10 Hz each in random order. Power spectral density (PSD) and TFA gain, phase, coherence of mean arterial pressure (MAP), and blood velocity in the middle cerebral artery (MCAv_mean) were measured in very low (VLF: 0.02-0.07 Hz) and low (LF: 0.07-0.20 Hz) frequencies. End-tidal CO₂ (EtCO₂) was continuously recorded throughout data collection. Compared with rest, RHE increased the PSD of MAP and MCAv_mean in VLF (444% and 273%, respectively) and LF (1,571% and 1,765%, respectively) (all <i>P</i> < 0.001). Coherence increased during RHE (VLF: 131%, LF: 128%) and SSM (VLF: 166%, LF: 136%) compared with rest (all <i>P</i> < 0.05). TFA gain and phase were similar between RHE and rest, but VLF gain was higher, whereas VLF and LF phases were lower during SSM than RHE (all <i>P</i> < 0.05). EtCO₂ was higher during SSM than rest and RHE (both <i>P</i> < 0.05), with the individual EtCO₂ changes positively correlated with VLF gain (<i>r</i> = 0.538, <i>P</i> < 0.001). These results indicate that RHE significantly increases arterial pressure oscillation and TFA coherence and may improve dCA assessment in individuals unable to perform repeated postural changes.<b>NEW & NOTEWORTHY</b> This is the first study investigating dynamic cerebral autoregulation (dCA) during light-intensity repeated handgrip exercise (RHE) compared with rest and sit-stand maneuvers (SSM) using transfer function analysis (TFA). Compared with rest, RHE significantly increased oscillations of arterial blood pressure and cerebral blood velocity and coherence, whereas SSM exhibited the highest oscillations and coherence. These findings suggest that RHE may serve as an alternative method for assessing dCA in individuals unable to perform repeated postural changes.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlled technological advances may be a positive ignition for better training practices.","authors":"Paulo Colaço, Ricardo J Fernandes","doi":"10.1152/japplphysiol.00409.2024","DOIUrl":"10.1152/japplphysiol.00409.2024","url":null,"abstract":"","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-dose orthotopic cancer implantation permits measurement of longitudinal functional changes associated with cachexia.","authors":"Ishan Roy, Benjamin Binder-Markey, Amber Willbanks, Danielle Sychowski, Tenisha Phipps, Addison Barber, Donna McAllister, Dominic D'Andrea, Colin K Franz, Rajeswari Pichika, Michael B Dwinell, Richard L Lieber","doi":"10.1152/japplphysiol.00173.2024","DOIUrl":"10.1152/japplphysiol.00173.2024","url":null,"abstract":"<p><p>Progressive functional decline is a key element of cancer-associated cachexia. Major barriers to translating preclinical therapies into the clinic include lack of cancer models that accurately mimic functional decline, which develops over time, and use of nonspecific measures, like grip strength, as surrogates for physical function. In this study, we aimed to extend the survival and longevity of a cancer model, to investigate cachexia-related function at the basic science level. Survival extension studies were performed by testing multiple cell lines, dilutions, and vehicle-types in orthotopic implantation of K-ras^LSL.G12D/+; Trp53^R172H/+; Pdx-1-Cre (KPC)-derived cells. One hundred twenty-eight animals in this new model were assessed for cachexia syndrome phenotype using a battery of anatomical, biochemical, and behavioral techniques. We extended the survival of the KPC orthotopic model to 8-9 wk postimplantation using a relatively low 100-cell dose of DT10022 KPC cells (<i>P</i> < 0.001). In this low-dose orthotopic (LO) model, progressive muscle wasting was detected in parallel to systemic inflammation; skeletal muscle atrophy at the fiber level was detected as early as 3 wk postimplantation compared with controls (<i>P</i> < 0.001). Gait speed in LO animals declined as early as 2 wk postimplantation, whereas grip strength change was a late event. Principal component and regression analyses revealed distinct cachectic and noncachectic animal populations, which we leveraged to show that the gait speed decline was specific to cachexia (<i>P</i> < 0.01), whereas grip strength decline was not (<i>P</i> = 0.19). Gait speed represents an accurate surrogate for cachexia-related physical function as opposed to grip strength.<b>NEW & NOTEWORTHY</b> Previous studies of cancer-induced cachexia have been confounded by the relatively rapid death of animal subjects. Using a lower dose of cancer cells in combination with a battery of behavioral, structural, histological, and biochemical techniques, we show that gait speed is actually the best indicator of functional decline due to cachexia. Future studies are required to define the underlying physiological basis of these findings.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When does technology become too advanced for track and field?","authors":"Bradley J Needles, Alena M Grabowski","doi":"10.1152/japplphysiol.00334.2024","DOIUrl":"https://doi.org/10.1152/japplphysiol.00334.2024","url":null,"abstract":"","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controversial technological advancements in sports.","authors":"Katherine M Couture, Jonathon W Senefeld","doi":"10.1152/japplphysiol.00423.2024","DOIUrl":"https://doi.org/10.1152/japplphysiol.00423.2024","url":null,"abstract":"","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of trunk position and pain location on lumbar extensor muscle recruitment strategies.","authors":"Julien Ducas, Alvaro Pano-Rodriguez, Stéphanie Couture, Alessio Gallina, Jacques Abboud","doi":"10.1152/japplphysiol.00086.2024","DOIUrl":"10.1152/japplphysiol.00086.2024","url":null,"abstract":"<p><p>The aim of this study was to investigate the effect of trunk position and experimental lumbar pain location on lumbar extensor muscle recruitment strategies. Nineteen healthy participants (10 men and 9 women), aged 25.3 ± 4.7 yr, performed isometric back extension contractions in three positions (neutral, 45°, and 90° trunk flexion) and under three conditions (no pain, caudal pain, and cranial pain). Lumbar muscle activation strategies were recorded using high-density surface electromyography. The effect of position and pain condition on muscle activity amplitude and spatial redistributions was assessed. Muscle activity amplitude was 43% higher in 45° trunk flexion than in neutral position on both sides (<i>P</i> < 0.05). In the 90° trunk flexion, participants showed a more lateral spatial distribution than in the 45° trunk flexion on the left side (<i>P</i> < 0.01, 5.4 mm difference) and the neutral position on both sides (<i>P</i> < 0.05, 8.2 mm difference). In the 45° trunk flexion, participants exhibited a more lateral spatial distribution compared with the neutral position on the right side (<i>P</i> < 0.05, 3.7 mm difference). A lateral spatial redistribution of muscle activity was observed in the caudal pain condition compared with the no pain condition on the right side (<i>P</i> < 0.05, 3.0 mm difference). Individual responses to pain varied across all variables. Different trunk positions result in different distributions of activation within the lumbar extensor muscles, possibly based on regional mechanical advantage. No clear indication of location-specific pain adaptation and no effect of task-dependent pain adaptation were found, whereas individual-specific adaptations were observed.<b>NEW & NOTEWORTHY</b> Changes in muscle activity amplitude and spatial redistribution of lumbar extensor muscles were observed in different trunk positions, potentially due to changes in their mechanical advantage. The results complement the current pain-adaptation theory by illustrating individual spatial redistributions of activation within lumbar extensor muscles during pain. The study found no clear indication of location-specific pain adaptation and no effect of task-dependent pain adaptation.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}