Disuse and subsequent recovery resistance training affect skeletal muscle angiogenesis related markers regardless of prior resistance training experience.

IF 3.3 3区医学 Q1 PHYSIOLOGY

Journal of applied physiology Pub Date : 2025-06-06 DOI:10.1152/japplphysiol.00988.2024

Mason C McIntosh, J Max Michel, Joshua S Godwin, Daniel L Plotkin, Derick A Anglin, Madison L Mattingly, Anthony Agyin-Birikorang, Nicholas J Kontos, Harsimran S Baweja, Matt S Stock, C Brooks Mobley, Michael D Roberts

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引用次数: 0

Abstract

We recently reported that resistance trained (T, n=10) and untrained (UT, n=11) young adults experience vastus lateralis (VL) muscle atrophy following two weeks of disuse, and 8 weeks of recovery resistance training (RT) promotes VL hypertrophy in both participant cohorts. Skeletal muscle angiogenesis is appreciated for supporting skeletal muscle hypertrophy, but its activity following disuse-induced atrophy in humans is largely unexplored in the context of RT. Thus, we sought to determine whether these outcomes were affected. VL biopsies were obtained at baseline (PRE), immediately after disuse (MID), and after RT (POST). Western blotting was used to assay angiogenesis markers and immunohistochemistry was performed in 16/21 participants to determine type I and II muscle fiber capillary number. Significant main effects of time (p<0.05) were observed for protein levels of VEGF (MID0.100). Although disuse and recovery RT affect skeletal muscle angiogenesis-related protein targets, prior training history does not differentially affect these outcomes.

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弃用和随后的恢复性阻力训练影响骨骼肌血管生成相关标志物，而不考虑先前的阻力训练经验。

我们最近报道了阻力训练（T, n=10）和未训练（UT, n=11）的年轻人在两周不使用后经历股外侧肌（VL）萎缩，8周的恢复性阻力训练（RT）在两个参与者队列中都促进了VL肥大。骨骼肌血管生成因支持骨骼肌肥大而受到赞赏，但其在人类废用性萎缩后的活性在很大程度上未在rt的背景下被探索。因此，我们试图确定这些结果是否受到影响。分别在基线（PRE）、停用后（MID）和RT后（POST）进行VL活检。采用Western blotting检测血管生成标志物，并对16/21的参与者进行免疫组化检测I型和II型肌纤维毛细血管数量。时间的主要影响显著（p0.100）。尽管停用和恢复RT影响骨骼肌血管生成相关蛋白靶点，但先前的训练历史对这些结果没有差异影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of applied physiology 医学-生理学

CiteScore

6.00

自引率

9.10%

发文量

296

审稿时长

2-4 weeks

期刊介绍： The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.