Journal of applied physiology最新文献

{"title":"Combination of running and energy restriction impairs bone parameters but does not inhibit endurance adaptations in fast-twitch muscle in young female rats.","authors":"Yuki Aikawa, Yusuke Wakasugi, Tomoya Fukuyasu, Nobuaki Sasai, Takenori Yamashita, Makoto Ohtsuki, Amane Hori, Kazuki Kioka, Naomi Omi, Naoya Nakai, Kazuhiko Higashida","doi":"10.1152/japplphysiol.00978.2024","DOIUrl":"10.1152/japplphysiol.00978.2024","url":null,"abstract":"<p><p>Low energy availability refers to a state where the body cannot provide sufficient energy to maintain essential physiological functions due to excessive exercise and inadequate energy intake. In athletes, low energy availability impairs bone parameters but may assist muscle adaptation from endurance training. This study was conducted to explore the effect of the combination of running and energy restriction (ER) on bone parameters and muscular endurance adaptations in young female rats. Seven-week-old female rats were divided into four groups: <i>1</i>) sedentary and ad libitum feeding (AL); <i>2</i>) voluntary wheel running and AL; <i>3</i>) sedentary and ER; and <i>4</i>) voluntary wheel running and ER. The experimental period was 11.5 wk. The ER groups were fed a 28% restricted diet compared with the sedentary and AL group. Our results demonstrated that the combination of running and ER decreased the body weight, uterus weight, plantaris and soleus muscle weight, bone mineral density of femur, tibia, and lumbar, and trabecular number of tibia. However, running increased the cross-sectional area (CSA) of type I and IIA fibers and the mitochondrial proteins levels in plantaris muscle under both AL and ER conditions. In the soleus muscle, running exerted no significant main effects on the transition to the myofiber type. ER did not affect the transition to the myofiber type and the mitochondrial protein levels in plantaris and soleus muscles. Our study reveals that the combination of running and ER impairs bone parameters; however, running induces endurance adaptations of plantaris muscle under both AL and ER conditions in young female rats.<b>NEW & NOTEWORTHY</b> Low energy availability impairs bone parameters but may assist muscle adaptation from endurance training. Our study demonstrated that the combination of running and energy restriction (ER) impaired bone mineral density and bone microarchitecture in young female rats. However, running increased the cross-sectional area of type I and IIA fibers, and the levels of mitochondrial proteins in plantaris muscle under both ad libitum feeding and ER conditions in young female rats.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":"14-26"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum for Hogwood et al., volume 137, 2024, p. 1503-1511.","authors":"","doi":"10.1152/japplphysiol.00323.2024_COR","DOIUrl":"https://doi.org/10.1152/japplphysiol.00323.2024_COR","url":null,"abstract":"","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":"139 1","pages":"162-163"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incorporating gravity into synergistic control of upper limb movements using phasic synergies with positive and negative weights.","authors":"Alessandro Scano, Cristina Brambilla, Marta Russo, Andrea d'Avella","doi":"10.1152/japplphysiol.00779.2024","DOIUrl":"10.1152/japplphysiol.00779.2024","url":null,"abstract":"<p><p>Two models have been proposed to describe how motor control is affected by gravity. According to the gravity-compensation model, accelerating and decelerating the limb through phasic muscle activations is independent of the control of gravity forces, with tonic muscle activations counteracting gravity force. The effort-optimization model, instead, hypothesizes that muscles exploit gravity, decreasing tonic activity to minimize effort using negative phasic EMG components. Muscle synergies have been used for assessing motor control in neurophysiological studies, but synergistic models so far have neglected explicit representations of gravity forces. Therefore, we aimed at incorporating the pervasive presence of gravity into muscle synergies by extracting synergies with negative weights to capture negative phasic EMG components. Muscle synergies with positive and negative weights were extracted using the mixed-matrix factorization (MMF) algorithm on a set of upper limb reaching movements performed by 15 healthy participants across targets in different planes designed to elicit positive and negative phasic activations. Movements were grouped depending on the tonic components at movement onset, needed for gravity exploitation, and identified as \"increasing tonic EMG\" (ITE) and \"decreasing tonic EMG\" (DTE). ITE showed better reconstruction accuracy than DTE when extracting five or fewer synergies. DTE exhibited more negative phasic activations and synergy weights showed more negative values. A bootstrap procedure showed that synergies extracted from ITE and DTE are different in structure, and cluster analysis found nine clusters for ITE and ten for DTE. These results indicate that compensation and effort minimization models can coexist within the muscle synergy framework.<b>NEW & NOTEWORTHY</b> For the first time, a novel approach based on muscle synergies with positive and negative weights allows to account for the exploitation of gravity into synergistic models. This is achieved by a synergistic controller that incorporates both simplicity, as a reduced set of synergies underlying movement and static gravity compensation (phasic and tonic synergies), and effort optimization, based on the exploitation of gravity through negative phasic components.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":"112-126"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Last Word on Viewpoint: Seven (.65) seconds away: the possibility and physiology of a women's sub-4 min mile.","authors":"Rebekah J Osborne, Brett S Kirby, Matthew I Black, Anni Vanhatalo, Andrew M Jones","doi":"10.1152/japplphysiol.00521.2025","DOIUrl":"https://doi.org/10.1152/japplphysiol.00521.2025","url":null,"abstract":"","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":"139 1","pages":"263-264"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normal variation in brain volumetrics, CSF dynamics, and ocular structures from magnetic resonance images of healthy participants over two years.","authors":"Katrina J Carter, Steven S Laurie, Katherine G Warthen, Stuart H Sater, Bryn A Martin, Ching Mei Feng, Millennia Young, Khader M Hasan, Larry A Kramer, Brandon R Macias","doi":"10.1152/japplphysiol.00596.2024","DOIUrl":"10.1152/japplphysiol.00596.2024","url":null,"abstract":"<p><p>Changes in ocular and brain structure and cerebral spinal fluid (CSF) dynamics from magnetic resonance imaging (MRI) data have been reported in astronauts following long-duration spaceflight. The purpose of this study was to quantify normal variation in these outcomes over a 2-year period in a healthy cohort similar in age to astronauts, but without spaceflight experience. Variation in MRI acquisition, observer measurement, or normal aging over a 2-year period was used to determine thresholds for interpreting measures following long-duration spaceflight. Ten healthy participants (5 male), aged 38 ± 8 yr (mean ± SD), underwent five MRI sessions at baseline, 2, 6, 12, and 24 mo to quantify intracranial volumetry, CSF dynamics, pituitary morphology, and ocular structures. Total within-person variation ([Formula: see text]), modeled as the sum of the variance components for each outcome measure, was used to define a sensitivity threshold of 2.00 × [Formula: see text]. Changes greater than these thresholds can be interpreted as a result of an intervention and have <5% probability of occurring due to expected variability. Thresholds for change due to all sources of variability were: 27 mL for gray matter volume, 16 mL for white matter volume, 0.9 mL for lateral ventricular volume, 26.0 µL for CSF aqueductal stroke volume, 3.2 cm/s for peak-to-peak aqueductal CSF velocity, 0.5 mm for pituitary height, 0.50 mm for optic nerve sheath diameter, and 10.2 mm³ for posterior optic globe volume displacement. Changes on brain MR images after an intervention need to exceed these thresholds to be attributable to that intervention.<b>NEW & NOTEWORTHY</b> We report estimated thresholds of normal variability from methodological and physiological sources in brain and ocular outcomes in healthy participants. Outcomes that exceed these thresholds have less than a 5% probability of occurring due to these sources of variation. One of the present findings suggests that about 50% of the spaceflight-induced increase in lateral ventricular volume exceeds contributions of expected sources of measurement variability.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":"1-13"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-based differences in peak oxygen uptake among individuals with heart failure: systematic review and meta-analysis.","authors":"Rachel J Skow, Stephen J Foulkes, Jing Wang, Devyn Walesiak, Thomas McMurtry, Megan Kennedy, Martin Halle, Stephan Mueller, Isabel Fegers-Wustrow, Frank Edelmann, Corey R Tomczak, Mark J Haykowsky","doi":"10.1152/japplphysiol.00153.2025","DOIUrl":"10.1152/japplphysiol.00153.2025","url":null,"abstract":"<p><p>Heart failure (HF) studies examining peak oxygen uptake (V̇o₂) have largely focused on males, leaving a significant gap in the understanding of the magnitude and the mechanisms underpinning the impairment in females with HF. The objective of this systematic review and meta-analysis is to examine sex differences in peak V̇o₂ in HF. Studies were found through Medline, EMBASE, Scopus, CINAHL, and SPORTDiscus and included if they compared peak V̇o₂ in males and females with HF. Data extraction and methodological quality assessment were completed by two independent coders. Main outcomes and measures included peak V̇o₂ (mL/kg/min, primary outcome) and its Fick determinants (secondary outcome). The weighted mean difference (WMD) was calculated for each outcome between females and males. After screening 1,579 articles, 33 studies were included. Peak V̇o₂ was lower in females versus males (<i>n</i> = 20,115, WMD: -2.1 mL/kg/min, 95% CI: -2.4 to -1.8 mL/kg/min). In studies reporting the Fick determinants, peak exercise cardiac output (<i>n</i> = 1,219, WMD: -1.3 L/min, 95% CI: -1.7 to -1.0 L/min), stroke volume (<i>n</i> = 1,151, WMD: -15.2 mL, 95% CI: -18.8 to -11.7 mL), and arterial-venous oxygen difference (<i>n</i> = 1,131, WMD: -1.4 mL/dL, 95% CI: -2.3 to -0.5 mL/dL) were lower, whereas peak heart rate was higher compared with males (<i>n</i> = 10,103, WMD: 2.4 beats/min, 95% CI: 0.1-4.7 beats/min). The greater peak V̇o₂ impairment among females with HF is likely due to lower peak exercise cardiac output and arterial-venous oxygen difference. Future research should prioritize interventions aimed at addressing these physiological constraints in females with HF.<b>NEW & NOTEWORTHY</b> This meta-analysis revealed that peak exercise oxygen uptake is 2.1 mL/kg/min lower in females with heart failure compared with males, which may be due to having a lower peak cardiac output and arterial-venous O2 content difference. These findings highlight the importance of developing sex-specific therapeutic approaches to better address the added physiological challenges faced by females with heart failure to improve cardiovascular and skeletal muscle health outcomes.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":"45-57"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating low-energy cooling strategies on thermal and cardiac strain in older adults exposed to very hot and dry heat with accompanying activities of daily living.","authors":"Zachary J McKenna, Whitley C Atkins, Satyam Sarma, Elizabeth A Gideon, Taysom Wallace, Isa A Farooqi, Zachary R Oldham, Craig G Crandall","doi":"10.1152/japplphysiol.00390.2025","DOIUrl":"10.1152/japplphysiol.00390.2025","url":null,"abstract":"<p><p>We tested the hypothesis that skin wetting would attenuate, whereas electric fans would increase, thermal and cardiac strain in older adults exposed to very hot and dry heat. Twenty-three older adults (66-84 yr) were exposed (randomized) to 3 h of ambient heating (47°C and 15% relative humidity) with water spray, fan use, water spray + fan use, or no cooling intervention. We assessed thermal, cardiovascular, and cardiac responses. Compared with control, water spray reduced the increase in core temperature by -0.24°C [95% CI: -0.42, -0.06] (<i>P</i> = 0.007), ending skin temperature by -2.1°C [-2.6, -1.5] (<i>P</i> < 0.001), sweat rate by -0.12 L/h [-0.15, -0.09] (<i>P</i> < 0.001), ending heart rate by -5 beats/min [-8, -1] (<i>P</i> = 0.004), and ending rate pressure product by -1,027 beats/min·mmHg [-1,733, -321] (<i>P</i> = 0.004). Fan use augmented the increase in core temperature by 0.60°C [0.36, 0.84] (<i>P</i> < 0.001), ending skin temperature by 1.5°C [0.9, 2.1] (<i>P</i> < 0.001), sweat rate by 0.17 L/h [0.13, 0.20] (<i>P</i> < 0.001), ending heart rate by 15 beats/min [8, 23] (<i>P</i> < 0.001), and ending rate pressure product by 2,326 beats/min·mmHg [780, 3,872] (<i>P</i> = 0.003). Water spray + fan had no effect on core temperature (<i>P</i> = 0.308) or skin temperature (<i>P</i> = 0.114). However, sweat rate (0.07 L/h [0.001, 0.13]; <i>P</i> = 0.031) and ending heart rate (8 beats/min [1, 15]; <i>P</i> = 0.046) were higher with water spray + fan. Water spray attenuates, whereas fans increase, thermal and cardiac strain in older adults exposed to very hot and dry conditions. Thus, electric fans are not advised as a cooling intervention under the assessed conditions. Water spray offers some cooling benefits when access to energy is unavailable.<b>NEW & NOTEWORTHY</b> Extreme heat increases morbidity and mortality, particularly among older adults. Air conditioning can mitigate heat strain but may be inaccessible; thus, there is a need to identify nonair conditioning-dependent cooling strategies. We show that water spray attenuates, whereas fans increase, thermal and cardiac strain in older adults exposed to very hot and dry conditions. Importantly, our findings highlight that water spray offers the greatest benefit for individuals who are vulnerable to hyperthermia and tachycardia associated with heat stress.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":"206-218"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One force: limited sex differences in retrospective assessment of physiological and psychological attributes of elite warfighters.","authors":"Holly L McClung, Harris R Lieberman, Lauren A Thompson, Emily K Farina, Meaghan E Beckner","doi":"10.1152/japplphysiol.00197.2025","DOIUrl":"10.1152/japplphysiol.00197.2025","url":null,"abstract":"<p><p>A physical performance gap between sexes exists with females generally performing worse than men. However, physical performance has improved over time across sex, with the rate of improvement greater for females. Given recent efforts by the US military to facilitate sex-integration, this study examined the extent to which sex differences are present in elite military personnel. Graduates of the US Army Ranger Course (70 M; 12 F) were compared across measures of body composition (anthropometry and dual-energy X-ray absorptiometry), aerobic capacity, biomarkers of health, and survey assessments of nutritional supplement intake, psychological and lifestyle factors. Graduates had similar time in service, military experience, grit, resilience, sport participation, and outdoor hobbies. Females attained a higher level of education (<i>P =</i> 0.015) and rank (<i>P</i> = 0.023) than males. Females had lower bone mineral content (<i>P</i> = 0.049) and fat-free mass (<i>P</i> = 0.014) than males with similar fat mass (<i>P</i> = 0.487). Absolute and relative aerobic capacity differed by sex (<i>P</i> = 0.001). There were no differences overall in nutritional supplement use, but females reported greater vitamin and mineral supplement-use than males (<i>P</i> = 0.004). Females had lower albumin, ferritin, glucose, and higher hemoglobin A1C, potassium, and sodium than males (<i>P <</i> 0.05). Sport participation, psychological attributes (i.e., grit and resilience), biomarkers of health, and nutritional supplement use were similar between male and female elite military schools graduates, though fat-free mass and aerobic capacity differed by sex as expected. This study suggests that when elite, high performing male and female soldiers are compared, their mental state and physical performance are more similar than same sex civilian counterparts.<b>NEW & NOTEWORTHY</b> A physical performance gap exists between sex, however over time the rate of improvement has been greater for females. Unlike trends in civilian sport, comparative analysis among elite warfighters revealed fewer sex differences in body composition, psychological outcomes, and self-directed lifestyle choices, including history of sport participation, military experience, and nutritional supplement use. This initial comparison indicates males and females are similar individuals with many common defining traits and characteristics of elite warfighters.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":"231-238"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interindividual variability in renal and muscle sympathetic responses to mental stress: contributions to blood pressure regulation.","authors":"André L Teixeira, Jordan B Lee, Massimo Nardone, Jamie F Burr, Philip J Millar","doi":"10.1152/japplphysiol.00575.2024","DOIUrl":"10.1152/japplphysiol.00575.2024","url":null,"abstract":"<p><p>Laboratory-based mental stress induces consistent increases in arterial blood pressure, while muscle sympathetic nerve activity (MSNA) responses are highly variable. Given the ability of sympathetic nervous system to be regulated in an organ-dependent manner, we hypothesized that interindividual variability in renal sympathetic vasoconstriction interacts with MSNA to control blood pressure during mental stress. Herein, renal artery blood velocity (Doppler ultrasound; <i>n</i> = 33, 19M/14F), MSNA (microneurography; <i>n</i> = 25, 17M/8F), and beat-to-beat mean arterial pressure (MAP; finger photoplethysmography) were measured at rest and during mental stress (arithmetic task) in young, healthy adults. Renal vascular resistance (RVR) was calculated as an index of sympathetically mediated renal vasoconstriction. Participants were classified as negative responders, nonresponders, or positive responders if RVR or MSNA was below, within, or above the baseline variability, respectively. The proportions of negative responders (24% vs. 36%), nonresponders (18% vs. 16%), and positive responders (58% vs. 48%) were significantly different between RVR and MSNA-responder types, respectively (<i>P</i> = 0.02). Within the participants in whom both MSNA and RVR were obtained (<i>n</i> = 25), only 13 (52%) displayed concordant response patterns (3 negative responders, 1 nonresponder, and 9 positive responders). Participants were further classified based on the combination of RVR and MSNA responsiveness as typically negative, mixed, or typically positive responders. Within this subanalysis, MAP reactivity was lower in typically negative compared with mixed and typically positive responders (2 ± 3 mmHg vs. 6 ± 3 mmHg vs. 7 ± 3 mmHg, respectively; <i>P</i> = 0.02). These findings suggest that the interindividual variability in renal and muscle vasoconstrictor responses contributes to blood pressure regulation during mental stress in young, healthy adults.<b>NEW & NOTEWORTHY</b> We found large interindividual variability in renal vascular resistance (RVR) and muscle sympathetic nerve activity (MSNA) responses to mental stress, with only 52% of participants exhibiting concordant response patterns. Individuals with typically negative responses (i.e., decreases in RVR and MSNA, or decreases in one and no changes in the other) displayed lower blood pressure reactivity than typically positive responders, highlighting the integrative contribution of renal and muscle vasoconstriction on blood pressure regulation during mental stress.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":"27-36"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrospinal fluid pH in chronic respiratory acidosis.","authors":"Jay M J R Carr, Travis D Gibbons, David B MacLeod, Erik R Swenson, Philip N Ainslie","doi":"10.1152/japplphysiol.00296.2025","DOIUrl":"10.1152/japplphysiol.00296.2025","url":null,"abstract":"<p><p>In this article, we extracted arterial and cerebrospinal fluid (CSF) acid-base data from 16 published articles concerning chronic respiratory acidosis. Using a traditional narrative review style literature search, we sought published research articles wherein arterial and CSF data were available in patients with chronic respiratory acidosis. We extracted individual data where possible, and mean and standard deviation data otherwise, representing 180 patients with respiratory acidosis and 184 healthy individuals. With these data, we demonstrate the differences in hydrogen ion (H⁺) buffering between the arterial blood and CSF. We also use these relationships to produce prediction equations for CSF pH in healthy and diseased conditions. Arterial pH explains ∼61% of the variation in CSF pH, whereas arterial partial pressure of CO₂ ([Formula: see text]) explains ∼55%. Using linear regression equations between arterial H⁺ concentration, arterial pH, [Formula: see text], and CSF pH produce mild to moderate agreement between predicted and actual CSF pH when used to predict CSF pH.<b>NEW & NOTEWORTHY</b> Cerebrospinal fluid pH is tightly regulated in healthy individuals, but in cases of respiratory acidosis, both acute and chronic, pH becomes derailed. Acid-base buffering is only able to compensate so far before pH becomes challenged. We find that pH in the CSF may not manage acidosis as well as the arterial buffering capacity. We also leverage these data to estimate the predictive power of arterial pH on CSF pH.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":"105-111"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}