Journal of Biobased Materials and Bioenergy最新文献

{"title":"Molecular Mechanisms of Phyllanthus urinaria in Cerebral Ischemia-Reperfusion Injury","authors":"Deyuan Qin, Jiangcun Wei, Xiumei Ma, Bing Qing, Meiyan Qiu, Peng Yang, Zhengteng Yang","doi":"10.1166/jbmb.2024.2350","DOIUrl":"https://doi.org/10.1166/jbmb.2024.2350","url":null,"abstract":"Phyllanthus urinaria (P. urinaria), a prominent herb in traditional Zhuang medicine, is characterized by its heat clearance, detoxification, diuresis, and detumescence. This study investigates the therapeutic effects and molecular mechanisms of P. urinaria on cerebral ischemia-reperfusion injury (CIRI). 60 adult SD rats were randomly divided into four groups: a sham operation group, a model group of right middle cerebral artery occlusion (MCAO), a low-dose group treated with P. urinaria at 5 g/kg, and a high-dose group treated with P. urinaria at 10 g/kg, each consisting of 15 rats. After seven days of continuous administration, a rat model of the right MCAO was established to simulate CIRI. Nerve function was assessed using the Longa scoring method, the cerebral infarction area was evaluated with TTC staining, and cytokine levels (IL-1β, TNF-α, IL-6) were measured via ELISA. PI3K and AKT protein expression in brain tissues was analyzed by Western blot. The results revealed a significant improvement in neurological function scores in both low and high-dose P. urinaria groups compared to the MCAO model group. Treatment with P. urinaria led to a notable reduction in cerebral infarction area after 72 hours of cerebral ischemia. The levels of inflammatory cytokines (IL-1β, TNF-α, IL-6) were decreased in both treatment groups compared to the MCAO model group. There was a significant increase in the expression of PI3K and AKT proteins in both treatment groups. In conclusion, P. urinaria exhibits a protective effect against CIRI by inhibiting inflammatory responses, improving neurological function, and reducing brain injury.","PeriodicalId":15157,"journal":{"name":"Journal of Biobased Materials and Bioenergy","volume":"3 8","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139124946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Steam Explosion on the Structure, Chemical Composition and Pyrolytic Volatile Composition of Tobacco Waste","authors":"Ze Liu, Gaoxiang Xu, Chenhao Song, Wen Zuo, Siyuan Li, Chao Gui, Na Liu, Peng Hu, Ji Yang, Guofu Zhou, Wei Zhang, Yubao Chen","doi":"10.1166/jbmb.2024.2353","DOIUrl":"https://doi.org/10.1166/jbmb.2024.2353","url":null,"abstract":"Tobacco stems are an important part of the tobacco leaf, containing a lot of cellulose, result in the low utilization of tobacco leaves in cigarettes. The pre-treatment technology of tobacco stems is a key to increase the utilization of tobacco stems. In this work, steam explosion treatment was carried out on tobacco stems with different moisture contents containing 2%, 5% and 10%, respectively. The steam explosion is carried out under different pressure and pressure holding time conditions, the changes in physical structure, chemical composition and pyrolysis volatiles of tobacco stem was investigated. The results indicate that steam explosion has a negligible impact on the crystalline structure of cellulose and low-order polysaccharide crystals, while it has an obvious effect on KCl. Steam explosion increases the specific surface area by destroying the amorphous structure on tobacco stems. The contents of chemical constituents and pyrolytic volatiles indicate that there is a significant leaching effect of lignin, but no change in cellulose content. Soluble polysaccharides, the main component of hemicellulose, were converted into pyrolytic volatiles e.g., furfural and furfuryl alcohol. In conclusion, the technology of steam explosion promotes the leaching, decomposition and chemical transformation of amorphous structures on tobacco stems, thus destroying the structure of the cell walls.","PeriodicalId":15157,"journal":{"name":"Journal of Biobased Materials and Bioenergy","volume":"56 19","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139127966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cleaning Process of Diosgenin from Dioscorea nipponica","authors":"Jinwei Liu, Weichang Xu, Feng Yan, Xinqi Liu, Yuan Wang","doi":"10.1166/jbmb.2024.2335","DOIUrl":"https://doi.org/10.1166/jbmb.2024.2335","url":null,"abstract":"This investigation employed HPLC and LC-MS techniques to elucidate the enzymolysis and acid hydrolysis mechanisms of diosgenin obtained through a cleaning process. The findings revealed that the enzymolysis led to the cleavage and subsequent recombination of the glycosidic bond at the C-26 position of protodioscin, resulting in the formation of dioscin present in the enzymatic hydrolysis filter residue. Leveraging this observation, a streamlined and eco-friendly method for diosgenin extraction was devised. Incorporating the Box-Behnken response surface methodology alongside wastewater assessment, the optimal parameters for the cleaning process were established: a sulfuric acid concentration of 3 mol · L−1, a solid–liquid ratio of 1:10, an acid hydrolysis temperature of 100 °C, and an acid hydrolysis duration of 3 h. Under these parameters, the yield and purity of diosgenin were 31.07±0.56% and 72.30±0.24% respectively. When benchmarked against the direct acid hydrolysis approach, there was an increase of 133.08% in diosgenin yield, 44.08% enhancement in diosgenin purity, 50% reduction in wastewater generation and acid utilization, and an 83.57% decrease in wastewater’s chemical oxygen demand (COD). This optimized cleaning process is viable for large-scale production and offers a sustainable method for diosgenin production.","PeriodicalId":15157,"journal":{"name":"Journal of Biobased Materials and Bioenergy","volume":"139 15","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139128275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Therapeutic Effect of Shengmai Yin Chinese Herbal Medicine in Pneumonia","authors":"Lili Wang, Shoucong Yi","doi":"10.1166/jbmb.2024.2336","DOIUrl":"https://doi.org/10.1166/jbmb.2024.2336","url":null,"abstract":"Health education is an important method to improve patients’ cognitive level and quality of life. Shengmai Yin (SMY) contain a variety of active ingredients of Chinese herbal medicine, pathology effect is relatively broad, plays an important role in a variety of chronic diseases treatment. This study aims to analyze the effect of nursing health education combined with the treatment with SMY on elderly patients with community-acquired pneumonia. Meanwhile, pharmaceutical information regarding the chemical composition, pharmacological effects, and pharmacokinetic characteristics of SMY in traditional Chinese medicine was summarized and analyzed. Animal experiments were conducted to analyze the immunomodulatory effects of SMY on elderly community acquired pneumonia. A total of 80 elderly patients with community-acquired pneumonia admitted to our hospital from July 2019 to July 2022 were selected as the research objects. According to different nursing models, they were divided into a control group and a study group, with 40 cases in each group. Patients in the control group were given routine nursing, while patients in the study group were given health education nursing and SMY treament on the basis of the control group. The overall differences were compared between the two groups. In rat experiment, a rat model of chronic bronchitis was used and divided into control, model control group, low-dose group, medium-dose group, and high-dose group according to the dosage. The levels of immunoglobulins (IgA, IgG, IgM), and cytokines (IL-1, IL-6, TNF-α) in rat serum were determined using ELISA. The disease knowledge, the quality of life score and the effect of health education of the study group was better than that of the control group (P < 0.05), the temperature remission time of the two groups was not significantly different (P > 0.05), but the respiratory rate remission time and cough remission time were shorter than that of the control group (P < 0.05). In rat experiment, The levels of IgA, IgG, IgM, IL-1, IL-6, and TNF-α in the serum of the model control group were higher than those in the normal control group. Compared with those in the model control group, the low-dose group exhibited lower levels of IgG, IgM, and IL-1, whereas the medium- and high-dose groups exhibited lower levels of IgA, IgG, IgM, IL-1, IL-6, and TNF-α (all P < 0.05). Health education and SMY treatment have a good impact on elderly patients with community-acquired pneumonia, which can effectively improve the patients’ mastery of health knowledge, treatment effect and quality of life. In addition, SMY had a significant downregulating effect on immunity and cytokines, providing anti-infective, antiallergic, and immunomodulatory effects, and is hence effective in treating bronchitis.","PeriodicalId":15157,"journal":{"name":"Journal of Biobased Materials and Bioenergy","volume":"44 19","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139126997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Evaluation of the Contribution of Cellulose, Hemicellulose and Lignin to Bio-Char Combustion and Adsorption Properties","authors":"Bing Dai, Zhaoguo Ding","doi":"10.1166/jbmb.2024.2338","DOIUrl":"https://doi.org/10.1166/jbmb.2024.2338","url":null,"abstract":"The present work focuses on the contribution of cellulose, hemicellulose, and lignin for bio-char application in two aspects: fuels and adsorbent. The pyrolysis behaviors were studied at 300 to 700 °C, and the yields and characterization of bio-chars were compared. The results showed that in the three components, lignin was responsible for the formation of bio-char products, representing the main source of bio-char characterized by high heating value. Lignin was the strongest support for prepared bio-char as fuel decided by physico-chemical properties and combustion reactivity, while cellulose was the major contributor for bio-char products as ignition fuel. Scanning electron microscopy (SEM) and surface area analysis of bio-char showed that, in the three components, cellulose derived bio-chars exhibited a distinctive fibrous structure and the surface area was the largest at the same pyrolysis temperature. Compared with lignin, hemicellulose was a better precursor for adsorption, it is mainly determined by complex and abundant pore structure. Further adsorption tests of toxic substances in soil showed that, cellulose represented major adsorption donator for phenol, all bio-char samples had better adsorption capacity for Pb(II) than Cu(II), the rule on adsorption capacity of three different precursors for Cu(II) was as follows: cellulose>hemicellulose>lignin, for Pb(II): hemicellulose> cellulose> lignin.","PeriodicalId":15157,"journal":{"name":"Journal of Biobased Materials and Bioenergy","volume":"8 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139129349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anomaly Detection in Species Distribution Patterns: A Spatio-Temporal Approach for Biodiversity Conservation","authors":"Mingyang He, Hao Chen","doi":"10.1166/jbmb.2024.2340","DOIUrl":"https://doi.org/10.1166/jbmb.2024.2340","url":null,"abstract":"Monitoring and maintaining biodiversity are crucial for the ecological balance and overall health of ecosystems. Detecting anomalies in species distribution patterns is essential for identifying areas of concern and implementing timely conservation measures. This paper introduces an approach to detect anomalies in spatiotemporal species activity data by integrating time series analysis, machine learning techniques, and spatial statistics. Our method identifies distribution patterns of various species and groups regions with similar patterns, enabling the segmentation of the study area into distinct categories. Within these categorized regions, we apply a combination of clustering algorithms and outlier detection techniques to pinpoint anomalous behaviors in species distribution. In order to confirm the reliability of our findings, we cross-reference them with verified data acquired through field observations or other credible data sources. These corroborations indicate that anomalies are frequently indicative of sudden variations in species numbers or unexpected alterations in spatial distribution at certain places and times. To gain a more robust understanding of how species are distributed, we curate a data set that excludes these anomalous observations and use it to develop a predictive algorithm. Our analysis shows that a predictive model trained on this refined, anomaly-free dataset achieves a lower normalized mean square error (NMSE), which suggests a higher level of predictive accuracy as compared to a model trained on data containing anomalies. Utilizing this methodology can facilitate the creation of effective conservation plans and contribute to more sustainable ecosystem management.","PeriodicalId":15157,"journal":{"name":"Journal of Biobased Materials and Bioenergy","volume":"29 27","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139129523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bee Pollen: An Antioxidant and Antimicrobial Agent for Beef Sausage","authors":"I. M. Taha, K. A. Ismail, R. Sami, Huda Aljumayi, G. Alshehry, Eman Algarni, Adel Aljumayi, Mohammad Y. Alshahrani, Tahani Y. A. Asseri, Zayed Alsharari, Fadi Baakdah, El-Kazafy A. Taha","doi":"10.1166/jbmb.2024.2339","DOIUrl":"https://doi.org/10.1166/jbmb.2024.2339","url":null,"abstract":"Natural additives can enhance the microbial and oxidative quality of processed meat products. Bee pollen is a natural ingredient with valuable nutritional properties. It has been suggested as a natural antimicrobial and antioxidant agent. The goal of this research was to include bee pollen in beef sausage formulation as an antimicrobial and antioxidant agent for improving the quality criteria under cold storage. Five beef sausage formulas were prepared; the first formula was prepared from the basic formula (positive control) include butylatedhydroxytoluene (BHT), the second formula (negative control) was prepared like the basic formula without BHT and the other three formulations were prepared by including 1, 2 and 3% eucalyptus (Eucalyptus ssp.) bee pollen. All formulations were stored at 5±2 °C until spoilage symptoms appeared. Chemical composition, thiobarbituric acid reactive substance (TBA-RS), total volatile basic nitrogen (TVB-N), microbial counts and sensory properties were evaluated. The obtained results were compared with Egyptian criteria to assess their acceptability. In comparison with the sausage basic formula, formulas treated with BHT and bee pollen showed a significant reduction in TVB-N, TBA-RS, total aerobic bacteria count, psychrophilic count, molds and yeasts count. The sensory properties of all formulations prepared with bee pollen were acceptable. Bee pollen was superior as an antimicrobial and antioxidant agent for sausage. It could be concluded that bee pollen can be used by meat manufacturers for enhancing quality and extending the shelf-life.","PeriodicalId":15157,"journal":{"name":"Journal of Biobased Materials and Bioenergy","volume":"38 25","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139125658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Paclitaxel and Stroke: Mendelian Randomization","authors":"Bingwu Chen, Xian Zhou, Tao Yang, Mei-xia Xu, Tao Liu, Zhong Dai, Chuanhua Bi, Tao Xu","doi":"10.1166/jbmb.2024.2344","DOIUrl":"https://doi.org/10.1166/jbmb.2024.2344","url":null,"abstract":"Paclitaxel, a naturally derived anticancer drug extracted from the plant Taxus brevifolia, holds significant medicinal and clinical value. Recently, more and more studies have shown that paclitaxel may be involved in the risk of stroke. However, there is still controversy over the relationship between the two at present. The objective of this study is to investigate a causality between paclitaxel and stroke using a two-sample Mendelian randomization (MR). Summary statistics for paclitaxel and stroke were derived from multiple comprehensive genome-wide association studies. The Inverse-variance weighting (IVW) method was used for preliminary analysis. Additionally, MR Steiger was employed to evaluate the robustness of these genetic variants in relation to paclitaxel and stroke. This study did not find a correlation between paclitaxel and stroke (OR: 1.008; 95% CI: 0.894–1.013, P = 0.270). This relationship was supported by other analysis methods as well. Furthermore, MR Steiger’s analysis confirmed a causal relationship between paclitaxel and stroke ( “TRUE”). Our research has shown that paclitaxel does not lead to stroke, and further exploration of the relationship between the two is still needed.","PeriodicalId":15157,"journal":{"name":"Journal of Biobased Materials and Bioenergy","volume":"44 12","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139127627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Targeted Components in the Combination Extract of Hovenia dulcis and Phyllanthus emblica by UPLC-MS/MS","authors":"Mei Zhang, Hongyuan Zhang, Zhiwei Huang, Yanjie Zhang, Ling liang, Benyong Lou","doi":"10.1166/jbmb.2024.2346","DOIUrl":"https://doi.org/10.1166/jbmb.2024.2346","url":null,"abstract":"This study aimed to establish a UPLC-MS/MS method for rapid analysis and identification of target components in the combination extract of Hovenia dulcis and Phyllanthus emblica. The gradient elution was carried out with methanol (A) −0.2% formic acid solution (A) with low rate of 1.0 mL · min−1, column temperature of 30 °C, detection wavelength of 285 nm. The ESI ion source was used to collect data under the negative ion mode. Through analysis and identification, five target components were inferred, namely gallic acid, dihydromyricetin, corilagine, taxifolin, and ellagic acid in the combination extract. Quantitative analysis was conducted on the combination extract. By utilizing the theory of modern supramolecular technology in traditional Chinese medicine, the functional composite product was obtained by selecting the compound extraction of Hovenia dulcis and Phyllanthus emblica as raw materials, and quantitative analysis was conducted on on the combination extract. The results showed that the flavonoid extraction rate and the content of target components were both higher when the mass ratio of Hovenia dulcis to Phyllanthus emblica was 1:1 and 1:2. This indicates that the co-extraction of Hovenia dulcis and Phyllanthus emblica not only simplified the extraction process but also enhances the extraction rate of the flavonoids in Hovenia dulcis. The developed UPLC-MS/MS method is rapid, sensitive, which provides a technical basis for the selection of raw material mass ratios and product development of Hovenia dulcis and Phyllanthus emblica combination.","PeriodicalId":15157,"journal":{"name":"Journal of Biobased Materials and Bioenergy","volume":"23 6","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139129838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological and Photosynthetic Characteristics of Pumpkin Seedlings Cultivated Under Low-Light Stress","authors":"Yanfang Jiang, Zefa Liu, Hui Liu, M. Yusop, Shamsiah Abdullah","doi":"10.1166/jbmb.2024.2348","DOIUrl":"https://doi.org/10.1166/jbmb.2024.2348","url":null,"abstract":"Low-light stress is known to have a significant impact on pumpkin yield in greenhouse conditions, it is crucial to understand the characteristics of low-light tolerance and identify resistant germplasm resources. In this study, four pumpkins (Cucurbita moschata) varieties were used, including three inbred lines (10–32, NY-1, and JB-1) and one hybrid line (NY-1×JB-1). Various low-light treatments (T0, no shade; T40, 40% shading; T80, 80% shading) were set, to explore their effects on morphology, photosynthetic characteristics, osmotic regulation substance content, and antioxidant enzyme activity in pumpkin seedling leaves. In the results, seedlings of inbred lines 10–32 and JB-1, as well as hybrid NY-1×JB-1, exhibited low-light resistance with shading rate increases. The maximum photochemical quantum yield of photosystem II (Fv/Fm) of all varieties decreased under low-light stress. Catalase (CAT) activity initially increased and then decreased, while superoxide dismutase (SOD) activity showed the opposite trend. Peroxidase (POD) activity gradually increased in 10–32, JB-1, and NY-1×JB-1, with JB-1 showing a significant increase at T80, and NY-1 displaying an initial decrease followed by an increase. Noteablely, the soluble proline (Pro) content decreased in 10–32, NY-1, and NY-1×JB-1. Significant differences in malondialdehyde (MDA) content were observed among the seedlings of four varieties. The MDA contents increased in 10–32 and JB-1 under T0 and T40, while showed no significant change in NY-1. The MDA content at T80 significantly decreased in NY-1, and first decreased and then significantly increased in NY-1×B-1. The soluble sugar content in 10–32 remained unchanged between T0 and T40, but significantly increased at T80. While in JB-1 and NY-1, it initially increased then decreased with increasing shading rate. The trend in NY-1×JB-1 was opposite to that of JB-1 and NY-1, with initially decreased followed by a significant increase. In conclusion, morphological characteristics associated with low-light tolerance can serve as reference indices for breeding low-light tolerance pumpkins. These parameters can be used as reference indices to assess pumpkin resistance to low-light stress.","PeriodicalId":15157,"journal":{"name":"Journal of Biobased Materials and Bioenergy","volume":"13 4","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139126431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}