Journal of Autism and Developmental Disorders最新文献

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Sex Differences in Adult Autism Screening: A Comparison of Current Self-Report and Retrospective Parent-Report Measures. 成人自闭症筛查的性别差异:当前自我报告和回顾性父母报告的比较。
IF 3.2 2区 心理学
Journal of Autism and Developmental Disorders Pub Date : 2025-03-01 DOI: 10.1007/s10803-025-06753-8
Michael Terner, Ofer Golan
{"title":"Sex Differences in Adult Autism Screening: A Comparison of Current Self-Report and Retrospective Parent-Report Measures.","authors":"Michael Terner, Ofer Golan","doi":"10.1007/s10803-025-06753-8","DOIUrl":"https://doi.org/10.1007/s10803-025-06753-8","url":null,"abstract":"<p><p>This study investigated sex differences in adult autism screening by comparing self-reports on current traits (Autism Spectrum Quotient; AQ) and parent-reports on childhood traits (Relatives Questionnaire; RQ). The aim was to examine the differential contribution of these distinct measures to diagnostic classification in both sexes. The study compared 102 clinically diagnosed autistic adults (30 females) and 152 non-autistic adults (60 females), aged 17-35 years. Participants completed the AQ, while their parents completed the RQ. Multivariate analysis of variance and sex-stratified discriminant analyses were employed to evaluate measurement patterns in males and in females. Significant main effects were found for diagnostic group on both measures and for sex on the RQ only. Group × sex interactions were significant for both measures. Within the autistic group, males and females showed no significant difference in AQ scores, but females scored significantly lower than males on the RQ. Discriminant analyses revealed high classification accuracies for both males (95.1%) and females (96.7%), with different weighting patterns between males (AQ = 0.597 [CI: 0.413-0.720], RQ = 0.712 [CI: 0.553-0.789]) and females (AQ = 0.763 [CI: 0.637-0.898], RQ = 0.478 [CI: 0.191-0.616]). The findings suggest that current self-report may be more central for identifying autism in females, while a more balanced combination of current-self and past-parent reports may be optimal for males. These sex-specific patterns highlight the importance of considering both current self-reported traits and developmental history in adult autism screening, with potential implications for improving diagnostic accuracy across sexes.</p>","PeriodicalId":15148,"journal":{"name":"Journal of Autism and Developmental Disorders","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Centering Autistic Perspectives: Social Acceptability of Goals, Learning Contexts, and Procedures for Young Autistic Children. 以自闭症观点为中心:自闭症儿童的目标、学习环境和程序的社会可接受性。
IF 3.2 2区 心理学
Journal of Autism and Developmental Disorders Pub Date : 2025-03-01 Epub Date: 2024-02-17 DOI: 10.1007/s10803-024-06242-4
Kate T Chazin, Jennifer R Ledford, Jane M Wilson-Moses, Adithyan Rajaraman, A Pablo Juárez
{"title":"Centering Autistic Perspectives: Social Acceptability of Goals, Learning Contexts, and Procedures for Young Autistic Children.","authors":"Kate T Chazin, Jennifer R Ledford, Jane M Wilson-Moses, Adithyan Rajaraman, A Pablo Juárez","doi":"10.1007/s10803-024-06242-4","DOIUrl":"10.1007/s10803-024-06242-4","url":null,"abstract":"<p><p>Despite the importance of centering autistic perspectives in educational decision-making for autistic children, few studies have directly assessed autistic perspectives on the social acceptability of early childhood practices. We conducted an online survey to recruit perspectives of autistic adults on a current, comprehensive range of educational practices typically employed with autistic children. We also extended the survey to caregivers and early childhood practitioners, to identify commonalities and discrepancies between shareholder groups. We conducted a descriptive survey study to assess social acceptability of goals, learning contexts, and procedures typically implemented with young autistic children. We received responses from 660 individuals, 226 of whom identified as autistic. For Likert scale and ranked items, we reported median rating and ranking for each item, by shareholder group. For open-ended questions, we conducted open and axial coding, to determine consistent themes within and across shareholder groups. Respondents reported (a) high acceptability for goals promoting self-determination and low social validity for goals promoting masking; (b) high acceptability for antecedent interventions and low social validity for some forms of extinction; (c) that appropriate learning environments are highly context dependent, varying with individual needs; and (d) that the child is the most important shareholder in educational decision-making. We make recommendations to practitioners in response to survey results, including (a) respecting autistic culture and characteristics in selecting goals; (b) considering social, emotional, and psychological needs in selecting procedures; and (c) individualizing goals, learning contexts, and procedures based on the child's perspectives and unique needs.</p>","PeriodicalId":15148,"journal":{"name":"Journal of Autism and Developmental Disorders","volume":" ","pages":"812-831"},"PeriodicalIF":3.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139898030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality of Life in Hungarian Parents of Autistic Individuals. 匈牙利自闭症患者父母的生活质量。
IF 3.2 2区 心理学
Journal of Autism and Developmental Disorders Pub Date : 2025-03-01 Epub Date: 2024-01-27 DOI: 10.1007/s10803-024-06243-3
Marta Volgyesi-Molnar, Miklos Gyori, Valsamma Eapen, Zsofia Borsos, Agnes Havasi, Zoltan Jakab, Laszlone Janoch, Vivien Nemeth, Tamasne Oszi, Agota Szekeres, Krisztina Stefanik
{"title":"Quality of Life in Hungarian Parents of Autistic Individuals.","authors":"Marta Volgyesi-Molnar, Miklos Gyori, Valsamma Eapen, Zsofia Borsos, Agnes Havasi, Zoltan Jakab, Laszlone Janoch, Vivien Nemeth, Tamasne Oszi, Agota Szekeres, Krisztina Stefanik","doi":"10.1007/s10803-024-06243-3","DOIUrl":"10.1007/s10803-024-06243-3","url":null,"abstract":"<p><strong>Purpose: </strong>Parents of autistic individuals have been known to have a lower overall quality of life (QQL) than those of typically developing children. We present the first Hungarian large-sample study whose objective was to explore the differences in QOL between parents of autistic individuals (AS) and those of neurotypical (NT) persons.</p><p><strong>Methods: </strong>Based on the ABCX model we developed a questionnaire comprising standardized scales to characterize the life of parents involved. Our data came from parents of 842 individuals (ASD = 521, NT = 321) between 0 and 49 years. Battery deployed standardized instruments to examine quality of life (WHO-QQL BREF and Quality of Life in Autism questionnaire, QOLA). We assessed the families' socio-economic/demographic characteristics, parents' psychological well-being, the autistic/neurotypical individuals' characteristics, and the interventions.</p><p><strong>Results: </strong>Our data showed significantly lower QOL in parents of autistic individuals in all domains of questionnaires. We analyzed 20 relevant factors to uncover the predictors of parental QOL. We confirmed the existence of most but not all predictors present in earlier literature and identified intervention-related predictors.</p><p><strong>Conclusion: </strong>Our study confirms the importance of supporting parents in their role, and of providing health and social supports that focus on quality of life, in addition to child care.</p>","PeriodicalId":15148,"journal":{"name":"Journal of Autism and Developmental Disorders","volume":" ","pages":"1122-1137"},"PeriodicalIF":3.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139570494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Autism Spectrum Disorder (ASD) in Inpatient Adolescent Psychiatric Population. 青少年精神病住院患者中自闭症谱系障碍(ASD)的患病率。
IF 3.2 2区 心理学
Journal of Autism and Developmental Disorders Pub Date : 2025-03-01 Epub Date: 2023-04-06 DOI: 10.1007/s10803-023-05923-w
Graciela Kriegel, Sayani Paul, Kate H Leonard, Paul Sandor
{"title":"Prevalence of Autism Spectrum Disorder (ASD) in Inpatient Adolescent Psychiatric Population.","authors":"Graciela Kriegel, Sayani Paul, Kate H Leonard, Paul Sandor","doi":"10.1007/s10803-023-05923-w","DOIUrl":"10.1007/s10803-023-05923-w","url":null,"abstract":"<p><p>The prevalence of autism spectrum disorder (ASD) has increased in recent decades, much of which is related to changes in diagnostic criteria, and greater awareness among professionals and parents. Using a prospective cross-sectional study design, this study explores the prevalence of ASD among 173 adolescents admitted to two psychiatric facilities in Canada, and its association with some early pre and perinatal risk factors. The overall prevalence of ASD in the psychiatric population was 11.56% compared to 1.52% in children and youth in Canada. While prenatal and perinatal factors were not significantly associated with ASD, we found a frequent association of ASD with different comorbid psychiatric conditions. These findings further our knowledge in planning and management of ASD among this population.</p>","PeriodicalId":15148,"journal":{"name":"Journal of Autism and Developmental Disorders","volume":" ","pages":"1138-1145"},"PeriodicalIF":3.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9307280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensorimotor Features and Daily Living Skills in Autistic Children With and Without ADHD. 有多动症和无多动症自闭症儿童的感知运动特征和日常生活技能。
IF 3.2 2区 心理学
Journal of Autism and Developmental Disorders Pub Date : 2025-03-01 Epub Date: 2024-03-05 DOI: 10.1007/s10803-024-06256-y
Emily C Skaletski, Kelly Barry, Elizabeth Dennis, Ryan Donnelly, Celina Huerta, Andrez Jones, Kate Schmidt, Sabrina Kabakov, Karla K Ausderau, James J Li, Brittany G Travers
{"title":"Sensorimotor Features and Daily Living Skills in Autistic Children With and Without ADHD.","authors":"Emily C Skaletski, Kelly Barry, Elizabeth Dennis, Ryan Donnelly, Celina Huerta, Andrez Jones, Kate Schmidt, Sabrina Kabakov, Karla K Ausderau, James J Li, Brittany G Travers","doi":"10.1007/s10803-024-06256-y","DOIUrl":"10.1007/s10803-024-06256-y","url":null,"abstract":"<p><p>Attention-deficit/hyperactivity disorder (ADHD) commonly co-occurs in autistic children. However, additional research is needed to explore the differences in motor skills and sensory features in autistic children with and without ADHD, as well as the impacts of these factors on daily living skills (DLS). This observational study sought to fill this gap with 67 autistic children (6.14-10.84 years-old), 43 of whom had ADHD. Autistic children with ADHD demonstrated higher sensory features and lower motor skills than autistic children without ADHD. In examining autism and ADHD features dimensionally, we found that overall sensory features, seeking, and hyporesponsiveness were driven by both autism and ADHD features, whereas motor skills, enhanced perception, and hyperresponsiveness were driven by only autism features. Additionally, in using these dimensional variables of autism and ADHD features, we found that differences in motor skills, sensory and autism features, but not ADHD features, impact DLS of autistic children, with autism features and motor skills being the strongest individual predictors of DLS. Together, these results demonstrate the uniqueness of motor skills and sensory features in autistic children with and without ADHD, as well as how autism features, sensory features, and motor skills contribute to DLS, emphasizing the importance of a comprehensive understanding of each individual and complexities of human development when supporting autistic children.</p>","PeriodicalId":15148,"journal":{"name":"Journal of Autism and Developmental Disorders","volume":" ","pages":"1088-1100"},"PeriodicalIF":3.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140039485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brief Report: Longitudinal Role of Coping Strategies on Mental Health Outcomes in Autistic Youth and Adults. 简要报告:应对策略对自闭症青少年和成人心理健康结果的纵向作用。
IF 3.2 2区 心理学
Journal of Autism and Developmental Disorders Pub Date : 2025-03-01 Epub Date: 2023-04-05 DOI: 10.1007/s10803-023-05953-4
Melanie Muniandy, Amanda L Richdale, Samuel R C Arnold, Julian N Trollor, Lauren P Lawson
{"title":"Brief Report: Longitudinal Role of Coping Strategies on Mental Health Outcomes in Autistic Youth and Adults.","authors":"Melanie Muniandy, Amanda L Richdale, Samuel R C Arnold, Julian N Trollor, Lauren P Lawson","doi":"10.1007/s10803-023-05953-4","DOIUrl":"10.1007/s10803-023-05953-4","url":null,"abstract":"<p><p>The stress literature suggests that coping strategies are implicated in mental health outcomes. However, the longitudinal relationship between coping strategies and mental health in the autistic adult population has not yet been examined. This 2-year longitudinal study examined the predictive role of both baseline and change in coping strategy use over time (i.e., an increase or decrease) on anxiety, depression, and well-being after 2-years in 87 autistic adults aged 16 to 80 years. Controlling for baseline mental health, both baseline and increase in disengagement coping strategies (e.g., denial, self-blame) predicted higher anxiety and depression, and lower well-being, while an increase in engagement coping strategies (e.g., problem solving, acceptance) predicted higher well-being. These findings extend the current coping literature in autistic adults, offering insight into mental health support and intervention options.</p>","PeriodicalId":15148,"journal":{"name":"Journal of Autism and Developmental Disorders","volume":" ","pages":"1146-1155"},"PeriodicalIF":3.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9249050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing Diagnostic Follow-up and Care Coordination for Children with Autism in a Busy Resident Continuity Clinic: Leveraging the Electronic Health Record. 在繁忙的住院医师连续门诊中加强自闭症儿童的诊断随访和护理协调:利用电子健康记录。
IF 3.2 2区 心理学
Journal of Autism and Developmental Disorders Pub Date : 2025-03-01 Epub Date: 2024-01-30 DOI: 10.1007/s10803-024-06253-1
Laleh Bahrami, Cara T Miller, Holly Miller, Kathryn L Carlson, Tori E Foster, Abhinaya Ganesh, David Johnson, Barron L Patterson, Jeffrey F Hine
{"title":"Enhancing Diagnostic Follow-up and Care Coordination for Children with Autism in a Busy Resident Continuity Clinic: Leveraging the Electronic Health Record.","authors":"Laleh Bahrami, Cara T Miller, Holly Miller, Kathryn L Carlson, Tori E Foster, Abhinaya Ganesh, David Johnson, Barron L Patterson, Jeffrey F Hine","doi":"10.1007/s10803-024-06253-1","DOIUrl":"10.1007/s10803-024-06253-1","url":null,"abstract":"<p><strong>Purpose: </strong>A high-quality primary care clinic should provide clear action points and important care coordination for a child receiving a new diagnosis of autism spectrum disorder (ASD). Unfortunately, a substantial proportion of caregivers report little-to-no post-diagnosis support from their home clinics and primary care providers often report lack of training and resources in providing these supports.</p><p><strong>Methods: </strong>We implemented an intervention package to investigate the impact on the frequency and quality of follow-up care for children with ASD in a busy, high-volume resident continuity clinic. The package consisted of a care coordination scheduling pathway and a standardized clinical template-embedded in the electronic health record (EHR)-that guided providers through best-practice recommendations and patient resources.</p><p><strong>Results: </strong>As a result of these interventions, 74% of patients had ASD-specific follow-up, a more than threefold increase from baseline with a majority of providers using the EHR-embedded template to guide their visit. Providers also indicated a high degree of usability for the system and that it aided them in following best-practice guidelines for ASD care.</p><p><strong>Conclusion: </strong>Through explicit scheduling pathways and a novel EHR template, we saw a significant increase in ASD-specific follow-up visits and implementation of best practices for ASD care, demonstrating a new process for training and engaging primary care providers in clear action steps for post-diagnostic care without having to rely on tertiary referrals.</p>","PeriodicalId":15148,"journal":{"name":"Journal of Autism and Developmental Disorders","volume":" ","pages":"904-912"},"PeriodicalIF":3.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139575305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Motor Control Adherence to the Two-thirds Power Law Differs in Autistic Development. 自闭症患者的运动控制对三分之二幂律的遵循存在差异。
IF 3.2 2区 心理学
Journal of Autism and Developmental Disorders Pub Date : 2025-03-01 Epub Date: 2024-01-27 DOI: 10.1007/s10803-024-06240-6
Emily Fourie, Szu-Ching Lu, Jonathan Delafield-Butt, Susan M Rivera
{"title":"Motor Control Adherence to the Two-thirds Power Law Differs in Autistic Development.","authors":"Emily Fourie, Szu-Ching Lu, Jonathan Delafield-Butt, Susan M Rivera","doi":"10.1007/s10803-024-06240-6","DOIUrl":"10.1007/s10803-024-06240-6","url":null,"abstract":"<p><p>Autistic individuals often exhibit motor atypicalities, which may relate to difficulties in social communication. This study utilized a smart tablet activity to computationally characterize motor control by testing adherence to the two-thirds power law (2/3 PL), which captures a systematic covariation between velocity and curvature in motor execution and governs many forms of human movement. Children aged 4-8 years old participated in this study, including 24 autistic children and 33 typically developing children. Participants drew and traced ellipses on an iPad. We extracted data from finger movements on the screen, and computed adherence to the 2/3 PL and other kinematic metrics. Measures of cognitive and motor functioning were also collected. In comparison to the typically developing group, the autistic group demonstrated greater velocity modulation between curved and straight sections of movement, increased levels of acceleration and jerk, and greater intra- and inter-individual variability across several kinematic variables. Further, significant motor control development was observed in typically developing children, but not in those with autism. This study is the first to examine motor control adherence to the 2/3 PL in autistic children, revealing overall diminished motor control. Less smooth, more varied movement and an indication of developmental stasis in autistic children were observed. This study offers a novel tool for computational characterization of the autism motor signature in children's development, demonstrating how smart tablet technology enables accessible assessment of children's motor performance in an objective, quantifiable and scalable manner.</p>","PeriodicalId":15148,"journal":{"name":"Journal of Autism and Developmental Disorders","volume":" ","pages":"873-890"},"PeriodicalIF":3.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139570416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Similar Gap-Overlap Profiles in Children with Fragile X Syndrome and IQ-Matched Autism. 脆性 X 综合征患儿与智商匹配型自闭症患儿的间隙-重叠谱相似。
IF 3.2 2区 心理学
Journal of Autism and Developmental Disorders Pub Date : 2025-03-01 Epub Date: 2024-01-21 DOI: 10.1007/s10803-024-06245-1
Carla A Wall, Frederick Shic, Elizabeth A Will, Quan Wang, Jane E Roberts
{"title":"Similar Gap-Overlap Profiles in Children with Fragile X Syndrome and IQ-Matched Autism.","authors":"Carla A Wall, Frederick Shic, Elizabeth A Will, Quan Wang, Jane E Roberts","doi":"10.1007/s10803-024-06245-1","DOIUrl":"10.1007/s10803-024-06245-1","url":null,"abstract":"<p><strong>Purpose: </strong>Fragile X syndrome (FXS) is a single-gene disorder characterized by moderate to severe cognitive impairment and a high association with autism spectrum disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD). Atypical visual attention is a feature of FXS, ASD, and ADHD. Thus, studying early attentional patterns in young children with FXS can offer insight into early emerging neurocognitive processes underlying challenges and contribute to our understanding of common and unique features of ASD and ADHD in FXS.</p><p><strong>Methods: </strong>The present study examined visual attention indexed by the gap-overlap paradigm in children with FXS (n = 39) compared to children with ASD matched on intellectual ability and age (n = 40) and age-matched neurotypical controls (n = 34). The relationship between gap-overlap performance and intellectual ability, ASD, and ADHD across groups was characterized. Saccadic reaction times (RT) were collected across baseline, gap, and overlap conditions.</p><p><strong>Results: </strong>Results indicate no group differences in RT for any conditions. However, RT of the ASD and NT groups became slower throughout the experiment whereas RT of the FXS group did not change, suggesting difficulties in habituation for the FXS group. There was no relationship between RT and intellectual ability, ADHD, or ASD symptoms in the FXS and ASD groups. In the NT group, slower RT was related to elevated ADHD symptoms only.</p><p><strong>Conclusion: </strong>Taken together, findings suggest that the social attention differences documented in FXS and ASD may be due to other cognitive factors, such as reward or motivation, rather than oculomotor control of visual attention.</p>","PeriodicalId":15148,"journal":{"name":"Journal of Autism and Developmental Disorders","volume":" ","pages":"891-903"},"PeriodicalIF":3.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11260273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139512552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Double-Blind Randomised Controlled Trial of Prebiotic Supplementation in Children with Autism: Effects on Parental Quality of Life, Child Behaviour, Gastrointestinal Symptoms, and the Microbiome. 自闭症儿童补充益生元的双盲随机对照试验:对家长生活质量、儿童行为、胃肠道症状和微生物组的影响。
IF 3.2 2区 心理学
Journal of Autism and Developmental Disorders Pub Date : 2025-03-01 Epub Date: 2024-01-31 DOI: 10.1007/s10803-024-06239-z
Jacqueline K Palmer, Jolieke C van der Pols, Karen A Sullivan, Heidi M Staudacher, Rebecca Byrne
{"title":"A Double-Blind Randomised Controlled Trial of Prebiotic Supplementation in Children with Autism: Effects on Parental Quality of Life, Child Behaviour, Gastrointestinal Symptoms, and the Microbiome.","authors":"Jacqueline K Palmer, Jolieke C van der Pols, Karen A Sullivan, Heidi M Staudacher, Rebecca Byrne","doi":"10.1007/s10803-024-06239-z","DOIUrl":"10.1007/s10803-024-06239-z","url":null,"abstract":"<p><strong>Purpose: </strong>Modifying gut bacteria in children with autism may influence behaviour, with potential to improve family functioning. We conducted a randomised controlled trial to assess the effect of prebiotics on behaviour, gastrointestinal symptoms and downstream effects on parental quality of life.</p><p><strong>Method: </strong>Children with autism (4-10yrs) were randomised to 2.4 g/d of prebiotic (GOS) or placebo for six weeks. Pre and post stools samples were collected, and validated questionnaires used to measure change in social and mealtime behaviours, GI symptoms and pQOL. Linear mixed models evaluated group differences for behavioural variables, and Mann Whitney U tests were used to compare change between-groups for GI symptoms, differential abundance of genera and alpha diversity of the microbiome.</p><p><strong>Results: </strong>Thirty-three parent-child dyads completed the trial. No group difference was seen for behavioural variables but both groups improved significantly from baseline. There was a medium effect size between groups for GI symptoms (d = 0.47) and pQOL (d = 0.44) driven by greater improvements in the prebiotic group. Bifidobacterium increased threefold following prebiotics (1.4-5.9%, p < 0.001) with no change in controls. Supplements were well tolerated, compliance with dose 94%.</p><p><strong>Conclusion: </strong>Prebiotics modify levels of Bifidobacterium and prove well tolerated but in this instance, resulted in only marginal effects on GI symptoms and pQOL. A larger sample of children with more severe symptoms could help to determine the potential of prebiotics in autism.</p><p><strong>Trial registration: </strong>https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12619000615189 .</p>","PeriodicalId":15148,"journal":{"name":"Journal of Autism and Developmental Disorders","volume":" ","pages":"775-788"},"PeriodicalIF":3.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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