journal of applied pharmaceutical science最新文献_第6页

Bibliometric analysis of antibacterial activity of Centella asiatica: A study based on Scopus database 积雪草抗菌活性的文献计量学分析:基于Scopus数据库的研究

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI: 10.7324/japs.2023.139686

Asti Arum Sari, Rima Munawaroh, Eko Naning Sofyanita

引用次数: 0

Development of volumetric absorptive microsampling for analysis phenytoin levels and its application to monitoring therapy in epilepsy patients 容量吸收微进样法分析苯妥英含量及其在癫痫患者治疗监测中的应用

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI: 10.7324/japs.2023.125948

Rizka Mardhiani, Yahdiana Harahap, Winnugroho Wiratman, Fitri Octaviana, Irwandi Jaswir

引用次数: 0

The cytotoxicity and SAR analysis of biflavonoids isolated from Araucaria hunsteinii K. Schum. leaves against MCF-7 and HeLa cancer cells 黄芪双黄酮的细胞毒性及合成孔径孔径分析。抗MCF-7和HeLa癌细胞

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI: 10.7324/japs.2023.145302

Purwantiningsih Sugita, Dhea Demitri Agusta, Hanhan Dianha, Irma Herawati Suparto, Kurniawanti Kurniawanti, Dyah Utami Cahyaning Rahayu, Luthfan Irfana

引用次数: 0

Avicularin: The major secondary metabolite isolated from Saurauia vulcani as a potential anti-colorectal cancer agent Avicularin:从火神藤(sauauia vulcani)中分离出的主要次生代谢物，是一种潜在的抗结直肠癌药物

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI: 10.7324/japs.2023.80076

Gunawan Pasaribu, Sumi Hudiyono, Antonius Herry Cahyana, Gustan Pari, Andi Rifki Rosandi, Sofa Fajriah

引用次数: 0

Anticancer property of marine coral-derived Streptomyces sp. SS162 against A549 lung adenocarcinoma cancer cells 海洋珊瑚源链霉菌SS162对A549肺腺癌细胞的抗癌作用

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI: 10.7324/japs.2023.144118

Tran Hoang Ngau, Truong Thi Bich Ngoc, Le Thi Y. Nhi, Nguyen Hoang Chuong, Dang Thi Phuong Thao

引用次数: 0

Synthesis, Mycobacterium tuberculosis H37Rv inhibitory activity, and molecular docking study of pyrazinamide analogs 吡嗪酰胺类似物的合成、结核分枝杆菌H37Rv抑制活性及分子对接研究

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI: 10.7324/japs.2023.140149

Muhammad Zulqurnain, Nur Pasca Aijijiyah, First A. Wati, Arif Fadlan, Azminah Azminah, Mardi Santoso

引用次数: 0

A validated LC-MS/MS method for simultaneous quantification of antitubercular drugs in rat plasma and its application for a pharmacokinetic interaction study with Immusante® 经验证的LC-MS/MS同时定量大鼠血浆中抗结核药物及其与Immusante®药动学相互作用研究

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI: 10.7324/japs.2023.118956

Lakavalli Mohankumar Sharath Kumar, M. Azeemuddin, K. C. Routhu, K. Priya, U. Babu, S. Pai

{"title":"A validated LC-MS/MS method for simultaneous quantification of antitubercular drugs in rat plasma and its application for a pharmacokinetic interaction study with Immusante®","authors":"Lakavalli Mohankumar Sharath Kumar, M. Azeemuddin, K. C. Routhu, K. Priya, U. Babu, S. Pai","doi":"10.7324/japs.2023.118956","DOIUrl":"https://doi.org/10.7324/japs.2023.118956","url":null,"abstract":"Tuberculosis is caused by Mycobacterium tuberculosis , and it is a contagious disease. Primary empiric treatment for tuberculosis comprises a four-drug regimen: Isoniazid, Rifampicin, Pyrazinamide, and Ethambutol. The disease and its treatment may pose undernutrition due to the increased metabolic load and decreased food intake. Immunomodulators and micronutrients are consumed by patients, worldwide, to counteract nutritional insufficiencies. Immusante ® is a polyherbal formulation recommended as an immunomodulator in various immunocompromised states, including tuberculosis. This study aims to identify the pharmacokinetic interactions between the first-line antituberculosis (anti-TB) drugs, that is, AKT-4 tablets (a combination of isoniazid, rifampicin, pyrazinamide, and ethambutol), and Immusante ® . We developed a method of sensitive liquid chromatography with tandem mass spectrometry for the simultaneous quantification of isoniazid, rifampicin, pyrazinamide, and ethambutol in rat plasma and validated it as per the European Medicines Agency guidelines. The method was used to quantify all four drugs in rat plasma treated with a combination of AKT-4 and Immusante ® . No significant alterations in the values of various pharmacokinetic parameters such as V d , t 1/2 , CL, t max , C max , and AUC were observed, indicating that coadministration of Immusante ® does not influence the pharmacokinetic profiles of the anti-TB drugs. Thus, Immusante ® can be recommended as an adjuvant for its immunomodulatory activity in anti-TB drug therapy.","PeriodicalId":15126,"journal":{"name":"journal of applied pharmaceutical science","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90168028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Amino acid profiling in wild Chamaenerion angustifolium populations applying chemometric analysis 应用化学计量学分析野生鹅尾草群体的氨基酸谱

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI: 10.7324/japs.2023.108931

K. Uminska, Z. Gudžinskas, L. Ivanauskas, V. Georgiyants, Alla Kozurak, Maria Skibytska, O. Mykhailenko

{"title":"Amino acid profiling in wild Chamaenerion angustifolium populations applying chemometric analysis","authors":"K. Uminska, Z. Gudžinskas, L. Ivanauskas, V. Georgiyants, Alla Kozurak, Maria Skibytska, O. Mykhailenko","doi":"10.7324/japs.2023.108931","DOIUrl":"https://doi.org/10.7324/japs.2023.108931","url":null,"abstract":"Evaluation of the amino acid composition of plants is a determining parameter in assessing their potential effect as food supplements. Chamaenerion angustifolium (Onagraceae), commonly known as “fireweed,” is a traditional food and medicinal plant in Europe. Current research has focused on comparative analysis of the aerial part of 15 fireweed samples collected in Ukraine and Lithuania using Gas chromatography–mass spectrometry (GC-MS) method. The overall amino acid composition in samples of C. angustifolium was similar. Sulfur-containing amino acids (cysteine and methionine) were absent in all samples. The alanine content in the samples was the highest, and in the samples from Kharkiv (Ukraine), Ivano-Frankivsk (Ukraine), and Plungė district (Lithuania), it ranked first among others (its content in samples was 2.350, 6.090, and 2.44 mg/g, respectively). The high amount of free amino acids was recorded in the sample from Ivano-Frankivsk (Ukraine). The results of chemometric analysis indicated L-alanine and L-phenylalanine could be used as potential quality markers for the evaluation of the plant quality. The results indicate the potential for further pharmacological studies of fireweed raw material. Considering the content of amino acids in the aerial parts of C. angustifolium , its raw material could be used for development of medicines and dietary supplements.","PeriodicalId":15126,"journal":{"name":"journal of applied pharmaceutical science","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88435002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diosmin attenuates paracetamol-induced hepato- and nephrotoxicity via inhibition of CY2E1-mediated metabolism in rats 地奥司明通过抑制cy2e1介导的大鼠代谢，减轻对乙酰氨基酚诱导的肝和肾毒性

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI: 10.7324/japs.2023.125993

Ravindrababu Pingili, S. Vemulapalli, Uday Bhaskar Narra, Sree Varsha Potluri, N. Kilaru

{"title":"Diosmin attenuates paracetamol-induced hepato- and nephrotoxicity via inhibition of CY2E1-mediated metabolism in rats","authors":"Ravindrababu Pingili, S. Vemulapalli, Uday Bhaskar Narra, Sree Varsha Potluri, N. Kilaru","doi":"10.7324/japs.2023.125993","DOIUrl":"https://doi.org/10.7324/japs.2023.125993","url":null,"abstract":"Cytochrome P-450 2E1 (CYP2E1) is responsible for forming a toxic metabolite N -acetyl- p -benzoquinoneimine (NAPQI) of paracetamol. In this study, we investigated the effect of diosmin, a flavonoid on the CYP2E1-mediated metabolism of paracetamol and NAPQI formation in Wistar rats. For 28 days, animals were orally administered with paracetamol (300 mg/kg) with and without diosmin (25 and 50 mg/kg). The blood samples were collected on the 28th day and the plasma concentrations of paracetamol and NAPQI were determined using the reverse phase high-pressure liquid chromatography. Paracetamol combination with diosmin (25 and 50 mg/kg) showed a dose-dependent increase in the area under the plasma concentration-time curve (AUC 0–∞ )and the peak plasma concentration ( C max ) of paracetamol and a dose-dependent decrease of AUC 0–∞ and C max of NAPQI compared to paracetamol control ( p < 0.001). Simultaneously, serum biomarkers and histopathological studies were conducted to evaluate the effect of diosmin on the liver and kidneys. Interestingly, compared to the paracetamol control group, the combination with diosmin significantly reduced the elevated functional biomarkers of liver and kidney. In addition, diosmin ameliorated paracetamol-induced hepatotoxicity and nephrotoxicity. The current study results revealed that diosmin showed a significant hepato- and nephroprotective activity by decreasing the formation of NAPQ1 through the inhibition of CYP2E1- mediated metabolism of paracetamol","PeriodicalId":15126,"journal":{"name":"journal of applied pharmaceutical science","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84712778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bibliometric analysis and visualization of research on nanotechnology in dentistry from 1999 to 2022 1999 - 2022年牙科纳米技术研究的文献计量分析与可视化

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI: 10.7324/japs.2023.146431

Namrata Dagli, B. Patel, Rushabh J Dagli, Nihad Adnan, Rahnuma Ahmad, Mainul Haque, Santosh Kumar

引用次数: 0