journal of applied pharmaceutical science最新文献_第5页

Essential minerals and heavy elements assay in the scalp hair of Jordanian children with specific language impairment compared to their fluent control 约旦特殊语言障碍儿童头皮头发中必需矿物质和重元素的测定与流利对照

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI: 10.7324/japs.2023.100489

M. Bashtawi, O’la AL- Fawares, A. H. B. Rashaid, Mazin Alqhazo

引用次数: 0

3’-Hydroxypterostilbene and pinostilbene: Their chemistry, sources, anticancer and other pharmacological properties, pharmacokinetics, and patents 3′-羟基苯乙烯和蒎烯苯乙烯:它们的化学成分、来源、抗癌等药理特性、药代动力学和专利

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI: 10.7324/japs.2023.99205

E. Chan

{"title":"3’-Hydroxypterostilbene and pinostilbene: Their chemistry, sources, anticancer and other pharmacological properties, pharmacokinetics, and patents","authors":"E. Chan","doi":"10.7324/japs.2023.99205","DOIUrl":"https://doi.org/10.7324/japs.2023.99205","url":null,"abstract":"of 3’-hydroxypterostilbene (HPS) and pinostilbene (PS) are reviewed for the first time. Their chemical structures consist of a catechol moiety with two aromatic rings A and B. HPS has two hydroxyl groups and two methoxy groups, while PS has two hydroxyl groups and one methoxy group. Both methoxylated stilbenes are commercially available. The anticancer properties of HPS have been reported in leukemia, colon, and skin cancer cells, while those of PS have been reported in colon, tongue, and nasopharyngeal cancer cells. Other pharmacological properties of HPS include anti-inflammatory, antioxidant, hepatoprotective, anticolitis, antiadipogenesis, sirtuin 1 modulatory, and α-glucosidase inhibitory activities. Those of PS include anti-inflammatory, cytochrome P450 inhibitory, neuroprotective, antioxidant, antityrosinase, α-glucosidase inhibitory, antiplasmodial, lactase dehydrogenase activity release, antimelanogenesis, antiadipogenesis, suppression of hepatic stellate cell activation, and tight junction protection activities. Some fields for further research are suggested. Sources of information in this review were Google, Google Scholar, ScienceDirect, PubMed, J-Stage, and PubChem.","PeriodicalId":15126,"journal":{"name":"journal of applied pharmaceutical science","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81941767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The correlation of gene mutation of coagulopathy cascade with elevated D-dimer levels in COVID-19 patients COVID-19患者凝血功能级联基因突变与d -二聚体水平升高的相关性

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI: 10.7324/japs.2023.145308

M. Albalbaki, Ola Al-fawares, Walid Aburayyan, Nesrin Seder, O. Al-Sanabra, Lamya AL- Tahrawe, M. N. Shatnawi

{"title":"The correlation of gene mutation of coagulopathy cascade with elevated D-dimer levels in COVID-19 patients","authors":"M. Albalbaki, Ola Al-fawares, Walid Aburayyan, Nesrin Seder, O. Al-Sanabra, Lamya AL- Tahrawe, M. N. Shatnawi","doi":"10.7324/japs.2023.145308","DOIUrl":"https://doi.org/10.7324/japs.2023.145308","url":null,"abstract":"SARS-CoV-2 had a pertinent implication on people’s daily lives and medical procedures during the pandemic or even after it. COVID-19 infections varied in the clinical aspect from mortality to asymptomatic episodes. The symptoms included fever, cough, difficulty breathing, loss of mobility, and chest pain. On the other hand, the patients who passed away from COVID-19 showed multiple organ failure, respiratory dysfunction, and disseminated coagulations throughout the body. D-dimer is a biomarker implemented in blood clotting and is commonly elevated in patients with thrombotic complications. This review sheds light on the correlation between gene mutations in the coagulopathy cascade among COVID-19 patients with high D-dimer levels. The elevated D-dimer levels are significantly associated with mutations in genes involved in the coagulopathy cascade. The findings suggest that these mutations may play an important role in developing thrombotic problems in COVID-19 patients. As a result, understanding the genetic basis of thrombotic development in COVID-19 could lead to new ways of avoiding and treating thrombotic problems.","PeriodicalId":15126,"journal":{"name":"journal of applied pharmaceutical science","volume":"175 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76765014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secondary metabolite of Aspergillus oryzae impairs cell envelope integrity Klebsiella pneumoniae producing extended-spectrum beta-lactamase 米曲霉次生代谢物破坏细胞膜完整性肺炎克雷伯菌产生广谱β -内酰胺酶

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI: 10.7324/japs.2023.106333

Lailia Nur Rachma, L. Fitri, S. Prawiro, T. Raras

引用次数: 0

Antiproliferative, proapoptotic, and antimigration activities of marine sponges against human colon cancer cell line (HCT116) 海洋海绵对人结肠癌细胞株(HCT116)的抗增殖、促凋亡和抗迁移活性

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI: 10.7324/japs.2023.113246

A. Ang, S. Tabugo, M. Uy

{"title":"Antiproliferative, proapoptotic, and antimigration activities of marine sponges against human colon cancer cell line (HCT116)","authors":"A. Ang, S. Tabugo, M. Uy","doi":"10.7324/japs.2023.113246","DOIUrl":"https://doi.org/10.7324/japs.2023.113246","url":null,"abstract":"Marine sponges’ anticancer potential relies on various cellular and molecular pathways. Agelas sp. , Ircinia sp., and Petrosia weinbergi were collected off the coast of Iligan Bay, Misamis Oriental, Philippines. The antiproliferation, proapoptotic, and antimigration properties of their hexane (H), dichloromethane (DCM), and methanol: water (MW) extracts against Human colorectal carcinoma cell line (HCT116) carcinoma cells were investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), Caspase-Glo ® 3/7, and in vitro scratch wound assay, respectively. The extracts exhibited cytotoxicity against HCT116. The viability of the treated cells was significantly lower ( p < 0.05) than the negative control. Treatment of the HCT116 with MW and DCM extracts of P. weinbergi and DCM extract of Ircinia sp . resulted in a statistically higher ( p < 0.05) luminescence than the negative control. Relative to dimethyl sulfoxide, the extracts increased caspase-3/7 activity more than onefold. This suggests the proapoptotic activity through the activation of the caspase-3/7. Lastly, the MW extract of Ircinia sp . and the H extract of P. weinbergi significantly ( p < 0.05) inhibited the migration of HCT116 after wounding. Thus, Ircinia sp . and P. weinbergi were found to show potential antiproliferative, proapoptotic, and antimigration properties against HCT116. Further investigation of compounds and the mechanism of action involved in their anticancer property are thus recommended.","PeriodicalId":15126,"journal":{"name":"journal of applied pharmaceutical science","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75211089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antibacterial and cytotoxic secondary metabolites from endophytic fungi associated with Antidesma bunius leaves 与黄刺马叶相关的内生真菌的抗菌和细胞毒性次生代谢产物

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI: 10.7324/japs.2023.101347

N. P. Ariantari, I. P. Y. A. Putra, N. P. E. Leliqia, P. S. Yustiantara, M. Proborini, Nadzifa Nugraheni, Ummi Maryam Zulfin, R. Jenie, E. Meiyanto

{"title":"Antibacterial and cytotoxic secondary metabolites from endophytic fungi associated with Antidesma bunius leaves","authors":"N. P. Ariantari, I. P. Y. A. Putra, N. P. E. Leliqia, P. S. Yustiantara, M. Proborini, Nadzifa Nugraheni, Ummi Maryam Zulfin, R. Jenie, E. Meiyanto","doi":"10.7324/japs.2023.101347","DOIUrl":"https://doi.org/10.7324/japs.2023.101347","url":null,"abstract":"Endophytic fungi isolated from Antidesma bunius leaves were investigated in this study. Six fungal endophytes were identified as Penicillium steckii AAB-01, Nemania bipapillata AAB-02, Xylaria feejeensis AAB-03, Hypomontagnella monticulosa AAB-04, Daldinia eschscholtzii AAB-05, and Phyllosticta capitalensis AAB-06. All of the isolated endophytic fungi were subjected to fermentation on rice media, followed by extraction with ethyl acetate. When tested for antibacterial activity, P. steckii AAB-01 extract showed the most potent inhibition against Staphylococcus aureus ATCC 6538 and Staphylococcus epidermidis ATCC 12228. Toxicity screening employing brine shrimp lethality test (BSLT) revealed potential toxicity of P. steckii AAB-01 and X. feejeensis AAB-03 extracts. Further investigation showed P. steckii AAB-01 extract had the highest inhibition toward MCF-7 cells, while D. eschscholtzii AAB-05 extract revealed the strongest cytotoxicity against 4T1 cells. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis tentatively identified five compounds, where indole acetic acid, O -acetylharmol, and oxindole I were suggested as the major metabolites in P. steckii AAB-01 extract, while 6-hydroxymelatonin and 2-methyl-6-pentadecylpyridine were suggested as the major metabolites in D. eschscholtzii AAB-05 extract. This is the first report on LC-MS/MS identification of the main metabolites from bioactive extracts of P. steckii AAB-01 and D. eschscholtzii AAB-05 isolated from the leaves of A. bunius , which might contribute to the antibacterial and cytotoxic properties of the extracts. Thus, a detailed investigation of antibacterial and cytotoxic metabolites from these endophytes merits further studies.","PeriodicalId":15126,"journal":{"name":"journal of applied pharmaceutical science","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75429989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Microwave-assisted extraction of polyphenols from Eleutherine bulbosa Mill. Urb. bulbs using choline chloride-sorbitol based natural deep eutectic solvent 微波辅助提取红叶葱多酚的研究。市区。球茎采用氯化胆碱-山梨醇为基础的天然深共熔溶剂

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI: 10.7324/japs.2023.130962

Laode Rijai, S. Tang, Mukti Priastomo, S. Siska, Niken Indriyanti, N. Ambarwati, Islamudin Ahmad

{"title":"Microwave-assisted extraction of polyphenols from Eleutherine bulbosa Mill. Urb. bulbs using choline chloride-sorbitol based natural deep eutectic solvent","authors":"Laode Rijai, S. Tang, Mukti Priastomo, S. Siska, Niken Indriyanti, N. Ambarwati, Islamudin Ahmad","doi":"10.7324/japs.2023.130962","DOIUrl":"https://doi.org/10.7324/japs.2023.130962","url":null,"abstract":"Eleutherine bulbosa Mill. Urb. is a potential plant to be developed as a raw pharmaceutical active ingredient. This plant can be utilized as raw materials for herbal medicine production. A green solvent is one of the innovative approaches to developing and utilizing natural products as a source of raw materials. This study aims to design and optimize the microwave-assisted extraction (MAE) of polyphenols from E. bulbosa bulbs using choline chloride- sorbitol-based natural deep eutectic solvent (NADES). The MAE method with choline chloride and sorbitol as the deep eutectic solvent composition was used to extract polyphenols content from E. bulbosa . Experimental design with some independent variables was involved, including NADES (choline chloride-sorbitol) ratio, liquid-solid ratio, microwave power, and extraction time. Response surface methodology with the Box-Behnken Design (using Design-Expert v12 program) was used to optimize the extraction condition based on the total polyphenols content (TPC) as a dependent variable. TPC value was determined using the Folin–Ciocalteu reagent and measured using a UV–Vis spectrophotometer at 761 nm. According to the study results, the optimum MAE condition was obtained at 1:1 g/g NADES (choline chloride-sorbitol) ratio, 5 minutes extraction time, 20%W microwave power, and 12:1 ml/g liquid-solid ratio. A 50 g sample was extracted under the ideal MAE conditions for the scale-up confirmation test, yielding a TPC value of 39.88 mgGAE/g sample. The MAE of polyphenols with choline chloride-sorbitol-based NADES produced a higher TPC as a target secondary metabolite and was conducted efficiently, rapidly, and in an environment-friendly way.","PeriodicalId":15126,"journal":{"name":"journal of applied pharmaceutical science","volume":"196 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72744565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Retraction of ‘Enhancing the yield of antitubercular compounds from fenugreek [Trigonella foenum-graecum (Methi)] seeds using response surface methodology' “利用响应面法提高葫芦巴[葫芦巴]种子中抗结核化合物的产量”的撤回

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI: 10.7324/japs.2023.135.retraction

引用次数: 0

Optimal liquid culture conditions and bioactivity of Pycnoporus sanguineus 血螺最佳液体培养条件及生物活性研究

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI: 10.7324/japs.2023.51227

Janice S. Aguilar, R. M. Dulay, S. Kalaw, R. Reyes

{"title":"Optimal liquid culture conditions and bioactivity of Pycnoporus sanguineus","authors":"Janice S. Aguilar, R. M. Dulay, S. Kalaw, R. Reyes","doi":"10.7324/japs.2023.51227","DOIUrl":"https://doi.org/10.7324/japs.2023.51227","url":null,"abstract":"Pycnoporus sanguineus is a species of mushroom in the Philippines with promising nutritional and pharmacological potentials. In this study, the optimum nutritional and physical growth preferences of P. sanguineus in submerged conditions were established and the biological activities of ethanol extract of its mycelia were determined. The highest yield (100.13 mg/30ml) was produced in rice bran broth with a wide range of pH concentration. Biomass production was favored under 28°C, in lighted and agitated conditions with 147.20 mg/30 ml, 168.47 mg/30 ml, and 413.30 mg/30 ml, respectively. The extract inhibited the growth of Staphylococcus aureus while no antibacterial activity was observed in Escherichia coli . It was found toxic to brine shrimp with an LC 50 value of 190.55 µg/ml. Exposure of zebrafish embryos to the extract caused delayed growth resulting in a lower hatching rate. Growth retardation was the most noticeable teratogenic effect of the extract after 48 hours and high mortality rates were observed in high extract concentrations. This study suggests that the optimum biomass yield of P. sanguineus can be achieved when incubated under the most favorable conditions . Mycelia of P. sanguineus could be a valuable resource of antibacterial and cytotoxic compounds.","PeriodicalId":15126,"journal":{"name":"journal of applied pharmaceutical science","volume":"144 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77519198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcome and attributable cost associated with bacterial resistant infections in a tertiary care hospital 三级医院中与细菌耐药感染相关的结果和可归因成本

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI: 10.7324/japs.2023.93322

Prashant Chandra, Stanly Elstin Anburaj, Kunikatta Vijayanarayana, Kalwaje Eshwara Vandana, Chiranjay Mukhopadhyay, Udupi Dinesh Acharya, Mallayasamy , Surulivelrajan, Vilakkathala Rajesh

引用次数: 1