journal of applied pharmaceutical science最新文献

{"title":"Updates on the roles of epigenetics in the mechanism, diagnosis, and treatment of triple-negative breast cancer: A review","authors":"Eko Fuji Ariyanto, Abdan Syakura Danil, Rima Destya Triatin, Salsabila Ariefani","doi":"10.7324/japs.2023.93439","DOIUrl":"https://doi.org/10.7324/japs.2023.93439","url":null,"abstract":"HER-2 targeted immunonanoparticles for breast cancer chemotherapyRitu Dhankar, Parmender Rathee, Arvind K Jain, Sahil Arora, Murugesan Senthil Kumar, Goutam Rath, Ajit Kumar Saxena, P.R. Sharma, Gousia Chashoo, Amit K. Goyal","PeriodicalId":15126,"journal":{"name":"journal of applied pharmaceutical science","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135959814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer and immunostimulatory activities of Houttuynia cordata Thunb. Extract and the isolated flavonoids: An in vitro/in vivo investigation","authors":"Tran Viet Hung, Phan Nguyen Truong Thang, Nguyen Thi Thu Phuong, Duy Toan Pham, Ha Minh Hien, Duyen Thi My Huynh","doi":"10.7324/japs.2023.147199","DOIUrl":"https://doi.org/10.7324/japs.2023.147199","url":null,"abstract":"Assessment of cytotoxicity, antibacterial activity and phytochemical screening of ethanol extract of Phyllanthus acidus L. (family: Euphorbiacceae) BarkSubrata Kumar Biswas, Anusua Chowdhury, Joysree Das, Utpal Kumar Karmakar, Manik Chandra Shill, Sheikh Zahir Raihan","PeriodicalId":15126,"journal":{"name":"journal of applied pharmaceutical science","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134888553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on ethnobotany, phytochemistry, and pharmacology of Microdesmis keayana and Microdesmis puberula (Pandaceae)","authors":"Uchenna Benjamin Okeke, Onome Mary Adeboye, Funmilayo Racheal Adeniyi, E. Agbebi","doi":"10.7324/japs.2023.97651","DOIUrl":"https://doi.org/10.7324/japs.2023.97651","url":null,"abstract":"Microdesmis keayana and Microdesmis puberula (Pandaceae) are two major plant species in the genus Microdesmis . They are dioecious shrubs, very similar in their morphology, botanical distribution, and medicinal uses, and native to most tropical and subtropical African regions. Traditionally, they are commonly used to treat erectile dysfunction, general body pain, snake bites, skin and intestinal infections, tumors, diarrhea, diabetes, obesity, headache, and migraine. This review is aimed to provide a compendium of ethnopharmacological and phytochemical information on the Microdesmis plants for future research and drug development initiatives. Relevant books and electronic databases were sourced during the literature review. Several phytochemical investigations resulted in the isolation and identification of about eight compounds from M. keayana and M. puberula , including four spermines and five spermidine alkaloids, and a quinoline, which were all isolated from the methanol and hydromethanolic root extracts of the two plants. In vivo and in vitro pharmacological studies of the plants showed aphrodisiac, antimalarial, antimicrobial, antioxidant, analgesic, antistress, and antisickling activities, which gave credence to their use in ethnomedicine. The plants can potentially be used for several disease conditions, including erectile dysfunction, malaria, infections, and pains, with a view to isolating bioactive lead compounds for drug development.","PeriodicalId":15126,"journal":{"name":"journal of applied pharmaceutical science","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84882196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical diversity and therapeutic potentialities of seaweeds and marine sponges collected from the Red Sea: An update","authors":"Sally El Said Abo Halawa Abdelrahman, Engy Mohsen, M. Ghareeb, Ahmed A. Hamed, S. E. Hawary","doi":"10.7324/japs.2023.128836","DOIUrl":"https://doi.org/10.7324/japs.2023.128836","url":null,"abstract":"The marine environment is a vast and diverse ecosystem that is a valuable source of biologically active ingredients for the drug industry. For decades, natural products from marine organisms have been a major supplier of curative agents. Over 30,000 metabolites have been recorded from different marine organisms and associated microorganisms. Marine-derived compounds have diverse chemical structures, biological and pharmacological applications, making them a promising platform for drug discovery from natural sources. This review highlights a comprehensive survey of the phytochemical and biological aspects of selected seaweed and marine sponges found in the Red Sea. These organisms, such as seagrass ( Thalassia hemprichii ) and marine sponges ( Siphonochalina siphonella , Latrunculia magnifica , and Crella (Grayella) cyathophora ), have been found to contain numerous chemical ingredients with therapeutic properties. Phenolic compounds in T. hemprichii have antioxidant and anticancer properties while marine sponges contain structurally diverse amides, alkaloids, terpenes, and steroids with cytotoxic, antiviral, and antimicrobial activities. The habitats of these organisms affect both the chemical components and their biological properties. These findings are encouraging and may be used in the development of new pharmaceuticals.","PeriodicalId":15126,"journal":{"name":"journal of applied pharmaceutical science","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90571495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated bioinformatic analysis for the identification of potential biomarkers of kidney damage in hyperoxaluria","authors":"U. Adiga, Shreyas Adiga, T.M. Desy, N. Honnalli, Tirthal Rai","doi":"10.7324/japs.2023.137646","DOIUrl":"https://doi.org/10.7324/japs.2023.137646","url":null,"abstract":"Hyperoxaluria is described by an augmented urinary elimination of oxalate. Systemic oxalosis is the term for the condition that occurs when the burden of calcium oxalate (CaOx) surpasses the renal capacity to excrete it. When individuals acquire chronic renal disease, elevated urinary oxalate levels aid in diagnosis, whereas plasma oxalate levels are probably more reliable. Based on bioinformatic analysis, the study aimed to identify differentially expressed genes (DEGs) and miRNA as potential biomarkers to differentiate normal versus hyperoxaluric state compared to the stage of CaOx crystals in the kidney. Published microarray data for gene expression patterns of normal controls, hyperoxaluric kidney tissue, and kidney tissue at the stage of crystal formation were collected from the National Center for Biotechnology Information Gene Expression Omnibus database. Integrated bioinformatics methods were utilized to analyze and compare these gene expression patterns. The data processing was conducted using R software. Gene ontology and the Kyoto Encyclopedia of Genes and Genomes database were employed to explore the enrichment of pathways and functions in the DEGs. Additionally, the STRING database was utilized to investigate protein–protein interactions. Tarbase, Mirnda, and DIANA software were used to obtain miRNAs for the top 10 DEGs. A total of 62,966 genes were screened, 2,814 were differentially expressed, out of which 603 genes were statistically significantly differentially expressed, after analyzing the GSE89028 dataset. A total of 2,810 genes were downregulated and only 4 genes were upregulated on day 14. The genes Cdt1 and cdhr4 were highly significantly differentiated with log2 (fold change) being −3.085 and −3.966, respectively, −log 10 ( p -value) being 6.857 and 6.196, respectively, at 14 days. On day 28, 62,976 genes were screened, out of which 356 were significantly differentiated. Only four genes were upregulated and 240 genes were downregulated. Csmd1, Olr154, Cntfr, Zbtb16 log2 (fold change) being 1.188, 1.527, 1.782, and 2.636, respectively; −log 10 ( p -value) being 4.071, 3.804, 4.357, and 4.061, respectively. The text mining evidence was observed on string analysis in both the contexts. The strength of alternative splicing (cellular enrichment) was 1.16 with a false discovery rate of 0.0409. The study showcases the effectiveness of bioinformatics analytical methods in pinpointing potential pathogenic genes associated with hyperoxaluria and the deposition of crystals in the kidneys. The interaction network identified two miRNAs, hsa-miR-6884-5p and hsa-miR-4653-5p, and two genes CDHR4 and EGR2 as significant players.","PeriodicalId":15126,"journal":{"name":"journal of applied pharmaceutical science","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90883970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMBILOSE: A novel lactose-based co-processed excipient for direct compression","authors":"S. Somnache, Karkala Pai Vasantakumar, A. M. Godbole, P. Gajare, A. Pednekar","doi":"10.7324/japs.2023.37613","DOIUrl":"https://doi.org/10.7324/japs.2023.37613","url":null,"abstract":"Lactose is the commonly used diluent in the manufacturing of tablets dosage form. However, the poor flowability and compressibility of lactose limit its use as direct compressible filler binder. In this research work, composite excipient COMBILOSE was developed as directly compressible filler binder by coprocessing technique. Lactose monohydrate was co-processed with maltose monohydrate and maize starch by co-freezing and co-drying technique. Physical blends of lactose monohydrate and maize starch were prepared in ratio of 20:1. Prepared physical blends were dispersed in 5% w/v, 10% w/v, and 15% w/v aqueous solutions of maltose monohydrate. Dispersions were subjected to co-freezing followed by co-drying. Microfine granules of COMBILOSE were obtained by comminution and sifting of the dried composites. The developed composite excipients were evaluated for various excipient functionalities. The results of studies showed that coprocessing of lactose monohydrate with maize starch and maltose monohydrate can improve flowability and tabletability. COMBILOSE containing 10% w/v of maltose monohydrate showed better dilution potential and reduced lubricant sensitivity. Improvement in compressibility was observed, which could be due to pre-gelatinization of maize starch during development process. In conclusion, a blend of lactose monohydrate and maize starch in a ratio of 20:1 when processed with 10% of maltose monohydrate could provide good compressibility and better dilution potential with a reduced lubricant sensitivity.","PeriodicalId":15126,"journal":{"name":"journal of applied pharmaceutical science","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83136461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal outcomes associated with antimicrobial resistance: A retrospective cross-sectional study","authors":"P. Chandra, F. Iqbal, M. K. Unnikrisnan, P. Jayashree, P. Shenoy, Stanly Elstin Anburaj, Vilakkathala Rajesh, M. Surulivelrajan, L. Lewis","doi":"10.7324/japs.2023.120166","DOIUrl":"https://doi.org/10.7324/japs.2023.120166","url":null,"abstract":"Neonatal sepsis (NS) is a leading cause of morbidity and mortality requiring immediate admission and prolonged neonatal intensive care unit (NICU) stay. This study attempts to identify factors associated with NS and its outcomes. A total of 186 NS cases records (January 2017 to September 2019) were analyzed retrospectively. Multiple logistic regression and linear regression were employed to determine the factors associated with mortality, length of NICU stay, and treatment cost with a significance level of p ≤ 0.05. The mean neonatal age was 6.8 ± 9.5 days. Culture reports identified Klebsiella pneumonia (69%) as the major pathogen. Forty-four percent of neonates died, of whom 57% and 44% suffered early-onset sepsis and late-onset sepsis respectively. Logistic regression showed that mortality was significantly associated with platelet count (OR = 0.998; 95% CI =0.996–1.000) and very low birth weight (LBW) (OR = 2.427; 95% CI = 1.103–5.342). Linear regression showed that the number of definitive antibiotics used was associated with prolonged length of NICU stay. Also, length of NICU stay, number of definitive antibiotics, seizures, and heart disease, were significantly associated with overall cost. Mortality was higher with early-onset of sepsis than with late-onset of sepsis. The study could help policymakers and clinical practitioners to develop and implement targeted interventions that potentially reduce the global prevalence of NS.","PeriodicalId":15126,"journal":{"name":"journal of applied pharmaceutical science","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81687935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear receptors and other molecular targets in type 2 diabetes mellitus","authors":"D. Sugumar, Emdormi Rymbai, Soumya Vasu, Divakar Selvaraj","doi":"10.7324/japs.2023.132467","DOIUrl":"https://doi.org/10.7324/japs.2023.132467","url":null,"abstract":"Diabetes is a group of metabolic disorders characterized by chronic hyperglycemia and glucose intolerance. Diabetes occurs because of defects in insulin secretion, insulin action, or both. Type 2 diabetes mellitus (T2DM), with a prevalence of more than 95%, is the most prevalent form of diabetes. Over the years, the effectiveness of the drugs used to treat diabetes has reduced. For this reason, targeting newer molecular targets might lead to the effectiveness of drugs. Over the years, there has been a great interest in targeting nuclear receptors for the treatment of T2DM. Some of these targets have been applied at the clinical level. However, other molecular targets belonging to G-coupled protein receptors, enzymes, and kinases have also been explored. Hence, in this review, we will discuss a few potential targets that have been applied clinically or could be the target for the treatment of T2DM.","PeriodicalId":15126,"journal":{"name":"journal of applied pharmaceutical science","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89578515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing high-performance liquid chromatography for piperine determination in traditional Thai formulas","authors":"Yaowared Chulikhit, Juthamart Maneenet, O. Monthakantirat, Charinya Khamphukdee, Yutthana Chotritthirong, Suphatson Limsakul, Chantana Boonyarat, S. Daodee","doi":"10.7324/japs.2023.137317","DOIUrl":"https://doi.org/10.7324/japs.2023.137317","url":null,"abstract":"Piperine, the major bioactive compound, was found in Piper nigrum . This present investigation aimed to find the factors that can affect high-performance liquid chromatography (HPLC) conditions for the evaluation of piperine content from Thai herbal medicines. Box–Behnken design for the response surface methodology was selected to assess the interaction between three factors (% acetonitrile in the mobile phase, flow rate, and detection wavelength) and five outputs (retention time, peak area, theoretical plate, tailing factor, and capacity factor). The optimal HPLC system was found to be a mobile phase containing 35% acetonitrile with a flow rate of 1.2 ml/minute at wavelength 254 nm. The evolved HPLC condition was subjected to system suitability and robustness testing. The results indicated a slight change to the acetonitrile ratio affected the retention time, peak area, tailing factor, and capacity factor. This HPLC method was reliable and was applied to determine the piperine constituent in seven Thai herbal recipes, ranging from 0.256 ± 0.064 to 22.284 ± 0.802 mg/g extract. Overall, the experimental design was very helpful in studying the factors that affect the HPLC conditions and robustness of this method, which was discovered to be uncomplicated to carry out and acceptable for the exploration of piperine in Thai herbal medicines.","PeriodicalId":15126,"journal":{"name":"journal of applied pharmaceutical science","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80846695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemistry and pharmacology of Curculigo orchioides Gaertn: A review","authors":"Pallishree Bhukta, Santosh Kumar Ranajit, P. Sahu, Deepankar Rath","doi":"10.7324/japs.2023.135164","DOIUrl":"https://doi.org/10.7324/japs.2023.135164","url":null,"abstract":"Curculigo orchioides Gaertn. is a rare rasayana herb (family Amaryllidaceae) popularly known as “Kali Musli”. Traditionally used in Ayurvedic medicine as an aphrodisiac and adaptogen, the plant is native to India. There is evidence that the plant contains mucilage, phenolic glycosides, saponins, and aliphatic compounds. This folk medicine can treat a wide range of ailments, including impotency, aphrodisiacs, tonics, jaundice, and skin conditions. There are also many scientists who have investigated its antioxidant, anticancer, and hepatoprotective properties. Curculigo was isolated for its chlorophenolic glucosides, curculigine, phenolic glycosides, orcinosides, and polysaccharides. As an herbal medicine, Curculigo ’ s quality can be controlled through new analyzing methods. Furthermore, Curculigo has been investigated for its pharmacological activity against diabetes, bacteria, inflammation, osteoporosis, oxidative stress, cancer, and neurodegeneration. Scientific methods were gradually developed for the application of herbal medicine. A more comprehensive pharmacological study of the genus Curculigo is needed to determine its medicinal value. An updated and comprehensive review of the medicinal plant C. orchioides Gaertn is presented here describing traditional uses, phytochemistry, pharmacology, and toxicology, and understanding its future research and development prospects.","PeriodicalId":15126,"journal":{"name":"journal of applied pharmaceutical science","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91243043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}