Journal of Babol University of Medical Sciences最新文献

{"title":"Effect of Pioglitazone on Antioxidant Capacity and Oxidative Damage after Spinal Cord Injury in Rat","authors":"Z. Jahanbakhsh, H. Ghoshooni, M. Mohammadi, M. Salehi","doi":"10.18869/ACADPUB.JBUMS.20.5.16","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.5.16","url":null,"abstract":"J Babol Univ Med Sci; 20(5); May 2018; PP: 16-22 Received: Oct 17 2017, Revised: Feb 27 2018, Accepted: Apr 17 2018. ABSTRACT BACKGROUND AND OBJECTIVE: Reduction of the antioxidant capacity and oxidative damage has a crucial role in development of damage after spinal cord injury. Since pioglitazone (PPAR-gamma agonist) have a powerful antioxidant property, the present study aimed to evaluate the effect of pioglitazone on antioxidant capacity and oxidative damage in the injured areas of spinal cord in rat. METHODS: In the present experimental study eighteen male Wistar rats divided into three groups as follow (n=6); sham, control injured and pioglitazone-treated injured group. Spinal cord injury was performed according to the PingWeight Drop (contusion) model in rat. The animals received pioglitazone (3 mg/kg) intraperitoneally at times of 15 min after injury and then each 12 hours until a week. At the end, malondialdehyde level, activity of catalase and superoxide dismutase (SOD) enzymes and also histopathological alterations of spinal cord were assessed. FINDINGS: Induction of spinal cord injury in control injured animals significantly increased the malondialdehyde levels (56%) and decreased the activity of catalase (48%) and SOD (65%) enzymes compared to sham group (P=0.004, P=0.001 and P=0.008, respectively). Pioglitazone in treated injured group significantly decreased the malondialdehyde levels (38%) and increased the activity of catalase (34%) enzyme compared to control injured group (P=0.038 and P=0.014, respectively). Also, pioglitazone prevented the histopathological changes of injured areas in spinal cord. CONCLUSION: The findings of present study indicate that treatment with pioglitazone through potentiation of the antioxidant defense capacity of injured spinal cord decreases oxidative damage and also histopathological changes of spinal cord. KEY WORD: Spinal cord injury, Pioglitazone, Oxidative damage, Malondialdehyde, Antioxidant capacity.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"36 1","pages":"16-22"},"PeriodicalIF":0.0,"publicationDate":"2018-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81088158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of AFT and Cox models in analysis of factors influencing the survival of women with breast cancer in Yazd city","authors":"H. Fallahzadeh, M. Mohammadzadeh, Nima Pahlevani, S. Taghipour, Pahlevani","doi":"10.18869/ACADPUB.JBUMS.20.5.74","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.5.74","url":null,"abstract":"BACKGROUND AND OBJECTIVE: Breast cancer is one of the most common cancers in women. The statistical methods in the survival analysis of these patients are accelerated time models and Cox model. The purpose of this study is to evaluate two models in determining the effective factors in the survival of breast cancer. METHODS: The study was an analytical and cohort study of survival analysis. The 538 of the patients referred to Ramezanzade Radiotherapy Center who had breast cancer and recorded survival status as a census from the April 2005 until March 2012 in Yazd. and survived by phone call. The Kaplan-Meier estimate was used to describe the survival of the patients. The research variables included clinical and demographic factors. The choice of final variables in the model was done by the methods of diminishing the dimension and all possible Cox regressions by the acaian criterion. Then, the best accelerated time model was considered Getting different distributions was also determined by the Akayake criteria. FINDINGS: The most effective Cox model among all Cox models was variables including Age, Her2 and Ki67 variables (AIC=30270). The generalized gamma model was the most optimal accelerated time model (AIC 463.966). Her2 was significant in both accelerated and cox models (p 0.05). CONCLUSION: In both accelerated time-Generalized Gamma-models and Cox Models, the Her2 variable was identified as a risk factor for breast cancer and There is a positive impact on the risk of death and reduced survival. © 2018, Babol University of Medical Sciences. All rights reserved.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"41 1","pages":"74-80"},"PeriodicalIF":0.0,"publicationDate":"2018-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87286500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship between Perceived Stress and Attitude towards Delivery and Choosing Mode of Delivery among Pregnant Women","authors":"A. Sinaei, Z. Abbaspoor, S. Hashemi, N. Javadifar","doi":"10.18869/ACADPUB.JBUMS.20.5.61","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.5.61","url":null,"abstract":"1.Faculty of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, I.R.Iran. 2.Research Center of Reproductive Health Promotion, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, I.R.Iran. 3.Faculty of Psychology, Ahvaz Shahid Chamran University, Ahvaz, I.R.Iran. 4.Department of Midwifery and Reproductive Health, Faculty of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, I.R.Iran.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"81 1","pages":"61-67"},"PeriodicalIF":0.0,"publicationDate":"2018-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84082758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type and Rate of Prophylactic Antibiotic Use in the Orthopedic Patients Underwent Elective Surgeries in Shahid Beheshti Hospital in Babol","authors":"A. Shabanian, M. H. K. Nasab, M. Azar, S. Ganji","doi":"10.18869/ACADPUB.JBUMS.20.5.68","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.5.68","url":null,"abstract":"BACKGROUND AND OBJECTIVE: Postoperative infection has been one of the most frequent problems in orthopedics that the prescription of antibiotics to prevent surgical infection is an effective strategy to reduce infections after surgery.The aim of this study was investigating type and amount of prophylactic antibiotics used in the orthopedic cases administered in Shahid Beheshti Hospital in Babol, northern Iran. METHODS: This cross-sectional study was conducted on 450 traumatic and non-traumatic patients underwent elective orthopedic surgeries and received antibiotic prophylaxis during 2015-2016. The necessary data were collected from the patients' records using a predesigned checklist. This checklist consisted of demographic information, type and mechanism of trauma and information related to prophylaxis (name of antibiotic, dosage, administration method, time to start prophylaxis, administration intervals and overall prophylaxis duration). FINDINGS: Out of 450 patients, 300 (66.7%) were male and others were female. The mean age was 42.37±21.53. The most commonly used antibiotic was cefazolin (n=437, 97.3%) and gentamycin (n=276, 62%), and the lowest was amikacin (n=8, 1.8%). Mean duration of use was 4.92±1.8 days, ranging from 1 to 15 days. CONCLUSION: The results showed that the use of prophylactic antibiotics is high and they should be administered with more precise control. The most commonly used antibiotic for prophylaxis was cefazolin and the least was amikacin.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"41 8","pages":"68-73"},"PeriodicalIF":0.0,"publicationDate":"2018-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72440378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship between Chronic Diseases and Disability in Daily Activities and Instrumental Activities of Daily Living in the Elderly","authors":"Hosseini, A. Zabihi, Jafarian Amiri, Ali Bijani","doi":"10.18869/ACADPUB.JBUMS.20.5.23","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.5.23","url":null,"abstract":"J Babol Univ Med Sci; 20(5); May 2018; PP: 23-9 Received: Nov 9 2017, Revised: Mar 17 2018, Accepted: Apr 16 2018. ABSTRACT BACKGROUND AND OBJECTIVE: Chronic disease is one of the major causes of disability in doing daily activities. The aim of this study is to determine the relationship between chronic disease and disability in daily activities and instrumental activities of daily living in the elderly. METHODS: This cross-sectional study was conducted among the elderly of Amirkola. Demographic characteristics (age, gender, level of education and occupation), daily activities and instrumental activities of daily living were collected using a questionnaire. The ability to perform daily activities and instrumental activities was categorized as independently, with the help of others and completely dependent, and ultimately, completely dependent people and those using the help of others were placed in the disability group. The presence of chronic diseases in the elderly was characterized and examined by reviewing the medical records. FINDINGS: Of 1,500 elderly who were eligible to enter the study, 832 people (55.5%) were male and 668 people (44.5%) were female. In this study, 38 people (2.5%) had a disability in daily activities and 723 (48.2%) had disability in instrumental activities of daily living. The number of associated diseases (p<0.003, CI-95%=1.08–1.46, OR=1.261), cognitive impairment (p<0.009, CI-95%=1.308–6.508, OR=2.917) and old age had a significant relationship with daily activity. The highest significant relationship was between the instrumental activities of daily living and gender (p<0.000, CI-95%=1.53–2.69, OR=2.029), age (p=0.000), education level (p=0.000), the number of associated diseases (p=0.000, CI-95%=1.13–1.28, OR=1.2) and cognitive impairment (p=0.000, CI-95%=1.487–2.596, OR=1.965). CONCLUSION: According to the results of this study, the presence of chronic diseases, especially cognitive impairment, is one of the effective factors in disability in daily activities and instrumental activities of daily living.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"1 1","pages":"23-29"},"PeriodicalIF":0.0,"publicationDate":"2018-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72969976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of Lentiviral Vector of Apoptin and Investigating its Cytotoxic Effect on Reh Acute Lymphoblastic Leukemia Cells","authors":"A. A. Najmedini, R. Vahabpour, F. Jalali, D. Bashash","doi":"10.18869/ACADPUB.JBUMS.20.5.48","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.5.48","url":null,"abstract":"J Babol Univ Med Sci; 20(5); May 2018; PP: 48-53 Received: Apr 1","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"24 1","pages":"48-53"},"PeriodicalIF":0.0,"publicationDate":"2018-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84734939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Expression of EGFR And FGFR4 Genes in Patients with Lung Cancer","authors":"M. Chitsaz, Ardeshir Hesampour","doi":"10.18869/ACADPUB.JBUMS.20.4.17","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.4.17","url":null,"abstract":"J Babol Univ Med Sci; 20(4); Apr 2018; PP: 17-23 Received: Nov 26 2017, Revised: Feb 24 2018, Accepted: Apr 17 2018. ABSTRACT BACKGROUND AND OBJECTIVE: Lung cancer is a disorder that is caused by genetic and epigenetic changes and activates oncogenes and inactivates tumor suppressor genes. The aim of this study is to quantitative evaluation of EGFR and FGFR4 genes expression level in blood samples of lung cancer in compare with normal people to investigate the role of these two genes as biomarkers during lung cancer diagnosis and screening. METHODS: This case-control study was performed on 50 blood samples of lung cancer patients compared with 50 normal controls.. Total RNA from Blood samples were extracted and cDNA is synthesized. The specific primers for detection of markers are designed and expression level of BRIP1, PALB2 in presence of gene GAPDH by using Real Time PCR method was quantitatively studied. FINDINGS: Significant increase was observed in the expression of target biomarkers in cancer patients compared to control population. Results showed quantitative increase of FGFR4 and EGFR genes with 4.46 and 3.03 fold respectively for lung cancer in compare with normal samples (p=0.003). Also, there was a significant relationship between grade of the disease and biomarkers expression level, so that with increasing the stage and degree of severity of cancer, the expression of biomarkers increased (p=0.003). CONSLUSION: Based on this study results we could predict the expression level of (EGFR, FGFR4) gens in suffered patients quantitatively which could use as biomarker indicator during screening of lung cancer samples.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"20 1","pages":"17-23"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87555571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Effects of LED and QTH Light Cure Devices on Composite Hardness","authors":"A. Shirazi, S. Majidinia, Z. Hosseinyar","doi":"10.18869/ACADPUB.JBUMS.20.4.42","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.4.42","url":null,"abstract":"1.Department of Pediatric Dentistry, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, I.R.Iran. 2.Dental Research Center, Mashhad University of Medical Sciences, Mashhad, I.R.Iran. 3.Department of Restorative Dentistry, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, I.R.Iran. 4.Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, I.R.Iran","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"4 1","pages":"42-47"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74348312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"کیس پپتین: تنظیم کننده کلیدی محور هیپوتالاموس-هیپوفیز-غدد جنسی","authors":"رحمت اله پرندین, مرتضی بهنام رسولی","doi":"10.18869/ACADPUB.JBUMS.20.4.59","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.4.59","url":null,"abstract":"","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"53 1","pages":"59-67"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84702472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship between Gestational Diabetes and Polycystic Ovary Syndrome","authors":"R. Nikbakht, F. Moramezi, K. Shojaie, M. Motlagh","doi":"10.18869/acadpub.jbums.20.4.7","DOIUrl":"https://doi.org/10.18869/acadpub.jbums.20.4.7","url":null,"abstract":"J Babol Univ Med Sci; 20(4); Apr 2018; PP: 7-11 Received: Aug 9 2017, Revised: Dec 2 2017, Accepted: Dec 25 2018. ABSTRACT BACKGROUND AND OBJECTIVE: Women with polycystic ovary syndrome (PCOS) are at risk of insulin resistance and pregnancy complications. The aim of this study is to determine the relationship between gestational diabetes and polycystic ovary syndrome. METHODS: This cross-sectional study was performed on 126 pregnant women with PCOS and infertility history who became pregnant after stimulation of ovulation and referred to Imam Khomeini Hospital in Ahvaz. These patients underwent screening with 75 g OGTT (Oral Glucose Tolerance Test) during the first trimester and during 24-28 weeks of gestation. They were divided into two groups of PCOS with gestational diabetes and without gestational diabetes. Variables such as age, gestational diabetes, parity and BMI were measured and the relationship between BMI and gestational diabetes was examined. FINDINGS: The mean age of patients in the two PCOS groups with and without gestational diabetes was 26.09±2.03 and 27.07±3.03 years, respectively. Of the 126 pregnant women with PCOS, 30 (23.8%) patients were diagnosed with gestational diabetes in the first trimester of pregnancy and 11 (8.7%) patients during 24-28 weeks of gestation. Overall, 41(32.5%) patients had gestational diabetes and 85 (67.5%) patients did not have gestational diabetes. There was no significant difference in the mean BMI between the two PCOS groups with and without gestational diabetes. CONCLUSION: The results of the study showed that more than one third of women with PCOS experience gestational diabetes during pregnancy.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"48 5 Suppl 1 1","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88137005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}