Journal of Babol University of Medical Sciences最新文献_第6页

ژنهای چسبندگی بینسلولی (ica) مرتبط با تشکیل بیوفیلم و اسلایم در ایزولههای بالینی استافیلوکوکوس اورئوس حامل ژن mecA

Journal of Babol University of Medical Sciences Pub Date : 2018-06-15 DOI: 10.18869/acadpub.jbums.20.6.27

ندا یوسفی نوجوکامبری, سجاد یزدان ستاد, عبدالله اردبیلی, مرتضی صاکی, احسان نجاری

引用次数: 0

Preparation and Evaluation of Rivax Protein Loading in Chitosan Nanoparticles 壳聚糖纳米颗粒负载Rivax蛋白的制备及性能评价

Journal of Babol University of Medical Sciences Pub Date : 2018-06-10 DOI: 10.18869/ACADPUB.JBUMS.20.6.62

Davood Sadeghi, F. Ebrahimi, M. Zeinoddini, Y. Tarverdizadeh, Mostafa Bakhshi, MJ Bageripor, SM Agaii

{"title":"Preparation and Evaluation of Rivax Protein Loading in Chitosan Nanoparticles","authors":"Davood Sadeghi, F. Ebrahimi, M. Zeinoddini, Y. Tarverdizadeh, Mostafa Bakhshi, MJ Bageripor, SM Agaii","doi":"10.18869/ACADPUB.JBUMS.20.6.62","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.6.62","url":null,"abstract":"BACKGROUND AND OBJECTIVE: Ricin toxin is a heterodimer glycoprotein which, due to its high toxicity, is used as a bioterrorism agent. Immunogenicity studies against ricin are now focused on two subunit vaccine candidates, including RiVax and RVEc. These studies have examined the vaccine candidate immunization as an alone and in combination with adjuvant, however, there is not a published study on the immunogenicity evaluation of the candidate vaccine through the delivery by nanoparticles. The aim of this study was preparation and evaluation of RiVax recombinant vaccine-loading in chitosan nanoparticles. METHODS: In this experimental study, After transferring the RiVax gene to the bacterium, inducing the expression and purification of the RiVax protein by affinity chromatography column, the RiVax protein was loaded with Ionic Gelation method in chitosan nanoparticles. Then, the properties of nanoparticles including size, morphology, loading percentage and release pattern of RiVax protein from nanoparticles and stability of this protein during acidic loading conditions in nanoparticles by SDS-PAGE were evaluated. Also, Immunization study were performed on 3 mouse groups (n=4/group) by RiVax protein, Nanoparticles containing protein and phosphate buffer. FINDING: The results of this study showed that the nanoparticles containing protein had a size of 178 nm and a Zeta potential of +27.8 MV and a polydispersity index of 0.193. Also, according to SDS-PAGE results, it was found that the RiVax recombinant protein was denatured during the process of preparing the chitosan nanoparticles. CONCLUSION: The results of this study showed that the RiVax protein has been unstable in acidic conditions for the production of chitosan nanoparticles and Ionic Gelation method is not suitable for loading this protein in chitosan nanoparticles.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"48 1","pages":"62-69"},"PeriodicalIF":0.0,"publicationDate":"2018-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87550344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Kangaroo Mother Care on Mental Health of Mothers with Premature Infants 袋鼠式母亲护理对早产儿母亲心理健康的影响

Journal of Babol University of Medical Sciences Pub Date : 2018-06-10 DOI: 10.18869/ACADPUB.JBUMS.20.6.7

Y. Pasha, A. Salarmanesh, S. Khafri, S. Mouodi, A. Arzani

引用次数: 8

Evaluating the Performance of Flow Cytometric Method in Identification of Platelet Resistance in Patients with Acute Myeloid Leukemia (AML) 流式细胞术检测急性髓性白血病(AML)患者血小板耐药性的效果评价

Journal of Babol University of Medical Sciences Pub Date : 2018-06-10 DOI: 10.18869/ACADPUB.JBUMS.20.6.20

M. Ghorbani, M. Hojjati

{"title":"Evaluating the Performance of Flow Cytometric Method in Identification of Platelet Resistance in Patients with Acute Myeloid Leukemia (AML)","authors":"M. Ghorbani, M. Hojjati","doi":"10.18869/ACADPUB.JBUMS.20.6.20","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.6.20","url":null,"abstract":"J Babol Univ Med Sci; 20(6); June 2018; PP: 20-26 Received: Nov 4 2017, Revised: Jan 18 2018, Accepted: Feb 26 2018. ABSTRACT BACKGROUND AND OBJECTIVE: Immune platelet resistance is a condition in which antibodies are produced against platelet antigens and cause damage to injected platelets by phagocytes and macrophages. The aim of this study is to evaluate the efficacy of flow cytometry in predicting the results of platelet injections and platelet resistance and selecting compatible platelet for patients. METHODS: This case-control study was performed on 15 patients with acute myeloid leukemia (AML) with two or multiple injections of platelets and 15 healthy subjects without a history of platelet injection. After marking the platelets with 5-Chloromethylfluorescein diacetate (CMFDA) and their adjacency to the serum of patients, the amount of phagocytosis of platelets by monocytes was assessed in the two groups. FINDINGS: The mean phagocytic power of platelets by monocyte was 18.27 ± 2.86% in the control group, 68.47 ± 10.40% in the group of patients with immune platelet resistance, and 36.73 ± 15.21 in the group of patients without immune platelet resistance (p = 0.001). In addition, there was a significant negative correlation between phagocytic power of platelets by monocyte and Corrected Count Increment (CCI) at 1 and 24 hours (p = 0.001). CONCLUSION: Based on the results of this study and considering the high sensitivity of the flow cytometric method, the use of CMFDA is highly appropriate for evaluating platelet studies, and it can also be used for platelet crossmatch by flow cytometry. KEY WORD: Platelet Resistance, Flow Cytometry, CCI, Phagocytosis, 5-Chloromethylfluorescein diacetate.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"67 1","pages":"20-26"},"PeriodicalIF":0.0,"publicationDate":"2018-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78143236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstacles and Challenges in the Use of Probiotics 使用益生菌的障碍和挑战

Journal of Babol University of Medical Sciences Pub Date : 2018-06-10 DOI: 10.18869/ACADPUB.JBUMS.20.6.53

S. Sadeghi, F. J. Ansari, H. Jalili

{"title":"Obstacles and Challenges in the Use of Probiotics","authors":"S. Sadeghi, F. J. Ansari, H. Jalili","doi":"10.18869/ACADPUB.JBUMS.20.6.53","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.6.53","url":null,"abstract":"BACKGROUND AND OBJECTIVE: Probiotics are living microorganisms whose adequate intake has shown healthful effects in the host body and have been suggested to have beneficial effects in the prevention and treatment of many diseases. This study was conducted to investigate the obstacles and challenges of probiotic products in the production process and their effects on human health. METHODS: For data collection in this review article, articles containing one of the terms “probiotic”, “lactobacillus”, “bifidobacterium”, “biogenic amine” and “antibiotic resistance” from 1990 to 2017 were searched and reviewed at Thomson Reuters, Pubmed, Scopus, Science Direct and Islamic World Science Citation Center(ISC). FINDING: Research has shown that systematic infections and chronic diseases, over-stimulation of the immune system, transfer of antibiotic resistance genes, production of biogenic amines and D-lactic acidosis, lack of survival and sustainability of microorganisms and ultimately the change in the taste and flavor of probiotic products are among the obstacles and challenges facing the production of probiotics. The use of bifidobacterium to transfer antibiotic resistance genes is safer than other microorganisms for the production of probiotic products. CONCLUSION: Based on the results of this study, probiotics are only safe in healthy people, although they are very useful for human health, but their use in children, pregnant women and people with a weakened immune system causes","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"759 1","pages":"53-61"},"PeriodicalIF":0.0,"publicationDate":"2018-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85427280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Recovery of Acute Pulmonary Edema Following Drowning Due to Seizure: Report of Two Cases 溺水后癫痫发作急性肺水肿的恢复:附2例报告

Journal of Babol University of Medical Sciences Pub Date : 2018-06-10 DOI: 10.18869/ACADPUB.JBUMS.20.6.70

P. Amri

{"title":"Recovery of Acute Pulmonary Edema Following Drowning Due to Seizure: Report of Two Cases","authors":"P. Amri","doi":"10.18869/ACADPUB.JBUMS.20.6.70","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.6.70","url":null,"abstract":"J Babol Univ Med Sci; 20(6); Jun 2018; PP: 70-5 Received: Aug 31 2017, Revised: Mar 3 2018, Accepted: May 7 2018. ABSTRACT BACKGROUND AND OBJECTIVE: Drowning is a process of respiratory impairment due to the full immersion under fluids that about one third of patients with drowning experience pulmonary edema. In this article, two patients with acute pulmonary edema after drowning due to seizure who were admitted to the ICU department at Ayatollah Rouhani Hospital in Babol have been presented. CASE REPORT: An 18-year-old man with a history of epilepsy was drowned while swimming in the pool after a seizure. Due to hypoxia, he was treated with supplemental oxygen and NIV for 12 hours. After partial recovery, he was treated with oxygen for three days. The patient on the fourth day was discharged with a good general condition. Second patient: An 36-year old man, with a previous history of brain trauma was drowned while swimming in the sea after a seizure. The patient was intubated due to severe hypoxemia despite administration of oxygen (pao2 = 44mmHg) and low blood pressure (BP = 80 / 50mmHg), and was transferred to ICU at Ayatollah Rouhani Hospital. The patient was treated for mechanical ventilation and positive end expiratory pressure (PEEP) for 12 days. After recovery, he was separated from the ventilator and was discharged on the 14th day. CONCLUSION: In acute pulmonary edema after drowning, administration of oxygen and non-invasive ventilation is recommended. In the absence of response, tracheal intubation and invasive mechanical ventilation are recommended.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"189 1","pages":"70-75"},"PeriodicalIF":0.0,"publicationDate":"2018-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74415254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lack of Genetic Association between Interleukin-18 Gene Polymorphism (rs1946518) and Chronic Hepatitis B Infection 白细胞介素-18基因多态性(rs1946518)与慢性乙型肝炎感染缺乏遗传关联

Journal of Babol University of Medical Sciences Pub Date : 2018-06-10 DOI: 10.18869/ACADPUB.JBUMS.20.6.46

M. Salehi, Mohebbi, M. Karkhane, Shabnam Kazemian, P. Azimzadeh, M. S. Niasar, A. Sharifian, Zali

{"title":"Lack of Genetic Association between Interleukin-18 Gene Polymorphism (rs1946518) and Chronic Hepatitis B Infection","authors":"M. Salehi, Mohebbi, M. Karkhane, Shabnam Kazemian, P. Azimzadeh, M. S. Niasar, A. Sharifian, Zali","doi":"10.18869/ACADPUB.JBUMS.20.6.46","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.6.46","url":null,"abstract":"BACKGROUND AND OBJECTIVE: Interleukin 18 is a member of the cytokines that play an important role in the Th1-mediated immune response by inducing interferon-gamma activity in collaboration with Interleukin-12 (IL-18). Interleukin 12 and Interleukin 18 can play an important role in purifying viruses. Considering the importance of IL-18, this study was conducted to investigate the relationship between Interleukin-18 Gene polymorphism (-607 C/A: rs1946518) and the susceptibility to chronic hepatitis B infection. METHODS: In this case-control study, the genomic DNA of 115 patients with chronic hepatitis B (with positive results of HBsAg and Anti-HBcAb serology testing) and 115 non-HBV-infected controls (negative results of HBsAg and AntiHbcAb serology testing and no history of liver disease) was extracted by salting-out method and the genotype of singlenucleotide polymorphism (-607 C / A: rs1946518) was sequenced using PCR-RFLP method. FINDING: The genotype frequency of TT, GT, and GG in patients was 40%, 49.6%, and 10.4% in patients, and 41.7%, 42.6%, and 15.7% in the control group, respectively. No significant difference was found between the patients group and the control group. CONCLUSION: Based on the results of this study, there was no clear relationship between IL-18 polymorphism and the potential for chronic hepatitis B infection. Therefore, this polymorphism cannot be a potential factor for chronic hepatitis B.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"7 1","pages":"46-52"},"PeriodicalIF":0.0,"publicationDate":"2018-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82276527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Soft Tissue Calcification in Panoramic Radiographs in Northern of Iran 伊朗北部全景x线片软组织钙化的患病率

Journal of Babol University of Medical Sciences Pub Date : 2018-06-10 DOI: 10.18869/ACADPUB.JBUMS.20.6.41

M. Safabakhsh, M. Johari, Ali Bijani, S. Haghanifar

{"title":"Prevalence of Soft Tissue Calcification in Panoramic Radiographs in Northern of Iran","authors":"M. Safabakhsh, M. Johari, Ali Bijani, S. Haghanifar","doi":"10.18869/ACADPUB.JBUMS.20.6.41","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.6.41","url":null,"abstract":"BACKGROUND AND OBJECTIVE: Soft tissue calcification is a relatively common issue in panoramic radiography. Some of these calcifications may have non-specific clinical symptoms as feeling of foreign body, dysphagia, otalgia and non-reflective cough. Therefore, for correct diagnosis and avoiding incorrect and excess treatments it’s necessary to have information about prevalence of these calcifications in regional populations. This study aimed to determine the prevalence of soft tissue calcification in panoramic radiographs in a selected population in northern Iran. METHODS: In this cross sectional study, panoramic radiographs of 5000 patients referring to Oral & Maxillofacial radiology department of Babol dental school from 2014 to 2017 were examined. Radiographs were evaluated for the presence of any calcification, and their prevalence and their relationship with age were evaluated in two groups of under and over 40 years of age and gender. FINDING: The prevalence of the observed soft tissue calcifications including calcification of stylohyoid ligands was 484 cases (9.7%), tonsilolith 52 cases (1%), calcification of lymph nodes 9 cases (0.2%), calcification of carotid artery 22 cases (0.4%) and thyroid cartilage calcification was 17 cases (0.3%). No cases of rhinolith, antrolith, sialolith and phlebolitis were found. The amount of tonsilolith (34 to 18 cases) and lymph node calcification (7 versus 2 cases) were significantly higher in men. (p=0.002 and p =0.048). Also, the prevalence of calcification of stylohyoid ligament (290 versus 194 cases) (p=0.001), tonsilolith (13% vs. 39 cases) (p=0.001), calcification of carotid artery (18 versus 4) (p=0.001), and thyroid (14 versus 3) (p=0.003) were significantly relevant with age. CONCLUSION: The results of this study showed that soft tissue calcifications are prevalent and the most common is stylohyoid ligament calcification.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"49 1","pages":"41-45"},"PeriodicalIF":0.0,"publicationDate":"2018-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76640014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

مقایسه چای سبز و سیاه با فلوراید در ریزسختی و پیشگیری از دمینرالیزاسیون مینای دندان های شیری

Journal of Babol University of Medical Sciences Pub Date : 2018-06-10 DOI: 10.18869/ACADPUB.JBUMS.20.6.14

مریم نظرزاده ده بزرگی, مریم قاسمپور, غزاله احمدی, ثریا خفری

引用次数: 0

The Effect of Camellia Sinensis Ointment on Perineal Wound Healing in Primiparous Women 山茶软膏对初产妇会阴创面愈合的影响

Journal of Babol University of Medical Sciences Pub Date : 2018-05-15 DOI: 10.18869/ACADPUB.JBUMS.20.5.7

H. Shahrahmani, Ns Kariman, S. Jannesari, M. Rafieian-kopaei, M. Mirzaei, N. Shahrahmani

{"title":"The Effect of Camellia Sinensis Ointment on Perineal Wound Healing in Primiparous Women","authors":"H. Shahrahmani, Ns Kariman, S. Jannesari, M. Rafieian-kopaei, M. Mirzaei, N. Shahrahmani","doi":"10.18869/ACADPUB.JBUMS.20.5.7","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.5.7","url":null,"abstract":"BACKGROUND AND OBJECTIVE: Delay in recovery of episiotomy can lead to infection and persistence of perineal pain. Perineal pain is a stressful problem for primiparous women and has a negative effect on their function.The present study was conducted to determine the effect of Green tea ointment on the healing process of episiotomy. \u0000METHODS: This three-blind clinical trial was conducted on 60 primiparous participated in this research, were divided \u0000in two groups: Green tea ointment and placebo ointment. According to the routine of the hospital, 500 mg capsule \u0000cephalexin was given to all mothers every six hours for seven days. Mothers used an ointments every 12 hours for a \u0000period of ten days in the area of sutures. Wound healing was measured on the fifth and tenth day after delivery using \u0000REEDA scale. \u0000FINDINGS: There was no significant difference in demographic features and obstetric variables (for example age and \u0000weight newborn). Before the intervention, two groups did not have a significant difference in score of the perineal \u0000evaluation scale (p=0.475). The average of this scale on the fifth day in the green tea group was (1.83±1.147) and in \u0000placebo group it was (3.33±1.155) on the 10th day, the average of the perineal evaluation scale was (1.2±0.805) for the green tea group and (2.63±1.066) for the placebo group. The average of REEDA scores on the 5th and 10th day after \u0000delivery was significantly different between the two groups(p<0.00001) CONCLUSION: Green tea can improve episiotomy wound healing, due to its healing properties.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"10 1","pages":"7-15"},"PeriodicalIF":0.0,"publicationDate":"2018-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74915546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2