Journal of Babol University of Medical Sciences最新文献_第8页

اثرات ویتامین E بر آسیبهای کبدی و کلیوی ناشی از مصرف دیانابول در موشهای سفید کوچک آزمایشگاهی

Journal of Babol University of Medical Sciences Pub Date : 2018-04-10 DOI: 10.18869/ACADPUB.JBUMS.20.9.36

حسن مروتی, محمدعلی بابایی, زهرا طوطیان, سیمین فاضلی پور, حجت عنبرا, عظیم اکبرزاده

引用次数: 0

The association of mir-451 and mir-21 in plasma with lymph node metastases in breast cancer 血浆中mir-451和mir-21与乳腺癌淋巴结转移的关系

Journal of Babol University of Medical Sciences Pub Date : 2018-04-10 DOI: 10.18869/ACADPUB.JBUMS.20.4.12

M. Motamedi, M. Chaleshtori, S. Ghasemi, S. Kheiri, A. Gholami

{"title":"The association of mir-451 and mir-21 in plasma with lymph node metastases in breast cancer","authors":"M. Motamedi, M. Chaleshtori, S. Ghasemi, S. Kheiri, A. Gholami","doi":"10.18869/ACADPUB.JBUMS.20.4.12","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.4.12","url":null,"abstract":"BACKGROUND AND OBJECTIVE: The expression of some circulating microRNAs (miRNAs) in biological fluids of healthy individuals is different from cancerous patients. circulating miRNAs are a new class of cancer biomarkers because of their high stability and sensitivity, ease of measurement and specificity due to their correlation with various cancer states. According to the miR-451 and miR-21 functions in the metastasis of some cancers, the aim of this study was to investigate the differences of expression levels of miR-451 and miR-21 in the plasma of breast cancer (BC) patients with and without lymph nodes metastasis (LNM). METHODS: In this descriptive-analytical study, blood samples were collected from 47 women with BC and 24 healthy women with mammography confirmation. The presence/or absence of LNM was recognized from patients' medical records. The expression levels of miR-451 and miR-21 in the plasma, were investigated using Real-Time PCR. FINDINGS: The median of expression of miR-451 in BC patients with LNM and without LNM was 1.739 and 3.187, respectively, and its expression in lymph node metastatic patients decreased 0.444 folds in comparison with non-metastatic patients (p=0.031). The median of expression of miR-21 in patients with LNM and in non-metastatic lymph nodes patients was 5.922 and 2.157, respectively, and its expression in metastatic status was 2 folds higher than non-metastatic (p=0.029). CONCLUSION: The results of this study indicated that decreased miR-451 and increased miR-21 expression in plasma of BC patients was associated with LNM status. © 2018, Babol University of Medical Sciences.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"10 1","pages":"12-16"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87388150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Comparison between the Plasma Levels of Long Noncoding RNA BDNF-AS in Patients with Alzheimer's disease and Healthy Subjects 阿尔茨海默病患者与健康人血浆长链非编码RNA BDNF-AS水平的比较

Journal of Babol University of Medical Sciences Pub Date : 2018-04-10 DOI: 10.18869/ACADPUB.JBUMS.20.4.24

R. A. Aghali, M. Khalaj, N. Zeinalzadeh, H. Feizi, M. Farhoudi, M. Talebi

引用次数: 3

Experimental Models of Thrombocytopenia in Laboratory Animals and their Application in Identifying the Complications of Chemotherapy Drugs 实验动物血小板减少的实验模型及其在化疗药物并发症鉴定中的应用

Journal of Babol University of Medical Sciences Pub Date : 2018-04-10 DOI: 10.18869/ACADPUB.JBUMS.20.4.48

H. Kamali, Khazaei, E. Shobeiri, M. Khazaei

{"title":"Experimental Models of Thrombocytopenia in Laboratory Animals and their Application in Identifying the Complications of Chemotherapy Drugs","authors":"H. Kamali, Khazaei, E. Shobeiri, M. Khazaei","doi":"10.18869/ACADPUB.JBUMS.20.4.48","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.4.48","url":null,"abstract":"BACKGROUND AND OBJECTIVE: Thrombocytopenia is one of the complications of chemotherapy drugs that may cause death. Different animal models of thrombocytopenia are used for clinical research and identification of its causes, each with advantages and disadvantages. The aim of this review article is to investigate the methods of thrombocytopenia induction in laboratory animals and their advantages and disadvantages. METHODS: This systematic review was conducted using the keywords “thrombocytopenia platelet”, “chemotherapy”, “animal model”, in PubMed, Science Direct and Scopus databases from 1990 until October 2017. The title and abstract of several articles were reviewed, and after excluding the unrelated items, final articles were selected and reviewed. FINDINGS: Animal models of thrombocytopenia are of two types of immune and non-immune. Non-immune models reduce platelet production through bone marrow suppression. Antiplatelet antibodies are used in immune models. The immune and non-immune thrombocytopenic models have some advantages and limitations and are selected according to the current therapeutic goals. Mice and rats are commonly used as laboratory animals, and cyclophosphamide and carboplatin are the most commonly used drugs. CONCLUSION: According to the results of this study, due to the limitations of human subject research in diseases that lead to thrombocytopenia, there is a need to develop appropriate animal models for studying and identifying the factors affecting thrombocytopenia.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"90 1","pages":"48-58"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78408663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

فراوانی چاقی مرکزی و ارتباط آن با شاخصهای خونی و فشارخون در افراد کاندید آنژیوگرافی الکتیو مراجعه کننده به بیمارستان حشمت شهر رشت در سال 1395

Journal of Babol University of Medical Sciences Pub Date : 2018-04-10 DOI: 10.18869/ACADPUB.JBUMS.20.4.35

مرجان مهدوی روشن, ارسلان سالاری, مریم شکیبا, مونا نقشبندی, محبوبه قلی پور

引用次数: 0

The Evaluation of the Anatomical Variations of Osteomeatal Complex in Cone Beam Computed Tomography Images 锥形束计算机断层图像中骨突复合体解剖变化的评价

Journal of Babol University of Medical Sciences Pub Date : 2018-04-10 DOI: 10.18869/ACADPUB.JBUMS.20.4.30

F. Abesi, S. Haghanifar, S. Khafri, Ali Montazeri

引用次数: 4

Compare the Effects of Caffeine on QTc Interval and Blood Pressure During Isometric and Isotonic Contractions in Male Athletes and Non-Athletes 比较咖啡因对男性运动员和非运动员等长收缩和等张收缩期间QTc间隔和血压的影响

Journal of Babol University of Medical Sciences Pub Date : 2018-03-10 DOI: 10.18869/ACADPUB.JBUMS.20.3.7

M. Kashef, N. Nejatmand, Ar Kashef, R. Gheyratmand

引用次数: 0

بررسی نتایج اکوکاردیوگرافی پس از ترمیم جراحی نارسایی شدید دریچه میترال قلب

Journal of Babol University of Medical Sciences Pub Date : 2018-03-10 DOI: 10.18869/ACADPUB.JBUMS.20.3.59

محمدرضا صالحی عمران, حمیدرضا وفایی, حسن صالحی عمران

引用次数: 0

ارزیابی بافت شناسی انواع سلول های ماستوسیت در فلاپ پوستی به کمک سلول های بنیادی مزانشیمی مغز استخوان از طریق فاکتور رشد بیو لوژیکی

Journal of Babol University of Medical Sciences Pub Date : 2018-03-10 DOI: 10.18869/acadpub.jbums.20.3.21

فرزانه چهل چراغی, خاطره عنبری

{"title":"ارزیابی بافت شناسی انواع سلول های ماستوسیت در فلاپ پوستی به کمک سلول های بنیادی مزانشیمی مغز استخوان از طریق فاکتور رشد بیو لوژیکی","authors":"فرزانه چهل چراغی, خاطره عنبری","doi":"10.18869/acadpub.jbums.20.3.21","DOIUrl":"https://doi.org/10.18869/acadpub.jbums.20.3.21","url":null,"abstract":"J Babol Univ Med Sci; 20(3); Mar 2018; PP: 21-8 Received: Sep 26 2017, Revised: Dec 9 2017, Accepted: Jan 9 2018. ABSTRACT BACKGROUND AND OBJECTIVE: Skin flap is one of the most commonly used methods in plastic surgery. Postoperative skin flap necrosis is one of the complications of flap skin. The aim of this study was to evaluate the effect of bone marrow mesenchymal stem cells (BM-MSCs) and chick embryo extract (CEE) on mast cells in a randomized skin flap in rats. METHODS: In this experimental study, 40 male albino Wistar rats weighing 250 – 300 g were divided into four groups of 10 (control, CEE/BM-MSCs, CEE and BM-MSCs). Skin flap (30 × 80 mm) was created behind the animals. Surgery was performed on day zero and therapeutic intervention was done on the same day. Mesenchymal stem cells were extracted from rat bone marrow and were injected. CEE was prepared from a 9-day-old embryo of Marandi chicken. On the seventh day after the surgery, samples were assessed in term of type, and the total number of mast cells (type 1 to 3) in the transfer line. FINDINGS: The difference between the mean number of mast cells type 1 (3.67±1.91) (p=0.99), and type 3 (1.9±1.47) (p=0.384) was not significant in the study groups, but was statistically significant in type 2 (2.27±1.42) in different study groups (p=0.005). There was also a statistically significant difference between the mean total number of mast cells (2.32±0.84) in the BM-MSCs group and other experimental groups (p=0.001). CONCLUSION: Based on the results of this study, increase in mast cell type 2, the improvement of small vessels and decrease in mast cell type 3 lead to the reduction of scarring and fibrosis.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"97 1","pages":"21-28"},"PeriodicalIF":0.0,"publicationDate":"2018-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82749229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ارتباط نئوواسکولاریزاسیون آندومتریومای تخمدانی با شدت درد لگنی

Journal of Babol University of Medical Sciences Pub Date : 2018-03-10 DOI: 10.18869/ACADPUB.JBUMS.20.3.15

الهام شبیری, محمد غریب صالحی, محسن فتاحی باوندپور, جمال حسینی

引用次数: 0