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How do cytokines trigger genomic instability? 细胞因子是如何引发基因组不稳定性的?
Journal of Biomedicine and Biotechnology Pub Date : 2012-01-01 Epub Date: 2012-06-17 DOI: 10.1155/2012/536761
Ioannis L Aivaliotis, Ioannis S Pateras, Marilena Papaioannou, Christina Glytsou, Konstantinos Kontzoglou, Elizabeth O Johnson, Vassilis Zoumpourlis
{"title":"How do cytokines trigger genomic instability?","authors":"Ioannis L Aivaliotis,&nbsp;Ioannis S Pateras,&nbsp;Marilena Papaioannou,&nbsp;Christina Glytsou,&nbsp;Konstantinos Kontzoglou,&nbsp;Elizabeth O Johnson,&nbsp;Vassilis Zoumpourlis","doi":"10.1155/2012/536761","DOIUrl":"https://doi.org/10.1155/2012/536761","url":null,"abstract":"<p><p>Inflammation is a double-edged sword presenting a dual effect on cancer development, from one hand promoting tumor initiation and progression and from the other hand protecting against cancer through immunosurveillance mechanisms. Cytokines are crucial components of inflammation, participating in the interaction between the cells of tumor microenvironment. A comprehensive study of the role of cytokines in the context of the inflammation-tumorigenesis interplay helps us to shed light in the pathogenesis of cancer. In this paper we focus on the role of cytokines in the development of genomic instability, an evolving hallmark of cancer.</p>","PeriodicalId":15089,"journal":{"name":"Journal of Biomedicine and Biotechnology","volume":" ","pages":"536761"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/536761","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30735115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 46
The role of T-cell leukemia translocation-associated gene protein in human tumorigenesis and osteoclastogenesis. t细胞白血病易位相关基因蛋白在人类肿瘤发生和破骨细胞发生中的作用。
Journal of Biomedicine and Biotechnology Pub Date : 2012-01-01 Epub Date: 2011-11-24 DOI: 10.1155/2012/675317
Shigeru Kotake, Toru Yago, Manabu Kawamoto, Yuki Nanke
{"title":"The role of T-cell leukemia translocation-associated gene protein in human tumorigenesis and osteoclastogenesis.","authors":"Shigeru Kotake,&nbsp;Toru Yago,&nbsp;Manabu Kawamoto,&nbsp;Yuki Nanke","doi":"10.1155/2012/675317","DOIUrl":"https://doi.org/10.1155/2012/675317","url":null,"abstract":"<p><p>Synovial tissues of patients with rheumatoid arthritis (RA) include factors regulating bone resorption, such as receptor activator NF-κB ligand (RANKL), TNF-α, IL-6, IL-17, and IFN-γ. However, in addition to these cytokines, other factors expressed in synovial tissues may play a role in regulating bone resorption. In 2009, we demonstrated that novel peptides from T-cell leukemia translocation-associated gene (TCTA) protein expressed in synovial tissues from patients with RA inhibit human osteoclastogenesis, preventing cellular fusion via the interaction between TCTA protein and a putative counterpart molecule. Only a few studies on the role of TCTA protein have been reported. Genomic Southern blots demonstrated a reduced TCTA signal in three of four small cell lung cancer cell lines, suggesting the loss of one of the two copies of the gene. In the current paper, we reviewed the roles of TCTA protein in lung cancer cell lines and human osteoclastogenesis.</p>","PeriodicalId":15089,"journal":{"name":"Journal of Biomedicine and Biotechnology","volume":" ","pages":"675317"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/675317","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30330375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
BMP9-induced osteogenetic differentiation and bone formation of muscle-derived stem cells. bmp9诱导的肌源性干细胞成骨分化和骨形成。
Journal of Biomedicine and Biotechnology Pub Date : 2012-01-01 Epub Date: 2012-01-26 DOI: 10.1155/2012/610952
Li Xiang, Chen Liang, Ke Zhen-Yong, Yin Liang-Jun, Deng Zhong-Liang
{"title":"BMP9-induced osteogenetic differentiation and bone formation of muscle-derived stem cells.","authors":"Li Xiang,&nbsp;Chen Liang,&nbsp;Ke Zhen-Yong,&nbsp;Yin Liang-Jun,&nbsp;Deng Zhong-Liang","doi":"10.1155/2012/610952","DOIUrl":"https://doi.org/10.1155/2012/610952","url":null,"abstract":"<p><p>Efficient osteogenetic differentiation and bone formation from muscle-derived stem cells (MDSCs) should have potential clinical applications in treating nonunion fracture healing or bone defects. Here, we investigate osteogenetic differentiation ability of MDSCs induced by bone morphogenetic protein 9 (BMP9) in vitro and bone formation ability in rabbit radius defects repairing model. Rabbit's MDSCs were extracted by type I collagenase and trypsin methods, and BMP9 was introduced into MDSCs by infection with recombinant adenovirus. Effects of BMP9-induced osteogenetic differentiation of MDSCs were identified with alkaline phosphatase (ALP) activity and expression of later marker. In stem-cell implantation assay, MDSCs have also shown valuable potential bone formation ability induced by BMP9 in rabbit radius defects repairing test. Taken together, our findings suggest that MDSCs are potentiated osteogenetic stem cells which can be induced by BMP9 to treat large segmental bone defects, nonunion fracture, and/or osteoporotic fracture.</p>","PeriodicalId":15089,"journal":{"name":"Journal of Biomedicine and Biotechnology","volume":" ","pages":"610952"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/610952","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30446921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 33
Good oral health and diet. 良好的口腔健康和饮食。
Journal of Biomedicine and Biotechnology Pub Date : 2012-01-01 Epub Date: 2012-01-26 DOI: 10.1155/2012/720692
G A Scardina, P Messina
{"title":"Good oral health and diet.","authors":"G A Scardina,&nbsp;P Messina","doi":"10.1155/2012/720692","DOIUrl":"https://doi.org/10.1155/2012/720692","url":null,"abstract":"<p><p>An unhealthy diet has been implicated as risk factors for several chronic diseases that are known to be associated with oral diseases. Studies investigating the relationship between oral diseases and diet are limited. Therefore, this study was conducted to describe the relationship between healthy eating habits and oral health status. The dentistry has an important role in the diagnosis of oral diseases correlated with diet. Consistent nutrition guidelines are essential to improve health. A poor diet was significantly associated with increased odds of oral disease. Dietary advice for the prevention of oral diseases has to be a part of routine patient education practices. Inconsistencies in dietary advice may be linked to inadequate training of professionals. Literature suggests that the nutrition training of dentists and oral health training of dietitians and nutritionists is limited.</p>","PeriodicalId":15089,"journal":{"name":"Journal of Biomedicine and Biotechnology","volume":" ","pages":"720692"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/720692","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30485316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 79
An experimental model for resistance exercise in rodents. 啮齿动物抗阻运动的实验模型。
Journal of Biomedicine and Biotechnology Pub Date : 2012-01-01 Epub Date: 2012-02-16 DOI: 10.1155/2012/457065
Humberto Nicastro, Nelo Eidy Zanchi, Claudia Ribeiro da Luz, Daniela Fojo Seixas Chaves, Antonio Herbert Lancha
{"title":"An experimental model for resistance exercise in rodents.","authors":"Humberto Nicastro,&nbsp;Nelo Eidy Zanchi,&nbsp;Claudia Ribeiro da Luz,&nbsp;Daniela Fojo Seixas Chaves,&nbsp;Antonio Herbert Lancha","doi":"10.1155/2012/457065","DOIUrl":"https://doi.org/10.1155/2012/457065","url":null,"abstract":"<p><p>This study aimed to develop an equipment and system of resistance exercise (RE), based on squat-type exercise for rodents, with control of training variables. We developed an operant conditioning system composed of sound, light and feeding devices that allowed optimized RE performance by the animal. With this system, it is not necessary to impose fasting or electric shock for the animal to perform the task proposed (muscle contraction). Furthermore, it is possible to perform muscle function tests in vivo within the context of the exercise proposed and control variables such as intensity, volume (sets and repetitions), and exercise session length, rest interval between sets and repetitions, and concentric strength. Based on the experiments conducted, we demonstrated that the model proposed is able to perform more specific control of other RE variables, especially rest interval between sets and repetitions, and encourages the animal to exercise through short-term energy restriction and \"disturbing\" stimulus that do not promote alterations in body weight. Therefore, despite experimental limitations, we believe that this RE apparatus is closer to the physiological context observed in humans.</p>","PeriodicalId":15089,"journal":{"name":"Journal of Biomedicine and Biotechnology","volume":" ","pages":"457065"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/457065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30569905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Various jobs of proteolytic enzymes in skeletal muscle during unloading: facts and speculations. 卸载过程中骨骼肌蛋白水解酶的各种作用:事实与推测。
Journal of Biomedicine and Biotechnology Pub Date : 2012-01-01 Epub Date: 2012-02-08 DOI: 10.1155/2012/493618
E V Kachaeva, B S Shenkman
{"title":"Various jobs of proteolytic enzymes in skeletal muscle during unloading: facts and speculations.","authors":"E V Kachaeva,&nbsp;B S Shenkman","doi":"10.1155/2012/493618","DOIUrl":"https://doi.org/10.1155/2012/493618","url":null,"abstract":"<p><p>Skeletal muscles, namely, postural muscles, as soleus, suffer from atrophy under disuse. Muscle atrophy development caused by unloading differs from that induced by denervation or other stimuli. Disuse atrophy is supposed to be the result of shift of protein synthesis/proteolysis balance towards protein degradation increase. Maintaining of the balance involves many systems of synthesis and proteolysis, whose activation leads to muscle adaptation to disuse rather than muscle degeneration. Here, we review recent data on activity of signaling systems involved in muscle atrophy development under unloading and muscle adaptation to the lack of support.</p>","PeriodicalId":15089,"journal":{"name":"Journal of Biomedicine and Biotechnology","volume":" ","pages":"493618"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/493618","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30569908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
Development of tyrosine-based radiotracer 99mTc-N4-Tyrosine for breast cancer imaging. 以酪氨酸为基础的99mtc - n4 -酪氨酸放射示踪剂用于乳腺癌成像的研制。
Journal of Biomedicine and Biotechnology Pub Date : 2012-01-01 Epub Date: 2012-03-05 DOI: 10.1155/2012/671708
Fan-Lin Kong, Mohammad S Ali, Alex Rollo, Daniel L Smith, Yinhan Zhang, Dong-Fang Yu, David J Yang
{"title":"Development of tyrosine-based radiotracer 99mTc-N4-Tyrosine for breast cancer imaging.","authors":"Fan-Lin Kong,&nbsp;Mohammad S Ali,&nbsp;Alex Rollo,&nbsp;Daniel L Smith,&nbsp;Yinhan Zhang,&nbsp;Dong-Fang Yu,&nbsp;David J Yang","doi":"10.1155/2012/671708","DOIUrl":"https://doi.org/10.1155/2012/671708","url":null,"abstract":"<p><p>The purpose of this study was to develop an efficient way to synthesize (99m)Tc-O-[3-(1,4,8,11-tetraazabicyclohexadecane)-propyl]-tyrosine ((99m)Tc-N4-Tyrosine), a novel amino acid-based radiotracer, and evaluate its potential in breast cancer gamma imaging. Precursor N4-Tyrosine was synthesized using a 5-step procedure, and its total synthesis yield was 38%. It was successfully labeled with (99m)Tc with high radiochemical purity (>95%). Cellular uptake of (99m)Tc-N4-Tyrosine was much higher than that of (99m)Tc-N4 and the clinical gold standard (18)F-2-deoxy-2-fluoro-glucose ((18)F-FDG) in rat breast tumor cells in vitro. Tissue uptake and dosimetry estimation in normal rats revealed that (99m)Tc-N4-Tyrosine could be safely administered to humans. Evaluation in breast tumor-bearing rats showed that although (99m)Tc-N4-Tyrosine appeared to be inferior to (18)F-FDG in distinguishing breast tumor tissue from chemical-induced inflammatory tissue, it had high tumor-to-muscle uptake ratios and could detect breast tumors clearly by planar scintigraphic imaging. (99m)Tc-N4-Tyrosine could thus be a useful radiotracer for use in breast tumor diagnostic imaging.</p>","PeriodicalId":15089,"journal":{"name":"Journal of Biomedicine and Biotechnology","volume":" ","pages":"671708"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/671708","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30570802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Antiproliferative and anti-invasive effect of piceatannol, a polyphenol present in grapes and wine, against hepatoma AH109A cells. 葡萄和葡萄酒中的多酚picetanol对肝癌AH109A细胞的抗增殖和抗侵袭作用。
Journal of Biomedicine and Biotechnology Pub Date : 2012-01-01 Epub Date: 2012-02-08 DOI: 10.1155/2012/672416
Yuichiro Kita, Yutaka Miura, Kazumi Yagasaki
{"title":"Antiproliferative and anti-invasive effect of piceatannol, a polyphenol present in grapes and wine, against hepatoma AH109A cells.","authors":"Yuichiro Kita,&nbsp;Yutaka Miura,&nbsp;Kazumi Yagasaki","doi":"10.1155/2012/672416","DOIUrl":"https://doi.org/10.1155/2012/672416","url":null,"abstract":"<p><p>Piceatannol is a stilbenoid, a metabolite of resveratrol found in red wine. Piceatannol and sera from rats orally given piceatannol were found to dose-dependently suppress both the proliferation and invasion of AH109A hepatoma cells in culture. Its antiproliferative effect was based on cell cycle arrest at lower concentration (25~50 μM) and on apoptosis induction at higher concentration (100 μM). Piceatannol suppressed reactive oxygen species-potentiated invasive capacity by scavenging the intracellular reactive oxygen species. These results suggest that piceatannol, unlike resveratrol, has a potential to suppress the hepatoma proliferation by inducing cell cycle arrest and apoptosis induction. They also suggest that the antioxidative property of piceatannol, like resveratrol, may be involved in its anti-invasive action. Subsequently, piceatannol was found to suppress the growth of solid tumor and metastasis in hepatoma-bearing rats. Thus, piceatannol may be a useful anticancer natural product.</p>","PeriodicalId":15089,"journal":{"name":"Journal of Biomedicine and Biotechnology","volume":" ","pages":"672416"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/672416","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30570803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 58
Dickkopf-1 expression is a novel prognostic marker for gastric cancer. Dickkopf-1表达是胃癌新的预后指标。
Journal of Biomedicine and Biotechnology Pub Date : 2012-01-01 Epub Date: 2012-03-04 DOI: 10.1155/2012/804592
Chengcheng Gao, Rui Xie, Chengcheng Ren, Xiaozhong Yang
{"title":"Dickkopf-1 expression is a novel prognostic marker for gastric cancer.","authors":"Chengcheng Gao,&nbsp;Rui Xie,&nbsp;Chengcheng Ren,&nbsp;Xiaozhong Yang","doi":"10.1155/2012/804592","DOIUrl":"https://doi.org/10.1155/2012/804592","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the involvement of Dickkopf-1 expression in gastric cancer.</p><p><strong>Methods: </strong>Dickkopf-1 mRNA and protein expression were determined by real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and immunohistochemistry in specimens of primary cancer and their adjacent noncancerous tissues in gastric cancer patients.</p><p><strong>Results: </strong>Dickkopf-1 mRNA and protein expression levels were both significantly upregulated in gastric cancer lesions compared with adjacent noncancerous tissues. Its positive expression was correlated with depth of invasion, vessel invasion, lymph node and distant metastasis, and TNM stage of tumors. Additionally, in stages I, II, and III gastric cancers, the 5- year survival rate of patients with a high expression of Dickkopf-1 was significantly lower than that in patients with low expression. In stage IV, Dickkopf-1 expression did not correlate with the 5-year survival rate. Further multivariate analysis suggested that the up-regulation of Dickkopf-1 was an independent prognostic indicator for gastric cancer.</p><p><strong>Conclusion: </strong>A subset of cases with gastric cancer revealed the up-regulation of Dickkopf-1, which was associated with a progressive pathological feature and an aggressive clinical course. Therefore, Dickkopf-1 expression may be predictor for poor prognosis in patients with gastric cancer. This is the first report describing the involvement of Dickkopf-1 in gastric cancer.</p>","PeriodicalId":15089,"journal":{"name":"Journal of Biomedicine and Biotechnology","volume":" ","pages":"804592"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/804592","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30570805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 29
Cytotoxicity of selected medicinal and nonmedicinal plant extracts to microbial and cervical cancer cells. 选定的药用和非药用植物提取物对微生物和宫颈癌细胞的细胞毒性。
Journal of Biomedicine and Biotechnology Pub Date : 2012-01-01 Epub Date: 2012-02-22 DOI: 10.1155/2012/106746
Gary M Booth, Robert D Malmstrom, Erica Kipp, Alexandra Paul
{"title":"Cytotoxicity of selected medicinal and nonmedicinal plant extracts to microbial and cervical cancer cells.","authors":"Gary M Booth,&nbsp;Robert D Malmstrom,&nbsp;Erica Kipp,&nbsp;Alexandra Paul","doi":"10.1155/2012/106746","DOIUrl":"https://doi.org/10.1155/2012/106746","url":null,"abstract":"<p><p>This study investigated the cytotoxicity of 55 species of plants. Each plant was rated as medicinal, or nonmedicinal based on the existing literature. About 79% of the medicinal plants showed some cytotoxicity, while 75% of the nonmedicinal plants showed bioactivity. It appears that Asteraceae, Labiatae, Pinaceae, and Chenopodiaceae were particularly active against human cervical cancer cells. Based on the literature, only three of the 55 plants have been significantly investigated for cytotoxicity. It is clear that there is much toxicological work yet to be done with both medicinal and nonmedicinal plants.</p>","PeriodicalId":15089,"journal":{"name":"Journal of Biomedicine and Biotechnology","volume":" ","pages":"106746"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/106746","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30571511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
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