Journal of Asthma and Allergy最新文献

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The Morphologic Characteristics of Meibomian Glands in Allergic Conjunctivitis-Related Dry Eye in Children. 儿童变应性结膜炎干眼症睑板腺的形态学特征。
IF 3 3区 医学
Journal of Asthma and Allergy Pub Date : 2025-09-13 eCollection Date: 2025-01-01 DOI: 10.2147/JAA.S535595
Xiao-Jiao Tang, Lin Chen, Qing Liu, Yong Li
{"title":"The Morphologic Characteristics of Meibomian Glands in Allergic Conjunctivitis-Related Dry Eye in Children.","authors":"Xiao-Jiao Tang, Lin Chen, Qing Liu, Yong Li","doi":"10.2147/JAA.S535595","DOIUrl":"10.2147/JAA.S535595","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the morphological characteristics of the meibomian glands (MGs) in children with allergic conjunctivitis (AC)-related dry eye (DE).</p><p><strong>Methods: </strong>Children with a clinical diagnosis of seasonal allergic conjunctivitis (SAC) and perennial allergic conjunctivitis (PAC) were recruited. Age- and sex-matched children without a history of allergy or dry eye were recruited as controls. All participants completed the 5-item Dry Eye Questionnaire (DEQ-5) and ocular surface examination, including assessment of the tear meniscus height (TMH), noninvasive tear breakup time (NIBUT), and morphology of the upper lower MGs by noncontact infrared meibography (Oculus Keratograph 5M). Receiver operating characteristic (ROC) curve analysis was performed to determine the predictive value of the morphological characteristics of the MGs for AC-related DE.</p><p><strong>Results: </strong>Sixty-two children with AC (31 with DE and 31 without DE) and 33 healthy children were enrolled in the study. The mean age was 7.67 (ranging from 5-13.5) years. More morphological changes were observed in the upper eyelids of AC children with DE than in healthy children. No morphological feature difference was found between AC children without DE and healthy children. ROC curve analysis showed that the morphological characteristics with good predictive value for DE were shortened upper eyelid MGs (AUC=0.72, P<0.001) and hooked upper eyelid MGs (AUC=0.71, P<0.001).</p><p><strong>Conclusion: </strong>The grading of MG morphology according to the DREAM Study may be a valuable predictor for AC-related DE in children.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"1269-1281"},"PeriodicalIF":3.0,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of Magnetic Particle Chemiluminescence Technology to Detect Sensitization in Patients in Guangzhou, China: A Study Based on Real-World Medical Data. 应用磁颗粒化学发光技术检测中国广州患者的致敏性:基于真实医学数据的研究
IF 3 3区 医学
Journal of Asthma and Allergy Pub Date : 2025-09-12 eCollection Date: 2025-01-01 DOI: 10.2147/JAA.S534408
Huimin Huang, Yifan Chen, Haisheng Hu, Peiyan Zheng, Wenting Luo, Yanting Fang, Yinghong Lin, Baoqing Sun
{"title":"Application of Magnetic Particle Chemiluminescence Technology to Detect Sensitization in Patients in Guangzhou, China: A Study Based on Real-World Medical Data.","authors":"Huimin Huang, Yifan Chen, Haisheng Hu, Peiyan Zheng, Wenting Luo, Yanting Fang, Yinghong Lin, Baoqing Sun","doi":"10.2147/JAA.S534408","DOIUrl":"10.2147/JAA.S534408","url":null,"abstract":"<p><strong>Objective: </strong>Magnetic particle chemiluminescence is a novel allergen detection technology recently introduced in clinical practice in China. This study analyzed the application of the ALLEOS assay using real-world clinical data from Guangzhou to identify regional allergen sensitization patterns.</p><p><strong>Methods: </strong>A retrospective review of 20,406 suspected allergy patients, tested for 28 specific allergens using the ALLEOS 2000 system at the First Affiliated Hospital of Guangzhou Medical University from June 2021 to January 2024.</p><p><strong>Results: </strong>The highest positive rate was observed for Dermatophagoides farinae (53.4%), followed by D. pteronyssinus (43.2%) and tropical mites (20.4%). Children showed significantly higher positivity rates for most allergens compared to adults, except for dog dander and German cockroach (P < 0.05). Among allergic diseases, children predominated in rhinitis (84.9%), while adults predominated in asthma (56.5%). In terms of severity, asthma and rhinitis patients exhibited higher sensitization levels (Class 3-6) to D. pteronyssinus (81.6% and 86.3%) and D. farinae (86.7% and 87.3%), while dermatitis patients were more sensitized to egg (19.7%) and milk (17.9%) allergens. Allergen positivity rates varied by season, with children showing significantly higher sensitization to both daisy and dandelion<b> </b>in autumn (11.1% and 8.8%) and winter (11.8% and 16.7%). In childhood (ages 0-4), egg (31.4%) and milk (27.1%) sensitization rates peaked and declined with age, whereas animal dander showed lower rates (<10.0%). Multiple sensitizations were observed in 22.2% of patients. Analysis of sensitization patterns revealed three main categories for inhalation allergens: mite-dominant, animal dander-dominant, and pollen-dominant sensitizations, with a Cronbach's α of 0.889. Similarly, food allergies were categorized into egg and milk-dominant, nut-dominant, and seafood-dominant patterns, with a Cronbach's α of 0.932.</p><p><strong>Conclusion: </strong>This real-world study revealed age-, disease-, and season-specific allergen sensitization patterns in southern China. Inhalant and food allergens formed three major sensitization clusters each. These findings support region- and population-specific testing strategies and may inform clinical decision-making.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"1255-1267"},"PeriodicalIF":3.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: Evaluating Safety and Effectiveness of Switching Biologics in Managing Severe Asthma Patients [Corrigendum]. 评估转换生物制剂在治疗严重哮喘患者中的安全性和有效性[勘误]。
IF 3 3区 医学
Journal of Asthma and Allergy Pub Date : 2025-09-05 eCollection Date: 2025-01-01 DOI: 10.2147/JAA.S562799
{"title":"Erratum: Evaluating Safety and Effectiveness of Switching Biologics in Managing Severe Asthma Patients [Corrigendum].","authors":"","doi":"10.2147/JAA.S562799","DOIUrl":"10.2147/JAA.S562799","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2147/JAA.S516225.].</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"1253-1254"},"PeriodicalIF":3.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12420914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Indian Cross-Sectional Study to Evaluate In-Clinic Allergic Rhinitis Prevalence in Patients Having Nasal Symptoms Using the SFAR Questionnaire. 一项使用SFAR问卷评估有鼻症状患者临床变应性鼻炎患病率的印度横断面研究
IF 3 3区 医学
Journal of Asthma and Allergy Pub Date : 2025-09-04 eCollection Date: 2025-01-01 DOI: 10.2147/JAA.S516448
Carlton David Periera, Vijay Warad, J P Rodrigues, Gayatri Subray Pandit, Vaishali Gupte, Gurmeet Kaur Thakur, Ashish Upadhyaya, Jaideep Gogtay
{"title":"An Indian Cross-Sectional Study to Evaluate In-Clinic Allergic Rhinitis Prevalence in Patients Having Nasal Symptoms Using the SFAR Questionnaire.","authors":"Carlton David Periera, Vijay Warad, J P Rodrigues, Gayatri Subray Pandit, Vaishali Gupte, Gurmeet Kaur Thakur, Ashish Upadhyaya, Jaideep Gogtay","doi":"10.2147/JAA.S516448","DOIUrl":"10.2147/JAA.S516448","url":null,"abstract":"<p><strong>Purpose: </strong>Allergic rhinitis (AR) is a global health concern caused by allergen exposure. This Indian study utilized the Score for Allergic Rhinitis (SFAR) questionnaire to estimate the prevalence of AR among patients with nasal symptoms visiting doctors' clinics/hospitals.</p><p><strong>Patients and methods: </strong>This multicenter, cross-sectional study assessed AR using the SFAR questionnaire in patients with nasal symptoms visiting doctors' clinics/hospitals. It included patients aged ≥11 years across 19 states/union territories of India from September 2022 to April 2023. The score was digitally calculated using the Kribado<sup>TM</sup> device, with a score of ≥7 indicating the presence of AR. Patient-reported data covered demographics, seasonal patterns, symptoms, allergens/triggers, and prevalence. Associations among various risk factors were analyzed.</p><p><strong>Results: </strong>This study involved 3358 doctors, including ENT surgeons and chest physicians, and 40,001 patients across India. Among all patients, 53.7% (n=21,480) had SFAR scores ≥7. Sneezing was the most common symptom, reported by 69.1% of patients overall and 86.8% in the AR+ subgroup. House dust mites were the most prevalent allergens, affecting 73.8% of patients. Nose-related issues peaked from October to January. Half of the patients had a family history of asthma, eczema, or AR. In the AR+ subgroup, only 46% were diagnosed with allergies by a doctor, and 31.5% underwent allergy testing. After adjusting for variables, AR was significantly linked to nasal symptoms, including itchy and watery eyes, and a history of doctor-diagnosed allergies.</p><p><strong>Conclusion: </strong>The in-clinic prevalence of AR in patients with nasal symptoms, as indicated by the SFAR questionnaire, is substantially high in India. A positive family history, indoor dust exposure, nasal symptoms, the months of October to January, and females were strongly linked to AR in Indian patients. The SFAR score is an effective in-clinic screening tool to support early AR diagnosis and management in India.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"1239-1251"},"PeriodicalIF":3.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and Healthcare Cost Characteristics of Severe Asthma Patients with Long-Term Control on Omalizumab: A Comparative Analysis with Patients Who Switched to Other Biologics. 奥玛单抗长期控制的重症哮喘患者的临床和医疗成本特征:与切换到其他生物制剂的患者的比较分析
IF 3 3区 医学
Journal of Asthma and Allergy Pub Date : 2025-09-03 eCollection Date: 2025-01-01 DOI: 10.2147/JAA.S523832
Hironobu Sunadome, Hisako Matsumoto, Tadao Nagasaki, Yusuke Hayashi, Satoru Terada, Kenta Nishi, Natsuko Nomura, Mariko Kogo, Chie Morimoto, Tsuyoshi Oguma, Susumu Sato, Toyohiro Hirai
{"title":"Clinical and Healthcare Cost Characteristics of Severe Asthma Patients with Long-Term Control on Omalizumab: A Comparative Analysis with Patients Who Switched to Other Biologics.","authors":"Hironobu Sunadome, Hisako Matsumoto, Tadao Nagasaki, Yusuke Hayashi, Satoru Terada, Kenta Nishi, Natsuko Nomura, Mariko Kogo, Chie Morimoto, Tsuyoshi Oguma, Susumu Sato, Toyohiro Hirai","doi":"10.2147/JAA.S523832","DOIUrl":"10.2147/JAA.S523832","url":null,"abstract":"<p><strong>Background and purpose: </strong>Biologics are crucial for severe asthma treatment, but their high costs pose challenges. Omalizumab (OML) is dosed on the basis of patient-specific factors. The purpose of this study is to clarify the clinical characteristics of severe asthmatics who maintain long-term control on omalizumab including healthcare cost considerations.</p><p><strong>Patients and methods: </strong>A retrospective, multicenter cohort study was conducted. Patients receiving OML at three institutions were enrolled. Patients continuing OML (C-OML) were compared with those switching to other biologics (S-OML) in terms of clinical background, cost-effectiveness, and type-2 inflammation levels.</p><p><strong>Results: </strong>Forty-seven patients were enrolled. The C-OML group achieved exacerbation control comparable to that of the S-OML group, with a median OML dose of 300 mg/month, resulting in significantly lower personal payments (<i>p</i> < 0.01). Compared with the S-OML group, the C-OML group had a greater prevalence of overweight (<i>p</i> = 0.04), a lower prevalence of eosinophilic chronic rhinosinusitis (<i>p</i> < 0.01), and a trend toward a higher prevalence of allergic rhinitis (<i>p</i> = 0.06). Effective asthma control with OML was associated with nonsevere type-2 inflammation (eosinophils < 300/μL and FeNO < 50 ppb).</p><p><strong>Conclusion: </strong>Patients with nonsevere type-2 inflammation and a high BMI can achieve effective asthma control with OML, reducing treatment costs. Identifying this phenotype can improve the cost-effectiveness of biologic therapies for patients with severe asthma.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"1229-1237"},"PeriodicalIF":3.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12415621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three Biologic-Naïve Patients with Allergic Bronchopulmonary Aspergillosis Showing Significant Clinical Improvement with Tezepelumab. 3例Biologic-Naïve变应性支气管肺曲霉病患者应用Tezepelumab临床疗效显著改善
IF 3 3区 医学
Journal of Asthma and Allergy Pub Date : 2025-08-28 eCollection Date: 2025-01-01 DOI: 10.2147/JAA.S541770
Masafumi Yamaguchi, Akio Yamazaki, Hiroaki Nakagawa, Daisuke Kinose, Yasutaka Nakano
{"title":"Three Biologic-Naïve Patients with Allergic Bronchopulmonary Aspergillosis Showing Significant Clinical Improvement with Tezepelumab.","authors":"Masafumi Yamaguchi, Akio Yamazaki, Hiroaki Nakagawa, Daisuke Kinose, Yasutaka Nakano","doi":"10.2147/JAA.S541770","DOIUrl":"10.2147/JAA.S541770","url":null,"abstract":"<p><p>Allergic bronchopulmonary aspergillosis is characterized by hypersensitivity to <i>Aspergillus</i> spp. and often causes intractable asthma. Studies have been conducted on biologics administered to patients with allergic bronchopulmonary aspergillosis; however, treatment may not always be successful. This may be due to the limitations of the current biologics that selectively target a single cytokine. Tezepelumab, a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin, broadly suppresses type 2 inflammation by regulating the upstream cascade of airway inflammation. Therefore, it is expected to have favorable effects in patients with allergic bronchopulmonary aspergillosis. We report three cases of allergic bronchopulmonary aspergillosis with uncontrolled symptoms despite the maximal use of conventional anti-asthmatic drugs such as inhalative agents, anti-leukotriene receptor antagonists, and antifungal drugs. None of the patients had previously received biologics. The addition of tezepelumab produced a marked clinical response in all three patients, which included fewer exacerbations and a reduced dosage of oral systemic corticosteroids and/or reduced as-needed short-acting beta-2 agonists. The patients' pulmonary symptoms were better controlled, peripheral blood eosinophil counts and immunoglobulin E levels decreased, and quality of life scores and respiratory function parameters improved. Mucous plugs accompanied by atelectasis and infiltrative shadows observed on chest computed tomography also improved. Tezepelumab may be a promising treatment option for allergic bronchopulmonary aspergillosis in patients with severe asthma, offering effective symptom control and enabling reduction in systemic corticosteroid use.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"1221-1227"},"PeriodicalIF":3.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12402420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing Fluticasone Propionate and Ciclesonide pMDI Delivery: The Protective Role of Valved Holding Chambers Against Inhalation Timing Errors. 优化丙酸氟替卡松和环来奈德pMDI输送:带阀保持室对吸入时机错误的保护作用。
IF 3 3区 医学
Journal of Asthma and Allergy Pub Date : 2025-08-27 eCollection Date: 2025-01-01 DOI: 10.2147/JAA.S536404
Leon L Csonka, Lauri Lehtimäki, Péter Csonka
{"title":"Optimizing Fluticasone Propionate and Ciclesonide pMDI Delivery: The Protective Role of Valved Holding Chambers Against Inhalation Timing Errors.","authors":"Leon L Csonka, Lauri Lehtimäki, Péter Csonka","doi":"10.2147/JAA.S536404","DOIUrl":"10.2147/JAA.S536404","url":null,"abstract":"<p><strong>Introduction: </strong>Discoordination between inhalation and pressurized metered-dose inhaler (pMDI) actuation when delivering inhaled corticosteroids (ICS) is a common technique error that can lead to worsened treatment outcomes. Valved holding chambers (VHCs) are thought to improve the delivered dose if inhalation is delayed, but this effect has not been sufficiently quantified.</p><p><strong>Methods: </strong>The aerodynamic particle size distribution of fluticasone propionate (FP) and ciclesonide (CIC) was studied under three conditions: inhalation initiated before actuation without a VHC, inhalation started at actuation without a VHC, and inhalation started at actuation with a VHC. We used a Next Generation Impactor connected to an anatomical adult throat model and a breathing simulator that produced a single, adult-type inhalation.</p><p><strong>Results: </strong>We found that when inhalation was initiated simultaneously with actuation, the effective dose delivered decreased markedly for both FP and CIC compared to when inhalation was begun correctly, ie, before actuation. However, when a VHC was used and inhalation was started at actuation, delivered dose improved substantially for both medications. This protective effect of the VHC was especially pronounced for CIC, with both the fraction of particles in the 1-5 µm range and those under 1 µm returning to the same levels as when inhalation was initiated correctly.</p><p><strong>Discussion: </strong>Although our study was conducted in vitro and did not involve patients, the findings likely have relevance for clinical practice. Therefore, promoting the use of VHCs in both children and adults may be beneficial, but this should be confirmed in clinical studies.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"1211-1219"},"PeriodicalIF":3.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into Local Grass and Weed Pollen Sensitization in Bangkok, Thailand: IgE Reactivity Patterns, Cross-Reactivity, and Putative Allergens. 深入了解当地的草和杂草花粉致敏在曼谷,泰国:IgE反应模式,交叉反应,和假定的过敏原。
IF 3 3区 医学
Journal of Asthma and Allergy Pub Date : 2025-08-21 eCollection Date: 2025-01-01 DOI: 10.2147/JAA.S533633
Sirirat Aud-In, Yotin Juprasong, Pongsakorn Tantilipikorn, Wisuwat Songnuan
{"title":"Insights into Local Grass and Weed Pollen Sensitization in Bangkok, Thailand: IgE Reactivity Patterns, Cross-Reactivity, and Putative Allergens.","authors":"Sirirat Aud-In, Yotin Juprasong, Pongsakorn Tantilipikorn, Wisuwat Songnuan","doi":"10.2147/JAA.S533633","DOIUrl":"10.2147/JAA.S533633","url":null,"abstract":"<p><strong>Background: </strong>Allergic rhinitis (AR) triggered by pollen is a growing global public health concern. This study aimed to: 1) analyze IgE reactivity to grass and weed pollen in Thai AR patients; 2) assess the prevalence and intensity of IgE-reactive protein bands; and 3) investigate cross-reactivity among pollen species.</p><p><strong>Methods: </strong>Sera were collected from Thai adult AR patients in Bangkok, Thailand, and skin prick test (SPT) data were obtained. ELISA assessed IgE reactivity to pollen extracts from four grasses (Bermuda grass, para grass, Johnson grass, Manila grass) and two weeds (nutsedge, careless weed) using 119 patient sera. Immunoblot identified IgE-reactive protein bands using 65 patient sera with positive SPT. Cross-reactivity was confirmed by immunoblot and ELISA inhibition assays.</p><p><strong>Results: </strong>Johnson grass showed the highest ELISA optical density (OD) values. Significant positive correlations <i>(r<sub>s</sub></i> = 0.740 to 0.935, <i>p</i> < 0.0001) in IgE reactivity were observed among pollen species, with stronger correlations among grasses. Immunoblot identified 30 kDa and 63 kDa proteins as major IgE-reactive proteins in grasses, and 25 kDa and 75 kDa proteins in nutsedge. Strong positive correlations were found within grass species for number of bands, ELISA OD, and SPT wheal size. A positive correlation existed between ELISA and SPT results <i>(r<sub>s</sub></i> = 0.27, <i>p</i> = 0.030). Inhibition assays confirmed cross-reactivity among grass and weed species.</p><p><strong>Conclusion: </strong>This study highlights variability in pollen sensitization, cross-reactivity, and potential novel allergens in Thai AR patients. These findings are crucial for enhancing pollen allergy understanding and improving diagnostic and treatment, particularly in tropical/subtropical regions.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"1193-1210"},"PeriodicalIF":3.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12377386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence in the Management of Asthma: A Review of a New Frontier in Patient Care. 人工智能在哮喘管理中的应用:对患者护理新领域的回顾。
IF 3 3区 医学
Journal of Asthma and Allergy Pub Date : 2025-08-16 eCollection Date: 2025-01-01 DOI: 10.2147/JAA.S535264
Laren D Tan, Nolan Nguyen, Enrique Lopez, Daniel Peverini, Mathew Shedd, Abdullah Alismail, H Bryant Nguyen
{"title":"Artificial Intelligence in the Management of Asthma: A Review of a New Frontier in Patient Care.","authors":"Laren D Tan, Nolan Nguyen, Enrique Lopez, Daniel Peverini, Mathew Shedd, Abdullah Alismail, H Bryant Nguyen","doi":"10.2147/JAA.S535264","DOIUrl":"10.2147/JAA.S535264","url":null,"abstract":"<p><p>Asthma, a chronic respiratory condition, impacts over 339 million individuals globally, including 25 million in the United States, contributing to significant morbidity and healthcare costs. Despite advances, challenges persist in managing exacerbations, ensuring medication adherence, and patient education. This narrative review explores the transformative potential of artificial intelligence (AI) in improving asthma management through predictive analytics, personalized treatment, and continuous patient engagement. A search of the United States National Library of Medicine's PubMed database was performed for articles pertaining to asthma and artificial intelligence, machine learning (ML), neural network, or deep learning. The current research on AI applications in asthma care was then reviewed, including algorithms, AI-driven tools for personalized medicine, and digital platforms for patient engagement. Case studies and clinical trials assessing AI's impact on predictive accuracy and treatment adherence were reviewed. AI, particularly ML, enhances asthma management by analyzing data from wearables and patient records to predict exacerbations, stratify risk, and inform personalized treatment. Studies demonstrate AI's capability to recommend tailored interventions, monitor adherence through smart applications, and facilitate real-time treatment adjustments. Ethical challenges include ensuring patient trust, data security, and equitable technology access. In conclusion, AI's integration in asthma care holds significant promise for predictive interventions, personalized regimens, and continuous support, ultimately aiming to improve patient outcomes and reduce healthcare burdens. Continued advancements in AI will bridge current care gaps, fostering a patient-centric, proactive approach in asthma management.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"1179-1191"},"PeriodicalIF":3.0,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive Value of Computed Tomographic Ethmoid-to-Maxillary Ratio in Patients with Chronic Rhinosinusitis and Nasal Polyp. ct筛颌比对慢性鼻窦炎和鼻息肉的预测价值。
IF 3 3区 医学
Journal of Asthma and Allergy Pub Date : 2025-08-12 eCollection Date: 2025-01-01 DOI: 10.2147/JAA.S536368
Pei-Wen Wu, Zih-Hao Wei, Chi-Che Huang, Po-Hung Chang, Ta-Jen Lee, Chien-Chia Huang
{"title":"Predictive Value of Computed Tomographic Ethmoid-to-Maxillary Ratio in Patients with Chronic Rhinosinusitis and Nasal Polyp.","authors":"Pei-Wen Wu, Zih-Hao Wei, Chi-Che Huang, Po-Hung Chang, Ta-Jen Lee, Chien-Chia Huang","doi":"10.2147/JAA.S536368","DOIUrl":"10.2147/JAA.S536368","url":null,"abstract":"<p><strong>Objective: </strong>Different types of inflammation in the sinuses require different treatments. Ethmoid dominance was proposed as an indicator on computed tomography (CT) images for type 2 chronic rhinosinusitis with nasal polyp (CRSwNP). This study evaluated the predictive value of the ethmoid-to-maxillary (E/M) ratio based on different CT scoring systems in type 2 CRSwNP.</p><p><strong>Methods: </strong>Adult patients with bilateral CRSwNP planning to undergo sinus surgery were prospectively recruited. CT images were evaluated using the Lund-Mackay (L-M) and Zinreich scoring systems which involved a more meticulous quantification of opacification on CT images. Tissue eosinophil count (TEC) was determined by histopathological analysis. The expression levels of type 2 cytokines in nasal polyps, including IL-5, IL-13, and eosinophil cationic protein (ECP), were measured using real-time PCR.</p><p><strong>Results: </strong>A total of 174 participants were enrolled. Eighty of these participants exhibited an E/M ratio >1, 49 presented with E/M ratio=1, and 45 showed an E/M ratio <1 based on L-M CT scores. Twenty of the 49 (40.8%) patients with E/M ratio=1 on L-M score turned to E/M ratio >1 after re-evaluation by Zinreich scoring system. The E/M ratio based on the L-M and Zinreich scoring systems both exhibited correlation with the tissue markers of type 2 inflammation, including TEC, interleukin (IL)-5, IL-13, and ECP expression levels, although the Zinreich E/M ratio showed a higher correlation coefficient.</p><p><strong>Conclusion: </strong>The E/M ratio based on the L-M and Zinreich scoring systems correlated with tissue markers of type 2 inflammation. A scale with an E/M ratio of 1 in the L-M system should be further investigated using a more detailed scoring system to determine the presence of an ethmoid-dominant shadow. This could help clinicians better evaluate CT images to determine the severity of type 2 inflammation in patients with CRSwNP and provide optimal therapeutic strategies.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"1167-1177"},"PeriodicalIF":3.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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