Journal of Asthma and Allergy最新文献

{"title":"Forecasting Hospitalization for Adult Asthma Patients in Emergency Departments Based on Multiple Environmental and Clinical Factors.","authors":"Hanxu Xi, Yudi Zhang, Rui Zuo, Wei Li, Chen Zhang, Yongchang Sun, Hong Ji, Zhiqiang He, Chun Chang","doi":"10.2147/JAA.S512405","DOIUrl":"10.2147/JAA.S512405","url":null,"abstract":"<p><strong>Background: </strong>Asthma is the world's second most prevalent chronic respiratory disease. Current clinical decisions regarding hospitalization for adult asthma patients in emergency departments (EDs) primarily rely on presenting clinical status, acute exacerbation severity, therapeutic response and high-risk factors. Assessing the need for hospitalization of patients with complex comorbidities remains a significant challenge.</p><p><strong>Research question: </strong>This study aims to develop models that integrate various environmental and clinical factors to predict the hospitalization of adult asthma patients in EDs and to interpret these models.</p><p><strong>Study design and methods: </strong>A retrospective analysis was conducted utilizing data from asthma patients at a single ED from 2016 to 2023; the data included demographics, vital signs, illness severity, laboratory test results, and comorbidities, along with environmental variables. Predictive models were constructed using the extreme gradient boosting (XGBoost), light gradient boosting machine (LightGBM), support vector machine (SVM), logistic regression (LR), and random forest (RF). Area under the receiver operating characteristic curve (AUC), accuracy, and F1 score were the primary metrics used to assess model performance.</p><p><strong>Results: </strong>The analysis included 1140 ED visits. The median age was 51.0 years (interquartile range: 31.0 to 67.0 years), and 56.5% of the patients (644) were female. Overall, 21.8% of patients (249) required hospitalization after their ED visits. The AUC results for predicting hospitalization without external environmental factors were 0.8075 for XGBoost, 0.8233 for LightGBM, 0.7935 for SVM, 0.8033 for LR, and 0.8272 for RF. After integrating ambient air pollutant and meteorological features, the RF model consistently outperformed the other models, achieving an AUC of 0.8555. The most critical parameters for predicting hospitalization were found to be illness severity, oxygen saturation, age, and heart rate.</p><p><strong>Interpretation: </strong>Machine learning (ML) models based on clinical, meteorological, and air pollution data can rapidly and accurately predict hospitalization of adult asthma patients in EDs.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"861-876"},"PeriodicalIF":3.7,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric Analysis on the Central Regulation of Airway Allergic Hyperreactivity Diseases Based on Bibliometric Analysis: From Lung-Brain Axis to Nasal-Brain Axis.","authors":"Xiaoxi Shi, Xiaojia Zhu, Haoxiang Zhang, Yanjie Wang, Xueping Qi, Fengli Cheng, Danni Xu, Luyao Wang, Hongying Duan, Changqing Zhao","doi":"10.2147/JAA.S509434","DOIUrl":"10.2147/JAA.S509434","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to systematically analyze the neuro-regulation mechanisms of airway hyperreactivity disease using bibliometrics, focusing on the research status and progress of two key regulatory networks: the \"lung-brain axis\" and the \"nasal-brain axis\", to further characterize the \"nasal-brain axis\".</p><p><strong>Methods: </strong>A bibliometric analysis of 626 articles published between 1991 and 2024 was conducted to assess the growing interest in the impact of neuro-immune mechanisms and psychological stress on airway diseases, including asthma and allergic rhinitis (AR).</p><p><strong>Results: </strong>The study findings revealed that interactions between neuro-immune signaling pathways and the central nervous system are crucial for understanding airway hyperreactivity, with the United States leading research contributions. Key themes identified in this study include allergic asthma, neuroinflammation, and the lung-brain axis, revealing bidirectional communication pathways between peripheral and central immune responses.</p><p><strong>Conclusion: </strong>Based on studies of asthma and the lung-brain axis, we anticipate that AR and the nasal-brain axis likely involve similar neuro-immune mechanisms and peripheral-central response circuits. The nasal-brain axis theory was further supported by its integration with the unified airway hypothesis, solidifying its role as a crucial regulatory mechanism in airway inflammation research.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"877-890"},"PeriodicalIF":3.7,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of Pollen Concentration Changes in Xi'an and Their Correlation with Allergy-Related Diseases.","authors":"Qirui Zhan, Hui Lyu, Zhen He, Xueyan Zhang, Chenchen Wang, Yuanqi Gao, Qingyuan Guo, Nan Zhang, Cong Liu, Yu Shi, Yu Lei, Bingjie Xu, Yanni Mi, Tianxi Gao, Kang Zhu, Xiaoyong Ren, Yuhui Ouyang, Jingguo Chen","doi":"10.2147/JAA.S525694","DOIUrl":"10.2147/JAA.S525694","url":null,"abstract":"<p><strong>Objective: </strong>Airborne pollen is a major contributor to allergic diseases. This study investigates the correlation between airborne pollen dynamics and allergic rhinitis (AR) incidence in Xi'an (2020-2023) and compared with 1984 data for informing evidence-based prevention strategies.</p><p><strong>Methods: </strong>The species and concentration of daily pollen in Xi'an were monitored for 4 consecutive years (2020-2023). Daily pollen concentrations were analyzed alongside clinical AR records from the Second Affiliated Hospital of Xi'an Jiaotong University and public health awareness metrics (Baidu search indices for \"allergic rhinitis\", \"pollen allergy\", and \"loratadine\").</p><p><strong>Results: </strong>The pollen season in Xi'an occurred from March to May and from August to October, with higher concentrations in spring. Compared to the 1984 data, pollen counts increased significantly (+121.9%, P>0.05). Correlation analysis revealed a positive relationship between pollen concentration and the number of AR patients during the autumn pollen season from 2020 to 2022 (r=0.307~0.636, <i>P</i><0.05). \"Pollen allergy\" search index correlated positively lwith pollen concentration over the four-year autumn period (r=0.512~0.750, <i>P</i><0.001), while trends for \"allergic rhinitis\" and \"loratadine\" search indices were less consistent, showing positive correlation only in the autumn pollen season. The public perception of sensitized pollen species in Xi'an did not match the actual AR-related pollen species.</p><p><strong>Conclusion: </strong>Pollen counts increased significantly in Xi'an, whereas pollen species diversity decreased in the last 40 years. Our results showed the 40-year characteristics comparison of pollen concentration in Xi'an can serve as a basis for developing effective preventive and management measures for patients with pollen-related allergies, including environmental control, timely pollen monitoring, desensitization therapy, and patient health education, to guide the scientific control and prevention of pollen-induced allergic diseases. This study underscores the need for integrated environmental and public health strategies to mitigate pollen-induced AR in rapidly urbanizing regions.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"847-859"},"PeriodicalIF":3.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Activity and Sedentary Time Correlate with Body Composition in Patients with Asthma; a Multicenter Observational Study.","authors":"Mayuka Yamane, Hiroshi Iwamoto, Kazuma Kawamoto, Toshihito Otani, Naoko Higaki, Keita Murakawa, Ayumi Fukatsu-Chikumoto, Tsunahiko Hirano, Yoshihiro Amano, Takeshi Isobe, Kazuto Matsunaga, Noboru Hattori, Akihito Yokoyama","doi":"10.2147/JAA.S514541","DOIUrl":"10.2147/JAA.S514541","url":null,"abstract":"<p><strong>Background: </strong>Increasing physical activity is recommended as a non-pharmacological approach for improving the symptoms, quality of life, and overall health in patients with asthma. However, the systemic effect of physical activity, especially sedentary behavior, in patients with asthma remains unclear.</p><p><strong>Objective: </strong>The aim of this study was to investigate the association of objectively measured physical activity, including sedentary time, with body composition data and clinical characteristics in patients with asthma.</p><p><strong>Methods: </strong>The study included 85 patients with asthma and 38 healthy controls. Physical activity indices were assessed for 2 weeks using accelerometers. We investigated the relationship between physical activity levels and clinical characteristics, along with its association with body composition data assessed using dual-energy X-ray absorptiometry and computed tomography in patients with asthma.</p><p><strong>Results: </strong>In patients with asthma, high blood eosinophil counts and poor asthma control, as assessed by the Asthma Control Questionnaire score, were associated with prolonged sedentary time and reduced step count. Moreover, reduced step count was independently associated with an elevated fat mass index, whereas a prolonged sedentary time and high oral corticosteroid doses were independently associated with a low lean mass index in patients with asthma. Prolonged sedentary time demonstrated a negative correlation with erector spinae muscle area after adjusting for background factors.</p><p><strong>Conclusion: </strong>Sedentary behavior and physical inactivity are associated with body composition in patients with asthma, suggesting the need for interventions targeting these behaviors to improve health outcomes.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"835-846"},"PeriodicalIF":3.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CARE: Combination of Acetylcysteine and Acebrophylline in Moderate to Severe Asthma and COPD Patients.","authors":"Raja Dhar, Rakesh K Chawla, Moumita Rahaman, Aditya K Chawla, Gaurav Chaudhary, Ashutosh Gautam, Rajat Singal","doi":"10.2147/JAA.S513358","DOIUrl":"10.2147/JAA.S513358","url":null,"abstract":"<p><strong>Objective: </strong>To assess the efficacy and safety of the combination of N-acetylcysteine and acebrophylline (Combination named Abiways), in patients with moderate to severe COPD and Asthma.</p><p><strong>Materials and methods: </strong>In this non-randomized, interventional, prospective, single-arm, post-marketing surveillance study, participants were administered Abiways as an add-on therapy for 90 days. The primary endpoint was Quality of Life, evaluated using the COPD Assessment Test (CAT) and Asthma Control Test (ACT) questionnaires. Secondary endpoints included mean FEV1 and FVC changes. Adverse events were recorded throughout the study.</p><p><strong>Results: </strong>97 (of 102 subjects enrolled) completed the study (76 COPD and 21 Asthma patients, respectively; mean age 57.9 ± 8.1 years; 33 females, 64 males). Overall, FEV1 improved significantly from 1.287L to 1.484L (p < 0.001) with similar statistical improvements in COPD (1.237 L to 1.414 L; p = 001) and asthma (1.477 L to 1.747 L; p = 0.004) subpopulations. COPD patients showed statistically significant improvements in CAT scores (17.2 ± 1.0 to 10.6 ± 0.9, p = 0.0001); however, such significance was not observed in the ACT scores for asthma patients. FVC remained unchanged in all subgroups. No severe adverse events were reported.</p><p><strong>Conclusion: </strong>The combination of N-acetylcysteine and acebrophylline improves QoL in moderate to severe COPD patients and FEV1 in both COPD and asthma patients with a favorable safety and tolerability profile. The combination appears safe and effective for managing obstructive airway disease.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"827-834"},"PeriodicalIF":3.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Benralizumab in Reducing FeNO in Severe Eosinophilic Asthma: The Role of CRSwNP.","authors":"Juan Luis Garcia-Rivero, Beatriz Abascal-Bolado, Nieves Aranda Sobrino, Cristina Ghadban Garrido","doi":"10.2147/JAA.S506835","DOIUrl":"10.2147/JAA.S506835","url":null,"abstract":"<p><strong>Background: </strong>Benralizumab, targeting the IL-5 receptor, reduces exacerbations and improves lung function in severe eosinophilic asthma. Data on its effect on fractional exhaled nitric oxide (FeNO), particularly in patients with and without chronic rhinosinusitis with nasal polyps (CRSwNP), are limited.</p><p><strong>Objective: </strong>This study evaluates benralizumab's impact on FeNO levels in severe eosinophilic asthma, focusing on the presence of CRSwNP.</p><p><strong>Methods: </strong>We retrospectively analyzed 43 patients with severe eosinophilic asthma treated with benralizumab. Patients were divided into CRSwNP (N=13) and non-CRSwNP (N=30) groups. Baseline characteristics, FeNO levels, FEV1, FVC, ACT scores, exacerbations, and oral corticosteroid (OCS) use were recorded at baseline, 3, 6, and 12 months.</p><p><strong>Results: </strong>At baseline, FeNO levels were higher in CRSwNP patients than in non-CRSwNP (82.80 ppb vs 41.86 ppb, P = 0.019). Over 12 months, FeNO significantly decreased in CRSwNP patients (-29.69 ppb, P = 0.036) and remained stable in non-CRSwNP patients (+3.55 ppb, P = 0.036). Significant improvements were observed in FEV1 (0.59L vs 0.38L, P = 0.017) and ACT scores (6.46 vs 4.01, P < 0.001) in CRSwNP patients. Both groups showed a notable reduction in exacerbations, which was more pronounced in CRSwNP patients (-3.12 vs -3.60, P < 0.001). OCS withdrawal was achieved in 53.8% of CRSwNP patients and 43.3% of non-CRSwNP patients.</p><p><strong>Conclusion: </strong>Benralizumab reduces FeNO levels and improves clinical outcomes in severe eosinophilic asthma, especially in patients with CRSwNP. Monitoring FeNO levels provides additional insights into treatment response, highlighting its potential role as a marker in specific patient subgroups.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"817-826"},"PeriodicalIF":3.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NOD2-NLRP3 Axis and Asthma.","authors":"Xulong Cai","doi":"10.2147/JAA.S526788","DOIUrl":"10.2147/JAA.S526788","url":null,"abstract":"<p><p>Patients with asthma frequently experience recurrent symptoms including coughing, wheezing, shortness of breath, and chest tightness. Asthma is a common public health concern. It is characterized by chronic airway inflammation. However, The pathogenesis of asthma is complex. Inflammasomes are signaling platforms that regulate the inflammatory response. There is a correlation between inflammasomes and asthma. Pattern recognition receptors recognize danger signals and participate in inflammasome activation. Nucleotide-binding and oligomerization domain-containing 2 (NOD2), a pattern recognition receptor, senses microbial components and triggers immune responses. There have been studies showing a correlation between NOD2 and asthma. The nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) participates in the formation of inflammasomes. NLRP3 are involved in asthma pathogenesis. In this review, we discuss the roles of NOD2 and NLRP3 in the pathogenesis of asthma.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"769-777"},"PeriodicalIF":3.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture's Immunomodulatory Effects on Macrophages in Allergic Disorders: A Systematic Review.","authors":"Yang Qu, Yunhe Gu, Xiaoying Zhang, Yanlong Wang, Xueliang Xing","doi":"10.2147/JAA.S516732","DOIUrl":"10.2147/JAA.S516732","url":null,"abstract":"<p><p>The incidence of allergic diseases has been increasing annually, severely affecting the quality of life of patients. With the growing recognition of traditional medicine, acupuncture, an ancient Chinese therapeutic method, has gradually gained attention for its potential in immune modulation. Studies have shown that macrophages play a crucial role in the development of allergic diseases, and acupuncture may influence allergic reactions by modulating the function of macrophages. This article aims to systematically evaluate the regulatory effects of acupuncture on macrophages in allergic diseases and the corresponding mechanisms. It analyzes existing research findings and explores the clinical application prospects of acupuncture in this context. By understanding how acupuncture affects the activation, secretion, and role of macrophages in immune responses, we hope to provide new insights and directions for the treatment of allergic diseases.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"801-815"},"PeriodicalIF":3.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Biologics in the Treatment of Asthma in the Past Two Decades: A Bibliometric Analysis and Beyond.","authors":"Zicong Zhou, Xiaoying Chen, Shixiu Liang, Jing Li, Nanshan Zhong, Ruchong Chen","doi":"10.2147/JAA.S514250","DOIUrl":"10.2147/JAA.S514250","url":null,"abstract":"<p><p>This study aims to demonstrate the bibliometric characteristics of articles on biologics for asthma treatment over the past two decades. There were 3395 articles published in 653 journals from 91 countries/regions from January 1, 2000 to September 30, 2023. The results showed biologics changes the course of asthma has attracted the interest of researchers and asthma remission has recently been proposed by researchers. Therefore, the goal of T2-high asthma management was shifted from controlling to complete remission. There was also growing interest among researchers in alleviating symptoms in T2-low asthma. New biological targets also need to be discovered when patients do not achieve satisfactory therapeutic outcomes with biologic agent, and one of the potential future direction for a treatment breakthrough lies in the combination of two biologics or the utilization of novel biologics that target dual sites. The development of biologics has progressed rapidly and has demonstrated their effectiveness in clinic, however, biologics still face multifaceted challenges and require further research to identify additional targets or enhance efficacy.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"779-793"},"PeriodicalIF":3.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Non-Response to Biologic Treatment in Patients with Severe Asthma.","authors":"Hassan Mobayed, Maryam Al-Nesf, Tayseer Ibrahim, Sami Aqel, Mona Al-Ahmad, Jean Bousquet","doi":"10.2147/JAA.S517784","DOIUrl":"10.2147/JAA.S517784","url":null,"abstract":"<p><p>Biologic therapies have revolutionized the management of severe asthma (SA), offering significant symptom control and reduced exacerbations for many patients. However, up to 25% of individuals do not show satisfactory responses to these treatments and are categorized as non-responders. Definitions of response and primary non-response to biologics in SA are well-established. In secondary nonresponse, patients show initial response to biological treatment in the first 6-12 months but later lose asthma control, and in SA this phenomenon remains undefined and unstudied in literature. We present 4 cases of severe asthma treated with different biologic agents. All patients demonstrated significant clinical improvement during the first 12 months of therapy but followed by a gradual loss of asthma control, indicative of secondary nonresponse. We discuss the clinical features, potential mechanisms, and implications of secondary nonresponse to biologics in severe asthma, highlighting an unmet need for further research to define this phenomenon and guide future therapeutic strategies.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"795-800"},"PeriodicalIF":3.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}