Journal of Asthma and Allergy最新文献

{"title":"Associations of Protein Classes With Cross-Reactivity and Cross-Sensitization in Furry Animal Allergens: A Component-Resolved Diagnostics Study.","authors":"Jiancai Lu, Huiqing Zhu, Qingqing Yang, Yunjian Xu, Zhifeng Huang, Baoqing Sun","doi":"10.2147/JAA.S505066","DOIUrl":"10.2147/JAA.S505066","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the molecular sensitization patterns of cats, dogs, and horses in patients with cat and/or dog sensitization and the IgE cross-reactivity with other furry animals.</p><p><strong>Methods: </strong>In 95 patients diagnosed with allergic diseases and sensitized to cats and/or dogs (confirmed by specific Immunoglobulin E (sIgE) ≥ 0.35 kU_A/L to crude cat and/or dog dander extracts), sIgE levels of cat components (Fel d 1/2/4), dog components (Can f 1/2/3/5), horse dander (Equ c 1), as well as allergens from cow, guinea pig, mouse, rat, rabbit, and chicken, were measured. Sensitization profiles and cross-reactivity were analyzed. Inhibition tests using serum albumin (SA) and lipocalin proteins were performed.</p><p><strong>Results: </strong>Sensitization rates of crude extracts from other furry animals ranged from 16.8% to 49.5%. A strong positive correlation between cat and dog serum albumin (Fel d 2 and Can f 3) and rabbit epithelium, mouse epithelium, guinea pig epithelium and rat epithelium (rs: 0.66-0.87, all P < 0.05), while the lipocalin family (Fel d 4, Can f 1, Can f 2 and Equ c 1) only had a low to moderate correlation with the epithelial allergens of the above four animals (rs: 0.36-0.65, all P < 0.05). Simultaneous sensitization to SA and these four furry animal allergens accounted for 42.4%. sIgE levels of furry animal extracts were significantly higher in SA-positive groups (all P < 0.05) The results of the inhibition test showed that Fel d 2 and Can f 3 had high inhibition rates of four epithelial allergens, ranging from 66.5% to 91.8% and 75.8% to 91.9%, respectively. When lipocalin family components were used as inhibitors, the sIgE inhibition rates of these furry animal extracts were almost all lower than 50%.</p><p><strong>Conclusion: </strong>SA is the primary driver of cross-sensitization between cats, dogs, and other furry animals, rather than lipocalins.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"363-375"},"PeriodicalIF":3.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Airway Microbiota Profiles in Children With and Without Asthma: A Comparative Study.","authors":"Aisha Alamri, Meshal Alhassan, Abdullah K Almutairi, Nithya Jayaseeli, Rebecca P Berg, Christen Rune Stensvold, Lee O'Brien Andersen, Henrik Vedel Nielsen, Suzan A AlKhater","doi":"10.2147/JAA.S498803","DOIUrl":"10.2147/JAA.S498803","url":null,"abstract":"<p><strong>Background: </strong>Asthma is a common chronic respiratory disease that affects children and adults and can have a serious impact on their quality of life. Factors contributing to the development of asthma and related exacerbations are multifactorial, with microbial communities colonizing the airways possibly playing a key role.</p><p><strong>Methods: </strong>The study included asthmatic (79) and healthy children (57) aged 5-16 years. Nasal and throat swabs were collected, and bacterial (16s rRNA) and fungal (18s rRNA) amplicon sequence analysis was performed. Diversity indices and the most abundant microbial genera were estimated accordingly.</p><p><strong>Results: </strong>At the level of the bacteriome in the nasal samples, the asthma group had significantly lower diversity than the control group (p = 0.02). However, the microbiota of the asthma cohort was more evenly distributed, and <i>staphylococci</i> were enriched in the control group. Throat samples collected from the asthma cohort revealed significantly lower diversity (p < 0.0001), with a significant difference in species composition between the two groups (p = 0.005). Enriched bacterial species were different within the asthma subgroups (controlled vs uncontrolled asthma). The fungal microbiome of the nasal and throat samples showed no difference in species richness between the two groups, however, a significant difference in beta diversity (species composition) was detected. The nasal samples from the control group were enriched with <i>Malassezia</i> species, while the asthma cases were enriched with <i>Mucor</i> species. On the other hand, throat specimens of the asthma group were found to be enriched with <i>Candida</i> and <i>Saccharomyces.</i></p><p><strong>Conclusion: </strong>Our findings suggest that asthmatic samples were less diverse than the control samples with certain microbial genera enriching some study groups. Addressing the biomarkers that influence the progression of asthma could lead to improved care for children suffering from severe asthmatic episodes, possibly by including targeted therapies and prevention strategies.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"349-361"},"PeriodicalIF":3.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Ubiquitin-Proteasome System (UPS) in Asthma Pathology.","authors":"Shuzhou Deng, Le Ding, Yisong Qian, Xuan Huang","doi":"10.2147/JAA.S490039","DOIUrl":"10.2147/JAA.S490039","url":null,"abstract":"<p><p>Asthma represents a major global health concern, underscoring an imperative for further exploration into its pathogenesis to inform the development of more effective treatment strategies. As a key mechanism for intracellular protein degradation and regulation, the ubiquitin-proteasome system (UPS) plays a crucial but complex and multifaceted role in the pathological process of asthma. This study systematically reviews the functions and mechanisms of E3 ubiquitin ligases and deubiquitinases within the UPS in asthma. The study explores the impact of these mechanisms on the occurrence of inflammation and the alteration of airway hyperresponsiveness by regulating the synthesis and release of inflammatory factors, as well as the proliferation or differentiation of key inflammatory cells. A comprehensive understanding of the pathological mechanism of UPS in asthma will help to provide new theoretical basis and potential drug targets for the precision treatment, which holds great promise for the treatment of asthma in the future.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"307-330"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucagon-Like Peptide 1 Receptor (<i>Glp1r</i>) Deficiency Does Not Appreciably Alter Airway Inflammation or Gut-Lung Microbiome Axis in a Mouse Model of Obese Allergic Airways Disease and Bariatric Surgery.","authors":"Yeon Ji Kim, Victoria M Ihrie, Pixu Shi, Mark D Ihrie, Jack T Womble, Anna Hill Meares, Joshua A Granek, Claudia K Gunsch, Jennifer L Ingram","doi":"10.2147/JAA.S478329","DOIUrl":"10.2147/JAA.S478329","url":null,"abstract":"<p><strong>Purpose: </strong>High body mass index (≥30 kg/m²) is associated with asthma severity, and nearly 40% of asthma patients exhibit obesity. Furthermore, over 40% of patients with obesity and asthma that receive bariatric surgery no longer require asthma medication. Increased levels of glucagon-like peptide 1 (GLP-1) occur after bariatric surgery, and recent studies suggest that GLP-1 receptor (GLP-1R) signaling may regulate the gut microbiome and have anti-inflammatory properties in the lung. Thus, we hypothesized that increased GLP-1R signaling following metabolic surgery in obese and allergen-challenged mice leads to gut/lung microbiome alterations, which together contribute to improved features of allergic airways disease.</p><p><strong>Methods: </strong>Male and female <i>Glp1r</i>-deficient (<i>Glp1r^-/-</i> ) and replete (<i>Glp1r^+/+)</i> mice were administered high fat diet (HFD) to induce obesity with simultaneous intranasal challenge with house dust mite (HDM) allergen to model allergic airway disease with appropriate controls. Mice on HFD received either no surgery, sham surgery, or vertical sleeve gastrectomy (VSG) on week 10 and were sacrificed on week 13. Data were collected with regard to fecal and lung tissue microbiome, lung histology, metabolic markers, and respiratory inflammation.</p><p><strong>Results: </strong>HFD led to metabolic imbalance characterized by lower GLP-1 and higher leptin levels, increased glucose intolerance, and alterations in gut microbiome composition. Prevalence of bacteria associated with short chain fatty acid (SCFA) production, namely <i>Bifidobacterium, Lachnospiraceae UCG-001</i>, and <i>Parasutterella</i>, was reduced in mice fed HFD and positively associated with serum GLP-1 levels. Intranasal HDM exposure induced airway inflammation. While <i>Glp1r^-/-</i> genotype affected fecal microbiome beta diversity metrics, its effect was limited.</p><p><strong>Conclusion: </strong>Herein, GLP-1R deficiency had surprisingly little effect on host gut and lung microbiomes and health, despite recent studies suggesting that GLP-1 receptor agonists are protective against lung inflammation.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"285-305"},"PeriodicalIF":3.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Asthma With Bronchial Hypersecretion: Expression of Mucins and Toll-Like Receptors in Sputum and Blood [Corrigendum].","authors":"","doi":"10.2147/JAA.S523941","DOIUrl":"https://doi.org/10.2147/JAA.S523941","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2147/JAA.S142200.].</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"283-284"},"PeriodicalIF":3.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Gut Microbiome Alterations in Children With Allergic Rhinitis: Associations With Allergen-Specific IgE Levels and Sensitization Patterns.","authors":"Junyang Li, Yanan Shi, Lanye Hu, Wenjun He, Youjin Li","doi":"10.2147/JAA.S496477","DOIUrl":"10.2147/JAA.S496477","url":null,"abstract":"<p><strong>Background: </strong>The relationship between gut microbiota composition and allergen exposure in children with allergic rhinitis (AR) remains insufficiently explored, particularly concerning variations in gut microbiota at different allergen-specific IgE (sIgE) levels and the distinction between monosensitization and polysensitization to allergens.</p><p><strong>Methods: </strong>We employed metagenomic shotgun sequencing to compare the fecal microbiota of 50 healthy controls (HC) to 88 children with AR induced by house dust mites (HDM-AR). We further examined differences in gut microbiota among HDM-AR subgroups with extremely high house dust mite-sIgE (EH-HDM), high HDM-sIgE (H-HDM), as well as between monosensitized (mono-HDM) and polysensitized (poly-HDM) individuals.</p><p><strong>Results: </strong>While no significant differences in overall gut microbiome diversity were observed between the HC and HDM-AR groups, a notable increase in the relative abundance of <i>Streptococcus sanguinis</i> within the genus was identified in children with AR. Further analysis revealed a significant enrichment of the <i>Streptococcus</i> genus in the EH-HDM group, particularly highlighting an increased relative abundance of the <i>Streptococcus salivarius</i>. Functional gene analysis via KEGG pathways indicated substantial enrichment in the salivary secretion pathway. Additionally, in comparisons among the HC, mono-HDM, and poly-HDM groups, <i>Streptococcus salivarius</i> emerged as the key differential species, showing a marked increase in the mono-HDM group.</p><p><strong>Conclusion: </strong>Our study suggests that specific bacterial strains, particularly <i>Streptococcus salivarius</i>, may be potential biomarkers for assessing varying degrees and patterns of HDM sensitization. These findings open the avenues for developing targeted interventions aimed at mitigating the pathophysiology of AR.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"269-281"},"PeriodicalIF":3.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Eosinophil Count in Asthma Is Associated With Increased Abdominal Aortic Diameter and Increased Vascular Stiffness.","authors":"Leonie Biener, Andrea Budimovska, Dirk Skowasch, Carmen Pizarro, Ben Christoph Frisch, Georg Nickenig, Max Jonathan Stumpf, Christian A Schaefer, Nadjib Schahab","doi":"10.2147/JAA.S483504","DOIUrl":"10.2147/JAA.S483504","url":null,"abstract":"<p><strong>Background: </strong>Asthma is associated with atherosclerosis and abdominal aortic aneurysm (AAA). However, the underlying pathomechanisms remain elusive. Blood eosinophil count (BEC) is implicated in both eosinophilic asthma and arterial wall inflammation.</p><p><strong>Objective: </strong>To explore the possible association of BEC in asthma and abdominal aortic artery changes.</p><p><strong>Methods: </strong>112 outpatients were prospectively enrolled in this exploratory study. Abdominal aortic diameter was measured using ultrasonography imaging, while vascular speckle tracking was utilized to evaluate vascular strains. Patients were stratified into two groups, with n=66 patients with a BEC of ≥300 n/µL and n=46 patients with <300 n/µL. Both groups exhibited no significant disparities in cardiovascular risk factors; however, the high BEC group was more frequently male.</p><p><strong>Results: </strong>The aortic diameter was wider in patients with a BEC ≥300 n/µL (1.46 ± 0.25 cm vs 1.67 ± 0.63 cm, p=0.018). Three patients were diagnosed with an AAA, all had a BEC ≥300 n/µL. Patients with a BEC ≥300 n/µL exhibited lower strain values, indicative of higher vascular stiffness, including radial strain (2.65 ± 1.38% vs 4.46 ± 2.59%; p<0.001). BEC exhibited a positive correlation with abdominal aortic diameter (R²=0.131, b=0.000, p<0.001), and a negative correlation with radial strain values (R²=0.131, b=-0.002, p=0.001) in sex-adjusted linear regression.</p><p><strong>Conclusion: </strong>In patients with asthma, blood eosinophil count (BEC) is correlated with a wider aortic diameter and heightened vascular stiffness in the abdominal aorta. Hence, they may be at an elevated risk of developing an AAA.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"245-255"},"PeriodicalIF":3.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative Therapeutic Strategies for Asthma: The Role of Gut Microbiome in Airway Immunity.","authors":"Yaqin Liu, Junjie Dai, Guibao Zhou, Rongchang Chen, Chengwen Bai, Fei Shi","doi":"10.2147/JAA.S504571","DOIUrl":"10.2147/JAA.S504571","url":null,"abstract":"<p><p>There is a growing acknowledgment of the gut microbiome's impact on widespread immune responses, which holds considerable importance for comprehending and addressing asthma. Recent research has clarified the complex interactions between gut microbiota and airway immune systems, demonstrating that microbial diversity and composition can affect both the initiation and advancement of asthma. Gut microbial species and metabolites primarily short-chain fatty acids (SCFAs) may either worsen or reduce airway inflammation by regulating the balance of helper T cell 1 (Th1) / helper T cell 2 (Th2) and other immune mediators. This interaction presents innovative therapeutic possibilities, including modulation of gut microbiome during early life through breastfeeding and control of antibiotic use, particularly with prebiotics, which could selectively stimulate the growth of beneficial bacteria, promote immune maturation, reducing susceptibility to asthma and allergic airway inflammation. Besides, investigating the gut-lung axis reveals new opportunities for personalized medicine in asthma treatment, emphasizing the necessity for integrated strategies that take individual microbiome profiles into account. This paper examines the latest developments in comprehending the mechanisms by which gut microbiota affect airway inflammation and hypersensitivity, especially focusing on treatment strategies.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"257-267"},"PeriodicalIF":3.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air Pollution and Childhood Asthma Hospitalizations in Chengdu, China: A Time-Series Study.","authors":"Zijin Chen, Lei Zhang, Tao Ai, Yinghong Fan, Yanru Liu, Li Wang, Cheng Xie","doi":"10.2147/JAA.S498234","DOIUrl":"10.2147/JAA.S498234","url":null,"abstract":"<p><strong>Purpose: </strong>Research on the relationship between air pollutants and hospitalization for asthma in children in developing countries remains inadequate. This study aimed to assess the short-term effects of air pollutants, including sulfur dioxide (SO₂), nitrogen dioxide (NO₂), carbon monoxide (CO), ozone (O₃), particulate matter ≤ 2.5 µm (PM_2.5), and particulate matter ≤ 10 µm (PM₁₀), on children hospitalized for asthma in Chengdu, China, from 2017-2022.</p><p><strong>Patients and methods: </strong>During the study period, 5592 children were hospitalized for asthma. A generalized additive model was used to control for seasonality, long-term trends, weather, day of the week, and holidays. The analysis was further stratified by age, sex, and season to estimate the associations.</p><p><strong>Results: </strong>PM_2.5, PM₁₀, SO₂, NO_2, and CO were significantly associated with an increased risk of hospitalization due to asthma. A 10 μg/m³ increase in PM_2.5, PM_10, and CO at lag04 corresponded to an increase of 2.07%, 1.56%, and 0.33% in daily hospital admissions for asthma, respectively. A 10 μg/m³ increase in SO₂ and NO₂ at lag05 corresponded to an increase of 45.69% and 8.16% in daily hospital admissions for asthma, respectively. Further analysis by age found that PM₁₀ and PM_2.5 had a greater impact on children aged 5-6 years old while NO₂ and CO mainly affected children under 7 years old. Analysis by by sex found that pollutants had a greater impact on hospital admissions in girls. Seasonal analysis revealed that pollutants had a more significant effect on admission during the winter.</p><p><strong>Conclusion: </strong>Our results suggest that increased concentrations of PM_2.5, PM₁₀, SO₂, NO_2, and CO in Chengdu lead to hospitalization for asthma in children and that a lag effect was observed, especially with SO₂. These findings highlight the need for stricter air quality controls to reduce childhood asthma hospitalizations.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"229-243"},"PeriodicalIF":3.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasal Symptoms Among Allergic Rhinitis Patients Could Contribute to Sexual Dysfunction.","authors":"Hailing Zhang, Hongping Zhang, Peng Jin, Kena Yu, Xiaoxue Zi, Xu Liang, HongYang Zhang, Li Zhao","doi":"10.2147/JAA.S483507","DOIUrl":"10.2147/JAA.S483507","url":null,"abstract":"<p><strong>Background: </strong> Allergic rhinitis (AR) is a prevalent chronic inflammatory airway disease with a range of symptoms that can significantly impact quality of life. This study aimed to explore the relationship between the severity of nasal symptoms and sexual function in AR patients.</p><p><strong>Methods: </strong> A case-control study involving 1034 AR patients and 422 healthy controls was conducted. Nasal symptoms were assessed using Visual Analog Scale (VAS) scores, while sexual function was evaluated using the International Index of Erectile Function (IIEF) for males and the Female Sexual Function Index (FSFI) for females.</p><p><strong>Results: </strong>In female AR patients, total FSFI scores, as well as scores for subjective arousal, orgasmic function, and intercourse satisfaction, were significantly decreased compared to controls. Nasal obstruction scores were significantly correlated with sexual desire, subjective arousal, orgasmic function, intercourse satisfaction, and total FSFI scores (<i>r</i>=-0.3176, <i>r</i>=-0.2106, <i>r</i>=-0.6129, <i>r</i>=-0.3430, <i>r</i>=-0.5233). Dysosmia scores also correlated with subjective arousal, orgasmic function, intercourse satisfaction, and total FSFI scores (<i>r</i>=-0.4331, <i>r</i>=-0.3123, <i>r</i>=-0.5259, <i>r</i>=-0.5436). Overall disease severity correlated significantly with subjective arousal, orgasmic function, intercourse satisfaction and total scores (<i>r</i>=-0.2908, <i>r</i>=-0.3703, <i>r</i>=-0.3739, <i>r</i>=-0.4225). Among male AR patients, lower total IIEF scores were observed, with reductions in erectile function, sexual desire, and overall satisfaction. Nasal obstruction scores were negatively correlated with erectile function, orgasmic function, sexual desire, and total IIEF scores (<i>r</i>=-0.8544, <i>r</i>=-0.3869, <i>r</i>=-0.2772, <i>r</i>=-0.6855). Furthermore, rhinorrhea scores showed significant correlations with overall satisfaction and total IIEF scores (<i>r</i>=-0.3711, <i>r</i>=-0.2680), and dysosmia scores were significantly associated with erectile function, orgasmic function, sexual desire, and total IIEF scores (<i>r</i>=-0.5048, <i>r</i>= -0.2904, <i>r</i>=-0.5607, <i>r</i>=-0.4733). Overall disease severity correlated significantly with erectile function, orgasmic function, sexual desire and total scores (<i>r</i>=-0.5385, <i>r</i>=-0.2034, <i>r</i>=-0.3257, <i>r</i>=-0.4833).</p><p><strong>Conclusion: </strong> This study underscores the negative correlations between nasal symptoms and sexual function in AR patients, suggesting that AR may contribute to sexual dysfunction.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"219-227"},"PeriodicalIF":3.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}