Lei Zhao, Yiting Wu, Hui Zhu, Yanmei Lin, Hang Su, Jingwei Hu, Min Zhang, Wuping Bao
{"title":"特应性患者总IgE和嗜酸性粒细胞的年龄、性别和症状依赖性变化：一项为期五年的回顾性研究","authors":"Lei Zhao, Yiting Wu, Hui Zhu, Yanmei Lin, Hang Su, Jingwei Hu, Min Zhang, Wuping Bao","doi":"10.2147/JAA.S519591","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Total immunoglobulin E (t-IgE) and eosinophils as central effector molecular and cells are crucial biomarkers for allergic diseases. Age, sex and allergic symptoms may influence these biomarkers and the relationship among t-IgE, eosinophils, and atopic diseases remained unknown.</p><p><strong>Methods: </strong>A five-year retrospective study enrolled 7654 patients with allergic symptoms underwent allergen testing. We collected age, sex, symptoms, and complete blood counts and explored variations in t-IgE and eosinophil across demographic and clinical parameters.</p><p><strong>Results: </strong>Among atopic patients, t-IgE levels peaked in children, decreasing with age, with a slight increase in the elderly, mirroring eosinophil trends. Females consistently exhibited lower t-IgE and eosinophil levels than males, regardless of atopic status. High t-IgE and eosinophils were the most common in patients ≥12 years with respiratory symptoms. Dust mites often caused respiratory symptoms. Egg allergies typically affected the ear, nose, and throat (ENT). Seafood/peanut allergies were linked to skin symptoms. Interestingly, elevated t-IgE and eosinophil levels did not consistently correlate with positive allergen tests. Among atopic patients, 44.5% exhibited normal t-IgE, and 41.4% had normal eosinophils. In the subgroup (22.8%) with both markers normal, more were females (62.5%). Sensitization to allergens like soy, shrimp, mold combination, Artemisia argyi, common ragweed, and willow/aspen/elm may fail to elevate t-IgE and eosinophils.</p><p><strong>Conclusion: </strong>Characteristics such as older age, female, skin and ENT symptoms, and allergens may correlate with lower t-IgE and eosinophils in the allergic populations which means we should pay more attention to these population, even if their t-IgE and eosinophils are normal, the allergen test is necessary for treatment strategies.</p><p><strong>Clinical trial registration: </strong>ChiCTR2300067700 (Date of Registration: 2023-01-18).</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"915-926"},"PeriodicalIF":3.7000,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145109/pdf/","citationCount":"0","resultStr":"{\"title\":\"Age, Sex, and Symptom-Dependent Variations in Total IgE and Eosinophils in Atopic Patients: A Five-Year Retrospective Study.\",\"authors\":\"Lei Zhao, Yiting Wu, Hui Zhu, Yanmei Lin, Hang Su, Jingwei Hu, Min Zhang, Wuping Bao\",\"doi\":\"10.2147/JAA.S519591\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Total immunoglobulin E (t-IgE) and eosinophils as central effector molecular and cells are crucial biomarkers for allergic diseases. Age, sex and allergic symptoms may influence these biomarkers and the relationship among t-IgE, eosinophils, and atopic diseases remained unknown.</p><p><strong>Methods: </strong>A five-year retrospective study enrolled 7654 patients with allergic symptoms underwent allergen testing. We collected age, sex, symptoms, and complete blood counts and explored variations in t-IgE and eosinophil across demographic and clinical parameters.</p><p><strong>Results: </strong>Among atopic patients, t-IgE levels peaked in children, decreasing with age, with a slight increase in the elderly, mirroring eosinophil trends. Females consistently exhibited lower t-IgE and eosinophil levels than males, regardless of atopic status. High t-IgE and eosinophils were the most common in patients ≥12 years with respiratory symptoms. Dust mites often caused respiratory symptoms. Egg allergies typically affected the ear, nose, and throat (ENT). Seafood/peanut allergies were linked to skin symptoms. Interestingly, elevated t-IgE and eosinophil levels did not consistently correlate with positive allergen tests. Among atopic patients, 44.5% exhibited normal t-IgE, and 41.4% had normal eosinophils. In the subgroup (22.8%) with both markers normal, more were females (62.5%). Sensitization to allergens like soy, shrimp, mold combination, Artemisia argyi, common ragweed, and willow/aspen/elm may fail to elevate t-IgE and eosinophils.</p><p><strong>Conclusion: </strong>Characteristics such as older age, female, skin and ENT symptoms, and allergens may correlate with lower t-IgE and eosinophils in the allergic populations which means we should pay more attention to these population, even if their t-IgE and eosinophils are normal, the allergen test is necessary for treatment strategies.</p><p><strong>Clinical trial registration: </strong>ChiCTR2300067700 (Date of Registration: 2023-01-18).</p>\",\"PeriodicalId\":15079,\"journal\":{\"name\":\"Journal of Asthma and Allergy\",\"volume\":\"18 \",\"pages\":\"915-926\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-06-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145109/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Asthma and Allergy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/JAA.S519591\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"ALLERGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asthma and Allergy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/JAA.S519591","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ALLERGY","Score":null,"Total":0}
Age, Sex, and Symptom-Dependent Variations in Total IgE and Eosinophils in Atopic Patients: A Five-Year Retrospective Study.
Background: Total immunoglobulin E (t-IgE) and eosinophils as central effector molecular and cells are crucial biomarkers for allergic diseases. Age, sex and allergic symptoms may influence these biomarkers and the relationship among t-IgE, eosinophils, and atopic diseases remained unknown.
Methods: A five-year retrospective study enrolled 7654 patients with allergic symptoms underwent allergen testing. We collected age, sex, symptoms, and complete blood counts and explored variations in t-IgE and eosinophil across demographic and clinical parameters.
Results: Among atopic patients, t-IgE levels peaked in children, decreasing with age, with a slight increase in the elderly, mirroring eosinophil trends. Females consistently exhibited lower t-IgE and eosinophil levels than males, regardless of atopic status. High t-IgE and eosinophils were the most common in patients ≥12 years with respiratory symptoms. Dust mites often caused respiratory symptoms. Egg allergies typically affected the ear, nose, and throat (ENT). Seafood/peanut allergies were linked to skin symptoms. Interestingly, elevated t-IgE and eosinophil levels did not consistently correlate with positive allergen tests. Among atopic patients, 44.5% exhibited normal t-IgE, and 41.4% had normal eosinophils. In the subgroup (22.8%) with both markers normal, more were females (62.5%). Sensitization to allergens like soy, shrimp, mold combination, Artemisia argyi, common ragweed, and willow/aspen/elm may fail to elevate t-IgE and eosinophils.
Conclusion: Characteristics such as older age, female, skin and ENT symptoms, and allergens may correlate with lower t-IgE and eosinophils in the allergic populations which means we should pay more attention to these population, even if their t-IgE and eosinophils are normal, the allergen test is necessary for treatment strategies.
Clinical trial registration: ChiCTR2300067700 (Date of Registration: 2023-01-18).
期刊介绍：
An international, peer-reviewed journal publishing original research, reports, editorials and commentaries on the following topics: Asthma; Pulmonary physiology; Asthma related clinical health; Clinical immunology and the immunological basis of disease; Pharmacological interventions and new therapies.
Although the main focus of the journal will be to publish research and clinical results in humans, preclinical, animal and in vitro studies will be published where they shed light on disease processes and potential new therapies.
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