Journal of atrial fibrillation最新文献

{"title":"Extensive Left Atrial Low-Voltage Area During Initial Ablation is Associated with A Poor Clinical Outcome Even Following Multiple Procedures.","authors":"T. Kanda, M. Masuda, M. Asai, O. Iida, S. Okamoto, T. Ishihara, Kiyonori Nanto, T. Tsujimura, Y. Matsuda, Y. Hata, H. Uematsu, T. Mano","doi":"10.22541/AU.161547823.37636408/V1","DOIUrl":"https://doi.org/10.22541/AU.161547823.37636408/V1","url":null,"abstract":"Background\u0000Some patients fail to respond to persistent atrial fibrillation (PeAF) catheter ablation in spite of multiple procedures and ablation strategies, including low voltage area (LVA)-guided, linear, and complex fractionated atrial electrogram (CFAE)-guided ablation procedures. We hypothesized that LVA extent could predict non-responseto Pe AF catheter ablation in spite of multiple procedures.\u0000\u0000\u0000Methods\u0000This study included 510 patients undergoing initial ablation procedures for PeAF. LVAs were defined as regions with bipolar peak-to-peak voltages of <0.50 mV after PVI during sinus rhythm. Patients were categorized by LVA size into groups A(0-5 cm2), B (5-20 cm2), and C (over 20 cm2). The primary endpoint was AF-free survival after the last procedure.\u0000\u0000\u0000Results\u0000During a median follow-up of 25 (17, 36) months, AF recurrence was observed in 101 (20%) patients after 1.4±0.6 ablation procedures (maximum 4). Comparison of clinical outcomes after multiple procedures in the three groups showed that the results depended on the extent of LVA. Multivariate analysis of AF-free survival after the last procedure showed that LVAs > 20 cm2 was an independent factor associated with AF recurrence after the final procedure(Hazard ratio, 7.94; 95% confidence interval, 2.91 to 21.67, P <0.001).\u0000\u0000\u0000Conclusions\u0000Extensive LVA after initial PVI was associated with poor clinical benefit despite multiple catheter based ablations.","PeriodicalId":15072,"journal":{"name":"Journal of atrial fibrillation","volume":"14 2 1","pages":"20200491"},"PeriodicalIF":0.0,"publicationDate":"2021-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47119142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with Moderate Physical Activity Among Older Adults with Atrial Fibrillation.","authors":"Jordy Mehawej, Jane S Saczysnki, Catarina I Kiefe, Eric Ding, Hawa O Abu, Darleen Lessard, Robert H Helm, Benita A Bamgbade, Connor Saleeba, Weijia Wang, David D McManus, Robert J Goldberg","doi":"10.4022/jafib.2454","DOIUrl":"10.4022/jafib.2454","url":null,"abstract":"<p><strong>Objective: </strong>Engaging patients with atrial fibrillation (AF) in moderate-intensity physical activity has been encouraged by published guidelines. We examined factors associated with engagement in moderate physical activity among older adults with AF.</p><p><strong>Methods: </strong>This was a retrospective study involving ninety patients with episodes of Afib with RVR duData are from the SAGE (Systematic Assessment of Geriatric Elements)-AF study. Older adults (≥ 65 years) with AF and a CHA₂DS₂-VASc ≥ 2 were recruited from several clinics in Massachusetts and Georgia between 2015 and 2018. The Minnesota Leisure Time Physical Activity questionnaire was used to assess whether participants engaged in moderate-intensity physical activity (i.e. at least 150 minutes of moderate exercise). Logistic regression was utilized to examine the sociodemographic and clinical characteristics and geriatric elements associated with engaging in moderate-intensity physical activity.</p><p><strong>Results: </strong>Participants were on average 76 years old and 48% were women. Approximately one-half (52%) of study participants engaged in moderate-intensity physical activity. Morbid obesity (adjusted OR [aOR]=0.41, 90%CI=0.23-0.73), medical history of renal disease (aOR= aOR=0.68,90%CI= 0.48-0.96), slow gait speed (aOR=0.44, 90%CI=0.32-0.60), cognitive impairment (aOR=0.74, 90%CI=0.56-0.97), and social isolation (aOR=0.58, 90%CI= 0.40-0.84) were independently associated with a lower likelihood, while higher AF related quality of life score (aOR=1.64, 90%CI=1.25-2.16) a greater likelihood, of meeting recommended levels of moderate physical activity.</p><p><strong>Conclusions: </strong>Nearly one-half of older adults with NVAF did not engage in moderate-intensity exercise. Clinicians should identify older patients with NVAF who are less likely to engage in physical activity and develop tailored interventions to promote regular physical activity.</p>","PeriodicalId":15072,"journal":{"name":"Journal of atrial fibrillation","volume":" ","pages":"2454"},"PeriodicalIF":0.0,"publicationDate":"2021-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691360/pdf/jafib-13-02454.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39760643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Afterload-Integrated Diastolic Indexon Prognosis in Elderly Patients with Heart Failure with Preserved Ejection Fraction with and without Atrial Fibrillation.","authors":"Shiro Hoshida,&nbsp;Yukinori Shinoda,&nbsp;Koichi Tachibana,&nbsp;Tomoko Minamisaka,&nbsp;Takahisa Yamada,&nbsp;Yoshio Yasumura,&nbsp;Shunsuke Tamaki,&nbsp;Takaharu Hayashi,&nbsp;Masamichi Yano,&nbsp;Shungo Hikoso,&nbsp;Yasushi Sakata","doi":"10.4022/jafib.2469","DOIUrl":"https://doi.org/10.4022/jafib.2469","url":null,"abstract":"<p><strong>Objects: </strong>We aimed to clarify the differences in the of the ratio of diastolic elastance (Ed) to arterial elastance (Ea), [Ed/Ea=(E/e')/(0.9×systolic blood pressure)], anafterload-integrateddiastolic index that reflects left atrial pressure overload, on prognosis between patients with heart failure with preserved ejection fraction (HFpEF) with and without atrial fibrillation (AF).</p><p><strong>Methods: </strong>We studied 552 HFpEF patients hospitalized for acute decompensated heart failure (sinus rhythm/AF:352/200).Blood testing and transthoracic echocardiography were performed before discharge. Primary endpoint was all-cause mortality after discharge.</p><p><strong>Results: </strong>During a median follow-up of 508 days, 88 patients (sinus rhythm/AF: 54/34) had all-cause mortality. In the subgroup with sinus rhythm, but not AF, Ed/Ea was significantly higher in patients with than without all-cause mortality. In a multivariate Cox hazard analysis, Ed/Ea was significantly associated with all-cause mortality independent of N-terminal pro-brain natriuretic peptide level in patients with sinus rhythm, but not with AF.</p><p><strong>Conclusions: </strong>Ed/Ea providedlesser important information for predicting all-cause mortality in HFpEF patients with AF than with sinus rhythm. The prognostic risk factors may differ between elderly HFpEF patients with and without AF.</p>","PeriodicalId":15072,"journal":{"name":"Journal of atrial fibrillation","volume":" ","pages":"2469"},"PeriodicalIF":0.0,"publicationDate":"2021-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691356/pdf/jafib-13-02469.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39621003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Acute Atrial Fibrillation and Flutter Hospitalization across 7 U.S. Emergency Departments: A Prospective Study.","authors":"Bory Kea, E Margaret Warton, Dustin W Ballard, Dustin G Mark, Mary E Reed, Adina S Rauchwerger, Steven R Offerman, Uli K Chettipally, Patricia C Ramos, Daphne D Le, David S Glaser, David R Vinson","doi":"10.4022/jafib.2355","DOIUrl":"10.4022/jafib.2355","url":null,"abstract":"<p><strong>Introduction: </strong>International rates of hospitalization for atrial fibrillation and flutter (AFF) from the emergency department (ED) vary widely without clear evidence to guide the identification of high-risk patients requiring inpatient management. We sought to determine (1) variation in hospital admission and (2) modifiable factors associated with hospitalization of AFF patients within a U.S. integrated health system.</p><p><strong>Methods: </strong>This multicenter prospective observational study of health plan members with symptomatic AFF was conducted using convenience sampling in 7 urban community EDs from 05/2011 to 08/2012. Prospective data collection included presenting symptoms, characteristics of atrial dysrhythmia, ED physician impression of hemodynamic instability, comorbid diagnoses, ED management, and ED discharge rhythm. All centers had full-time on-call cardiology consultation available. Additional variables were extracted from the electronic health record. We identified factors associated with hospitalization and included predictors in a multivariate Poisson Generalized Estimating Equations regression model to estimate adjusted relative risks while accounting for clustering by physician.</p><p><strong>Results: </strong>Among 1,942 eligible AFF patients, 1,074 (55.3%) were discharged home and 868 (44.7%) were hospitalized. Hospitalization rates ranged from 37.4% to 60.4% across medical centers. After adjustment, modifiable factors associated with increased hospital admission from the ED included non-sinus rhythm at ED discharge, no attempted cardioversion, and heart rate reduction.</p><p><strong>Discussion: </strong>Within an integrated health system, we found significant variation in AFF hospitalization rates and identified several modifiable factors associated with hospital admission. Standardizing treatment goals that specifically address best practices for ED rate reduction and rhythm control may reduce hospitalizations.</p>","PeriodicalId":15072,"journal":{"name":"Journal of atrial fibrillation","volume":"13 5","pages":"2355"},"PeriodicalIF":0.0,"publicationDate":"2021-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691349/pdf/jafib-13-02355.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10085322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcutaneouscardiac Rhythm Monitors: A Comprehensive Review.","authors":"Gaurav Aggarwal,&nbsp;Saurabh Aggarwal,&nbsp;Venkata Alla,&nbsp;Bharat Narasimhan,&nbsp;Kyungmoo Ryu,&nbsp;Courtney Jeffery,&nbsp;Dhanunjaya Lakkireddy","doi":"10.4022/jafib.2387","DOIUrl":"https://doi.org/10.4022/jafib.2387","url":null,"abstract":"<p><p>Subcutaneous loop recorders (SCRMs) are subcutaneous electronic devices which have revolutionized the field of arrhythmia detection. They have become increasingly appealing due to advances such as miniaturization of device, longer battery life, bluetooth capabilities and relatively simple implantation technique without the need for complex surgical suites. They can be implanted in the office, patient bedside without the need to go to the operating room. One of the most common indications for their implantation is detection of atrial fibrillation (AF) after a cryptogenic stroke. They have also been utilized for assessing the success of rhythm control strategies such post pulmonary venous isolation. More recently studies have assessed the utility of SCRMs for detecting silent AF in at risk populations such as patients with sleep apnea or those on hemodialysis. In this paper, we review the evolution of SCRMs, the clinical studies assessing their value for different indications, their role incurrent clinical practice and future avenues in the era of smart wearable devices like apple watch etc.</p>","PeriodicalId":15072,"journal":{"name":"Journal of atrial fibrillation","volume":" ","pages":"2387"},"PeriodicalIF":0.0,"publicationDate":"2021-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691353/pdf/jafib-13-02387.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39760642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Immature Platelet Fraction and Factors Associated with Inflammation, Thrombosis and Platelet Reactivity Between Left and Right Atria in Patients with Atrial Fibrillation.","authors":"Olga Perelshtein Brezinov,&nbsp;Ziv Sevilya,&nbsp;Ella Yahud,&nbsp;Michael Rahkovich,&nbsp;Yonatan Kogan,&nbsp;Gergana Marincheva,&nbsp;Yana Kakzanov,&nbsp;Eli Lev,&nbsp;Avishag Laish-Farkash","doi":"10.4022/jafib.2459","DOIUrl":"https://doi.org/10.4022/jafib.2459","url":null,"abstract":"<p><strong>Background: </strong>Recent trials found poor temporal relationship between atrial fibrillation (AF) episodes and strokes. Thus, stroke in AF patients probably involves more mechanisms than cardiac embolism. We compared factors of inflammation, thrombosis and platelet reactivity between left (LA) and right atria (RA) and femoral vein (FV) in patients with AF.</p><p><strong>Methods: </strong>Blood samples were collected from patients undergoing AF-ablation from the FV, RA and LA for neutrophil to lymphocyte ratio (NLR), immature platelet fraction (IPF) and count (IPC), CD40 ligand, P-selectin and E-Selectin. IPF was measured by an autoanalyzer; CD40 ligand, P-selectin, and E-Selectin were measured by ELISA and NLR was calculated from complete blood counts.</p><p><strong>Results: </strong>Sixty-seven patients were included (age 65±10y, 63% male, CHA₂DS₂-VASc score 2.8±1.8, LA volume index 40±24 mL/m², 63% paroxysmal AF). There was no difference between FV, RA and LA regarding NLR and CD40 ligand. Factors associated with platelets activity: P-selectin, IPC and IPF% were higher in RA vs LA (60.3 IQR 49.0-76.4 ng/ml vs. 59.3 IQR 49.0-74.7, respectively, p=0.03 for P-selectin, 7.5 IQR 5.2-10 103/μL vs. 7.1 IQR 5-9.8, p<0.01 for IPC, and 3.6 IQR 2.7-5.0 % vs. 3.6 IQR 2.6-4.8, p<0.01 for IPF%). Similar trends were for E-selectin (41.2 IQR 31.1-51.2 ng/mL vs. 38.7 IQR 27.9-50.4 p=0.09). Similar significant differences were found in patients with CHA₂DS₂-VASC≥2 but not in patients with low score.</p><p><strong>Conclusions: </strong>Patients with AF, especially those with CHA₂DS₂-VASc≥2, have higher markers of thrombogenicity in RA compared to LA. There was no difference in inflammatory properties between the atria.</p>","PeriodicalId":15072,"journal":{"name":"Journal of atrial fibrillation","volume":" ","pages":"2459"},"PeriodicalIF":0.0,"publicationDate":"2021-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691358/pdf/jafib-13-02459.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39621004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for Atrial Fibrillation in Community and Primary CareSettings: A Scoping Review.","authors":"Emma Canty,&nbsp;Claire MacGilchrist,&nbsp;Wael Tawfick,&nbsp;Caroline McIntosh","doi":"10.4022/jafib.2452","DOIUrl":"https://doi.org/10.4022/jafib.2452","url":null,"abstract":"<p><strong>Background: </strong>Atrial Fibrillation (AF) is the most common tachyarrhythmia and is associated with increased risk of stroke, morbidity and mortality. AF is responsible for up to a quarter of all strokes and is often asymptomatic until a stroke occurs.Screening for AF is a valuable approach to reduce the burden of stroke in the population.</p><p><strong>Objectives: </strong>The motivation for this review was to synthesise and appraise the evidence for screening for AF in the community. The aims of this scoping review are 1). To describe the prevalence of newly diagnosed AF in screening programmes 2). Identify which techniques/ tools are employed for AF screening 3). To describe the setting and personnel involved in screening for AF.</p><p><strong>Eligibility criteria: </strong>All forms of AF screening in adults (≥18 years) in primary and community care settings.</p><p><strong>Methods: </strong>This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping reviews (PRISMA-ScR).</p><p><strong>Results: </strong>Fifty-nine papers were included; most were cross-sectional studies (n=41) and RCTs (n=7). Prevalence of AF ranged from 0-34.5%. Screening tools and techniquesincluded the 12-lead ECG (n=33), the 1-lead ECG smartphone based Alivecor® (n=14) and pulse palpation (n=12). Studies were undertaken in community settings (n=30) or in urban/rural primary care (n=28). Personnel collecting research data were in the main members of the research team (n=31), GPs (n=16), practice nurses (n=10), participants (n=8) and pharmacists (n=4).</p><p><strong>Conclusion: </strong>Prevalence of AF increased with advancing age. AF screening should target individuals at greatest risk of the condition including older adults≥65 years of age. Emerging novel technologies may increase the accessibility of AF screening in community and home settings. There is a need for high quality research to investigate AF prevalence and establish accuracy and validity for traditional versus novel screening tools used to screen for AF.</p>","PeriodicalId":15072,"journal":{"name":"Journal of atrial fibrillation","volume":" ","pages":"2452"},"PeriodicalIF":0.0,"publicationDate":"2021-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691352/pdf/jafib-13-02452.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39760640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catheter Ablation for Hospitalized Atrial Fibrillation Patients with Reduced Systolic Function: Analysis of Inpatient Mortality, Resource Utilization and Complications.","authors":"Muhammad Bilal Munir,&nbsp;Muhammad Zia Khan,&nbsp;Pratik Agrawal,&nbsp;Zain Ul Abideen Asad,&nbsp;Moinuddin Syed,&nbsp;Kinjan Patel,&nbsp;BilYasir Abdul Ghaffarlal,&nbsp;Muhammad U Khan,&nbsp;Safi U Khan,&nbsp;Sudarshan Balla,&nbsp;Jonathan C Hsu","doi":"10.4022/jafib.2480","DOIUrl":"https://doi.org/10.4022/jafib.2480","url":null,"abstract":"<p><strong>Background: </strong>Randomized trials have shown improvement in hard clinical end points when catheter ablation (CA) is employed as a management strategy for certain atrial fibrillation (AF) patients with heart failure and reduced ejection fraction (HFrEF). Limited data, however, exist in this realm outside the controlled clinical trial settings. We sought to determine real-world data on mortality and complications after utilization of CA in such patients.</p><p><strong>Methods and results: </strong>Data were derived from National Inpatient Sample from January 2008 to August 2015. Patients were identified using the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codes. Baseline characteristics and outcomes were compared among HFrEF and AF patients undergoing CA or not. Propensity matching was done to mitigate selection bias and balance confounding variables. Various CA related complications were assessed. Logistic regression was done to determine predictors of mortality in our study cohort. A total of 2,569,919 patients were analyzed and a total of 7773 patients underwent CA. Mortality was significantly better in CA group in both unmatched (1.2% vs. 4.9%, p < 0.01) and propensity matched cohorts (1.2% vs. 3.6%, p < 0.01). Overall complication rate was 10.2% in CA cohort and primarily driven by cardiac and neurological etiologies. In regression analysis, CA remained a strong predictor of reduced mortality (OR 0.301, 95% CI 0.184-0.494).</p><p><strong>Conclusions: </strong>CA is associated with improved mortality in admitted AF patients with concomitant HFrEF. Overall complication rate after CA was modest at 10.2%. Consideration can be given to the utilization of this therapeutic modality in hospitalized AF patients with concomitant HFrEF.</p>","PeriodicalId":15072,"journal":{"name":"Journal of atrial fibrillation","volume":" ","pages":"2480"},"PeriodicalIF":0.0,"publicationDate":"2021-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691359/pdf/jafib-13-02480.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39621005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why is the Tilt Table Test Still Useful to Define who Should or Should Not Get A Pacemaker with Vasovagal Syncope?","authors":"Tolga Aksu,&nbsp;Kıvanc Yalin","doi":"10.4022/jafib.2384","DOIUrl":"https://doi.org/10.4022/jafib.2384","url":null,"abstract":"<p><p>The the tilt table test (TTT )has been used identify appropriate candidates for pacing in the majority of randomized trials. However, in recent years, it has been claimed-based largely on International Study on Syncope of Uncertain Etiology (ISSUE) studies-that the TTT demonstrates only a weak correlation with the mechanism documented by implantable loop recorder (ILR) at the time of syncope and thus confounds the correct diagnosis. Thus, cardiac pacing was supported in patients with recurrent vasovagal syncope (VVS) in whom clinically relevant asystole had been documented by ILR. In the present Editorial, we tried to discuss potential role of TTT in diagnostic workflow of VVS based on current data.</p>","PeriodicalId":15072,"journal":{"name":"Journal of atrial fibrillation","volume":" ","pages":"2384"},"PeriodicalIF":0.0,"publicationDate":"2021-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691355/pdf/jafib-13-02384.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39760639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of Cancer Treatment Induced Arrhythmia Associated with Immune Checkpoint Inhibitors.","authors":"Luke Joseph,&nbsp;Andrew C Nickel,&nbsp;Akshar Patel,&nbsp;Nabil F Saba,&nbsp;Angel R Leon,&nbsp;Mikhael F El-Chami,&nbsp;Faisal M Merchant","doi":"10.4022/jafib.2461","DOIUrl":"https://doi.org/10.4022/jafib.2461","url":null,"abstract":"<p><strong>Background: </strong>Cancer treatmentinduced arrhythmia (CTIA) is a well-recognized form of cardiotoxicity associated with chemotherapy. Immune checkpoint inhibitors (ICI) have been associated with important forms of cardiotoxicity, including myocarditis. However, the incidence of CTIA associated with ICI has not been well characterized.</p><p><strong>Methods: </strong>We reviewed all patients treated with ICIs at our institution from Jan. 2010 to Oct. 2015. CTIA was defined as a new diagnosis of clinically relevant arrhythmia within 6 months after ICI initiation.</p><p><strong>Results: </strong>During the study period, 268 patients were treated with immune checkpoint inhibitors, of whom 190 received monotherapy with ipilimumab (n=114), nivolumab (n=52) or pembrolizumab (n=24) and 78 received combination therapy: ipilimumab & nivolumab (n=37), ipilimumab & pembrolizumab (n=39) and nivolumab & pembrolizumab (n=2). Four patients (1.5%) developed CTIA. Of these, 3 patients developed a new diagnosis of atrial fibrillation (AF), one of whom required cardioversion. In 2 cases of new-onset AF, significant provoking factors were present in addition to ICI therapy including thyrotoxicosis in one and metabolic disarray in another. Six patients (2.2%) with a pre-existing diagnosis of paroxysmal AF experienced episodes within 6 months of initiating ICI therapy. None of the arrhythmic events were associated with known or suspected myocarditis.</p><p><strong>Conclusions: </strong>The incidence of arrhythmic complications associated with immune checkpoint inhibitors appears to be very low (~1.5%). Patients with a pre-existing diagnosis of AF may be at-risk of recurrence during ICI treatment and should be monitored accordingly. These suggest that from an arrhythmia perspective, ICIs appear to be very safe and well-tolerated.</p>","PeriodicalId":15072,"journal":{"name":"Journal of atrial fibrillation","volume":" ","pages":"2461"},"PeriodicalIF":0.0,"publicationDate":"2021-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691346/pdf/jafib-13-02461.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39760644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}