Journal of Bone Metabolism最新文献_第2页

Bone Mineral Density in Dual Energy X-Ray Absorptiometry and Hounsfield Units on Diagnostic Computed Tomography Scan: A Cross-Sectional Study. 双能x线骨密度吸收仪和Hounsfield单元诊断计算机断层扫描：一项横断面研究。

Journal of Bone Metabolism Pub Date : 2026-05-01 Epub Date: 2026-05-31 DOI: 10.11005/jbm.25.951

Won Ro Park, Yong Jae Kwon, Dong Ha Lee

{"title":"Bone Mineral Density in Dual Energy X-Ray Absorptiometry and Hounsfield Units on Diagnostic Computed Tomography Scan: A Cross-Sectional Study.","authors":"Won Ro Park, Yong Jae Kwon, Dong Ha Lee","doi":"10.11005/jbm.25.951","DOIUrl":"10.11005/jbm.25.951","url":null,"abstract":"Background: Previous studies have demonstrated a moderate correlation between bone mineral density (BMD) measured by dual energy X-ray absorptiometry (DXA) and Hounsfield units (HU) assessed on diagnostic computed tomography (CT), primarily in the lumbar spine. However, the correlation between HU values and DXA scores in other bones and at different anatomical landmarks remains underexplored. This study aimed to evaluate the relationship between HU values at various cortical and medullary regions and DXA-derived T-scores across multiple skeletal sites.Methods: In this retrospective cross-sectional study, 214 patients who underwent both DXA and diagnostic CT imaging were included. The bones analyzed included the proximal humerus (N=96), distal tibia (N=56), distal femur (N=34), and proximal tibia (N=28). HU measurements were taken at five anatomic landmarks: the medullary center, anteromedial cortex, anterolateral cortex, posteromedial cortex, and posterolateral cortex. Correlations were analyzed between these HU values and the lowest T-score from the DXA scan.Results: Significant moderate correlations were found between medullary HU values and the lowest T-scores in the proximal tibia (r=0.486, P=0.04) and distal tibia (r=0.458, P=0.01). In the proximal humerus, the anteromedial cortex HU also correlated with the lowest T-score (r=0.353, P=0.01). Mean HU values at several cortical and medullary regions significantly differed between osteoporotic and normal BMD groups.Conclusions: There is a moderate correlation between HU values at specific anatomical landmarks and DXA T-scores. These findings suggest that diagnostic CT scans may serve as a supplementary tool in assessing bone quality, especially when DXA is not available.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 2","pages":"161-168"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in Low Muscle Mass and Sarcopenia Prevalence in Korea Using Korea National Health and Nutrition Examination Survey (KNHANES) 2024 and 2008-2011: The KSBMR-KSOS KNHANES DXA Joint Task Force Report. 使用韩国国家健康和营养调查（KNHANES） 2024年和2008-2011年的韩国低肌肉量和肌肉减少症流行趋势：KSBMR-KSOS KNHANES DXA联合工作组报告。

Journal of Bone Metabolism Pub Date : 2026-05-01 Epub Date: 2026-04-24 DOI: 10.11005/jbm.26.1020

Namki Hong, Jun-Il Yoo, Jeonghoon Ha, Seong Hee Ahn, Young-Kyun Lee, Hyun Sik Gong, Ki-Hyun Baek, Yumie Rhee, Yong-Chan Ha

{"title":"Trends in Low Muscle Mass and Sarcopenia Prevalence in Korea Using Korea National Health and Nutrition Examination Survey (KNHANES) 2024 and 2008-2011: The KSBMR-KSOS KNHANES DXA Joint Task Force Report.","authors":"Namki Hong, Jun-Il Yoo, Jeonghoon Ha, Seong Hee Ahn, Young-Kyun Lee, Hyun Sik Gong, Ki-Hyun Baek, Yumie Rhee, Yong-Chan Ha","doi":"10.11005/jbm.26.1020","DOIUrl":"10.11005/jbm.26.1020","url":null,"abstract":"Background: Sarcopenia is increasingly recognized as a major age-related disease with important clinical and public health implications, leading to updated international consensus definitions. We evaluated temporal changes in dual energy X-ray absorptiometry (DXA)-derived low muscle mass and estimated the prevalence and associated comorbidities of sarcopenia using nationally representative data.Methods: We analyzed adults aged ≥50 years from the Korea National Health and Nutrition Examination Survey (KNHANES) 2008-2011 and 2024. Appendicular lean mass was assessed using wholebody DXA. Low muscle mass was defined according to the Asian Working Group for Sarcopenia 2025 criteria. Sarcopenia, defined as the coexistence of low muscle mass and low handgrip strength, was assessed only in KNHANES 2024. Sampling weight was applied to all analyses.Results: The age-standardized prevalence of low muscle mass increased from 27.2% in 2008-2011 to 47.1% in 2024, with similar trends observed in men and women. Male sex, greater height, lower body weight, lower total energy intake, a higher proportion of energy derived from fat, and diabetes mellitus were independently associated with a higher prevalence of low muscle mass. The between-period difference in prevalence remained statistically significant after multivariable adjustment. In 2024, the overall prevalence of sarcopenia was 6.7% and increased with age, reaching 21.5% among adults aged ≥80 years. Sarcopenia was independently associated with diabetes mellitus, anemia, malnutrition, poor self-rated health, and recent bedridden status.Conclusions: Low muscle mass and sarcopenia are increasingly prevalent among older adults in Korea and are strongly associated with comorbidities.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":" ","pages":"197-207"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormonal Stabilization of the Bone-Metabolic Environment: Implications for Anterior Cruciate Ligament Integrity and Bone-Graft Integration. 骨代谢环境的激素稳定：对前交叉韧带完整性和骨移植物整合的影响。

Journal of Bone Metabolism Pub Date : 2026-05-01 Epub Date: 2026-05-31 DOI: 10.11005/jbm.26.1022

Andro Koren, Luciana Koren

引用次数: 0

The Association between Sarcopenia and Chronic Kidney Disease among the Patients of Diabetes Mellitus: Korean National Health and Nutrition Examination Survey 2008-2011. 糖尿病患者肌肉减少症与慢性肾脏疾病的关系：2008-2011年韩国国民健康与营养调查

Journal of Bone Metabolism Pub Date : 2026-05-01 Epub Date: 2026-05-31 DOI: 10.11005/jbm.25.953

Min Ji Kim

{"title":"The Association between Sarcopenia and Chronic Kidney Disease among the Patients of Diabetes Mellitus: Korean National Health and Nutrition Examination Survey 2008-2011.","authors":"Min Ji Kim","doi":"10.11005/jbm.25.953","DOIUrl":"10.11005/jbm.25.953","url":null,"abstract":"Background: This study aims to investigate the association between sarcopenia and chronic kidney disease (CKD) among diabetes mellitus (DM) patients.Methods: The study used the data extracted from 1,855 patients collected by the Korean National Health and Nutrition Examination Surveys conducted in 2008-2011. Body mass index (BMI)-adjusted, weight-adjusted, and height2 -adjusted appendicular skeletal muscle mass were used to define sarcopenia, and the young reference group was analyzed for the cutoff values, which are 0.9 for men 0.6 for women in BMI-adjusted, 29.6 for men, and 23.3 for women in weight-adjusted, and 6.9 - men and 4.8 - women in height2-adjusted index. Participants were classified as having diabetes if they either presented with a fasting plasma glucose ≥126 mg/dL (7.00 mmol/L) or glycated hemoglobin ≥6.5% (48 mmol/moL) or provided any self-report of a physician's diagnosis or current treatment of diabetes. The equation developed by the CKD Epidemiology Collaboration was used to calculate the estimated glomerular filtration rate (eGFR). CKD was defined as having an eGFR less than 60 mL/min/1.73 m2. The association between sarcopenia and CKD was assessed using multiple logistic regression, adjusting for potential confounders.Results: The final analysis included 1,855 participants with diabetes. After adjusting for potential confounders, sarcopenia was significantly associated with an increased prevalence of CKD. Specifically, patients with sarcopenia had 1.826 times the odds of having CKD compared to those without sarcopenia (odds ratio, 1.826; 95% confidence interval, 1.092-3.054).Conclusions: There is an association between sarcopenia and CKD in DM patients.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 2","pages":"169-180"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Normocalcemic Hyperparathyroidism on Structural Bone Compromise: A Prospective Observational Cohort Study. 正常血钙水平甲状旁腺功能亢进对结构性骨损害的影响：一项前瞻性观察队列研究。

Journal of Bone Metabolism Pub Date : 2026-05-01 Epub Date: 2026-05-31 DOI: 10.11005/jbm.25.997

John Pietro, Amr Kaadan, Travis Cotton, Jon Olansen, Janine Molino, Roy Aaron

{"title":"Effects of Normocalcemic Hyperparathyroidism on Structural Bone Compromise: A Prospective Observational Cohort Study.","authors":"John Pietro, Amr Kaadan, Travis Cotton, Jon Olansen, Janine Molino, Roy Aaron","doi":"10.11005/jbm.25.997","DOIUrl":"10.11005/jbm.25.997","url":null,"abstract":"Background: Normocalcemic hyperparathyroidism (NCHPTH) is characterized by elevated serum parathyroid hormone (PTH) levels in the presence of normal serum calcium levels, with the exclusion of secondary causes. NCHPTH remains underdiagnosed and is often associated with structural compromise of bone, namely osteoporosis and fragility fractures. The purpose of this study was to perform a prospective observational cohort study investigating NCHPTH in our Metabolic Bone Disease Service (MBDS).Methods: Between January 2022 and June 2024, 815 patients were referred to our MBDS with an International Classification of Diseases, Tenth Revision diagnosis code of osteoporosis. Each patient underwent dual energy X-ray absorptiometry, and when indicated, assays for serum calcium, ionized calcium, 25-hydroxy-vitamin D (25[OH]D), and PTH.Results: NCHPTH was identified in 25 patients (3%), approximating one patient per month. Skeletal involvement was frequent in the NCHPTH cohort, with 72% presenting with a history of fragility fractures. Mean PTH levels were 130.8 pg/mL, while serum calcium and 25(OH)D levels remained within the normal range. We compared the prevalence of NCHPTH in our MBDS to other referral populations, finding an increased prevalence in our service, likely due to the high frequency of skeletal compromise in this population.Conclusions: These results indicate that NCHPTH is not merely a biochemical phenomenon but is rather frequently associated with skeletal pathology. We conclude that reliance on serum calcium alone likely leads to underdiagnosis of NCHPTH, whereas routine PTH testing can facilitate earlier detection, allow for preventative interventions, and enhance secondary fracture prevention efforts.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 2","pages":"152-160"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in Osteoporosis Prevalence in Korea Using Korea National Health and Nutrition Examination Survey (KNHANES) 2024 and 2008-2011: The KSBMR KNHANES DXA Task Force Report. 利用韩国国家健康和营养调查（KNHANES） 2024年和2008-2011年的韩国骨质疏松症流行趋势：KSBMR KNHANES DXA工作组报告。

Journal of Bone Metabolism Pub Date : 2026-05-01 Epub Date: 2026-04-24 DOI: 10.11005/jbm.26.003

Namki Hong, Jeonghoon Ha, Jun-Il Yoo, Seong Hee Ahn, Young-Kyun Lee, Hyun Sik Gong, Yong-Chan Ha, Ki-Hyun Baek, Yumie Rhee

{"title":"Trends in Osteoporosis Prevalence in Korea Using Korea National Health and Nutrition Examination Survey (KNHANES) 2024 and 2008-2011: The KSBMR KNHANES DXA Task Force Report.","authors":"Namki Hong, Jeonghoon Ha, Jun-Il Yoo, Seong Hee Ahn, Young-Kyun Lee, Hyun Sik Gong, Yong-Chan Ha, Ki-Hyun Baek, Yumie Rhee","doi":"10.11005/jbm.26.003","DOIUrl":"10.11005/jbm.26.003","url":null,"abstract":"Background: National estimates of osteoporosis prevalence in Korea has been based on dual energy X-ray absorptiometry (DXA) data from the Korea National Health and Nutrition Examination Survey (KNHANES) conducted between 2008 and 2011. In 2024, KNHANES resumed nationwide DXA testing, enabling updated prevalence estimates.Methods: We compared the prevalence of osteoporosis (DXA T-score ≤-2.5 at lumbar spine, femoral neck, or total hip) and low bone mass (-1.0>T-score>-2.5 at any sites) among Korean adults aged ≥50 years between KNHANES 2008-2011 and 2024. Age-standardized prevalence estimates accounting for complex sampling were calculated. The Poisson regression model was used to assess prevalence ratios (PRs) between survey periods, with adjustment for anthropometric measures, lifestyle factors, and nutritional intake.Results: The prevalence of osteoporosis declined between KNHANES 2008-2011 and 2024 from 20.8% to 14.6% (women, 32.6%-22.0%; men, 7.0%-4.9%; P<0.001 for all), with higher mean BMD at all skeletal sites in 2024. In women, the prevalence of low bone mass increased from 47.9% to 56.0%, while it declined from 47.4% to 33.3% in men. The proportions of physician-diagnosed osteoporosis (24.9%-34.5%) and treatment (11.1%-22.8%) increased over time, particularly among women. In men, PR of osteoporosis between periods was attenuated after adjustment for height and weight, whereas changes in anthropometry, lifestyle, and nutrition did not fully account for the decline in women.Conclusions: From 2008 to 2011 and 2024, the prevalence of osteoporosis among Korean adults aged ≥50 years decreased, accompanied by improvements in the proportion of diagnosis and treatment.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":" ","pages":"141-151"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Muscle Mass, Adiposity, and Bone Health in Surgical Care Setting: A Cross-Sectional Study. 外科护理环境中的肌肉质量、脂肪和骨骼健康：一项横断面研究。

Journal of Bone Metabolism Pub Date : 2026-05-01 Epub Date: 2026-05-31 DOI: 10.11005/jbm.25.973

Ngo Thi Thu Thuy, Le Van Thieu, Tran Vuong The Vinh

{"title":"Muscle Mass, Adiposity, and Bone Health in Surgical Care Setting: A Cross-Sectional Study.","authors":"Ngo Thi Thu Thuy, Le Van Thieu, Tran Vuong The Vinh","doi":"10.11005/jbm.25.973","DOIUrl":"10.11005/jbm.25.973","url":null,"abstract":"Background: Osteoporosis and sarcopenia are interrelated conditions that significantly affect surgical outcomes by impairing bone strength, mobility, and postoperative recovery. Understanding how body composition and metabolic factors influence bone mineral density (BMD) is essential for improving perioperative risk assessment and rehabilitation. This study aimed to evaluate the relationships between regional muscle mass, fat mass (FM), and circulating adipokines with BMD.Methods: A cross-sectional study was conducted in 199 patients. Whole-body dual energy X-ray absorptiometry (DXA) was used to assess regional lean and FM and BMD at multiple skeletal sites. Serum leptin and adiponectin were measured by enzyme-linked immunosorbent assay. Correlations were examined using Pearson's coefficients, and stepwise multiple linear regression identified independent predictors of T-score.Results: Trunk and gynoid muscle mass exhibited the strongest positive correlations with T-score (r=0.490 and r=0.475, both P<0.001). FM showed weaker associations, while adiponectin correlated inversely with BMD (r=-0.196, P=0.005). In multivariable analysis, trunk muscle mass (β=0.48, P<0.001), gynoid muscle mass (β=0.36, P=0.002), body mass index (β=0.18, P=0.031), and adiponectin (β=-0.22, P=0.008) remained independent predictors (adjusted R²=0.45).Conclusions: Skeletal muscle, particularly in the trunk and hip regions, is the primary determinant of bone density, while adiponectin negatively influences BMD. Incorporating muscle mass assessment and metabolic optimization into perioperative care may enhance fixation stability and postoperative recovery.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 2","pages":"181-187"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polypharmacy and Bone Health in Patients with Type 2 Diabetes Mellitus: A Narrative Review. 多药治疗与2型糖尿病患者骨健康：综述

Journal of Bone Metabolism Pub Date : 2026-05-01 Epub Date: 2026-05-31 DOI: 10.11005/jbm.25.975

Israa O Kashmoola, Shatha H Mohammad, Mohammad H Alsaaty

{"title":"Polypharmacy and Bone Health in Patients with Type 2 Diabetes Mellitus: A Narrative Review.","authors":"Israa O Kashmoola, Shatha H Mohammad, Mohammad H Alsaaty","doi":"10.11005/jbm.25.975","DOIUrl":"10.11005/jbm.25.975","url":null,"abstract":"Patients with type 2 diabetes mellitus (T2DM) commonly demonstrate reduced bone quality and elevated fracture risk rates despite having normal or elevated bone mineral density (BMD). Beyond the pathophysiological effect of diabetes, polypharmacy has emerged as a potential, yet underappreciated contributor of skeletal fragility. To explore this association, a thorough search of the literature was conducted using PubMed, Google Scholar, and Web of Science. and Scopus for articles published in English language until October 2025. Studies addressing diabetes, polypharmacy, bone health, and drug-related skeletal outcomes were identified and included. A divergent effect on bone health was evident in patients using antidiabetic agents, with thiazolidinediones, sulfonylurea and some insulin regimens increase fracture risk. Whereas metformin, incretinbased therapies and sodium-glucose co-transporter 2 inhibitors appear neutral or protective. Concerning non-antidiabetic medication used in T2DM, glucocorticoids, selective serotonin reuptake inhibitors, proton pump inhibitors and loop diuretics are among the drugs that worsen the bone architecture, causing increased fracture risk. On the other hand, statins, β-blockers, angiotensin converting enzyme inhibitors, thiazide diuretics and angiotensin receptor antagonists are bone protective. Such cumulative impact of polypharmacy involves drug-drug interactions, increased fall potential, and attenuation of antiresorptive therapy. Clinical interventions to prevent skeletal deterioration include periodic medications review, deprescribing of high-risk agents, calcium and vitamin D supplementation, and life-style modifications. Personalized and multidisciplinary strategies are essential to balance metabolic status with long-term skeletal preservation in patients with T2DM exposed to polypharmacy.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 2","pages":"127-140"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-Calibration of Bone Mineral Density and Body Composition between GE Lunar Prodigy and Hologic Horizon W Dual Energy X-Ray Absorptiometry Systems. GE Lunar Prodigy和Hologic Horizon W双能x射线吸收仪对骨密度和身体成分的交叉校准。

Journal of Bone Metabolism Pub Date : 2026-02-01 Epub Date: 2026-02-28 DOI: 10.11005/jbm.26.1014

Sujin Kim, Guen Young Lee, Jun-Il Yoo, Sang-Wook Lee, Yong-Chan Ha

{"title":"Cross-Calibration of Bone Mineral Density and Body Composition between GE Lunar Prodigy and Hologic Horizon W Dual Energy X-Ray Absorptiometry Systems.","authors":"Sujin Kim, Guen Young Lee, Jun-Il Yoo, Sang-Wook Lee, Yong-Chan Ha","doi":"10.11005/jbm.26.1014","DOIUrl":"10.11005/jbm.26.1014","url":null,"abstract":"Background: Dual energy X-ray absorptiometry (DXA) measurements vary among instruments from different manufacturers. This study aimed to assess the correlation between bone mineral density (BMD) and body composition measured by the GE Lunar Prodigy and Hologic Horizon W DXA systems and to develop conversion equations.Methods: A total of 120 healthy volunteers (59 males, 61 females) aged 20 to 70 years were scanned on both DXA systems on the same day. BMD was measured at the lumbar spine (L1-L4) and bilateral femurs. Body composition parameters were measured for the whole body and regional sites. Bland-Altman analysis, Pearson correlation, and concordance correlation coefficient (CCC) were used to assess agreement. Linear regression was performed to derive conversion equations.Results: The Hologic system measured BMD values 14% to 20% lower at the lumbar spine and 8% to 17% lower at femoral sites compared to the GE Lunar system (all P<0.0001). Lean mass values were 4% to 10% lower on the Hologic system. Very strong correlations were observed for both BMD (r=0.944-0.980) and lean mass (r=0.963-0.984). Cross-calibration equations were developed for all measurement sites.Conclusions: Despite significant systematic differences, there was very high correlation between the two DXA systems. The conversion equations can facilitate comparison of measurements between these systems in clinical practice and research.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 1","pages":"84-93"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fatty Acid-Sensing G Protein-Coupled Receptors in Skeletal Metabolism. 脂肪酸敏感G蛋白偶联受体在骨骼代谢中的作用。

Journal of Bone Metabolism Pub Date : 2026-02-01 Epub Date: 2026-02-28 DOI: 10.11005/jbm.25.937

Hyun-Ju Kim, Dong-Kyo Lee, Xiangguo Che, Sihoon Lee, Je-Yong Choi

{"title":"Fatty Acid-Sensing G Protein-Coupled Receptors in Skeletal Metabolism.","authors":"Hyun-Ju Kim, Dong-Kyo Lee, Xiangguo Che, Sihoon Lee, Je-Yong Choi","doi":"10.11005/jbm.25.937","DOIUrl":"10.11005/jbm.25.937","url":null,"abstract":"G protein-coupled receptors (GPCRs), commonly known as seven-transmembrane domain receptors, represent one of the largest and most functionally diverse families of membrane receptors. These receptors mediate cellular responses to external signals, thereby influencing various physiological processes. Recent studies have increasingly highlighted the importance of GPCRs in skeletal health, particularly in regulating bone metabolism and the pathogenesis of bone diseases, such as osteoporosis and osteoarthritis. Among GPCRs, a specific subset that responds to fatty acids, including GPR40, GPR120, GPR41, GPR43, GPR84, and GPR119, has received significant attention for its role in skeletal homeostasis. Acting as lipid sensors, these receptors detect changes in fatty acid availability and transduce signals that modulate the differentiation, function, and survival of key bone cell populations, including osteoclasts, osteoblasts, and chondrocytes. This review provides a comprehensive overview of the current understanding of fatty acid-sensing GPCRs in skeletal metabolism, highlighting their potential as novel therapeutic targets for metabolic bone diseases.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 1","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0