Journal of Bone Metabolism最新文献

{"title":"Trends in Low Muscle Mass and Sarcopenia Prevalence in Korea Using Korea National Health and Nutrition Examination Survey (KNHANES) 2024 and 2008-2011: The KSBMR-KSOS KNHANES DXA Joint Task Force Report.","authors":"Namki Hong, Jun-Il Yoo, Jeonghoon Ha, Seong Hee Ahn, Young-Kyun Lee, Hyun Sik Gong, Ki-Hyun Baek, Yumie Rhee, Yong-Chan Ha","doi":"10.11005/jbm.26.1020","DOIUrl":"https://doi.org/10.11005/jbm.26.1020","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia is increasingly recognized as a major age-related disease with important clinical and public health implications, leading to updated international consensus definitions. We evaluated temporal changes in dual energy X-ray absorptiometry (DXA)-derived low muscle mass and estimated the prevalence and associated comorbidities of sarcopenia using nationally representative data.</p><p><strong>Methods: </strong>We analyzed adults aged ≥50 years from the Korea National Health and Nutrition Examination Survey (KNHANES) 2008-2011 and 2024. Appendicular lean mass was assessed using wholebody DXA. Low muscle mass was defined according to the Asian Working Group for Sarcopenia 2025 criteria. Sarcopenia, defined as the coexistence of low muscle mass and low handgrip strength, was assessed only in KNHANES 2024. Sampling weight was applied to all analyses.</p><p><strong>Results: </strong>The age-standardized prevalence of low muscle mass increased from 27.2% in 2008-2011 to 47.1% in 2024, with similar trends observed in men and women. Male sex, greater height, lower body weight, lower total energy intake, a higher proportion of energy derived from fat, and diabetes mellitus were independently associated with a higher prevalence of low muscle mass. The between-period difference in prevalence remained statistically significant after multivariable adjustment. In 2024, the overall prevalence of sarcopenia was 6.7% and increased with age, reaching 21.5% among adults aged ≥80 years. Sarcopenia was independently associated with diabetes mellitus, anemia, malnutrition, poor self-rated health, and recent bedridden status.</p><p><strong>Conclusions: </strong>Low muscle mass and sarcopenia are increasingly prevalent among older adults in Korea and are strongly associated with comorbidities.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Osteoporosis Prevalence in Korea Using Korea National Health and Nutrition Examination Survey (KNHANES) 2024 and 2008-2011: The KSBMR KNHANES DXA Task Force Report.","authors":"Namki Hong, Jeonghoon Ha, Jun-Il Yoo, Seong Hee Ahn, Yong-Chan Ha, Ki-Hyun Baek, Yumie Rhee","doi":"10.11005/jbm.26.003","DOIUrl":"https://doi.org/10.11005/jbm.26.003","url":null,"abstract":"<p><strong>Background: </strong>National estimates of osteoporosis prevalence in Korea has been based on dual energy X-ray absorptiometry (DXA) data from the Korea National Health and Nutrition Examination Survey (KNHANES) conducted between 2008 and 2011. In 2024, KNHANES resumed nationwide DXA testing, enabling updated prevalence estimates.</p><p><strong>Methods: </strong>We compared the prevalence of osteoporosis (DXA T-score ≤-2.5 at lumbar spine, femoral neck, or total hip) and low bone mass (-1.0>T-score>-2.5 at any sites) among Korean adults aged ≥50 years between KNHANES 2008-2011 and 2024. Agestandardized prevalence estimates accounting for complex sampling were calculated. The Poisson regression model was used to assess prevalence ratios (PRs) between survey periods, with adjustment for anthropometric measures, lifestyle factors, and nutritional intake.</p><p><strong>Results: </strong>The prevalence of osteoporosis declined between KNHANES 2008-2011 and 2024 from 20.8% to 14.6% (women, 32.6%-22.0%; men, 7.0%-4.9%; P<0.001 for all), with higher mean BMD at all skeletal sites in 2024. In women, the prevalence of low bone mass increased from 47.9% to 56.0%, while it declined from 47.4% to 33.3% in men. The proportions of physician-diagnosed osteoporosis (24.9%-34.5%) and treatment (11.1%-22.8%) increased over time, particularly among women. In men, PR of osteoporosis between periods was attenuated after adjustment for height and weight, whereas changes in anthropometry, lifestyle, and nutrition did not fully account for the decline in women.</p><p><strong>Conclusions: </strong>From 2008 to 2011 and 2024, the prevalence of osteoporosis among Korean adults aged ≥50 years decreased, accompanied by improvements in the proportion of diagnosis and treatment.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Calibration of Bone Mineral Density and Body Composition between GE Lunar Prodigy and Hologic Horizon W Dual Energy X-Ray Absorptiometry Systems.","authors":"Sujin Kim, Guen Young Lee, Jun-Il Yoo, Sang-Wook Lee, Yong-Chan Ha","doi":"10.11005/jbm.26.1014","DOIUrl":"10.11005/jbm.26.1014","url":null,"abstract":"<p><strong>Background: </strong>Dual energy X-ray absorptiometry (DXA) measurements vary among instruments from different manufacturers. This study aimed to assess the correlation between bone mineral density (BMD) and body composition measured by the GE Lunar Prodigy and Hologic Horizon W DXA systems and to develop conversion equations.</p><p><strong>Methods: </strong>A total of 120 healthy volunteers (59 males, 61 females) aged 20 to 70 years were scanned on both DXA systems on the same day. BMD was measured at the lumbar spine (L1-L4) and bilateral femurs. Body composition parameters were measured for the whole body and regional sites. Bland-Altman analysis, Pearson correlation, and concordance correlation coefficient (CCC) were used to assess agreement. Linear regression was performed to derive conversion equations.</p><p><strong>Results: </strong>The Hologic system measured BMD values 14% to 20% lower at the lumbar spine and 8% to 17% lower at femoral sites compared to the GE Lunar system (all P<0.0001). Lean mass values were 4% to 10% lower on the Hologic system. Very strong correlations were observed for both BMD (r=0.944-0.980) and lean mass (r=0.963-0.984). Cross-calibration equations were developed for all measurement sites.</p><p><strong>Conclusions: </strong>Despite significant systematic differences, there was very high correlation between the two DXA systems. The conversion equations can facilitate comparison of measurements between these systems in clinical practice and research.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 1","pages":"84-93"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatty Acid-Sensing G Protein-Coupled Receptors in Skeletal Metabolism.","authors":"Hyun-Ju Kim, Dong-Kyo Lee, Xiangguo Che, Sihoon Lee, Je-Yong Choi","doi":"10.11005/jbm.25.937","DOIUrl":"10.11005/jbm.25.937","url":null,"abstract":"<p><p>G protein-coupled receptors (GPCRs), commonly known as seven-transmembrane domain receptors, represent one of the largest and most functionally diverse families of membrane receptors. These receptors mediate cellular responses to external signals, thereby influencing various physiological processes. Recent studies have increasingly highlighted the importance of GPCRs in skeletal health, particularly in regulating bone metabolism and the pathogenesis of bone diseases, such as osteoporosis and osteoarthritis. Among GPCRs, a specific subset that responds to fatty acids, including GPR40, GPR120, GPR41, GPR43, GPR84, and GPR119, has received significant attention for its role in skeletal homeostasis. Acting as lipid sensors, these receptors detect changes in fatty acid availability and transduce signals that modulate the differentiation, function, and survival of key bone cell populations, including osteoclasts, osteoblasts, and chondrocytes. This review provides a comprehensive overview of the current understanding of fatty acid-sensing GPCRs in skeletal metabolism, highlighting their potential as novel therapeutic targets for metabolic bone diseases.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 1","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution and Characteristics of Fall Risk Index-21 Scores in Patients with Fall-Related Hip Fractures.","authors":"Norifumi Fujii, Manabu Tsukamoto, Ryoichi Nakamura, Sachio Himei, Daisuke Nakagawa, Yoshiaki Ikejiri, Toru Yoshioka, Takayuki Nabeshima, Nobukazu Okimoto","doi":"10.11005/jbm.25.931","DOIUrl":"10.11005/jbm.25.931","url":null,"abstract":"<p><strong>Background: </strong>Fall risk assessment and preventive interventions are important for preventing secondary fractures after hip fracture. The aim of this study was to investigate the distribution and characteristics of Fall Risk Index-21 (FRI-21) scores based on prefracture living conditions in patients with fall-related unilateral hip fracture.</p><p><strong>Methods: </strong>This study included 95 people who had suffered a hip fracture after a fall and had undergone surgery. FRI-21, dual energy X-ray absorptiometry (DXA), and hip structure analysis/trabecular bone score based on DXA were performed within 1 week after surgery. We compared bone parameters between the two groups, which were divided according to the cutoff value of the FRI-21. We also performed cluster analysis on the components of the FRI-21 and compared the characteristics of the subgroups via analysis of variance and multiple comparison tests.</p><p><strong>Results: </strong>All participants had experienced a fall-related fracture, but 47 (49.5%) of the patients were judged to have low scores (<10) on the FRI-21. Moreover, cluster analysis revealed that the subjects were classified into three subgroups, and the characteristics of the items that constitute fall risk, namely, physical function, disease or geriatric syndrome, and environmental factors, were diverse.</p><p><strong>Conclusions: </strong>These results suggest that caution is needed when interpreting the FRI-21 total score based on preoperative living conditions in post-fracture patients, as it may not adequately reflect fall risk. Considering the characteristics of the FRI-21 score in patients with hip fractures, identifying appropriate fall prevention strategies and healthcare professionals involved may be important for preventing future re-fractures.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 1","pages":"73-83"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Bone Morphogenetic Protein Agonist Small Molecule, SB4, on Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells.","authors":"Fatemeh Naghshnejad, Bahman Zeynali, Iman Shabani, Azita Parvaneh Tafreshi","doi":"10.11005/jbm.25.899","DOIUrl":"10.11005/jbm.25.899","url":null,"abstract":"<p><strong>Background: </strong>Bone morphogenetic protein (BMP) signaling is crucial for osteogenic (OS) differentiation, bone growth, and repair. However, the clinical use of BMPs is limited due to their cost and challenges in delivery. SB4, a potent compound of benzoxazole, is a newly introduced small molecule shown to activate the BMP signaling pathway. In this study, we investigated the effects of SB4 on OS differentiation of adipose-derived mesenchymal stem cells (ADMSCs).</p><p><strong>Methods: </strong>We first examined whether BMP signaling is active in osteoinduced ADMSCs. ADMSCs were treated with SB4 (5 and 10 μM) for 24 hr, and mRNA expression of BMP direct target genes (ID1 and ID3) was analyzed. ADMSCs were then cultured with or without SB4 (10 μM) for 7, 14, and 21 days, followed by Alizarin red staining and real-time polymerase chain reaction analysis of mRNA expression of OS markers RUNX2, BMP2, alkaline phosphatase (ALP), and Osteopontin. To investigate the most effective time period of SB4 in osteogenesis, SB4 was applied every 3.5 days during the 21-day differentiation period.</p><p><strong>Results: </strong>After 24 hr of treatment with SB4 (5 and 10 μM), increased mRNA expression of BMP direct target genes (ID1 and ID3) confirmed that SB4 acts as an active BMP agonist. SB4-treated ADMSCs showed enhanced bone matrix production and increased mRNA expression of RUNX2, BMP2, ALP, and Osteopontin. Increased mRNA expression of OS markers, bone matrix formation, and ALP activity during the first 7 days of SB4 treatment suggested the importance of SB4 at the early stage of differentiation.</p><p><strong>Conclusions: </strong>These results indicate that SB4, with potential BMP-like activity, induces OS differentiation of ADMSCs, leading it to serve as a cost-effective BMP agonist for osteogenesis-related research as well as a potential therapeutic agent for bone repair and regeneration.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 1","pages":"18-29"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Trabecular Bone Score and Bone Mineral Density in Patients with Primary Hyperparathyroidism under 50 Years Old.","authors":"Yunkyung Jeon, Myungsoo Im, Doohwa Kim, Jihyun Kim, Kyoungjune Pak, Seong-Jang Kim, Keunyoung Kim","doi":"10.11005/jbm.25.885","DOIUrl":"10.11005/jbm.25.885","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the densitometric characteristics and qualitative bone status in patients with normocalcemic primary hyperparathyroidism (PHPT) compared with those in controls who were younger adults under 50 years.</p><p><strong>Methods: </strong>This retrospective study included 60 controls and 31 patients with PHPT who underwent dual energy X-ray absorptiometry (DXA) of the lumbar spine (LS), femoral neck (FN), and total hip (TH). Trabecular bone score (TBS) was derived from LS DXA images. Bone mineral density (BMD) values were assessed using Z-scores, and correlations between TBS, BMD, and laboratory parameters were examined.</p><p><strong>Results: </strong>The median ages of the control and PHPT groups were 41 and 42 years, respectively. The proportion of individuals classified as \"below the expected range for age\" based on Z-scores differed significantly between groups only when considering any site collectively. Median TBS was significantly lower in PHPT patients than in controls, even when BMD values at LS, FN, and TH fell within similar diagnostic categories. In controls, TBS and BMD demonstrated very low correlation coefficients. In contrast, PHPT patients showed a stronger correlation between TBS and femoral BMD, whereas the association between TBS and LS BMD was largely absent. Among laboratory markers, only serum intact parathyroid hormone was significantly negatively correlated with TBS.</p><p><strong>Conclusions: </strong>Young adults with PHPT exhibit impaired bone quality despite relatively preserved BMD, suggesting early microarchitectural deterioration. These findings support the combined use of LS and femoral BMD with TBS for more accurate assessment of skeletal health in PHPT.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 1","pages":"63-72"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Various Anti-Diabetic Drugs on the Risk of Fractures in Older Women with Type 2 Diabetes Mellitus.","authors":"Seong Hee Ahn, Kyoung Jin Kim, So Young Park, Su Jin Kwon, Ha Young Kim, Kyoung Min Kim","doi":"10.11005/jbm.25.895","DOIUrl":"10.11005/jbm.25.895","url":null,"abstract":"<p><strong>Background: </strong>To investigate the fracture risks associated with anti-diabetic drugs in older women with type 2 diabetes mellitus (T2DM), who are particularly susceptible to skeletal fragility.</p><p><strong>Methods: </strong>Using data from the Korean National Health Insurance Service, this nested case-control study included 10,104 older women with T2DM and osteoporotic fractures (aged 66.5±3.4 years) matched in a 1:3 ratio with controls by birthdate, Charlson Comorbidity Index, and cohort entry date. We analyzed the odds of major osteoporotic fracture (MOF), vertebral fracture (VF), and non-VF (NVF) in users of sulfonylurea, thiazolidinedione (TZD), dipeptidyl peptidase-4 inhibitor, and sodium-glucose cotransporter 2 inhibitor (SGLT2i), compared to metformin (Met)-only users using multivariable logistic regression.</p><p><strong>Results: </strong>During a follow-up period of 3.8±2.8 years, TZD users had a higher risk of MOF than Met-only users (odds ratio [OR], 1.35; 95% confidence interval [CI], 1.19-1.53; P<0.001). Risks of VF and NVF were also increased in the TZD group (OR, 1.21; 95% CI 1.03-1.42; P=0.022 and OR, 1.32; 95% CI 1.14-1.52; P<0.001, respectively). No significant differences were observed in other drug groups. The increased risk of VF and NVF in the TZD group were particularly pronounced in patients with normal or osteopenic bone mineral density (BMD) and in those with normal body mass index (BMI), respectively.</p><p><strong>Conclusions: </strong>In older women with T2DM, TZD use was associated with increased VF and NVF risks, particularly among those with normal or osteopenic BMD and normal BMI. SGLT2i showed no increased risk, but further large-scale studies are needed to confirm its skeletal safety.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 1","pages":"50-62"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic Architectural Cover Accelerates Osseointegration of Titanium Implants.","authors":"Su-Jin Kim, Eun Chae Kim, Weon-Young Choi, Seung-Jae Lee, Je-Hwang Ryu","doi":"10.11005/jbm.26.1003","DOIUrl":"10.11005/jbm.26.1003","url":null,"abstract":"<p><strong>Background: </strong>Although various surface modifications enhance titanium (Ti) implant osseointegration, achieving rapid bone formation comparable to native healing remains challenging. Current strategies primarily focus on micro-scale topography, often overlooking the critical role of macroscopic three-dimensional (3D) architecture in osteoconduction.</p><p><strong>Methods: </strong>We hypothesized that mimicking native bone's porous architecture is key to accelerating osseointegration. First, we verified the impact of structural continuity by comparing standard Ti implants with decellularized bone grafts in a mouse calvaria defect model. Subsequently, we developed a biomimetic polycaprolactone (PCL)-based 3D architectural cover (Cover-type) and evaluated its osseointegration efficacy in a rat femur model against conventional Ti implants.</p><p><strong>Results: </strong>The mouse study confirmed that decellularized bone integrated significantly faster than Ti, highlighting the necessity of 3D continuity. In the rat model, micro-computed tomography analysis indicated a clear trend of increased bone formation in the Cover-type group, though statistical significance was limited by sample size. However, histological analysis confirmed a statistically significant enhancement in bone-to-implant contact compared to controls (P<0.05). The PCL structure served as a scaffold for cell migration, effectively bridging the implant-bone gap.</p><p><strong>Conclusions: </strong>These findings suggest that providing a bone-like 3D environment via a PCL cover may enhance histological osseointegration, rather than relying solely on surface chemistry.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 1","pages":"30-39"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping a Decade of Osteoporosis and Fracture Research: A Bibliometric Analysis (2015-2025).","authors":"Oluwafemi Samson Balogun, Sunday Adewale Olaleye, Margaret Adebola Balogun, Esther Olubunmi Olaleye, Muhammad Zeshan Arshad, Keijo Haataja, Pekka Toivanen","doi":"10.11005/jbm.25.903","DOIUrl":"10.11005/jbm.25.903","url":null,"abstract":"<p><strong>Background: </strong>Osteoporosis is a major global health concern, affecting over 200 million individuals worldwide. Although numerous clinical and experimental studies exist, comprehensive analyses integrating fracture-related and drug-specific research remain limited. Examining global research trends can highlight evolving themes, key contributors, and areas requiring scientific attention.</p><p><strong>Methods: </strong>We performed a bibliometric analysis of literature on osteoporosis and fractures, including drug-specific terms (denosumab, romosozumab, teriparatide), published between 2015 and 2025 in the Scopus Core Collection. Data were assessed for publication trends, authorship, institutional output, international collaboration, and thematic evolution using Bibliometrix-Biblioshiny in RStudio. Network analyses included co-authorship and keyword co-occurrence mapping for both quantitative and qualitative insights.</p><p><strong>Results: </strong>From 4,450 articles, annual output showed steady growth, peaking between 2021 and 2024. The United States, Japan, and China led in publication volume and citation impact, while Osteoporosis International was the most productive journal. Citation averages declined recently due to lag in newer publications. Thematic mapping identified pharmacological therapies such as denosumab and teriparatide as core themes, while \"fracture prevention\" and \"DXA-based assessment\" emerged as active research fronts. International collaboration decreased after 2020, particularly affecting contributions from low- and middle-income countries.</p><p><strong>Conclusions: </strong>Global osteoporosis research demonstrates sustained productivity but declining collaboration and limited thematic diversification. Strengthening international networks, supporting underrepresented regions, and expanding focus to preventive and non-pharmacological strategies are essential for equitable and impactful progress.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 1","pages":"94-107"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}