Journal of Bone Metabolism最新文献

High Radiological Worsening in Patients with Vertebral Fragility Fractures and the Associated Factors. 椎体脆性骨折患者放射学高度恶化及其相关因素。

Journal of Bone Metabolism Pub Date : 2025-05-01 Epub Date: 2025-05-31 DOI: 10.11005/jbm.25.835

Mauricio Soto-Subiabre, Victor Mayoral, Lidia Valencia-Muntalà, Carlos González, Carmen Gómez-Vaquero

{"title":"High Radiological Worsening in Patients with Vertebral Fragility Fractures and the Associated Factors.","authors":"Mauricio Soto-Subiabre, Victor Mayoral, Lidia Valencia-Muntalà, Carlos González, Carmen Gómez-Vaquero","doi":"10.11005/jbm.25.835","DOIUrl":"https://doi.org/10.11005/jbm.25.835","url":null,"abstract":"Background: To investigate the contribution of radiological characteristics of baseline fragility vertebral fractures (FVF) and clinical characteristics to the development of radiological worsening (RW).Methods: Patients were recruited between 2015 and 2018. The primary outcome was the identification of RW in a radiological second image, defined as the progression of prevalent FVF, new FVF, or both. Data on fracture risk fractures, bone mineral density, analgesia requirements, and antiosteoporosis treatment were recorded. The radiological features of baseline FVF included fracture number, location(s), severity grade (Genant method), kyphosis angle, and spine index deformity.Results: A total of 223 patients with at least one follow-up radiological evaluation were included. Another 199 patients had no radiological follow-up. Of those with follow-up, 69% presented RW, accounting for 36.5% of the total cohort (422 patients). The incidence rate of RW was 73.8/1,000 patient-years. Among those with RW, 61% showed progression of FVF, 27% developed new FVF, and 12% had both. The multivariate analysis demonstrated that multiple FVF and worse grades of FVF at baseline were variables significantly associated with RW. Baseline characteristics of FVF that increased the risk of RW by progression of FVF was grade 1 (odds ratio [OR], 3.22; 95% confidence interval [CI], 1.47-7.02) and grade 2 (OR, 1.97; 95% CI, 1.05-3.68) and by new FVF was grade 3 (OR, 3.19; 95% CI, 1.39-7.33) FVF.Conclusions: Approximately one-third of patients with FVF experienced RW, with progression of FVF being the most common event. A higher number of FVF and a greater severity at baseline are associated with RW.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 2","pages":"143-154"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Positive Effect of Yerba Mate (Ilex paraguariensis) Consumption on Bone Mineral Density in Postmenopausal Women Assessed by Dual Energy X-Ray Absorptiometry-Based 3-Dimensional Modeling. 双能x线三维模型评估巴拉圭茶对绝经后妇女骨密度的积极影响

Journal of Bone Metabolism Pub Date : 2025-05-01 Epub Date: 2025-05-31 DOI: 10.11005/jbm.24.827

Lucas R Brun, Muriel M Henríquez, Luis A Ramírez Stieben, Mariana Cusumano, Jorge Homero Wilches-Visbal, Fernando Daniel Saraví, María Lorena Brance

{"title":"Positive Effect of Yerba Mate (Ilex paraguariensis) Consumption on Bone Mineral Density in Postmenopausal Women Assessed by Dual Energy X-Ray Absorptiometry-Based 3-Dimensional Modeling.","authors":"Lucas R Brun, Muriel M Henríquez, Luis A Ramírez Stieben, Mariana Cusumano, Jorge Homero Wilches-Visbal, Fernando Daniel Saraví, María Lorena Brance","doi":"10.11005/jbm.24.827","DOIUrl":"https://doi.org/10.11005/jbm.24.827","url":null,"abstract":"Background: Yerba mate (YM) drinking is associated with higher lumbar spine and femoral neck bone mineral density (BMD) in postmenopausal women. We analyzed its effect on total hip BMD and reported the contribution of the trabecular and cortical components to this effect.Methods: A control group of 147 non-drinkers was compared to 153 YM drinkers. Left hip BMD was measured using dual energy X-ray absorptiometry (DXA), and three-dimensional (3D)-Shaper software was used to estimate integral volumetric BMD (vBMD), cortical surface BMD (sBMD), and trabecular vBMD through 3D modeling.Results: No significant difference was found between groups in either age (p=0.746) or body mass index (BMI; p=0.329). The YM group had significantly higher total hip BMD, integral vBMD, cortical sBMD, and trabecular BMD (all p<0.0001). The frequency of DXA-based osteoporosis diagnosis was lower in YM drinkers (3.3% vs. 10.9%; odds ratio [OR], 0.276). The rate of low-impact fractures was significantly reduced in YM drinkers (5.9% vs. 12.9%; OR, 2.197). Linear regression analyses revealed that cortical and trabecular parameters correlated positively with BMI and negatively with age in both groups. The slope of the lines did not differ between groups, but the elevation was uniformly higher in the YM group (p=0.0004 to p<0.0001).Conclusions: Our study provides novel insights into YM consumption and bone health in postmenopausal women. We confirm its positive association with BMD and demonstrate, for the first time, that both cortical and trabecular compartments contribute to this effect. Our findings also suggest a potential protective role of YM against osteoporosis and fragility fractures.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 2","pages":"123-132"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vertebral Fractures Identified by Lateral Spine Dual Energy X-Ray Absorptiometry Scans and Mortality Risk in Adults. 成人侧脊柱双能x线吸收扫描鉴定的椎体骨折和死亡风险。

Journal of Bone Metabolism Pub Date : 2025-05-01 Epub Date: 2025-05-31 DOI: 10.11005/jbm.24.831

Carlos H Orces

{"title":"Vertebral Fractures Identified by Lateral Spine Dual Energy X-Ray Absorptiometry Scans and Mortality Risk in Adults.","authors":"Carlos H Orces","doi":"10.11005/jbm.24.831","DOIUrl":"https://doi.org/10.11005/jbm.24.831","url":null,"abstract":"Background: Vertebral fractures identified by radiographic morphometry are associated with increased mortality risk. However, there is limited data regarding the association between vertebral fractures detected by lateral spine dual energy X-ray absorptiometry (DXA) scans and the risk of mortality.Methods: The present study was based on data from participants aged 40 years and older in the 2013 to 2014 cycle of the National Health and Nutrition Examination Survey (NHANES). Vertebral fracture assessment (VFA) performed using lateral spine DXA scans was used to provide fracture information of the vertebrae from T4 to L4. Vertebral fracture severity was categorized according to Genant's semiquantitative technique and the NHANES 2019 public-use linked mortality files were used to determine mortality status.Results: Of 3,219 participants, the prevalence of vertebral fractures identified by VFA was 5.5% (95% confidence interval [CI], 4.7-6.5). During a median follow-up of 71.0 months, 277 participants died, 18.2% (95% CI, 12.2-26.3) with vertebral fractures and 6.3% (95% CI, 5.0-8.0) without fractures (p<0.0001). Cox regression analysis demonstrated that participants with moderate to severe vertebral fractures (>25% height loss) were 1.7 times more likely to die compared with their counterparts without (hazard ratio [HR], 1.79; 95% CI, 1.05-3.04). Notably, in a subgroup analysis, older adults (HR, 2.16; 95% CI, 1.41-3.30) and men with vertebral fractures (HR, 2.28; 95% CI, 1.49-3.47) had a 2-fold greater mortality risk compared to those without vertebral fractures.Conclusions: Vertebral fracture severity identified by VFA was significantly associated with greater all-cause mortality risk. This association was also observed among men and older adults with any baseline vertebral fractures.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 2","pages":"133-142"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Influence of Fish Bone Powders on the Bone Density in Corticosteroid-Induced Osteoporosis Rats. 鱼骨粉对皮质激素所致骨质疏松大鼠骨密度的影响。

Journal of Bone Metabolism Pub Date : 2025-05-01 Epub Date: 2025-04-18 DOI: 10.11005/jbm.24.819

Annis Catur Adi, Wizara Salisa, Sri Fatmawati, Emyr Reisha Isaura, Heni Rachmawati

{"title":"The Influence of Fish Bone Powders on the Bone Density in Corticosteroid-Induced Osteoporosis Rats.","authors":"Annis Catur Adi, Wizara Salisa, Sri Fatmawati, Emyr Reisha Isaura, Heni Rachmawati","doi":"10.11005/jbm.24.819","DOIUrl":"https://doi.org/10.11005/jbm.24.819","url":null,"abstract":"Background: The adequacy of calcium from food consumption is difficult to meet because of its low absorption rate, causing an increased risk of osteoporosis. One of the ways to increase calcium absorption is to increase its solubility by decreasing its particle size. This study aimed to observe the influence of particle size and mineral composition of various fish bone powders on bone density enhancement after oral administration to corticosteroid-induced osteoporosis rats.Methods: The test stages carried out include manufacturing fish bone flour and nanonization, characterization (particle size and nutritional content), conducting experimental tests on rats using blood serum samples, and observing bone growth and density. The types of fish studied were catfish, snakehead fish, mackerel, and snapper.Results: Nanonization processing has been proven to reduce the size of flour particles, increase its nutritional and mineral content, and maximize the calcium absorption rate in rats. The results of the test on experimental animals induced osteoporosis showed that rats given the intervention of milling snapper fish bone meal produced the best outcomes in body length, body mass index, calcium, magnesium, and serum phosphorus (P<0.05). While in bone parameters, catfish bone meal was the most optimal in encouraging bone density percentage.Conclusions: In conclusion, to increase serum minerals and bone density optimally, in addition to reducing particle size, the ratio of mineral content also needs to be considered.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 2","pages":"103-113"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tibial Mechanoadaptation in Male Mice is Modularised and Retained in Aging. 雄性小鼠的胫骨机械适应性模块化并在衰老过程中保持不变。

Journal of Bone Metabolism Pub Date : 2025-05-01 Epub Date: 2025-05-31 DOI: 10.11005/jbm.24.817

Roberto Lopes de Souza, Samuel Monzem, Andrew Anthony Pitsillides

{"title":"Tibial Mechanoadaptation in Male Mice is Modularised and Retained in Aging.","authors":"Roberto Lopes de Souza, Samuel Monzem, Andrew Anthony Pitsillides","doi":"10.11005/jbm.24.817","DOIUrl":"https://doi.org/10.11005/jbm.24.817","url":null,"abstract":"Background: The murine tibia is a remarkable bone in which to study mechanoadaptive responses. Studies into age-related shifts in these responses do not, however, fully explain sex-specific bone architectural changes related to age. Here, we generate data from male subjects to evaluate whether load-induced skeletal responses are modularised and age-related.Methods: Tibiae in young (12-week-old), mature (22-week-old), and aged (18-month-old) C57Bl/6 male mice were subjected to pre-calibrated right limb (left, control) loading for 2 weeks. Cortical bone formation was measured in young and mature mice at 3 positions, and new bone formation was evaluated in aged mice at a single location. Micro-computed tomography scans were used to measure trabecular changes.Results: We found that loading increased cortical formation at all tibial positions in young, and all except the most distal position in mature mice. Intriguingly, total cortical formation was also significantly greater in loaded tibiae in aged males. Loading failed to modify trabecular mass/architecture at any age.Conclusions: We conclude that load-induced cortical responses are partially retained, whereas trabecular bone appears resistant to loading in males of all ages. These data indicate modular patterns of mechanoadaptation across bone compartments that align with the emergence of age-related skeletal frailty.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 2","pages":"93-102"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D Deficiency in Young Elite Soccer Players Residing Permanently in Regions above 55 Degrees North Latitude. 常住北纬55度以上地区青少年优秀足球运动员维生素D缺乏的研究

Journal of Bone Metabolism Pub Date : 2025-05-01 Epub Date: 2025-04-18 DOI: 10.11005/jbm.24.821

Eduard Bezuglov, Mikhail Vinogradov, Ilsiuiar Anishchenko, Timur Vakhidov, Elvira Usmanova, Georgiy Malyakin, Elizaveta Kapralova

{"title":"Vitamin D Deficiency in Young Elite Soccer Players Residing Permanently in Regions above 55 Degrees North Latitude.","authors":"Eduard Bezuglov, Mikhail Vinogradov, Ilsiuiar Anishchenko, Timur Vakhidov, Elvira Usmanova, Georgiy Malyakin, Elizaveta Kapralova","doi":"10.11005/jbm.24.821","DOIUrl":"https://doi.org/10.11005/jbm.24.821","url":null,"abstract":"Background: Although the importance of maintaining optimal vitamin D levels is wellrecognized, vitamin D deficiency among athletes remains prevalent, particularly in regions located above 40 degrees north latitude. The study aimed to evaluate weekly cholecalciferol supplementation in correcting vitamin D deficiency in young soccer players.Methods: The study involved 49 young soccer players permanently residing above 55 degrees north latitude with 25-hydroxy-vitamin D (25[OH]D) deficiency, randomized into an experimental group (N=25; mean age, 13.0±2.78 years) and a control group (N=24; mean age, 12.3±3.14 years). Participants in the experimental group received 15,000 IU of cholecalciferol once a week for six weeks. Blood samples were collected twice in February and May: before and after the intervention. Serum levels of 25(OH)D, calcium, ionized calcium, phosphorus, and parathyroid hormone using mass spectrometry have been measured.Results: Baseline serum 25(OH)D levels were similar in both groups (15.59±2.66 ng/mL vs. 15.56±2.30 ng/mL; P>0.05). Post-intervention, levels rose to 30.25±5.17 ng/mL in the experimental group and 20.59±5.56 ng/mL in the control group, with significantly greater improvement in the experimental group (P<0.001). By the end, 60% of the experimental group reached normal 25(OH)D levels, compared to just 4.17% (N=1) in the control group. Other hematological parameters showed no significant intergroup differences (P>0.05).Conclusions: A six-week course of 15,000 IU weekly cholecalciferol effectively and safely corrects 25(OH)D deficiency in young soccer players residing permanently in regions above 55 degrees north latitude, with minimal impact from spring outdoor training.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 2","pages":"114-122"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alveolar Bone Mesenchymal Stem Cells Exhibit Osteogenic Potential with Fewer Macrophages. 肺泡骨间充质干细胞具有成骨潜能，巨噬细胞较少。

Journal of Bone Metabolism Pub Date : 2025-05-01 Epub Date: 2025-05-31 DOI: 10.11005/jbm.25.847

Zhao Wang, Jaemin Joun, Ju Han Song, Jeong-Tae Koh

{"title":"Alveolar Bone Mesenchymal Stem Cells Exhibit Osteogenic Potential with Fewer Macrophages.","authors":"Zhao Wang, Jaemin Joun, Ju Han Song, Jeong-Tae Koh","doi":"10.11005/jbm.25.847","DOIUrl":"https://doi.org/10.11005/jbm.25.847","url":null,"abstract":"Background: Mesenchymal stem cells (MSCs) derived from various tissues demonstrate regenerative potential in bone tissue engineering. However, bone marrow-derived MSCs (BMSCs) often contain macrophage contamination, necessitating additional purification steps such as liposomal clodronate treatment. In contrast, alveolar bone MSCs alveolar bone-derived MSCs (aBMSCs) may offer a distinct advantage due to their lower macrophage contamination.Methods: The aBMSCs were isolated from alveolar bone fragments through enzymatic digestion, and their macrophage contamination was compared to BMSCs using flow cytometry for MSC surface markers (CD44, CD105, CD90.2, CD140a) and macrophage markers (CD11b).Results: The aBMSCs exhibited significantly lower macrophage contamination compared to BMSCs and maintained osteogenic potential. Under inflammatory conditions in the presence of interleukin-1β (IL-1β), aBMSCs maintained their osteogenic capacity-unlike BMSCs, whose differentiation was impaired-accompanied by further activation of Protocadherin FAT4 (FAT4), which is known to initiate the osteogenic differentiation trajectory of aBMSCs.Conclusions: These results highlight aBMSCs as a promising cell source for bone regeneration, offering low macrophage contamination and sustained osteogenic potential under inflammatory conditions such as IL-1β exposure.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 2","pages":"83-92"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Differences in Cell Migration during the Osteogenic and Adipogenic Differentiation of the Bone Marrow-Derived Stem Cells. 骨髓干细胞成骨和成脂分化过程中细胞迁移差异的比较。

Journal of Bone Metabolism Pub Date : 2025-05-01 Epub Date: 2025-05-31 DOI: 10.11005/jbm.25.841

Anirban Sardar, Shikha Verma, Anuj Raj, Bhaskar Maji, Ritu Trivedi

{"title":"Comparison of Differences in Cell Migration during the Osteogenic and Adipogenic Differentiation of the Bone Marrow-Derived Stem Cells.","authors":"Anirban Sardar, Shikha Verma, Anuj Raj, Bhaskar Maji, Ritu Trivedi","doi":"10.11005/jbm.25.841","DOIUrl":"https://doi.org/10.11005/jbm.25.841","url":null,"abstract":"Background: The bone marrow niche comprises diverse cellular populations, including multipotent bone marrow-derived stem cells (BMSCs). Understanding the biology underlying the differentiation of BMSCs into osteogenic and adipogenic commitment in preserving bone health is key due to their inverse correlation. Biological processes such as cellular migration also serve as a crucial player during this differentiation and eventually contribute to various skeletal pathologies such as fractures, osteoporosis, and osteoarthritis. This is also crucial in developing various regenerative therapies involving BMSCs.Methods: To explore the differential migration of BMSCs, cells were initially directed into osteogenic or adipogenic commitment as confirmed by the mineralized matrix and lipid droplet formation for osteogenic and adipogenic commitment, respectively. The differential level of cellular migration was then assessed using the scratch wound healing assay, cell adhesion assay, and transwell migration assay.Results: The cellular differentiation was confirmed by the differential expression patterns of key markers, as determined by quantitative real-time reverse transcription-polymerase chain reaction and immunoblotting study. Moreover, the migration data indicates that BMSCs undergoing osteogenic commitment tend to migrate more compared to adipogenic cells, which is possibly attributed to the differential expression of integrins such as Itgα1, and Itgα5. The putative role of the Sdf1/Cxcr4 axis in this account was further established by utilizing a selective inhibitor of Cxcr4.Conclusions: This study sheds light on the differential migratory property of the BMSCs directed towards a specific lineage. It also highlights the need for a comprehensive understanding of the intricate biological interplay governing this peculiar cellular behaviour.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 2","pages":"69-82"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcium Supplementation: To Do or Not to Do. 补钙：做还是不做。

Journal of Bone Metabolism Pub Date : 2025-02-01 Epub Date: 2025-02-28 DOI: 10.11005/jbm.24.775

Emanuella Graciela Borges Fonseca, Carlos Marques Dos Santos, Felipe Freire da Silva, Ana Tereza Amoedo Martinez, Jozélio Freire de Carvalho

引用次数: 0

Treatment Goals for Prevention of Vertebral Fractures in Patients with Rheumatoid Arthritis. 类风湿关节炎患者椎体骨折预防的治疗目标。

Journal of Bone Metabolism Pub Date : 2025-02-01 Epub Date: 2025-02-28 DOI: 10.11005/jbm.24.811

Takeshi Mochizuki, Mari Ando, Koichiro Yano, Ryo Hiroshima, Katsunori Ikari, Ken Okazaki

{"title":"Treatment Goals for Prevention of Vertebral Fractures in Patients with Rheumatoid Arthritis.","authors":"Takeshi Mochizuki, Mari Ando, Koichiro Yano, Ryo Hiroshima, Katsunori Ikari, Ken Okazaki","doi":"10.11005/jbm.24.811","DOIUrl":"10.11005/jbm.24.811","url":null,"abstract":"Background: Patients with rheumatoid arthritis (RA) are at an increased risk of osteoporosis and vertebral fractures. This study aimed to investigate factors associated with vertebral fractures and treatment goals to prevent new vertebral fractures in patients with RA.Methods: The database used in this study included outpatient data of RA patients at the authors' hospital of RA patients taken from 2018 to 2022. The patients underwent annual imaging evaluations to assess parameters, including bone mineral density of the lumbar spine (LS; L2-4), total hip, and femoral neck, as well as vertebral fractures. Vertebral fractures were evaluated using radiographic images of the T8 to L5 vertebrae.Results: The prevalence rates of new vertebral fractures in 2018-2019, 2019-2020, 2020- 2021, and 2021-2022 were 2.0%, 1.3%, 2.3%, and 2.0%, respectively. The presence of existing vertebral fractures was associated with new vertebral fractures (p=0.003; odds ratio, 0.241; 95% confidence interval, 0.093-0.624). The cut-off T-score values for the LS for new vertebral fractures in patients with or without pre-existing vertebral fractures were -0.7 (sensitivity, 40.9%; specificity, 100%) and -1.4 (sensitivity, 69.0%; specificity, 62.5%), respectively.Conclusions: The presence of pre-existing vertebral fractures is an independent factor associated with new vertebral fractures. It is important to tailor treatment goals based on the presence or absence of vertebral fractures to effectively prevent new fractures.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 1","pages":"49-56"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0