Journal of Bone Metabolism最新文献_第10页

Patient Perception on Osteoporosis in Korean Female Patients with Osteoporosis. 韩国女性骨质疏松症患者对骨质疏松症的看法。

Journal of Bone Metabolism Pub Date : 2024-02-01 Epub Date: 2024-02-29 DOI: 10.11005/jbm.2024.31.1.63

Kyung-Hag Lee, Guhyun Lee, Taehyun Lee, Dong-Won Byun, Yong-Chan Ha

{"title":"Patient Perception on Osteoporosis in Korean Female Patients with Osteoporosis.","authors":"Kyung-Hag Lee, Guhyun Lee, Taehyun Lee, Dong-Won Byun, Yong-Chan Ha","doi":"10.11005/jbm.2024.31.1.63","DOIUrl":"10.11005/jbm.2024.31.1.63","url":null,"abstract":"Background: Patient perception is a key element in improving compliance with medications for osteoporosis. This study evaluated the awareness, perception, sources of information, and knowledge of osteoporosis among Korean women with osteoporosis.Methods: A questionnaire survey was conducted from July 22, 2021 to 13 August 2021. Patients who were followed up in endocrinology (Endo), orthopedic surgery (OS), and gynecology (GY) were recruited (N=40, 40, and 20 in each group). Patients were allocated according to their age, as follows: 15, 15, and 10 patients in their 60s, 70s, and 80s for Endo and OS, and 10 and 10 patients in their 60s and 70s for GY. The questionnaire was composed of the following topics: patient journey to the hospital, drug-related issues, communication with medical doctors, patient knowledge, and sources of information about osteoporosis.Results: The results of medical check-ups were the most common reason for patient visits to the hospital for an initial diagnosis of osteoporosis (61%). A knowledge gap regarding mortality, refracture, and drug-induced osteoporosis was observed. Doctors were the most preferred and trustful source of information, while health-related TV shows were the second most common source of information. Patients with OS reported lower perceived severity and higher drug discontinuation, along with a higher proportion of fractures, as the initial reasons for hospital visits for osteoporosis.Conclusions: Variations in perceptions according to the issue and group were identified. These should be considered during patient consultations to improve compliance with osteoporosis treatment.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"31 1","pages":"63-74"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted Coaching to Improve Osteoporosis Therapy Adherence: A Single Arm Variation of the C-STOP Study. 改善骨质疏松症治疗依从性的针对性辅导：C-STOP研究的单臂变异。

Journal of Bone Metabolism Pub Date : 2024-02-01 Epub Date: 2024-02-29 DOI: 10.11005/jbm.2024.31.1.13

Carrie Ye, Finlay A McAlister, Debbie Bellerose, Meng Lin

{"title":"Targeted Coaching to Improve Osteoporosis Therapy Adherence: A Single Arm Variation of the C-STOP Study.","authors":"Carrie Ye, Finlay A McAlister, Debbie Bellerose, Meng Lin","doi":"10.11005/jbm.2024.31.1.13","DOIUrl":"10.11005/jbm.2024.31.1.13","url":null,"abstract":"Background: In this pre-planned variation of the Comparing Strategies Targeting Osteoporosis to Prevent Fractures After an Upper Extremity Fracture (C-STOP) trial, we investigated whether adherence-specific coaching by the case manager (CM) further improved the adherence and persistence rates compared to those seen in the C-STOP trial.Methods: We conducted a prospective observational cohort study of community-dwelling adults 50 years or older who suffered an upper-extremity fracture and were not previously treated with osteoporosis medications, to assess whether a well-trained CM can partner with patients to improve adherence to and persistence with oral bisphosphonate intake. The primary outcome was adherence (taking > 80% of prescribed doses) to oral bisphosphonate intake at 12 months after study enrollment. Secondary outcomes included primary adherence to and 12-month persistence with oral bisphosphonate and calcium and vitamin D supplement intake at 12 months.Results: The study cohort consisted of 84 participants, of which 30 were prescribed an oral bisphosphonate. Twenty-two (73.3%) started treatment within 3 months. The adherence rate at 12 months was 77.3%. The persistence rate at 12 months was 95.5%. Of those not prescribed an oral bisphosphonate, 62.8% were taking supplemental calcium and 93.0% were taking supplemental vitamin D at 12 months. Depression was a significant predictor of 12-month non-adherence (adjusted odds ratio, 9.8; 95% confidence interval, 1.2-81.5).Conclusions: Adherence-specific coaching by a CM did not further improve the level of medication adherence achieved in the original C-STOP study. Importantly, these results can inform adherence in future intervention studies.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"31 1","pages":"13-20"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sarcopenia as the Mobility Phenotype of Aging: Clinical Implications. 肌肉疏松症是老龄化的行动能力表型：临床意义。

Journal of Bone Metabolism Pub Date : 2024-02-01 Epub Date: 2024-02-29 DOI: 10.11005/jbm.2024.31.1.1

Sunghwan Ji, Hee-Won Jung, Ji Yeon Baek, Il-Young Jang, Eunju Lee

{"title":"Sarcopenia as the Mobility Phenotype of Aging: Clinical Implications.","authors":"Sunghwan Ji, Hee-Won Jung, Ji Yeon Baek, Il-Young Jang, Eunju Lee","doi":"10.11005/jbm.2024.31.1.1","DOIUrl":"10.11005/jbm.2024.31.1.1","url":null,"abstract":"Sarcopenia, which is characterized by an age-related decline in muscle mass and function, poses significant challenges to geriatric care. Its definition has evolved from muscle-specific criteria to include muscle mass, muscle function, and physical performance, recognizing sarcopenia as a physical frailty. Sarcopenia is associated with adverse outcomes, including mortality, falls, fractures, cognitive decline, and admission to long-term care facilities. Neuromechanical factors, protein-energy balance, and muscle protein synthesis-breakdown mechanisms contribute to its pathophysiology. The identification of sarcopenia involves screening tests and a comprehensive assessment of muscle mass, strength, and physical function. Clinical approaches aligned with the principles of comprehensive geriatric assessment prioritize patient-centered care. This assessment aids in identifying issues related to activities of daily living, cognition, mood, nutrition, and social support, alongside other aspects. The general approach to factors underlying muscle loss and functional decline in patients with sarcopenia includes managing chronic diseases and evaluating administered medications, with interventions including exercise and nutrition, as well as evolving pharmacological options. Ongoing research targeting pathways, such as myostatin-activin and exercise mimetics, holds promise for pharmacological interventions. In summary, sarcopenia requires a multifaceted approach, acknowledging its complex etiology and tailoring interventions to individual patient needs.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"31 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone Health Status of Children with Spinal Muscular Atrophy. 脊髓肌肉萎缩症儿童的骨骼健康状况。

Journal of Bone Metabolism Pub Date : 2023-11-01 Epub Date: 2023-11-30 DOI: 10.11005/jbm.2023.30.4.319

Joanna Yuet-Ling Tung, Tsz-Kit Chow, Monique Wai, Jasmine Lo, Sophelia Hoi Shan Chan

{"title":"Bone Health Status of Children with Spinal Muscular Atrophy.","authors":"Joanna Yuet-Ling Tung, Tsz-Kit Chow, Monique Wai, Jasmine Lo, Sophelia Hoi Shan Chan","doi":"10.11005/jbm.2023.30.4.319","DOIUrl":"https://doi.org/10.11005/jbm.2023.30.4.319","url":null,"abstract":"Background: Spinal muscular atrophy (SMA) is a group of rare, inherited neuromuscular disorders. Bone health is often a neglected issue in children with SMA. This study aimed to evaluate the bone health status of children with SMA in Hong Kong.Methods: This retrospective study included children with SMA who were managed in the Neuromuscular Disorder Clinics of 2 quaternary centers in Hong Kong. Bone health status was assessed by fracture history, bone mineral density (BMD) measured by dual energy X-ray absorptiometry, and serum 25-hydroxy-vitamin D (25[OH]D) level.Results: Thirty-two children were included (males, 12). The median age was 10.8 years. BMD assessments were performed in 17 patients (SMA type 1=2, type 2=8, type 3=7). Low BMD was observed in 16 out of 17 patients. Four had a history of long bone fractures and were started on bisphosphonates. SMA types, age at last visit, sex, ambulation, and 25(OH)D level were not associated with fracture history or BMD Z-scores. Only one fulfilled the 2019 International Society for Clinical Densitometry (ISCD) pediatric definition of osteoporosis, with both low BMD and a history of clinically significant fracture.Conclusions: Children with SMA on disease-modifying treatments commonly had Low BMD and a history of fractures, but osteoporosis was uncommon according to the 2019 ISCD pediatric definition. A special definition of osteoporosis may be needed for this high-risk group.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"30 4","pages":"319-327"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10721381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138794609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness and Usefulness of Bone Turnover Marker in Osteoporosis Patients: A Multicenter Study in Korea. 骨质疏松症患者骨转换标志物的有效性和实用性：韩国一项多中心研究

Journal of Bone Metabolism Pub Date : 2023-11-01 Epub Date: 2023-11-30 DOI: 10.11005/jbm.2023.30.4.311

Jun-Il Yoo, So Young Park, Deog-Yoon Kim, Jeonghoon Ha, Yumie Rhee, Namki Hong, Jung-Taek Kim, Hyon-Seung Yi, Bu Kyung Kim, Young-Kyun Lee, Yong-Chan Ha, Yun Kyung Jeon, Ha-Young Kim, Seong Hee Ahn, Seongbin Hong, Sang-Yeob Lee

{"title":"Effectiveness and Usefulness of Bone Turnover Marker in Osteoporosis Patients: A Multicenter Study in Korea.","authors":"Jun-Il Yoo, So Young Park, Deog-Yoon Kim, Jeonghoon Ha, Yumie Rhee, Namki Hong, Jung-Taek Kim, Hyon-Seung Yi, Bu Kyung Kim, Young-Kyun Lee, Yong-Chan Ha, Yun Kyung Jeon, Ha-Young Kim, Seong Hee Ahn, Seongbin Hong, Sang-Yeob Lee","doi":"10.11005/jbm.2023.30.4.311","DOIUrl":"https://doi.org/10.11005/jbm.2023.30.4.311","url":null,"abstract":"Background: This study aimed to investigate real-world data of C-terminal telopeptide (CTX), propeptide of type I collagen (P1NP), and osteocalcin through present multicenter clinical study, and retrospectively analyze the usefulness of bone turnover markers (BTMs) in Koreans.Methods: The study focused on pre- and post-menopausal patients diagnosed with osteoporosis and excluded patients without certain test results or with test intervals of over 1 year. The demographic data and 3 BTMs (CTX, P1NP, and osteocalcin) were collected. The patients were classified by demographic characteristics and the BTM concentrations were analyzed by the group.Results: Among women with no history of fractures, the levels of P1NP (N=2,100) were 43.544±36.902, CTX (N=1,855) were 0.373 ±0.927, and osteocalcin (N=219) were 10.81 ±20.631. Among men with no history of fractures, the levels of P1NP (N=221) were 48.498±52.892, CTX (N=201) were 0.370±0.351, and osteocalcin (N=15) were 7.868 ±10.674. Treatment with teriparatide increased the P1NP levels after 3 months in both men and women, with a 50% increase observed in women. Similarly, treatment with denosumab decreased the CTX levels after 3 months in both men and women, with a reduction of 50% observed in women.Conclusions: The results of this study can contribute to the accurate assessment of bone replacement status in Koreans. We also provide the P1NP level in the Korean population for future comparative studies with other populations.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"30 4","pages":"311-317"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10721375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138794610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Fracture Risk Assessment Tool Probability and Trabecular Bone Score Mediate the Relationship between Sphingosine 1-phosphate Levels and Fracture Risk. 骨折风险评估工具概率和骨小梁评分介导1-磷酸肾上腺素水平与骨折风险之间的关系

Journal of Bone Metabolism Pub Date : 2023-11-01 Epub Date: 2023-11-30 DOI: 10.11005/jbm.2023.30.4.355

Seung Hun Lee, Jae Seung Kim, Jung-Min Koh

{"title":"The Fracture Risk Assessment Tool Probability and Trabecular Bone Score Mediate the Relationship between Sphingosine 1-phosphate Levels and Fracture Risk.","authors":"Seung Hun Lee, Jae Seung Kim, Jung-Min Koh","doi":"10.11005/jbm.2023.30.4.355","DOIUrl":"https://doi.org/10.11005/jbm.2023.30.4.355","url":null,"abstract":"Background: The sphingosine 1-phosphate (S1P) concentration is a potential biomarker of osteoporotic fracture and is associated with both the fracture risk assessment tool (FRAX) probability and trabecular bone score (TBS), which are well-known predictors of fracture. We sought to estimate the effect of the S1P concentration on fracture risk using the FRAX probability and TBS as mediators.Methods: Plasma S1P concentrations, FRAX variables, and TBSs were measured in 66 postmenopausal women with fractures and 273 postmenopausal women without fractures. Associations between S1P concentration, FRAX probability, TBS, and fracture risk were analyzed using correlation, logistic regression, and mediation analyses.Results: Subjects in the highest S1P concentration tertile had a higher fracture risk (odds ratio [OR], 5.09; 95% confidence interval [CI], 2.22-11.67) than those in the lowest S1P concentration tertile before adjustment. Subjects in the highest FRAX probability tertile had a higher fracture risk (OR, 14.59; 95% CI, 5.01-42.53) than those in the lowest FRAX probability tertile before adjustment. Subjects in the lowest TBS tertile had a higher fracture risk (OR, 4.76; 95% CI, 2.28-9.93) than those in the highest TBS tertile before adjustment. After adjustment for FRAX probability and TBS, the highest S1P concentration tertile was still associated with a higher fracture risk (OR, 3.13; 95% CI, 1.28-7.66). The FRAX probability and TBS accounted for 32.6% and 21.7%, respectively, of the relationship between the S1P concentration and fracture risk.Conclusions: The relationship between the circulating S1P concentration and fracture risk was partly mediated by the FRAX probability, bone microarchitecture, and other factors.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"30 4","pages":"355-364"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10721379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138795309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting Fractures Using Vertebral 18F-NaF Uptake in Prostate Cancer Patients. 利用前列腺癌患者椎体 18F-NaF 摄取预测骨折情况

Journal of Bone Metabolism Pub Date : 2023-11-01 Epub Date: 2023-11-30 DOI: 10.11005/jbm.2023.30.4.329

Helene Chesnais, Nikita Bastin, Sofia Miguez, Daniel Kargilis, Anita Kalluri, Ashley Terry, Chamith S Rajapakse

{"title":"Predicting Fractures Using Vertebral 18F-NaF Uptake in Prostate Cancer Patients.","authors":"Helene Chesnais, Nikita Bastin, Sofia Miguez, Daniel Kargilis, Anita Kalluri, Ashley Terry, Chamith S Rajapakse","doi":"10.11005/jbm.2023.30.4.329","DOIUrl":"https://doi.org/10.11005/jbm.2023.30.4.329","url":null,"abstract":"Background: Patients with prostate cancer tend to be at heightened risk for fracture due to bone metastases and treatment with androgen-deprivation therapy. Bone mineral density (BMD) derived from dual energy X-ray absorptiometry (DXA) is the standard for determining fracture risk in this population. However, BMD often fails to predict many osteoporotic fractures. Patients with prostate cancer also undergo 18F-sodium fluoride (18F-NaF)-positron emission tomography/computed tomography (PET/CT) to monitor metastases. The purpose of this study was to assess whether bone deposition, assessed by 18F-NaF uptake in 18F-NaF PET/CT, could predict incident fractures better than DXA- or CT-derived BMD in patients with prostate cancer.Methods: This study included 105 males with prostate cancer who had undergone full body 18F-NaF PET/CT. Standardized uptake value (SUVmean and SUVmax) and CT-derived Hounsfield units (HU), a correlate of BMD, were recorded for each vertebral body. The average SUVmean, SUVmax, and HU were calculated for cervical, thoracic, lumbar, and sacral areas. The t-test was used to assess significant differences between fracture and no-fracture groups.Results: The SUVmean and SUVmax values for the thoracic area were lower in the fracture group than in the no-fracture group. There was no significant difference in cervical, thoracic, lumbar or sacral HU between the 2 groups.Conclusions: Our study reports that lower PET-derived non-metastatic bone deposition in the thoracic spine is correlated with incidence of fractures in patients with prostate cancer. CT-derived HU, a correlate of DXA-derived BMD, was not predictive of fracture risk. 18F-NaF PET/CT may provide important insight into bone quality and fracture risk.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"30 4","pages":"329-337"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10721380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138795291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Position Statement: Postmenopausal Osteoporosis Treatment Strategies in Korea. 立场声明：韩国绝经后骨质疏松症治疗策略。

Journal of Bone Metabolism Pub Date : 2023-11-01 Epub Date: 2023-11-30 DOI: 10.11005/jbm.2023.30.4.289

So Young Park, Se Hwa Kim, Young-Kyun Lee, Jung-Ho Shin, Yong-Chan Ha, Ho Yeon Chung

{"title":"Position Statement: Postmenopausal Osteoporosis Treatment Strategies in Korea.","authors":"So Young Park, Se Hwa Kim, Young-Kyun Lee, Jung-Ho Shin, Yong-Chan Ha, Ho Yeon Chung","doi":"10.11005/jbm.2023.30.4.289","DOIUrl":"https://doi.org/10.11005/jbm.2023.30.4.289","url":null,"abstract":"Classifying patients with osteoporosis according to fracture risk and establishing adequate treatment strategies is crucial to effectively treat osteoporosis. The Korean Society for Bone and Mineral Research has issued a position statement regarding appropriate treatment strategies for postmenopausal osteoporosis. According to previous fragility fracture history, bone mineral density (BMD) test results, fracture risk assessment tool, and several clinical risk factors, fracture risk groups are classified into low, moderate, high, and very-high-risk groups. In high-risk groups, bisphosphonates (BPs) and denosumab are recommended as first-line therapies. Sequential BP treatment after denosumab discontinuation is required to prevent the rebound phenomenon. In the very high-risk group, anabolic drugs (teriparatide or romosozumab) are recommended as a first-line therapy; sequential therapy with antiresorptive agents is required to maintain BMD gain and reduce fracture risk. Fracture risk was reassessed annually, and the treatment plan was determined based on the results, according to the osteoporosis treatment algorithm for fracture risk.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"30 4","pages":"289-295"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10721382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138795283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge, Attitude, and Behavior Levels of Postmenopausal Women about Osteoporosis. 绝经后妇女对骨质疏松症的认识、态度和行为水平。

Journal of Bone Metabolism Pub Date : 2023-11-01 Epub Date: 2023-11-30 DOI: 10.11005/jbm.2023.30.4.347

Hazal Saltık, Furkan Öztürk, Canan Emiroğlu, Baki Hekimoğlu, Cenk Aypak

{"title":"Knowledge, Attitude, and Behavior Levels of Postmenopausal Women about Osteoporosis.","authors":"Hazal Saltık, Furkan Öztürk, Canan Emiroğlu, Baki Hekimoğlu, Cenk Aypak","doi":"10.11005/jbm.2023.30.4.347","DOIUrl":"https://doi.org/10.11005/jbm.2023.30.4.347","url":null,"abstract":"Background: Osteoporosis can be delayed by providing accurate and adequate information to people at risk. Therefore, we aimed to determine the knowledge, attitude, and behavior levels of women in the postmenopausal period, which is the largest group at risk.Methods: The study was conducted in a tertiary Training and Research Hospital between 1 December 2018 and 1 May 2019 in 225 postmenopausal women who applied to the Family Medicine outpatient clinic and bone mineral density (BMD) outpatient clinics for BMD measurement or had previously had this measurement at least once. A questionnaire evaluating the knowledge, attitudes, and behavior levels related to osteoporosis was applied to all patients included in the study.Results: The mean age was 58.05±9.1 years. The median osteoporosis knowledge score was 7 out of 19 points. A total of 119 (52.9%) had low knowledge scores and 106 (47.1%) had higher knowledge scores. Of the individuals with high scores, 40 (37.7%) were smoking, 64 (60.4%) did not sunbathe, 89 (84%) did not consume the recommended daily amount of calcium, and 58 (54.7%) were not exercising in the recommended time. It was seen that those who were university graduates, who had previously learned about osteoporosis from a health professional, and who had a family history of osteoporosis had higher knowledge levels.Conclusions: Even in postmenopausal women who are aware that they are in the risk group and that they should have BMD, their knowledge, attitude, and behavior levels on osteoporosis were found to be quite low.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"30 4","pages":"347-354"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10721378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138794718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of Osteoclastogenesis in Orthodontic Tooth Movement and Orthodontically Induced Tooth Root Resorption. 正畸牙齿移动和正畸诱发牙根吸收中的破骨细胞生成机制

Journal of Bone Metabolism Pub Date : 2023-11-01 Epub Date: 2023-11-30 DOI: 10.11005/jbm.2023.30.4.297

Yuta Nakai, Natnicha Praneetpong, Wanida Ono, Noriaki Ono

{"title":"Mechanisms of Osteoclastogenesis in Orthodontic Tooth Movement and Orthodontically Induced Tooth Root Resorption.","authors":"Yuta Nakai, Natnicha Praneetpong, Wanida Ono, Noriaki Ono","doi":"10.11005/jbm.2023.30.4.297","DOIUrl":"10.11005/jbm.2023.30.4.297","url":null,"abstract":"Orthodontic tooth movement (OTM) is achieved by the simultaneous activation of bone resorption by osteoclasts and bone formation by osteoblasts. When orthodontic forces are applied, osteoclast-mediated bone resorption occurs in the alveolar bone on the compression side, creating space for tooth movement. Therefore, controlling osteoclastogenesis is the fundamental tenet of orthodontic treatment. Orthodontic forces are sensed by osteoblast lineage cells such as periodontal ligament (PDL) cells and osteocytes. Of several cytokines produced by these cells, the most important cytokine promoting osteoclastogenesis is the receptor activator of nuclear factor-κB ligand (RANKL), which is mainly supplied by osteoblasts. Additionally, osteocytes embedded within the bone matrix, T lymphocytes in inflammatory conditions, and PDL cells produce RANKL. Besides RANKL, inflammatory cytokines, such as interleukin-1, tumor necrosis factor-α, and prostaglandin E2 promote osteoclastogenesis under OTM. On the downside, excessive osteoclastogenesis activation triggers orthodontically-induced external root resorption (ERR) through pro-osteoclastic inflammatory cytokines. Therefore, understanding the mechanisms of osteoclastogenesis during OTM is essential in reducing the adverse effects of orthodontic treatment. Here, we review the current concepts of the mechanisms underlying osteoclastogenesis in OTM and orthodontically induced ERR.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"30 4","pages":"297-310"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10721376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138795184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0