Journal of Bone Metabolism最新文献_第3页

Zoledronate Therapy in Osteogenesis Imperfecta: Perspectives in Indonesia Tertiary Hospital. 唑来膦酸盐治疗成骨不全症：印度尼西亚三级医院的视角。

Journal of Bone Metabolism Pub Date : 2024-11-01 Epub Date: 2024-11-04 DOI: 10.11005/jbm.24.767

Tri Wahyu Martanto, Aliefio Japamadisaw, Dian Nurhayati, Rob G H H Nelissen

{"title":"Zoledronate Therapy in Osteogenesis Imperfecta: Perspectives in Indonesia Tertiary Hospital.","authors":"Tri Wahyu Martanto, Aliefio Japamadisaw, Dian Nurhayati, Rob G H H Nelissen","doi":"10.11005/jbm.24.767","DOIUrl":"10.11005/jbm.24.767","url":null,"abstract":"Background: Osteogenesis imperfecta (OI) is a rare disease with an estimated incidence of between 1/25,000 and 1/10,000 globally. The main treatment for OI is the administration of bisphosphonate drugs. Research on clinical, radiographic, and biochemical markers to monitor patients with OI treated with zoledronate can be challenging in countries in which patients have limited national health insurance. We aimed to examine patients with OI treated in Indonesia with a minimum follow-up period of 2 years.Methods: An observational study was conducted of all patients with OI treated with zoledronate between 2021 and 2023 at a tertiary hospital in Indonesia. We evaluated the paediatric quality of life (PedsQL), bone mineral density (BMD), and alkaline phosphatase (ALP) level before and after zoledronate treatment. To monitor safety, serum creatinine and calcium levels were also measured.Results: Eleven boys (55%) and nine girls (45%), with an average age of 6.9 years (range, 4-17 years), were included. After 2 years of zoledronate treatment, the total PedsQL score increased from 66.7 to 76.9 (P=0.0001) and the mean lumbar and total body BMD increased from 0.467 and 0.501 to 0.599 g/cm2, and 0.626 g/cm2 (P=0.001), respectively. The ALP level decreased from 310.6 to 186.4 mg/mL (P=0.0001). Neither serum creatinine (P=0.586) nor calcium (P=0.53) levels changed from the pre-treatment to 2 years post-treatment time points.Conclusions: Zoledronate was safe and effective for the treatment of OI. There were significant improvements in the quality of life and BMD in patients with OI. The ALP level decreased, but serum creatinine and calcium levels were not affected by zoledronate.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":" ","pages":"290-295"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11658843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical Performance Level and Patient-Reported Outcomes in Female Patients with Distal Radius Fracture. 桡骨远端骨折女性患者的体能水平和患者报告的预后。

Journal of Bone Metabolism Pub Date : 2024-11-01 Epub Date: 2024-11-30 DOI: 10.11005/jbm.24.785

Byung Hun Oh, Rawdhah Kamil Kalantan, Jae Kwang Kim, Young Ho Shin

{"title":"Physical Performance Level and Patient-Reported Outcomes in Female Patients with Distal Radius Fracture.","authors":"Byung Hun Oh, Rawdhah Kamil Kalantan, Jae Kwang Kim, Young Ho Shin","doi":"10.11005/jbm.24.785","DOIUrl":"10.11005/jbm.24.785","url":null,"abstract":"Background: This study aimed to evaluate the influence of physical performance level on patient-reported outcomes after surgery for distal radius fractures (DRF).Methods: We retrospectively reviewed 157 women with DRF who underwent surgery and completed the short physical performance battery (SPPB) within one month of trauma between January 2019 and August 2022. Patient-reported outcomes were assessed one year postoperatively using the disabilities of the arm, shoulder, and hand (DASH) and patient-rated wrist evaluation (PRWE) questionnaires. Multivariate linear regression analysis was conducted using patient characteristics, fracture type, treatment-related factors, and SPPB results to evaluate the factors associated with patient-reported outcomes.Results: Multivariate linear regression model revealed that dominant hand involvement (B=7.329; 95% confidence interval [CI], 2.901-11.757; P=0.001) and lower SPPB scores (B=-2.145; 95% CI, -3.194 to -1.096; P<0.001) were significantly associated with higher DASH and PRWE scores.Conclusions: Physical performance level evaluated using the SPPB was significantly associated with poor clinical outcomes of DRF after surgery. Physicians should implement a systematic approach to enhance physical performance along with appropriate fracture treatment to improve clinical outcomes following surgery for DRF.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"31 4","pages":"316-325"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11658840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Utility of Bone Turnover Markers in Chronic Kidney Disease. 骨转换标志物在慢性肾脏疾病中的临床应用。

Journal of Bone Metabolism Pub Date : 2024-11-01 Epub Date: 2024-11-30 DOI: 10.11005/jbm.24.789

Praopilad Srisuwarn, Richard Eastell, Syazrah Salam

引用次数: 0

Incretin-Based Therapies: A Promising Approach for Modulating Oxidative Stress and Insulin Resistance in Sarcopenia. 基于内泌素的疗法：调节肌肉疏松症患者氧化应激和胰岛素抵抗的有效方法。

Journal of Bone Metabolism Pub Date : 2024-11-01 Epub Date: 2024-11-04 DOI: 10.11005/jbm.24.739

Raniah I Alnaser, Fawaz A Alassaf, Mohammed N Abed

{"title":"Incretin-Based Therapies: A Promising Approach for Modulating Oxidative Stress and Insulin Resistance in Sarcopenia.","authors":"Raniah I Alnaser, Fawaz A Alassaf, Mohammed N Abed","doi":"10.11005/jbm.24.739","DOIUrl":"10.11005/jbm.24.739","url":null,"abstract":"Background: Recent studies have linked sarcopenia development to the hallmarks of diabetes, oxidative stress, and insulin resistance. The anti-oxidant and insulin sensitivityenhancing effects of incretin-based therapies may provide a promising option for the treatment of sarcopenia. This review aimed to unveil the role of oxidative stress and insulin resistance in the pathogenesis of sarcopenia and explore the potential benefits of incretin-based therapies in individuals with sarcopenia.Methods: PubMed, the Cochrane Library, and Google Scholar databases were searched by applying keywords relevant to the main topic, to identify articles that met our selection criteria.Results: Incretin-based therapies manifested anti-oxidant effects by increasing the anti-oxidant defense system and decreasing free radical generation or by indirectly minimizing glucotoxicity, which was mainly achieved by improving insulin signaling and glucose homeostasis. Likewise, these drugs exhibit insulin-sensitizing activities by increasing insulin secretion, transduction, and β-cell function or by reducing inflammation and lipotoxicity.Conclusions: Incretin-based therapies, as modulators of oxidation and insulin resistance, may target the main pathophysiological factors of sarcopenia, thus providing a promising strategy for the treatment of this disease.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":" ","pages":"251-263"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11658841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abdominal Aorta Calcification Identified on DXA Scans and the Risk of Mortality in Adults. DXA 扫描发现的腹主动脉钙化与成人的死亡风险

Journal of Bone Metabolism Pub Date : 2024-08-01 Epub Date: 2024-08-31 DOI: 10.11005/jbm.2024.31.3.236

Carlos H Orces

{"title":"Abdominal Aorta Calcification Identified on DXA Scans and the Risk of Mortality in Adults.","authors":"Carlos H Orces","doi":"10.11005/jbm.2024.31.3.236","DOIUrl":"10.11005/jbm.2024.31.3.236","url":null,"abstract":"Background: Abdominal aortic calcification (AAC) on lateral lumbar radiographs increases the risk of cardiovascular events and mortality. However, data on the association between AAC detected in dual energy X-ray absorptiometry (DXA) and the risk of mortality in the general population are scarce.Methods: The present study was based on data from participants aged ≥40 years in the National Health and Nutrition Examination Survey (NHANES) cycle of 2013 to 2014. Vertebral assessment of lateral spine DXA scans was used to provide AAC measurements at vertebrae L1-L4. The extent of AAC was defined according to the Kauppila AAC-24 scores (0-1, 2-5, ≥6), and the NHANES 2019 public-use linked mortality files were used to assess mortality status.Results: Of the 2,962 participants who were included in this study, with a mean age of 57.4 years and a median follow-up of 69.9 months, 252 (8.5%) died. Of the deaths, 84 (33.3%) occurred due to cardiovascular disease. The Cox proportional hazards models revealed that participants with AAC-24 scores ≥6 were 1.7 times more likely to die than those with AAC-24 scores 0-1 (Hazard ratio, 1.75; 95% confidence interval, 1.13-2.71). Moreover, older adults and women with AAC-24 scores ≥6 were 2.8 and 2.4 times more likely to die than their counterparts with AAC-24 scores 0-1, respectively. Conversely, a non-significant risk of cardiovascular mortality was found among participants with AAC-24 scores ≥6.Conclusions: The extent of AAC detected on vertebral fracture assessment DXA was associated with an increased risk of all-cause mortality in adults, particularly older adults and women.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"31 3","pages":"236-245"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11416878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Denosumab in Osteoporosis: Predicting Long-Term Efficacy beyond 10 Years. 骨质疏松症中的地诺单抗：预测 10 年后的长期疗效。

Journal of Bone Metabolism Pub Date : 2024-08-01 Epub Date: 2024-08-31 DOI: 10.11005/jbm.2024.31.3.246

Jeongmin Lee, Youn-Ju Lee, Jeonghoon Ha

引用次数: 0

Thioredoxin Interacting Protein Expressed in Osteoblasts Mediates the Anti-Proliferative Effects of High Glucose and Modulates the Expression of Osteocalcin. 骨母细胞中表达的硫氧还蛋白交互蛋白介导高血糖的抗增殖作用并调节骨钙素的表达

Journal of Bone Metabolism Pub Date : 2024-08-01 Epub Date: 2024-08-31 DOI: 10.11005/jbm.2024.31.3.209

Sarah McGarry, Karen Kover, Francesco De Luca

{"title":"Thioredoxin Interacting Protein Expressed in Osteoblasts Mediates the Anti-Proliferative Effects of High Glucose and Modulates the Expression of Osteocalcin.","authors":"Sarah McGarry, Karen Kover, Francesco De Luca","doi":"10.11005/jbm.2024.31.3.209","DOIUrl":"10.11005/jbm.2024.31.3.209","url":null,"abstract":"Background: Hyperglycemia is associated with impaired bone health in patients with diabetes mellitus. Although a direct detrimental effect of hyperglycemia on the bone has been previously reported, the specific molecular mediator(s) responsible for the inhibitory effect of high glucose levels on the bone remains unclear. We hypothesized that thioredoxin-interacting protein (Txnip), an essential mediator of oxidative stress, is such a mediator.Methods: We cultured MG-63 cells (immortalized human osteoblasts) with normal or high glucose concentrations and transfected them with scrambled or Txnip-specific small interfering RNA (siRNA).Results: High glucose levels increased Txnip expression and reduced MG-63 cell proliferation. The high-glucose level mediated reduction in cell proliferation was prevented in Txnip siRNA-transfected cells. In addition, we demonstrated that silencing Txnip mRNA expression in osteoblasts reduced the expression of the osteocalcin gene. Our results suggest that high glucose levels or silencing of Txnip mRNA expression may induce apoptosis in osteoblasts.Conclusions: Our findings indicate that Txnip is an intracellular mediator of the anti-proliferative effects of extracellular high glucose levels on osteoblasts.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"31 3","pages":"209-218"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11416880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone Mineral Density and Clinical Outcome after Ankle Fracture. 骨质密度与踝关节骨折后的临床效果

Journal of Bone Metabolism Pub Date : 2024-08-01 Epub Date: 2024-08-31 DOI: 10.11005/jbm.2024.31.3.228

Hyunseong Kang, Ho-Hyup Kim, Chaemoon Lim

{"title":"Bone Mineral Density and Clinical Outcome after Ankle Fracture.","authors":"Hyunseong Kang, Ho-Hyup Kim, Chaemoon Lim","doi":"10.11005/jbm.2024.31.3.228","DOIUrl":"10.11005/jbm.2024.31.3.228","url":null,"abstract":"Background: No gold standard exists for bone mineral density (BMD) measurement of the ankle. This study aimed to determine the correlation between bone density using Hounsfield units (HU) based on computed tomography (CT) and BMD using dual energy X-ray absorptiometry (DXA) as well as to evaluate the correlation between HU and clinical outcome of ankle fracture.Methods: Fifty-one patients aged ≥65 years who underwent surgical treatment for trimalleolus or bimalleolus ankle fractures were included. The HU were measured at the distal tibia metaphyseal region approximately 1 cm proximal to the plafond on the axial images of preoperative CT. BMD was measured using DXA within one year before the injury. The clinical outcome was evaluated according to the Foot and Ankle Outcome Score (FAOS).Results: Although the HU of an osteoporosis group was lower than that of a non-osteoporosis group, we observed no significant difference between the two groups. The mean HU significantly correlated with the lumbar and total lumbar spine BMD using DXA. Increased HU significantly correlated with improved clinical outcomes in three of five FAOS subscales: symptoms, pain, activity of daily living (ADL), and quality of life (QOL). In a linear regression analysis adjusted for age and body mass index, increased HU significantly correlated with improved clinical outcomes in three of five FAOS subscales: symptoms, pain, ADL, and QOL.Conclusions: The correlations between bone density using HU and BMD and those between HU and the clinical outcome were confirmed in ankle fractures. The HU of preoperative CT might provide valuable information for predicting postoperative clinical outcomes.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"31 3","pages":"228-235"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11416874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Open, Active-Controlled Clinical Study to Evaluate the Correlation between Whole Body DEXA and BIA Muscle Measurements. 评估全身 DEXA 和 BIA 肌肉测量之间相关性的开放式主动控制临床研究。

Journal of Bone Metabolism Pub Date : 2024-08-01 Epub Date: 2024-08-31 DOI: 10.11005/jbm.2024.31.3.219

Yong-Chan Ha, Shinjune Kim, Jun-Il Yoo

{"title":"Open, Active-Controlled Clinical Study to Evaluate the Correlation between Whole Body DEXA and BIA Muscle Measurements.","authors":"Yong-Chan Ha, Shinjune Kim, Jun-Il Yoo","doi":"10.11005/jbm.2024.31.3.219","DOIUrl":"10.11005/jbm.2024.31.3.219","url":null,"abstract":"Background: Dual energy X-ray absorptiometry (DXA) is the gold standard for diagnosing sarcopenia. However, comparative studies using bioelectrical impedance analysis (BIA) would be required in the Korean population. This study aimed to evaluate the correlation between total-body bone density measuring devices (Hologic and GE Lunar) and a bioelectrical impedance measurement device (InBody 970) as well as the correlation between upper body muscle mass.Methods: A total of 119 participants were involved in this study, aged 20 to 70 years, with specific body mass index ranges and no severe health conditions used both DXA (or DEXA) and BIA technologies to assess body composition. The participants were scanned using a Hologic QDR-4500W DXA scanner and GE-Lunar Prodigy DXA systems, and the InBody 970 type of multi-frequency BIA machine. Statistical analysis was performed to determine the correlation between the devices, with a coefficient of at least 0.8.Results: The muscle mass measurement comparisons between the InBody 970 and Hologic devices demonstrated remarkably high correlation coefficients (exceeding 0.9) across all limbs. Similarly, the muscle mass comparison between the Inbody 970 and GE Lunar devices also revealed substantial correlation coefficients, ranging from 0.83 upwards, across all limbs.Conclusions: Limb muscle mass measurements using Hologic and GE Lunar whole-body DXA and Inbody 970 BIA demonstrated particularly high levels of concordance. In addition, a conversion formula that bridges limb muscle mass measurements from two widely used whole-body DXA machines and a BIA machine will facilitate sarcopenia research and patient management.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"31 3","pages":"219-227"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11416876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidiabetic Agents and Bone Quality: A Focus on Glycation End Products and Incretin Pathway Modulations. 抗糖尿病药物与骨质：关注糖化终产物和内分泌途径调节。

Journal of Bone Metabolism Pub Date : 2024-08-01 Epub Date: 2024-08-31 DOI: 10.11005/jbm.2024.31.3.169

Muthanna K Zaki, Mohammed N Abed, Fawaz A Alassaf

{"title":"Antidiabetic Agents and Bone Quality: A Focus on Glycation End Products and Incretin Pathway Modulations.","authors":"Muthanna K Zaki, Mohammed N Abed, Fawaz A Alassaf","doi":"10.11005/jbm.2024.31.3.169","DOIUrl":"10.11005/jbm.2024.31.3.169","url":null,"abstract":"Diabetes mellitus is associated with inadequate bone health and quality and heightened susceptibility to fractures, even in patients with normal or elevated bone mineral density. Elevated advanced glycation end-products (AGEs) and a suppressed incretin pathway are among the mechanisms through which diabetes affects the bone. Accordingly, the present review aimed to investigate the effects of antidiabetic medications on bone quality, primarily through AGEs and the incretin pathway. Google Scholar, Cochrane Library, and PubMed were used to examine related studies until February 2024. Antidiabetic medications influence AGEs and the incretin pathway directly or indirectly. Certain antidiabetic drugs including metformin, glucagon-like peptide-1 receptor agonists (GLP-1RA), dipeptidyl-peptidase-4 (DDP-4) inhibitors, α-glucosidase inhibitors (AGIs), sodium-glucose co-transporter-2 inhibitors, and thiazolidinediones (TZDs), directly affect AGEs through multiple mechanisms. These mechanisms include decreasing the formation of AGEs and the expression of AGEs receptor (RAGE) in tissue and increasing serum soluble RAGE levels, resulting in the reduced action of AGEs. Similarly, metformin, GLP-1RA, DDP-4 inhibitors, AGIs, and TZDs may enhance incretin hormones directly by increasing their production or suppressing their metabolism. Additionally, these medications could influence AGEs and the incretin pathway indirectly by enhancing glycemic control. In contrast, sulfonylureas have not demonstrated any obvious effects on AGEs or the incretin pathway. Considering their favorable effects on AGEs and the incretin pathway, a suitable selection of antidiabetic drugs may facilitate more protective effects on the bone in diabetic patients.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"31 3","pages":"169-181"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11416877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0