Journal of Bone Metabolism最新文献

{"title":"Distribution and Characteristics of Fall Risk Index-21 Scores in Patients with Fall-Related Hip Fractures.","authors":"Norifumi Fujii, Manabu Tsukamoto, Ryoichi Nakamura, Sachio Himei, Daisuke Nakagawa, Yoshiaki Ikejiri, Toru Yoshioka, Takayuki Nabeshima, Nobukazu Okimoto","doi":"10.11005/jbm.25.931","DOIUrl":"10.11005/jbm.25.931","url":null,"abstract":"<p><strong>Background: </strong>Fall risk assessment and preventive interventions are important for preventing secondary fractures after hip fracture. The aim of this study was to investigate the distribution and characteristics of Fall Risk Index-21 (FRI-21) scores based on prefracture living conditions in patients with fall-related unilateral hip fracture.</p><p><strong>Methods: </strong>This study included 95 people who had suffered a hip fracture after a fall and had undergone surgery. FRI-21, dual energy X-ray absorptiometry (DXA), and hip structure analysis/trabecular bone score based on DXA were performed within 1 week after surgery. We compared bone parameters between the two groups, which were divided according to the cutoff value of the FRI-21. We also performed cluster analysis on the components of the FRI-21 and compared the characteristics of the subgroups via analysis of variance and multiple comparison tests.</p><p><strong>Results: </strong>All participants had experienced a fall-related fracture, but 47 (49.5%) of the patients were judged to have low scores (<10) on the FRI-21. Moreover, cluster analysis revealed that the subjects were classified into three subgroups, and the characteristics of the items that constitute fall risk, namely, physical function, disease or geriatric syndrome, and environmental factors, were diverse.</p><p><strong>Conclusions: </strong>These results suggest that caution is needed when interpreting the FRI-21 total score based on preoperative living conditions in post-fracture patients, as it may not adequately reflect fall risk. Considering the characteristics of the FRI-21 score in patients with hip fractures, identifying appropriate fall prevention strategies and healthcare professionals involved may be important for preventing future re-fractures.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 1","pages":"73-83"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Bone Morphogenetic Protein Agonist Small Molecule, SB4, on Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells.","authors":"Fatemeh Naghshnejad, Bahman Zeynali, Iman Shabani, Azita Parvaneh Tafreshi","doi":"10.11005/jbm.25.899","DOIUrl":"10.11005/jbm.25.899","url":null,"abstract":"<p><strong>Background: </strong>Bone morphogenetic protein (BMP) signaling is crucial for osteogenic (OS) differentiation, bone growth, and repair. However, the clinical use of BMPs is limited due to their cost and challenges in delivery. SB4, a potent compound of benzoxazole, is a newly introduced small molecule shown to activate the BMP signaling pathway. In this study, we investigated the effects of SB4 on OS differentiation of adipose-derived mesenchymal stem cells (ADMSCs).</p><p><strong>Methods: </strong>We first examined whether BMP signaling is active in osteoinduced ADMSCs. ADMSCs were treated with SB4 (5 and 10 μM) for 24 hr, and mRNA expression of BMP direct target genes (ID1 and ID3) was analyzed. ADMSCs were then cultured with or without SB4 (10 μM) for 7, 14, and 21 days, followed by Alizarin red staining and real-time polymerase chain reaction analysis of mRNA expression of OS markers RUNX2, BMP2, alkaline phosphatase (ALP), and Osteopontin. To investigate the most effective time period of SB4 in osteogenesis, SB4 was applied every 3.5 days during the 21-day differentiation period.</p><p><strong>Results: </strong>After 24 hr of treatment with SB4 (5 and 10 μM), increased mRNA expression of BMP direct target genes (ID1 and ID3) confirmed that SB4 acts as an active BMP agonist. SB4-treated ADMSCs showed enhanced bone matrix production and increased mRNA expression of RUNX2, BMP2, ALP, and Osteopontin. Increased mRNA expression of OS markers, bone matrix formation, and ALP activity during the first 7 days of SB4 treatment suggested the importance of SB4 at the early stage of differentiation.</p><p><strong>Conclusions: </strong>These results indicate that SB4, with potential BMP-like activity, induces OS differentiation of ADMSCs, leading it to serve as a cost-effective BMP agonist for osteogenesis-related research as well as a potential therapeutic agent for bone repair and regeneration.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 1","pages":"18-29"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Trabecular Bone Score and Bone Mineral Density in Patients with Primary Hyperparathyroidism under 50 Years Old.","authors":"Yunkyung Jeon, Myungsoo Im, Doohwa Kim, Jihyun Kim, Kyoungjune Pak, Seong-Jang Kim, Keunyoung Kim","doi":"10.11005/jbm.25.885","DOIUrl":"10.11005/jbm.25.885","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the densitometric characteristics and qualitative bone status in patients with normocalcemic primary hyperparathyroidism (PHPT) compared with those in controls who were younger adults under 50 years.</p><p><strong>Methods: </strong>This retrospective study included 60 controls and 31 patients with PHPT who underwent dual energy X-ray absorptiometry (DXA) of the lumbar spine (LS), femoral neck (FN), and total hip (TH). Trabecular bone score (TBS) was derived from LS DXA images. Bone mineral density (BMD) values were assessed using Z-scores, and correlations between TBS, BMD, and laboratory parameters were examined.</p><p><strong>Results: </strong>The median ages of the control and PHPT groups were 41 and 42 years, respectively. The proportion of individuals classified as \"below the expected range for age\" based on Z-scores differed significantly between groups only when considering any site collectively. Median TBS was significantly lower in PHPT patients than in controls, even when BMD values at LS, FN, and TH fell within similar diagnostic categories. In controls, TBS and BMD demonstrated very low correlation coefficients. In contrast, PHPT patients showed a stronger correlation between TBS and femoral BMD, whereas the association between TBS and LS BMD was largely absent. Among laboratory markers, only serum intact parathyroid hormone was significantly negatively correlated with TBS.</p><p><strong>Conclusions: </strong>Young adults with PHPT exhibit impaired bone quality despite relatively preserved BMD, suggesting early microarchitectural deterioration. These findings support the combined use of LS and femoral BMD with TBS for more accurate assessment of skeletal health in PHPT.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 1","pages":"63-72"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Various Anti-Diabetic Drugs on the Risk of Fractures in Older Women with Type 2 Diabetes Mellitus.","authors":"Seong Hee Ahn, Kyoung Jin Kim, So Young Park, Su Jin Kwon, Ha Young Kim, Kyoung Min Kim","doi":"10.11005/jbm.25.895","DOIUrl":"10.11005/jbm.25.895","url":null,"abstract":"<p><strong>Background: </strong>To investigate the fracture risks associated with anti-diabetic drugs in older women with type 2 diabetes mellitus (T2DM), who are particularly susceptible to skeletal fragility.</p><p><strong>Methods: </strong>Using data from the Korean National Health Insurance Service, this nested case-control study included 10,104 older women with T2DM and osteoporotic fractures (aged 66.5±3.4 years) matched in a 1:3 ratio with controls by birthdate, Charlson Comorbidity Index, and cohort entry date. We analyzed the odds of major osteoporotic fracture (MOF), vertebral fracture (VF), and non-VF (NVF) in users of sulfonylurea, thiazolidinedione (TZD), dipeptidyl peptidase-4 inhibitor, and sodium-glucose cotransporter 2 inhibitor (SGLT2i), compared to metformin (Met)-only users using multivariable logistic regression.</p><p><strong>Results: </strong>During a follow-up period of 3.8±2.8 years, TZD users had a higher risk of MOF than Met-only users (odds ratio [OR], 1.35; 95% confidence interval [CI], 1.19-1.53; P<0.001). Risks of VF and NVF were also increased in the TZD group (OR, 1.21; 95% CI 1.03-1.42; P=0.022 and OR, 1.32; 95% CI 1.14-1.52; P<0.001, respectively). No significant differences were observed in other drug groups. The increased risk of VF and NVF in the TZD group were particularly pronounced in patients with normal or osteopenic bone mineral density (BMD) and in those with normal body mass index (BMI), respectively.</p><p><strong>Conclusions: </strong>In older women with T2DM, TZD use was associated with increased VF and NVF risks, particularly among those with normal or osteopenic BMD and normal BMI. SGLT2i showed no increased risk, but further large-scale studies are needed to confirm its skeletal safety.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 1","pages":"50-62"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic Architectural Cover Accelerates Osseointegration of Titanium Implants.","authors":"Su-Jin Kim, Eun Chae Kim, Weon-Young Choi, Seung-Jae Lee, Je-Hwang Ryu","doi":"10.11005/jbm.26.1003","DOIUrl":"10.11005/jbm.26.1003","url":null,"abstract":"<p><strong>Background: </strong>Although various surface modifications enhance titanium (Ti) implant osseointegration, achieving rapid bone formation comparable to native healing remains challenging. Current strategies primarily focus on micro-scale topography, often overlooking the critical role of macroscopic three-dimensional (3D) architecture in osteoconduction.</p><p><strong>Methods: </strong>We hypothesized that mimicking native bone's porous architecture is key to accelerating osseointegration. First, we verified the impact of structural continuity by comparing standard Ti implants with decellularized bone grafts in a mouse calvaria defect model. Subsequently, we developed a biomimetic polycaprolactone (PCL)-based 3D architectural cover (Cover-type) and evaluated its osseointegration efficacy in a rat femur model against conventional Ti implants.</p><p><strong>Results: </strong>The mouse study confirmed that decellularized bone integrated significantly faster than Ti, highlighting the necessity of 3D continuity. In the rat model, micro-computed tomography analysis indicated a clear trend of increased bone formation in the Cover-type group, though statistical significance was limited by sample size. However, histological analysis confirmed a statistically significant enhancement in bone-to-implant contact compared to controls (P<0.05). The PCL structure served as a scaffold for cell migration, effectively bridging the implant-bone gap.</p><p><strong>Conclusions: </strong>These findings suggest that providing a bone-like 3D environment via a PCL cover may enhance histological osseointegration, rather than relying solely on surface chemistry.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 1","pages":"30-39"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping a Decade of Osteoporosis and Fracture Research: A Bibliometric Analysis (2015-2025).","authors":"Oluwafemi Samson Balogun, Sunday Adewale Olaleye, Margaret Adebola Balogun, Esther Olubunmi Olaleye, Muhammad Zeshan Arshad, Keijo Haataja, Pekka Toivanen","doi":"10.11005/jbm.25.903","DOIUrl":"10.11005/jbm.25.903","url":null,"abstract":"<p><strong>Background: </strong>Osteoporosis is a major global health concern, affecting over 200 million individuals worldwide. Although numerous clinical and experimental studies exist, comprehensive analyses integrating fracture-related and drug-specific research remain limited. Examining global research trends can highlight evolving themes, key contributors, and areas requiring scientific attention.</p><p><strong>Methods: </strong>We performed a bibliometric analysis of literature on osteoporosis and fractures, including drug-specific terms (denosumab, romosozumab, teriparatide), published between 2015 and 2025 in the Scopus Core Collection. Data were assessed for publication trends, authorship, institutional output, international collaboration, and thematic evolution using Bibliometrix-Biblioshiny in RStudio. Network analyses included co-authorship and keyword co-occurrence mapping for both quantitative and qualitative insights.</p><p><strong>Results: </strong>From 4,450 articles, annual output showed steady growth, peaking between 2021 and 2024. The United States, Japan, and China led in publication volume and citation impact, while Osteoporosis International was the most productive journal. Citation averages declined recently due to lag in newer publications. Thematic mapping identified pharmacological therapies such as denosumab and teriparatide as core themes, while \"fracture prevention\" and \"DXA-based assessment\" emerged as active research fronts. International collaboration decreased after 2020, particularly affecting contributions from low- and middle-income countries.</p><p><strong>Conclusions: </strong>Global osteoporosis research demonstrates sustained productivity but declining collaboration and limited thematic diversification. Strengthening international networks, supporting underrepresented regions, and expanding focus to preventive and non-pharmacological strategies are essential for equitable and impactful progress.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 1","pages":"94-107"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trabecular Bone Score and Mortality Risk in a Population-Based Cohort of Older Adults.","authors":"Carlos H Orces","doi":"10.11005/jbm.25.917","DOIUrl":"10.11005/jbm.25.917","url":null,"abstract":"<p><strong>Background: </strong>Osteoporosis is consistently reported to increase mortality risk in older adults. Whether trabecular bone score (TBS), an indirect index of trabecular microarchitecture, increases mortality risk has not been widely studied.</p><p><strong>Methods: </strong>Participants aged 60 years and older in the National Health and Nutritional Examination Survey 2005 to 2008 with complete data on TBS lumbar vertebrae were linked to the public-use mortality files through December 31st, 2019. The X-tile software (version 3.6.1; Yale University) was used to obtain the overall and sex-specific optimal TBS cut-off values associated with all-cause mortality (log-rank test P<0.0001). Then, TBS was grouped into low (≤1.24), medium (1.25-1.39), and high (≥1.40) categories.</p><p><strong>Results: </strong>A total of 2,641 participants with a mean age of 69.8 (standard error 0.2) years comprised the study sample. Of those, 1,109 older adults died after a median follow-up of 140 months. Overall, survival probability progressively decreased across TBS categories, which was accentuated in subjects with low TBS. Cox regression analysis demonstrated that participants with low TBS had 47% (hazard ratio [HR], 1.47; 95% confidence interval [CI], 1.10-1.96) greater all-cause mortality risk than their counterparts with high TBS, even after accounting for potential confounders including bone mineral density. Notably, older adults with low TBS had 2-fold higher risk of cancer-related mortality than those with high TBS (HR, 2.07; 95% CI, 1.17-3.67).</p><p><strong>Conclusions: </strong>Low TBS was significantly associated with greater all-cause and cancer-related mortality in older adults.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"33 1","pages":"40-49"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano Calcium from Marine Fish Bones via High-Energy Ball Milling: A Potential Natural Supplement for Bone Health.","authors":"Devy N A Hasanuddin, Safira Prisya Dewi, Sri Fatmawati, Annis Catur Adi, Heni Rachmawati","doi":"10.11005/jbm.25.875","DOIUrl":"10.11005/jbm.25.875","url":null,"abstract":"<p><strong>Background: </strong>Calcium is essential for bone health, but its intake remains inadequate in populations with limited dairy consumption. Fish bones, abundant in calcium and phosphorus, represent a largely untapped natural resource for dietary calcium supplementation. The application of high-energy ball milling (HEM) presents a promising strategy to enhance calcium bioavailability by producing particles at the nanoscale.</p><p><strong>Methods: </strong>This study used HEM to convert fish bones from Euthynnus affinis (tuna) and Lutjanus sp. (snapper) into nanoparticles. The resulting powder was analyzed for particle size, morphology, crystallinity, thermal, flowability, hygroscopicity, mineral composition, and proximate constituents.</p><p><strong>Results: </strong>The HEM process successfully reduced the particle size of snapper and tuna bone powder to 729.83 and 847.93 nm, respectively, without altering their crystallinity. Morphological analysis revealed irregularly shaped particles, while thermal analysis indicated an exothermic decomposition pattern. No hygroscopic properties were observed in any of the samples. The nanonization process preserved the intrinsic mineral composition of the fish bones. Calcium/Phosphorus ratios remained >1.8. Elemental analysis confirmed high levels of calcium, phosphorus, and essential minerals such as potassium, magnesium, and sodium, while the protein and ash contents met nutritional standards.</p><p><strong>Conclusions: </strong>Fish bone-derived nanoparticles produced via HEM exhibit advantageous physicochemical characteristics for nutraceutical applications and represent a promising source of bioavailable calcium to support bone health.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 4","pages":"285-296"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12718991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145804431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Diet Quality and Knee Osteoarthritis: Insights from the Korea National Health and Nutrition Examination Survey 2013.","authors":"Hyunmi Han, Clara Yongjoo Park","doi":"10.11005/jbm.25.913","DOIUrl":"10.11005/jbm.25.913","url":null,"abstract":"<p><strong>Background: </strong>The association between diet quality (DQ) and osteoarthritis (OA) among the Asian population is unclear. Even within this population, the associations between DQ and OA may differ by region. We examined the relationship between DQ and radiologic knee OA (RKOA) among Koreans, stratifying participants by residential area.</p><p><strong>Methods: </strong>This cross-sectional study used data from the Korea National Health and Nutrition Examination Survey conducted in 2013. A total of 2,222 participants aged 50 years old and older with available data on RKOA and DQ were analyzed. DQ was evaluated using the Korean Healthy Eating Index (KHEI). RKOA was diagnosed via radiography and defined as having a Kellgren-Lawrence grade ≥2 in the knee. Participants were categorized by residential region: metropolitan cities, small to medium-sized cities, or rural areas. The odds ratios for RKOA across the three regions were analyzed using multiple logistic regression, adjusting for confounding factors.</p><p><strong>Results: </strong>High KHEI scores were associated with lower odds of RKOA (P for trend=0.03). This association was primarily observed in residents of metropolitan cities, particularly among men (P for trend=0.02).</p><p><strong>Conclusions: </strong>Better DQ is associated with reduced odds of RKOA in older Korean adults living in metropolitan areas.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 4","pages":"297-305"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12718990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145804641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Bone Mineral Density in Postmenopausal Women: The Role of Lean and Fat Mass by Dual Energy X-Ray Absorptiometry Assessment.","authors":"Luis A Ramírez Stieben, Lucas R Brun, Silvana Di Gregorio, Luis Miguel Del Río Barquero, María Lorena Brance","doi":"10.11005/jbm.25.881","DOIUrl":"10.11005/jbm.25.881","url":null,"abstract":"<p><strong>Background: </strong>Bone mineral density (BMD) is a key predictor of fracture risk in postmenopausal women. Evidence on the influence of fat and lean mass (LM) on BMD remains contradictory. This study aimed to assess the associations between BMD at different sites (whole-body, upper, and lower limbs) and anthropometric and body composition variables measured by dual energy X-ray absorptiometry (DXA) in postmenopausal women.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on 308 healthy postmenopausal women. Anthropometric data and whole-body DXA scans were used to measure BMD, total fat mass (FM), LM, appendicular LM index (ALMI), and abdominal fat. Pearson or Spearman correlation analyses were used according to variable distribution, and a correlation matrix along with variance inflation factor analyses was used to reduce 18 variables to a final set of 5. Multiple linear regression models were built for BMD at each site.</p><p><strong>Results: </strong>Age was negatively correlated with BMD at all sites. Total LM and ALMI demonstrated positive correlations with BMD, whereas body mass index (BMI) and abdominal fat exhibited weaker positive associations. In multivariable analyses, age was negatively associated with whole-body BMD, while total LM was positively associated. For lower-limb BMD, age and total LM were significant predictors, with BMI showing a positive but weaker association. For upper-limb BMD, total LM, and ALMI were all positively associated. The models demonstrated satisfactory fit (adjusted R², 0.341-0.438; global P<0.0001).</p><p><strong>Conclusions: </strong>Age and total LM were independently and consistently associated with BMD in postmenopausal women, whereas FM and BMI had a limited impact.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 4","pages":"306-314"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12719001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145803609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}