Journal of Biomedical Research最新文献_第4页

Cervical cancer perceived behavioral risk factors using logistic regression technique. 应用logistic回归技术分析宫颈癌感知危险因素行为。

IF 3.7 4区医学

Journal of Biomedical Research Pub Date : 2026-05-21 DOI: 10.7555/JBR.39.20250047

I M Elzein, Ashraf Chamseddine, Ahmad Eltanboly, Adam Elzein

{"title":"Cervical cancer perceived behavioral risk factors using logistic regression technique.","authors":"I M Elzein, Ashraf Chamseddine, Ahmad Eltanboly, Adam Elzein","doi":"10.7555/JBR.39.20250047","DOIUrl":"10.7555/JBR.39.20250047","url":null,"abstract":"Cervical cancer represents a considerable global health challenge, mainly because of ineffective screening programs in low-income countries. The current study aimed to forecast cervical cancer incidence by analyzing behavioral risk factors through logistic regression, employing feature engineering techniques such as principal component analysis (PCA). PCA successfully condensed the dataset into ten principal components, capturing 89% of the variance, while stratified K-fold cross-validation ensured a balanced representation of classes. With the application of L1 regularization, the logistic regression model achieved an accuracy of 97.2%, an area under the curve (AUC) of 98.1%, an F1 score of 97.2%, a specificity of 96.1%, and a log loss of 0.17. The performance of the models was comparatively evaluated, and the results revealed that the logistic regression model achieved the highest accuracy of 97.2% compared with decision trees at 93.33%, random forest at 93.33%, XGBoost at 93.33%, naive Bayes at 91.67%, and non-regularized logistic regression at 87.55%. This research underscores the importance of early prediction of cervical cancer based on behavioral risk factors and suggests a robust, easily implementable workflow to improve classification accuracy. Future research should concentrate on refining these predictive tools to overcome social and behavioral barriers to prevention, particularly within underserved populations.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":" ","pages":"280-290"},"PeriodicalIF":3.7,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13231354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STK11 rs12977689 C>A gene polymorphism as a risk factor for coronary artery disease in type 2 diabetes patients. STK11 rs12977689 C>A基因多态性与2型糖尿病患者冠状动脉疾病的危险因素

IF 3.7 4区医学

Journal of Biomedical Research Pub Date : 2026-05-21 DOI: 10.7555/JBR.39.20250136

Made Edwin Sridana, Wira Gotera, Bagus Ari, Pradnyana Dwi, Bagus Ari Pradnyana Dwi Sutanagera, Made Ratna Saraswati

引用次数: 0

Association between psoriasis and chronic bronchitis: Adverse reaction to therapy or neglected comorbidity? 银屑病与慢性支气管炎的关系：治疗不良反应或被忽视的合并症？

IF 3.7 4区医学

Journal of Biomedical Research Pub Date : 2026-05-21 DOI: 10.7555/JBR.39.20250178

Xinyi Dai, Chenxingyue Zhang, Zhiqiang Yin

引用次数: 0

hUMSC-derived exosomes alleviate hypoxic cerebrovascular injury via AMPK/NLRP3-mediated pyroptosis suppression and mitochondrial protection. humsc衍生的外泌体通过AMPK/ nlrp3介导的焦亡抑制和线粒体保护减轻缺氧脑血管损伤。

IF 3.7 4区医学

Journal of Biomedical Research Pub Date : 2026-05-21 DOI: 10.7555/JBR.39.20250189

Jinteng Liu, Yunlong Pan, Haolin Wu, Qingyun Guo, Xingyue Fang, Yingmei Lu, Qibing Liu

{"title":"hUMSC-derived exosomes alleviate hypoxic cerebrovascular injury via AMPK/NLRP3-mediated pyroptosis suppression and mitochondrial protection.","authors":"Jinteng Liu, Yunlong Pan, Haolin Wu, Qingyun Guo, Xingyue Fang, Yingmei Lu, Qibing Liu","doi":"10.7555/JBR.39.20250189","DOIUrl":"10.7555/JBR.39.20250189","url":null,"abstract":"As the most prevalent cause of death worldwide, ischemic stroke urgently requires innovative therapeutic strategies. The present study demonstrated the therapeutic potential of human umbilical cord-derived mesenchymal stem cell-derived exosomes (hUMSC-Exos) in ameliorating hypoxia-induced cerebrovascular endothelial dysfunction through modulation of the AMPK/NLRP3 signaling pathway. Bioinformatics analysis of DisGeNET and exosomal cargo databases revealed 283 overlapping cerebral ischemia-related genes, implicating hUMSC-Exos in inflammatory regulation. In vitro experiments showed that hUMSC-Exos rescued oxygen-glucose deprivation (OGD)-induced endothelial dysfunction in bEnd.3 mouse brain endothelial cells, restoring viability, migration, and mitochondrial integrity. Mechanistically, hUMSC-Exos reversed OGD-induced AMPK inactivation while suppressing NLRP3 inflammasome activation, caspase-1 cleavage, and gasdermin D (GSDMD)-mediated pyroptosis. Molecular docking revealed that DL-3-n-butylphthalide acts as a dual-target ligand for AMPK/NLRP3, synergizing with hUMSC-Exos to enhance endothelial protection. In vivo, combined therapy in the transient middle cerebral artery occlusion mouse model reduced cerebral infarction and improved neurological outcomes, accompanied by NLRP3/GSDMD downregulation and hippocampal neuron preservation. These findings establish hUMSC-Exos as regulators of AMPK/NLRP3-mediated pyroptosis and propose a translatable combinatorial regimen for ischemic stroke therapy.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":" ","pages":"312-326"},"PeriodicalIF":3.7,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13231368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

piR-61298 promotes colorectal cancer progression through destabilizing p53 by interacting with USP10. piR-61298通过与USP10相互作用破坏p53的稳定，从而促进结直肠癌的进展。

IF 3.7 4区医学

Journal of Biomedical Research Pub Date : 2026-05-21 DOI: 10.7555/JBR.39.20250137

Shenya Xu, Zhutao Ding, Shuai Ben, Chen Li, Silu Chen, Lingyan Zhao, Shuwei Li, Dongying Gu

{"title":"piR-61298 promotes colorectal cancer progression through destabilizing p53 by interacting with USP10.","authors":"Shenya Xu, Zhutao Ding, Shuai Ben, Chen Li, Silu Chen, Lingyan Zhao, Shuwei Li, Dongying Gu","doi":"10.7555/JBR.39.20250137","DOIUrl":"10.7555/JBR.39.20250137","url":null,"abstract":"PIWI-interacting RNAs (piRNAs) are a class of noncoding RNAs primarily found in germ cells. While piRNAs are known to be involved in various cancers, their specific roles in colorectal cancer (CRC) remain unclear. To elucidate the role of piRNAs in CRC, we first analyzed their expression characteristics by sequencing 10 pairs of tumor and adjacent normal tissues. Subsequently, differentially expressed piRNAs were identified through a two-stage reverse transcription-quantitative PCR (RT-qPCR) validation using 20 and 114 pairs of samples. Subcellular localization was assessed through nucleoplasmic separation and immunofluorescence staining assays. RNA pull-down mass spectrometry was employed to identify piRNA-interacting proteins. We identified piR-61298 as a piRNA significantly upregulated in CRC. Functional assays showed that piR-61298 promoted cell proliferation and migration, inhibited apoptosis, and promoted tumor growth. Mechanistically, piR-61298 bound to ubiquitin-specific peptidase 10 (USP10) in the cytoplasm, impairing its deubiquitinating activity toward p53, thereby leading to p53 ubiquitination and degradation. These findings suggest that piR-61298 plays a critical role in CRC progression by disrupting the USP10-p53 axis. Collectively, the current study highlights piR-61298 as a potential therapeutic target, offering a novel approach for CRC treatment by targeting piRNA-mediated regulation.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":" ","pages":"266-279"},"PeriodicalIF":3.7,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13231362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progressive IL-13 signaling promotes inflammation-associated liver fibrosis via IL-13RA2/MEK/ERK activation in Schistosoma japonicum infection. 进行性IL-13信号通过IL-13RA2/MEK/ERK激活在日本血吸虫感染中促进炎症相关的肝纤维化

IF 2.4 4区医学

Journal of Biomedical Research Pub Date : 2026-04-25 DOI: 10.7555/JBR.39.20250475

Ruiyan Xiong, Jiangyuan Du, Yuchen Yang, Yuxiao Zhu, Yangyue Ni, Lin Chen, Min Hou, Zhipeng Xu, Lu Chen, Minjun Ji

{"title":"Progressive IL-13 signaling promotes inflammation-associated liver fibrosis via IL-13RA2/MEK/ERK activation in Schistosoma japonicum infection.","authors":"Ruiyan Xiong, Jiangyuan Du, Yuchen Yang, Yuxiao Zhu, Yangyue Ni, Lin Chen, Min Hou, Zhipeng Xu, Lu Chen, Minjun Ji","doi":"10.7555/JBR.39.20250475","DOIUrl":"https://doi.org/10.7555/JBR.39.20250475","url":null,"abstract":"Progressive IL-13 signaling is closely associated with liver fibrosis. Among fibrotic diseases, liver fibrosis induced by Schistosoma japonicum in advanced schistosomiasis is the primary driver of portal hypertension, which is the leading cause of mortality in affected patients. RNA sequencing analysis of human hepatic stellate cells revealed that IL-13RA2 was markedly upregulated in activated hepatic stellate cells and enriched in the cytokine-receptor interaction pathways, suggesting a potential role for IL-13RA2 in hepatic stellate cell activation and fibrosis progression. Based on these findings, we aimed to investigate whether IL-13RA2 also contributes to liver fibrosis during Schistosoma japonicum infection. In this study, we established a murine model of Schistosoma japonicum infection. Compared with IL-13RA1, IL-13RA2 expression was significantly increased at week 9 post-infection in mice. IL-13RA2 was enriched within fibrotic regions and increased in parallel with collagen accumulation and stellate cell activation. The phosphorylation levels of MEK and ERK changed in parallel with IL-13RA2 abundance. Furthermore, overexpression of IL-13RA2 markedly accelerated hepatic fibrogenesis, while knockdown of IL-13RA2 attenuated liver fibrosis induced by schistosomiasis via the MEK/ERK pathway. Hence, IL-13RA2 may represent an effective and promising therapeutic target for the attenuation of liver fibrosis.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":" ","pages":"1-15"},"PeriodicalIF":2.4,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combating Pseudomonas aeruginosa biofilms: Pathogenesis, resistance mechanisms and novel treatment approaches in an era of emerging antimicrobial resistance. 抗铜绿假单胞菌生物膜：在新出现的抗菌素耐药性时代的发病机制，耐药机制和新的治疗方法。

IF 2.4 4区医学

Journal of Biomedical Research Pub Date : 2026-04-25 DOI: 10.7555/JBR.39.20250484

Sachin Kumar Sharma, Tsering Yangzom, Dhruva Kumar Sharma

{"title":"Combating Pseudomonas aeruginosa biofilms: Pathogenesis, resistance mechanisms and novel treatment approaches in an era of emerging antimicrobial resistance.","authors":"Sachin Kumar Sharma, Tsering Yangzom, Dhruva Kumar Sharma","doi":"10.7555/JBR.39.20250484","DOIUrl":"https://doi.org/10.7555/JBR.39.20250484","url":null,"abstract":"Biofilms are complex associations of microorganisms that are adhere to both biotic surfaces ( e.g., living tissues) and abiotic surfaces ( e.g., medical implants). These microorganisms, embedded in their own self-produced extracellular polymeric substance matrix, can be protected from unfavorable conditions. Among biofilm forming pathogens, Pseudomonas aeruginosa is an opportunistic bacteria associated with persistent and chronic infections due to its strong biofilm forming ability and high resistance to antibiotics. This paper focuses on P. aeruginosa biofilms, including the steps of biofilm development, their structural organization and genetic regulation, and the environmental factors affecting their survival. Biofilms exhibit significant resistance to conventional treatments, contributing to the persistence of chronic infections, implant-related infections, and non-healing wounds. The article discusses the diagnostic challenges and limitations of current antimicrobial treatment for P. aeruginosa biofilm associated infections. Recent approaches to improving clinical outcomes are also discussed, including the use of new antibiofilm compounds, mechanical solutions, and alternatives such as phage therapy, which integrate current knowledge of P. aeruginosa biofilm-related diseases to optimize therapeutic strategies for addressing antimicrobial resistance and improve patient outcomes.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":" ","pages":"1-16"},"PeriodicalIF":2.4,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cross-sectional analysis of metabolic syndrome and melanoma-specific risk in the US NHANES. 美国NHANES中代谢综合征和黑色素瘤特异性风险的横断面分析。

IF 2.4 4区医学

Journal of Biomedical Research Pub Date : 2026-03-25 DOI: 10.7555/JBR.39.20250425

Xinyi Dai, Jiliang Lu, Chenxingyue Zhang, Yunpeng Shi, Suwen Du, Zhiqiang Yin

引用次数: 0

WITHDRAWN: Biocompatibility of implants in plastic surgery and allergenic potential of materials. 整形外科植入物的生物相容性及材料的致敏性。

IF 2.4 4区医学

Journal of Biomedical Research Pub Date : 2026-03-25 DOI: 10.7555/JBR.39.20250334

Maria Zofia Lisiecka, Alicja Jakubowska

引用次数: 0

Editorial commentary on the special issue of immunology. 免疫学特刊社论评论。