Journal of Biological Rhythms最新文献

{"title":"Rhythms of Risk: Circadian Influences on Cardiac Electrophysiology and Drug-Induced Arrhythmias.","authors":"Mark É Czeisler","doi":"10.1177/07487304251374372","DOIUrl":"10.1177/07487304251374372","url":null,"abstract":"","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"24-27"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145368027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Circadian Phase and Sleep Timing in Preschool-Aged Children.","authors":"Lauren E Hartstein, Lameese D Akacem, Kenneth P Wright, Monique K LeBourgeois","doi":"10.1177/07487304251377616","DOIUrl":"10.1177/07487304251377616","url":null,"abstract":"<p><p>Early childhood represents a period of profound developmental changes for sleep and circadian biology. Although the relationship between sleep and circadian timing has been well characterized in older populations, such data in young children remain limited. Here, we provide fundamental data on the relationship between endogenous circadian phase and sleep timing in a sample of preschool-aged children. Participants were 49 healthy children ages 3.1 to 6.0 years (<i>M</i> = 4.44 years, <i>SD</i> = 0.69 years, 27 female). After 7 days of maintaining a consistent, parent-selected sleep schedule, children completed an in-home, dim-light circadian assessment. Saliva samples were collected in 30-min intervals throughout the evening to determine the timing of children's dim-light melatonin onset (DLMO). Children's DLMOs occurred an average of 35.0 ± 35.3 min before their bedtimes, with parent-selected bedtime occurring before DLMO for 18.4% of children. Children with later DLMOs had significantly later bedtimes (<i>r</i> = 0.65), sleep onset times (<i>r</i> = 0.74), midsleep times (<i>r</i> = 0.74), and wake times (<i>r</i> = 0.66) (all <i>p</i> < 0.001). For every hour later that DLMO occurred, average bedtime and sleep onset time were 28.0 and 33.4 min later, respectively. In addition, children with later DLMOs had higher scores on a parent-reported measure of chronotype (<i>r</i> = 0.56, <i>p</i> < 0.001), indicating greater eveningness. No association between DLMO time and sleep duration or social jetlag was observed. These data extend previous findings in toddlers, demonstrating a consistent relationship between circadian phase and sleep timing, as well as chronotype, throughout early childhood.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"139-145"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12614296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of Metabolic Rhythms by Glial Clocks.","authors":"Catarina Carvalhas-Almeida, Sara B Noya, Tianqi Wu, Ana Rita Álvaro, Cláudia Cavadas, Julie A Williams, Amita Sehgal","doi":"10.1177/07487304251386682","DOIUrl":"10.1177/07487304251386682","url":null,"abstract":"<p><p>Rhythmicity is a central feature of behavioral and physiological processes, including sleep, immune responses, and metabolism. Research on brain control of these processes has largely focused on neurons, with less known about the role of clock genes in glial cells. In this study, we addressed the function of glial clocks by targeting the expression of key clock genes in glia of <i>Drosophila melanogaster.</i> Loss of the <i>period (per</i>) gene in glia increases sleep following aseptic injury and loss of either <i>per</i> or <i>timeless</i> (<i>tim)</i> significantly reduces locomotor activity in light:dark cycles and in constant dark, but other than this, the major effect of clock gene loss in glia is on metabolic function. We demonstrate that disruption of either <i>tim</i> or <i>per</i> in glia affects glycogen stores and reduces metabolic rate. Disruption of either <i>tim</i> or <i>per</i> in glia also affects rhythms of feeding and overall food consumption. Notably, these effects of clock disruption are mediated by distinct glial subtypes, especially cortex glia. We propose that the major role of glial clocks is in the control of energy homeostasis and metabolic rhythms, which likely also accounts for effects on locomotor activity. These findings link metabolism and behavior via circadian regulation in glia.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"122-138"},"PeriodicalIF":3.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12694984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145668216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic-induced Dysbiosis of Gut Microbiota Increases Food Motivation and Anticipatory Activity Under a Time-restricted Feeding Protocol.","authors":"Manuel T Crespo, Alana Del Rio, Cristina Borio, Marcos Bilen, Juan J Chiesa, Patricia V Agostino","doi":"10.1177/07487304251359349","DOIUrl":"10.1177/07487304251359349","url":null,"abstract":"<p><p>Newly emerging evidence underscores the crucial role of the gut microbiota in regulating various aspects of mammalian physiology and behavior, including circadian rhythms. These rhythms, fundamental to behavioral and physiological processes, are orchestrated by a circadian pacemaker located in the suprachiasmatic nucleus (SCN) of the hypothalamus. Extra-SCN oscillators have been identified in brain regions beyond the SCN and in peripheral tissues temporizing wide physiological functions. Under a 12 h light: 12 h dark cycle (12:12 LD), restriction of food access to hours of light in nocturnal animals in a time-restricted feeding (TRF) protocol increases locomotor activity preceding the scheduled daily meal, so-called food anticipatory activity (FAA). This circadian behavior is independent from the SCN and controlled by a food-entrainable oscillator (FEO) dependent on reward-related signals. It is known that signals from the gut microbiota regulate behaviors such as motivation oriented by food reward. Thus, we hypothesized a physiological link between gut microbiota and FEO activity by studying the circadian FAA behavior under TRF and assessing food-oriented motivational behavior. For that aim, C57BL/6J mice treated with antibiotics for generating gut microbiota dysbiosis were subjected to a 3 h TRF protocol at zeitgeber time (ZT) 4-7. Mice treated with antibiotics exhibited greater FAA, lower time for its consolidation, and greater motivation levels for food reward. Moreover, tyrosine hydroxylase (TH) levels were increased in the nucleus accumbens (NAc) and ventral tegmental area (VTA) of antibiotic-treated mice. Finally, changes in the gut microbiota composition-including bacterial diversity and the abundance of certain genera-were observed. These results suggest that gut microbiota has a regulatory role in the circadian motivational output for food reward controlled by the FEO. Understanding this role is important for potential chronotherapeutics targeting gut microbiota in reward-related alterations such as addictions and eating disorders.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"81-93"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144846599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Abrupt Mid-1970s Shift in UK Birth Seasonality and Its Implications for Chronobiological Studies.","authors":"Timothy J Hearn, David Whitmore","doi":"10.1177/07487304251384348","DOIUrl":"10.1177/07487304251384348","url":null,"abstract":"<p><p>We present a comprehensive analysis of the historical fluctuations and rephasing of seasonal birth rates in the United Kingdom from 1955 to 2015. We analyzed monthly live-birth records for England and Wales together with national photoperiod and surface-temperature series to track the annual rhythm of human reproduction. Fast Fourier transforms confirmed a robust 12-month component across the entire record, but breakpoint tests located a sharp phase shift in 1974-1976. Before this transition, peak conceptions clustered tightly around the summer solstice and yielded a stable March birth maximum. After 1976, the rhythm decoupled: the spring peak in births collapsed, a secondary autumn peak emerged, and inter-annual phase variability more than doubled. Cross-correlation analyses showed that, up to 1974, photoperiod led birth counts by ≈11 months whereas temperature played only a minor role. Post 1976, photoperiod correlations disappeared and a weaker, inverse link with temperature persisted. Sliding-window statistics indicate that variability has narrowed again since the mid-1990s, hinting at partial re-stabilization of the seasonal pattern, now centered in late autumn conceptions. These results demonstrate that the mid-1970s marked a singular disruption of the United Kingdom's reproductive calendar, coincident with the nationwide roll-out of freely available hormonal contraception and other social shifts. The findings urge caution when pooling pre- and post-1974 cohorts in genetic or epidemiological studies-such as those using UK Biobank-to explore season-of-birth effects. More broadly, they highlight the plasticity of human annual timing and the need to disentangle biological from socio-environmental drivers of reproduction.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"28-41"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12804422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145633857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-Restricted Feeding Is Not Effective in Modulating Fibrosis in a Male MASH Model.","authors":"Stephany Flores Ramos, Kelly A Fogelson, Valentina B Muti, Wuling Zhong, Jingjing Hu, Mojgan Hosseini, Rohit Loomba, Amir Zarrinpar","doi":"10.1177/07487304251383253","DOIUrl":"10.1177/07487304251383253","url":null,"abstract":"<p><p>Time-restricted feeding (TRF), a dietary intervention that consolidates food intake to specific hours of the day, ameliorates key metabolic risk factors for metabolic-associated steatohepatitis (MASH), including adiposity, insulin resistance, and liver steatosis. However, whether TRF can directly mitigate steatohepatitis or fibrosis remains uncertain. Moreover, whether the protective effects of TRF against MASH-related complications, such as inflammation and fibrosis, depend exclusively on improvements in insulin sensitivity or involve additional mechanisms remains unknown. Here, we examine the impact of 8-hour TRF on the development of fibrosis and steatohepatitis using a streptozotocin/high-fat diet (STAM/HFD) model, which recapitulates key MASH characteristics, including steatohepatitis and fibrosis, in an insulin-deficient context. TRF does not prevent the development of MASH in STAM/HFD male mice where insulin signaling is impaired. Unlike diet-induced obesity models, which exhibit greatly perturbed feeding and circadian behaviors under HFD conditions, STAM/HFD mice did not develop obesity and maintained regular or less-pronounced disruptions to circadian behaviors. This may explain why TRF failed to produce beneficial effects in this model. These findings indicate that intact insulin signaling is likely essential for TRF to effectively protect against MASH.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"146-151"},"PeriodicalIF":3.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12629601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145540762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Pittendrigh-Aschoff Lecture 2024.","authors":"Till Roenneberg","doi":"10.1177/07487304251386670","DOIUrl":"10.1177/07487304251386670","url":null,"abstract":"<p><p>Chronobiology is one of the broadest disciplines in science - we can study and apply this system from molecules to shiftwork, from individuals to populations, from physiology to psychology, from mechanisms to medicine. Since I have an aversion against thinking in boxes, chronobiology was the only discipline I could faithfully live in for the past 55 years, giving me the privilege to witness its epitaxy from its pioneers to circadian medicine. I have tackled chronobiological questions with many different methods, but by far my favorite tool to understand are concepts.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"9-23"},"PeriodicalIF":3.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12804404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145700988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling Circadian Clock Regulation of Immune System Response to SARS-CoV-2 Infection and Antiviral Treatment.","authors":"Ning Wei, Soheil Saghafi, Emel Khan, Casey O Diekman","doi":"10.1177/07487304251370409","DOIUrl":"10.1177/07487304251370409","url":null,"abstract":"<p><p>Circadian clocks regulate the immune system, rendering humans more susceptible to infections at certain times of the day. Circadian modulation of SARS-CoV-2 infection has not yet been clearly established, nonetheless the circadian control of other respiratory viruses such as influenza A makes apparent the need to study the interaction between circadian rhythms and COVID-19 disease progression. We incorporated circadian oscillations into a mechanistic model of SARS-CoV-2 dynamics and immune response fit to viral load data from COVID-19 patients. The model predicts that circadian variation of parameters associated with the innate immune response and viral death rate lead to faster clearance of the virus, whereas circadian variation of parameters representing the susceptible cell infection rate, the viral production rate, and the adaptive immune response lead to slower clearance of the virus. We then used a model of remdesivir to simulate antiviral therapy. Our model simulations predict that the effectiveness of the treatment depends on the time of day the drug is administered. This prediction is conditional on the plausible, but entirely hypothetical, circadian interactions added to the model. Based on our proof-of-concept modeling results, we advocate for experimental and clinical studies to assess the impact that dosing time of day may have on the efficacy and toxicity of current COVID-19 antiviral drugs.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"594-604"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Associations of Sedentary Behavior and Physical Activity With Diurnal Rest-Activity Rhythms in Survivors of Colorectal Cancer Up to 5 Years Post-Treatment.","authors":"Koen G Frenken, Marvin Y Chong, Stéphanie O Breukink, Maryska Janssen-Heijnen, Eric T P Keulen, Joop Konsten, Wouter Bijnens, Laurien M Buffart, Kenneth Meijer, Frank A J L Scheer, Karen Steindorf, Judith de Vos-Geelen, Matty P Weijenberg, Martijn J L Bours, Eline H van Roekel","doi":"10.1177/07487304251363674","DOIUrl":"10.1177/07487304251363674","url":null,"abstract":"<p><p>Disrupted diurnal rest-activity rhythms (RAR), that is, daily 24-h patterns of rest and activity, have been associated with fatigue and decreased quality of life among survivors of colorectal cancer (CRC). To identify potential targets for interventions to improve RAR, we investigated longitudinal associations of time spent in sedentary behavior and physical activity with RAR parameters after CRC treatment. In a prospective cohort study, repeated measurements were performed among 268 survivors of stage I-III CRC at 6 weeks, 6 months, and 1, 2, and 5 years after treatment. Thigh-worn accelerometers were used to determine hours/day spent in sedentary behavior, standing, and total physical activity during waking time, as well as RAR parameters including mesor, amplitude, circadian quotient (CQ), dichotomy index (I < O) and 24 h-autocorrelation (R24). Self-reported light-intensity physical activity (LPA) and moderate-to-vigorous physical activity (MVPA) were determined via the validated SQUASH questionnaire. Longitudinal associations were analyzed using confounder-adjusted linear mixed models. More sedentary time was statistically significantly associated with a lower mesor, amplitude, I < O and R24 over the 5-year post-treatment period. More standing time was associated with a higher mesor, amplitude, CQ, and I < O but not with R24. Higher levels of objectively assessed total physical activity as well as self-reported MVPA were associated with higher values for all RAR parameters. LPA was not associated with any of the RAR parameters. In the years after CRC treatment, less sedentary behavior and more standing and physical activity were generally associated with higher RAR parameters indicating a more robust rhythm. Future studies should provide more insight into causality of these associations as RAR may be a potential new target for interventions to reduce fatigue after CRC.Trial registration: EnCoRe study NL6904 (https://www.Onderzoekmetmensen.nl/).</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"528-546"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12572352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Day Length on Brain Glucose Metabolism in Men: A Large-Scale Repeated Measures PET Study.","authors":"Kyoungjune Pak, Seunghyeon Shin, Keunyoung Kim, Jihyun Kim, Hyun-Yeol Nam, Lauri Nummenmaa, Pirjo Nuutila, Xingdang Liu, Lihua Sun","doi":"10.1177/07487304251360874","DOIUrl":"10.1177/07487304251360874","url":null,"abstract":"<p><p>The brain is the most energy-demanding organ, yet whether cerebral energy homeostasis exhibits seasonal rhythmicity remains unclear. In this study, 432 healthy men underwent a health checkup program with fasting-state brain [¹⁸F]fluorodeoxyglucose positron emission tomography (PET) scanning twice: first at the baseline and then at the 5-year follow-up. We analyzed the effect of day length on brain glucose uptake separately for both time points. In both baseline and follow-up scans, day length on the day of imaging significantly predicted glucose uptake in the socio-emotional circuit. A longer day length was associated with increased glucose uptake in the cuneus, precuneus, orbitofrontal cortex, pre- and postcentral gyrus, superior and middle temporal gyrus, posterior cingulate cortex, insula, and frontal pole. This large-scale longitudinal PET study provides landmark evidence for the impact of daylight exposure on brain glucose metabolism. Findings disclose the baseline seasonal variation of brain energy consumption in men.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"547-554"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}