Journal of Biological Rhythms最新文献

{"title":"Temporal Dissociation Between Activity and Body Temperature Rhythms of a Subterranean Rodent (<i>Ctenomys famosus</i>) in Field Enclosures.","authors":"Milene G Jannetti,&nbsp;Patricia Tachinardi,&nbsp;Veronica S Valentinuzzi,&nbsp;Gisele A Oda","doi":"10.1177/07487304231154715","DOIUrl":"https://doi.org/10.1177/07487304231154715","url":null,"abstract":"<p><p>Several wild rodents, such as the subterranean tuco-tucos (<i>Ctenomys famosus</i>), switch their time of activity from diurnal to nocturnal when they are transferred from field to the laboratory. Nevertheless, in most studies, different methods to measure activity in each of these conditions were used, which raised the question of whether the detected change in activity timing could be an artifact. Because locomotor activity and body temperature (Tb) rhythms in rodents are tightly synchronized and because abdominal Tb loggers can provide continuous measurements across field and laboratory, we monitored Tb as a proxy of activity in tuco-tucos transferred from a semi-field enclosure to constant lab conditions. In the first stage of this study (\"Tb-only group,\" 2012-2016), we verified high incidence (55%, <i>n</i> = 20) of arrhythmicity, with no consistent diurnal Tb rhythms in tuco-tucos maintained under semi-field conditions. Because these results were discrepant from subsequent findings using miniature accelerometers (portable activity loggers), which showed diurnal activity patterns in natural conditions (<i>n</i> = 10, \"Activity-only group,\" 2016-2017), we also investigated, in the present study, whether the tight association between activity and Tb would be sustained outside the lab. To verify this, we measured activity and Tb simultaneously across laboratory and semi-field deploying both accelerometers and Tb loggers to each animal. These measurements (<i>n</i> = 11, \"Tb + activity group,\" 2019-2022) confirmed diurnality of locomotor activity and revealed an unexpected loosening of the temporal association between Tb and activity rhythms in the field enclosures, which is otherwise robustly tight in the laboratory.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10004294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific Families.","authors":"Mary Harrington","doi":"10.1177/07487304231162492","DOIUrl":"https://doi.org/10.1177/07487304231162492","url":null,"abstract":"","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10022861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patricia J. DeCoursey (28 December 1932 to 1 January 2022).","authors":"Mary Harrington,&nbsp;Joseph S Takahashi","doi":"10.1177/07487304231161950","DOIUrl":"https://doi.org/10.1177/07487304231161950","url":null,"abstract":"Patricia DeCoursey was a pioneer in many ways. She was a research scientist and a professor at a time when few women held such jobs. For many years, she was a single mother (a widow) and was able to raise her family in a beautiful home. In her research, she helped to define a key function, the phase response curve (PRC) to light (DeCoursey, 1960a, 1960b). Her behavioral studies were meticulous and wonderfully detailed. She worked with others to publish what remains our core chronobiology textbook (Dunlap et al., 2004). In her later career, she conducted some of our field’s most impactful “clocks in the wild” studies (DeCoursey, 2014). Pat’s career as a Professor of Biological Sciences at the University of South Carolina included both laboratory and field studies. She studied flying squirrels and golden hamsters, and in her naturalistic studies, chipmunks, white-tailed antelope squirrels, and golden-mantled ground squirrels. From 2006 to 2019, Pat directed the W. Gordon Belser Arboretum, a 10-acre teaching forest for the university. Pat’s early life was unusual for several reasons. She was a triplet with an identical twin sister. Her family spent one summer camping in northern wilderness forests. When Pat was in fourth grade, she moved to Washington, DC, but she maintained a love of the wilderness. In high school in New York City, she completed a census of all the songbirds in a forest in Long Island, winning finalist status in the 1950 Westinghouse Science Talent Search. She attended Cornell University for her undergraduate degree in zoology and then received her PhD in zoology and biochemistry at the University of Wisconsin–Madison. She conducted postdoctoral research for 2 years at the Max-Planck Institute in Erling-Andechs, Germany, with Jurgen Aschoff. She even served as one of the early subjects of a “bunker” experiment, living in temporal isolation for 28 days. Her enthusiasm for science is nicely reflected in the text of a letter she wrote to her sister Cynthia at the time:","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9649129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Self-Rating of Biological Rhythm Disorder for Adolescents (SBRDA) Scale by Dim Light Melatonin Onset in Healthy Young Adults.","authors":"Yang Xie,&nbsp;Xiaoyan Wu,&nbsp;Xingyue Mou,&nbsp;Meng Wang,&nbsp;Shuman Tao,&nbsp;Yuhui Wan,&nbsp;Fangbiao Tao","doi":"10.1177/07487304221141939","DOIUrl":"https://doi.org/10.1177/07487304221141939","url":null,"abstract":"<p><p>Understanding the biological rhythms that influence young adult health is vital because the combination of biological changes and a circadian phase delay lead to young adults being at high risk of circadian misalignment. We have previously established a self-rating of biological rhythm disorder for adolescents (SBRDA). However, we did not externally validate the SBRDA against objective measures of biological rhythms such as dim light melatonin onset (DLMO)-the gold standard of the endogenous circadian phase. The purpose of this study was to verify the effectiveness of SBRDA in identifying individuals with biological rhythm disorders. Our participants were 42 (47.2%) boys and 47 (52.8%) girls with an average age of 18.5 ± 1.2 years. Saliva samples were collected from 4 h before bed time to 2 h after sleep every 60 min in a dim-light (<50 lx) laboratory environment. Biological rhythm parameters were assessed using questionnaires, including SBRDA, MEQ, and MCTQ. The mean DLMO time (h) was 22.2 ± 1.9. The DLMO correlated significantly with the SBRDA score (<i>r</i> = 0.33, <i>p</i> < 0.001), MEQ score (<i>r</i> = -0.24, <i>p</i> < 0.05), and MSFsc (<i>r</i> = 0.26, <i>p</i> < 0.05). ROC curve analysis showed that SBRDA was of diagnostic value for biological rhythm disorder (<i>p</i> < 0.05). Our observations demonstrate that SBRDA, which is consistent with MEQ and MCTQ, can be used to reflect endogenous circadian rhythm disorders in young adults. Exposure to dim light may activate melatonin secretion and lead to an earlier peak in young adults with biological rhythm disorder.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9250475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diurnal Changes in Capecitabine Clock-Controlled Metabolism Enzymes Are Responsible for Its Pharmacokinetics in Male Mice.","authors":"Yasemin Kubra Akyel,&nbsp;Dilek Ozturk Civelek,&nbsp;Narin Ozturk Seyhan,&nbsp;Seref Gul,&nbsp;Isil Gazioglu,&nbsp;Zeliha Pala Kara,&nbsp;Francis Lévi,&nbsp;Ibrahim Halil Kavakli,&nbsp;Alper Okyar","doi":"10.1177/07487304221148779","DOIUrl":"https://doi.org/10.1177/07487304221148779","url":null,"abstract":"<p><p>The circadian timing system controls absorption, distribution, metabolism, and elimination processes of drug pharmacokinetics over a 24-h period. Exposure of target tissues to the active form of the drug and cytotoxicity display variations depending on the chronopharmacokinetics. For anticancer drugs with narrow therapeutic ranges and dose-limiting side effects, it is particularly important to know the temporal changes in pharmacokinetics. A previous study indicated that pharmacokinetic profile of capecitabine was different depending on dosing time in rat. However, it is not known how such difference is attributed with respect to diurnal rhythm. Therefore, in this study, we evaluated capecitabine-metabolizing enzymes in a diurnal rhythm-dependent manner. To this end, C57BL/6J male mice were orally treated with 500 mg/kg capecitabine at ZT1, ZT7, ZT13, or ZT19. We then determined pharmacokinetics of capecitabine and its metabolites, 5'-deoxy-5-fluorocytidine (5'DFCR), 5'-deoxy-5-fluorouridine (5'DFUR), 5-fluorouracil (5-FU), in plasma and liver. Results revealed that plasma <i>C</i>_max and AUC_0-6h (area under the plasma concentration-time curve from 0 to 6 h) values of capecitabine, 5'DFUR, and 5-FU were higher during the rest phase (ZT1 and ZT7) than the activity phase (ZT13 and ZT19) (<i>p</i> < 0.05). Similarly, <i>C</i>_max and AUC_0-6h values of 5'DFUR and 5-FU in liver were higher during the rest phase than activity phase (<i>p</i> < 0.05), while there was no significant difference in liver concentrations of capecitabine and 5'DFCR. We determined the level of the enzymes responsible for the conversion of capecitabine and its metabolites at each ZT. Results indicated the levels of carboxylesterase 1 and 2, cytidine deaminase, uridine phosphorylase 2, and dihydropyrimidine dehydrogenase (<i>p</i> < 0.05) are being rhythmically regulated and, in turn, attributed different pharmacokinetics profiles of capecitabine and its metabolism. This study highlights the importance of capecitabine administration time to increase the efficacy with minimum adverse effects.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/10/ee/10.1177_07487304221148779.PMC10037547.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9244133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Alcohol Consumption Disrupts the Skeletal Muscle Circadian Clock in Female Mice.","authors":"Abigail L Tice,&nbsp;Joseph A Laudato,&nbsp;Bradley S Gordon,&nbsp;Jennifer L Steiner","doi":"10.1177/07487304221141464","DOIUrl":"https://doi.org/10.1177/07487304221141464","url":null,"abstract":"<p><p>The intrinsic skeletal muscle core clock has emerged as a key feature of metabolic control and influences several aspects of muscle physiology. Acute alcohol intoxication disrupts the core molecular clock, but whether chronic consumption, like that leading to alcoholic myopathy, is also a zeitgeber for skeletal muscle remains unknown. The purpose of this work was to determine whether chronic alcohol consumption dysregulates the skeletal muscle core molecular clock and clock-controlled genes (CCGs). C57BL/6Hsd female mice (14 weeks old) were fed a control (CON) or alcohol (EtOH) containing liquid diet for 6 weeks. Gastrocnemius muscles and serum were collected from CON and EtOH mice every 4-h for 24-h. Chronic alcohol consumption disrupted genes of the core clock including suppressing the rhythmic peak of expression of <i>Bmal1</i>, <i>Per1, Per2</i>, and <i>Cry2</i>. Genes involved in the regulation of <i>Bmal1</i> also exhibited lower rhythmic peaks including <i>Reverb</i> α and <i>Myod1</i>. The CCGs, <i>Dbp, Lpl, Hk2</i>, and <i>Hadh</i> were also suppressed by alcohol. The nuclear expression patterns of MYOD1, DBP, and REVERBα were shifted by alcohol, while no change in BMAL1 was detected. Overall, these data indicate that alcohol disrupted the skeletal muscle core clock but whether these changes in the core clock are causative or a consequence of alcoholic myopathy requires future mechanistic confirmation.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9304214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Caenorhabditis elegans</i> as a Promising Model Organism in Chronobiology.","authors":"María Laura Migliori,&nbsp;María Eugenia Goya,&nbsp;Melisa Luciana Lamberti,&nbsp;Francisco Silva,&nbsp;Rosana Rota,&nbsp;Claire Bénard,&nbsp;Diego Andrés Golombek","doi":"10.1177/07487304221143483","DOIUrl":"https://doi.org/10.1177/07487304221143483","url":null,"abstract":"<p><p>Circadian rhythms represent an adaptive feature, ubiquitously found in nature, which grants living beings the ability to anticipate daily variations in their environment. They have been found in a multitude of organisms, ranging from bacteria to fungi, plants, and animals. Circadian rhythms are generated by endogenous clocks that can be entrained daily by environmental cycles such as light and temperature. The molecular machinery of circadian clocks includes a transcriptional-translational feedback loop that takes approximately 24 h to complete. <i>Drosophila melanogaster</i> has been a model organism of choice to understand the molecular basis of circadian clocks. However, alternative animal models are also being adopted, each offering their respective experimental advantages. The nematode <i>Caenorhabditis elegans</i> provides an excellent model for genetics and neuro-behavioral studies, which thanks to its ease of use and manipulation, as well as availability of genetic data and mutant strains, is currently used as a novel model for circadian research. Here, we aim to evaluate <i>C. elegans</i> as a model for chronobiological studies, focusing on its strengths and weaknesses while reviewing the available literature. Possible zeitgebers (including light and temperature) are also discussed. Determining the molecular bases and the neural circuitry involved in the central pacemaker of the <i>C. elegans</i>' clock will contribute to the understanding of its circadian system, becoming a novel model organism for the study of diseases due to alterations of the circadian cycle.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9243613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steve Brown.","authors":"Ueli Schibler,&nbsp;Charna Dibner,&nbsp;Jürgen Ripperger","doi":"10.1177/07487304231152275","DOIUrl":"https://doi.org/10.1177/07487304231152275","url":null,"abstract":"119 What a shock when we learned that Steven A. Brown, 52, succumbed to injuries resulting from a crash landing near the airport in Happy Valley-Goose Bay, Canada, on 14 December 2022. Steve, professor of chronobiology and sleep research at the Faculty of Medicine, University of Zürich, was an excellent scientist, a dear friend, a wonderful collaborator, and an incredibly courageous adventurer. His sudden death immediately reminded us of the Billy Joel song: Only the good die young. Steve owned a Piper PA-46 Malibu aircraft that he had to bring to Florida for an annual control and update. In company with his wife Patrycja Paruch, he then piloted his airplane to Nashua, NH, where they visited Steve’s mother. The trip was to continue to Nuuk, Greenland, with an intermediate stop in Goose Bay, Canada, where the tragic incident occurred. Patrycja, a highly successful physics professor at the University of Geneva and a great friend of ours, survived the crash. We would like to express our wishes of a full and prompt recovery and offer our sincere condolences to Patrycja. Our deepest sympathy goes to family members, friends, and colleagues of Steve.","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a5/43/10.1177_07487304231152275.PMC10037542.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9255845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged Light Exposure Induces Circadian Impairment in Aquaporin-4-Knockout Mice.","authors":"Atsumi Murakami,&nbsp;Kouki Tsuji,&nbsp;Minako Isoda,&nbsp;Masahiro Matsuo,&nbsp;Yoichiro Abe,&nbsp;Masato Yasui,&nbsp;Hitoshi Okamura,&nbsp;Keiko Tominaga","doi":"10.1177/07487304221146242","DOIUrl":"https://doi.org/10.1177/07487304221146242","url":null,"abstract":"<p><p>Astrocytes are densely present in the suprachiasmatic nucleus (SCN), which is the master circadian oscillator in mammals, and are presumed to play a key role in circadian oscillation. However, specific astrocytic molecules that regulate the circadian clock are not yet well understood. In our study, we found that the water channel aquaporin-4 (AQP4) was abundantly expressed in SCN astrocytes, and we further examined its circadian role using AQP4-knockout mice. There was no prominent difference in circadian behavioral rhythms between <i>Aqp4</i>^-/- and <i>Aqp4</i>^+/+ mice subjected to light-dark cycles and constant dark conditions. However, exposure to constant light induced a greater decrease in the <i>Aqp4</i>^-/- mice rhythmicity. Although the damped rhythm in long-term constant light recovered after transfer to constant dark conditions in both genotypes, the period until the reappearance of original rhythmicity was severely prolonged in <i>Aqp4</i>^-/- mice. In conclusion, AQP4 absence exacerbates the prolonged light-induced impairment of circadian oscillations and delays their recovery to normal rhythmicity.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9605353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An External Coincidence Model for the Lunar Cycle Reveals Circadian Phase-Dependent Moonlight Effects on Coral Spawning.","authors":"Hideyuki Komoto,&nbsp;Che-Hung Lin,&nbsp;Yoko Nozawa,&nbsp;Akiko Satake","doi":"10.1177/07487304221135916","DOIUrl":"https://doi.org/10.1177/07487304221135916","url":null,"abstract":"<p><p>Many marine organisms synchronously spawn at specific times to ensure the success of external fertilization in the ocean. Corals are famous examples of synchronized spawning at specific lunar phases, and two distinct spawning patterns have been observed in two dominant taxa: merulinid corals spawn at regular lunar phases, several days after the full moon, whereas <i>Acropora</i> corals spawn at more irregular lunar phases around the full moon. Although it has been suggested that the two coral taxa have different responses to moonlight and seawater temperature, their spawning times have never been analyzed by integrating the two environmental factors, resulting in an incomplete understanding of the regulatory mechanisms of spawning. In this study, we developed a new predictive model of coral spawning days by integrating moonlight and temperature effects based on the external coincidence model for the lunar cycle. We performed model fitting using a 10-year monitoring record of coral spawning time in Taiwan. Our model successfully demonstrated the synergistic effects of moonlight and temperature on coral spawning time (days) and provided two testable hypotheses to explain the different spawning patterns regarding the preparation (maturation) process for spawning and the sensitivity to moonlight at different circadian phases: (1) <i>Acropora</i> corals may have an earlier onset and longer period of preparation for spawning than merulinid corals; and (2) merulinid corals may use moonlight signals near sunset, while <i>Acropora</i> corals may have a similar onset at approximately midnight. This is the first study to indicate the difference in circadian phase-dependent moonlight sensitivities between coral taxa, providing a basis for underlying coral spawning mechanisms for rhythmic studies.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9249324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}