Journal of Biological Rhythms最新文献

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School Attendance, Chronotype, and Day-of-the-Week Effect in Adolescent Male Basketball Players. 青少年男子篮球运动员的出勤率、睡眠类型和周中天数效应。
IF 3.5 3区 生物学
Journal of Biological Rhythms Pub Date : 2023-04-01 DOI: 10.1177/07487304221144340
Simone Bruno, Davide Benedetti, Andrea Bazzani, Francesca Ferri, Iacopo Granieri, Francy Cruz-Sanabria, Simona Fiori, Paola d'Ascanio, Paolo Frumento, Ugo Faraguna
{"title":"School Attendance, Chronotype, and Day-of-the-Week Effect in Adolescent Male Basketball Players.","authors":"Simone Bruno,&nbsp;Davide Benedetti,&nbsp;Andrea Bazzani,&nbsp;Francesca Ferri,&nbsp;Iacopo Granieri,&nbsp;Francy Cruz-Sanabria,&nbsp;Simona Fiori,&nbsp;Paola d'Ascanio,&nbsp;Paolo Frumento,&nbsp;Ugo Faraguna","doi":"10.1177/07487304221144340","DOIUrl":"https://doi.org/10.1177/07487304221144340","url":null,"abstract":"<p><p>Adolescents' conflict between circadian rhythm and early school start time is more pronounced in evening chronotypes, who tend to reduce sleep duration during school days compensating during the free days by oversleeping (i.e., social jetlag). Cumulative weekly sleep debt may impair sport performance, which relies on physical and cognitive skills modulated by sleep. We hypothesized that chronotype predicts sport performance, and that it may interact with the day of the week. Moreover, given the role sleep plays in motor memory consolidation, we tested the hypothesis that school attendance, and the related chronic sleep deprivation, might be detrimental for participants in a training phase. Ninety-three adolescent male basketball players performed multiple free throw sessions (<i>n</i> = 7880) during both the school and holiday periods. Chronotype and its interaction with the day of the week significantly predicted shooting accuracy when attending school, but not on holidays. Evening types' performance gradually decreased from Monday to Friday. Participants with a more unstable performance (i.e., who did not complete the acquisition of the free throw motor scheme) worsened their accuracy when attending school. Our results suggest that the impact of chronotype and day of the week on sport performance is related to the presence of an externally imposed sleep/wake schedule and is consistent with evening types' increased likelihood of experiencing social jetlag. Possibly due to early school start time, attending school worsened the performance of participants in a training phase. Further investigations are required to assess whether reducing the mismatch between biological and social clocks might improve sport performance, along with other aspects of adolescents' life.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9243611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Bench to Bedside and Back Again: Translating Circadian Science to Medicine. 从实验室到床边再回来:将昼夜节律科学转化为医学。
IF 3.5 3区 生物学
Journal of Biological Rhythms Pub Date : 2023-04-01 DOI: 10.1177/07487304221142743
Elizabeth B Klerman, Achim Kramer, Phyllis C Zee
{"title":"From Bench to Bedside and Back Again: Translating Circadian Science to Medicine.","authors":"Elizabeth B Klerman,&nbsp;Achim Kramer,&nbsp;Phyllis C Zee","doi":"10.1177/07487304221142743","DOIUrl":"https://doi.org/10.1177/07487304221142743","url":null,"abstract":"125 Clinicians, scientists, industry, occupational health and public health professionals, and patients are excited about the promising health and safety implications of circadian medicine. The award of the 2017 Nobel Prize in Physiology or Medicine to three scientists (Hall, Rosbash, and Young) for their work in elucidating the mechanisms of circadian rhythmicity introduced many people to the field. Now we and others are frequently asked when the results of basic research will be available for diagnosis, monitoring, and/or treatment of individual patients. Overwhelming evidence indicates that the circadian clock is essential for health and its disruption causes pathologies (Figure 1). A triad of circadian medicine approaches was recently proposed (Kramer et al., 2022): (a) detecting the clock (e.g. new diagnostic tools), (b) targeting the clock (e.g. improving or resynchronizing disrupted rhythms), and (c) exploiting the clock (e.g. using time-of-day adapted treatment regimens). Examples of each of these approaches already in use include the dim light melatonin onset (DLMO) for detecting circadian phase, light treatment for circadian and other disorders, and time-of-day recommendations for statin-type medications. These and other encouraging past and recent successes in circadian medicine suggest that greater and more comprehensive translation of basic chronobiological findings into medical practice is possible. We therefore recognize a need to provide for the circadian rhythms research community an outline of the steps, processes and time frame required to translate basic science findings to evidence based clinical care and/or public health and safety recommendations (Figure 2): how does a discovery become an approved approach, and then a guideline, a clinical care recommendation, and finally a policy? Each step along the way is performed with specific questions, protocols, variables, and analyses within a specific population, and each step should consider whether the target is etiology, health/disease balance, and/or recovery (Roenneberg et al., 2022). Each step applies to diagnosis/monitoring tests, interventions (e.g. drug, device), and/or analysis methods [biochemical or algorithmic (e.g. to calculate circadian phase or the optimal timing and/ or dose of an intervention)]. Most of the following steps apply to interventions, but the underlying principles are the same. Before efficacy and effectiveness conclusions/clinical guidelines can be drawn, data from multiple experiments and studies will have to be compiled in a stepwise approach.","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038822/pdf/nihms-1851162.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9250616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inducible Reporter Lines for Tissue-specific Monitoring of Drosophila Circadian Clock Transcriptional Activity. 用于组织特异性监测果蝇生物钟转录活性的诱导报告系。
IF 3.5 3区 生物学
Journal of Biological Rhythms Pub Date : 2023-02-01 DOI: 10.1177/07487304221138946
Lilyan M Mather, Meghan E Cholak, Connor M Morfoot, Katherine C Curro, Jacob Love, Daniel J Cavanaugh
{"title":"Inducible Reporter Lines for Tissue-specific Monitoring of <i>Drosophila</i> Circadian Clock Transcriptional Activity.","authors":"Lilyan M Mather,&nbsp;Meghan E Cholak,&nbsp;Connor M Morfoot,&nbsp;Katherine C Curro,&nbsp;Jacob Love,&nbsp;Daniel J Cavanaugh","doi":"10.1177/07487304221138946","DOIUrl":"https://doi.org/10.1177/07487304221138946","url":null,"abstract":"<p><p>Organisms track time of day through the function of cell-autonomous molecular clocks. In addition to a central clock located in the brain, molecular clocks are present in most peripheral tissues. Circadian clocks are coordinated within and across tissues, but the manner through which this coordination is achieved is not well understood. We reasoned that the ability to track in vivo molecular clock activity in specific tissues of the fruit fly, <i>Drosophila melanogaster</i>, would facilitate an investigation into the relationship between different clock-containing tissues. Previous efforts to monitor clock gene expression in single flies in vivo have used regulatory elements of several different clock genes to dictate expression of a luciferase reporter enzyme, the activity of which can be monitored using a luminometer. Although these reporter lines have been instrumental in our understanding of the circadian system, they generally lack cell specificity, making it difficult to compare molecular clock oscillations between different tissues. Here, we report the generation of several novel lines of flies that allow for inducible expression of a luciferase reporter construct for clock gene transcriptional activity. We find that these lines faithfully report circadian transcription, as they exhibit rhythmic luciferase activity that is dependent on a functional molecular clock. Furthermore, we take advantage of our reporter lines' tissue specificity to demonstrate that peripheral molecular clocks are able to retain rhythmicity for multiple days under constant environmental conditions.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10612062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood. 儿童早期昼夜节律时钟的夜间光强度和相位延迟。
IF 2.9 3区 生物学
Journal of Biological Rhythms Pub Date : 2023-02-01 Epub Date: 2022-11-22 DOI: 10.1177/07487304221134330
Lauren E Hartstein, Cecilia Diniz Behn, Kenneth P Wright, Lameese D Akacem, Shelby R Stowe, Monique K LeBourgeois
{"title":"Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood.","authors":"Lauren E Hartstein, Cecilia Diniz Behn, Kenneth P Wright, Lameese D Akacem, Shelby R Stowe, Monique K LeBourgeois","doi":"10.1177/07487304221134330","DOIUrl":"10.1177/07487304221134330","url":null,"abstract":"<p><p>Late sleep timing is prevalent in early childhood and a risk factor for poor behavioral and health outcomes. Sleep timing is influenced by the phase of the circadian clock, with later circadian timing linked to delayed sleep onset in young children. Light is the strongest zeitgeber of circadian timing and, in adults, evening light produces circadian phase delay in an intensity-dependent manner. The intensity-dependent circadian phase-shifting response to evening light in children, however, is currently unknown. In the present study, 33 healthy, good-sleeping children aged 3.0 to 4.9 years (M = 4.14 years, 39% male) completed a 10-day between-subjects protocol. Following 7 days of a stable sleep schedule, an in-home dim-light circadian assessment was performed. Children remained in dim-light across 3 days (55 h), with salivary melatonin collected in regular intervals throughout each evening. Phase-shifting effects of light exposure were determined via changes in the timing of the dim-light melatonin onset (DLMO) prior to (Day 8) and following (Day 10) a light exposure stimulus. On Day 9, children were exposed to a 1 h light stimulus in the hour before their habitual bedtime. Each child was randomly assigned to one intensity between 5 and 5000 lux (4.5-3276 melanopic EDI). Across light intensities, children showed significant circadian phase delays, with an average phase delay of 56.1 min (SD = 33.6 min), and large inter-individual variability. No relationship between light intensity and magnitude of the phase shift was observed. However, a greater percentage of melatonin suppression during the light exposure was associated with a greater phase delay (<i>r</i> = -0.73, <i>p</i> < 0.01). These findings demonstrate that some young children may be highly sensitive to light exposure in the hour before bedtime and suggest that the home lighting environment and its impact on circadian timing should be considered a possible contributor to behavioral sleep difficulties.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11302507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9174765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex Inclusion in Transcriptome Studies of Daily Rhythms. 日常节律转录组研究中的性别包含。
IF 3.5 3区 生物学
Journal of Biological Rhythms Pub Date : 2023-02-01 DOI: 10.1177/07487304221134160
Dora Obodo, Elliot H Outland, Jacob J Hughey
{"title":"Sex Inclusion in Transcriptome Studies of Daily Rhythms.","authors":"Dora Obodo,&nbsp;Elliot H Outland,&nbsp;Jacob J Hughey","doi":"10.1177/07487304221134160","DOIUrl":"https://doi.org/10.1177/07487304221134160","url":null,"abstract":"<p><p>Biomedical research on mammals has traditionally neglected females, raising the concern that some scientific findings may generalize poorly to half the population. Although this lack of sex inclusion has been broadly documented, its extent within circadian genomics remains undescribed. To address this gap, we examined sex inclusion practices in a comprehensive collection of publicly available transcriptome studies on daily rhythms. Among 148 studies having samples from mammals in vivo, we found strong underrepresentation of females across organisms and tissues. Overall, only 23 of 123 studies in mice, 0 of 10 studies in rats, and 9 of 15 studies in humans included samples from females. In addition, studies having samples from both sexes tended to have more samples from males than from females. These trends appear to have changed little over time, including since 2016, when the US National Institutes of Health began requiring investigators to consider sex as a biological variable. Our findings highlight an opportunity to dramatically improve representation of females in circadian research and to explore sex differences in daily rhythms at the genome level.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/92/bd/10.1177_07487304221134160.PMC9903005.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9594688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Night Shifts on 24-h Rhythms in the Urinary Metabolome of Police Officers on a Rotating Work Schedule. 夜班对轮岗警官尿液代谢组24小时节律的影响。
IF 3.5 3区 生物学
Journal of Biological Rhythms Pub Date : 2023-02-01 DOI: 10.1177/07487304221132088
Laura Kervezee, Anna Koshy, Nicolas Cermakian, Diane B Boivin
{"title":"The Effect of Night Shifts on 24-h Rhythms in the Urinary Metabolome of Police Officers on a Rotating Work Schedule.","authors":"Laura Kervezee,&nbsp;Anna Koshy,&nbsp;Nicolas Cermakian,&nbsp;Diane B Boivin","doi":"10.1177/07487304221132088","DOIUrl":"https://doi.org/10.1177/07487304221132088","url":null,"abstract":"<p><p>Shift workers face an increased risk of metabolic health problems, but the direct metabolic response to working nights is not fully understood. The aim of this study was to investigate the effect of night shifts on the 24-h urinary metabolome of shift workers. Eleven police officers working rotating shifts completed two 24-h laboratory visits that took place before and after they worked 7 consecutive nights. Sleep and meals were scheduled on a day schedule in the first visit and then on a night schedule (i.e., sleep and meals shifted by approximately 12 h) in the second visit. Targeted metabolomic analysis was performed on urine samples collected throughout these laboratory visits. Differential rhythmicity analysis was used to compare 24-h rhythms in urinary metabolites in both conditions. Our results show that on the day schedule, 24-h rhythms are present in the urinary levels of the majority of metabolites, but that this is significantly reduced on the night schedule, partly due to loss of organic acid rhythmicity. Furthermore, misalignment of 24-h metabolite rhythms with the shifted behavioral cycles in the night schedule was observed in more than half of the metabolites that were rhythmic in both conditions (all acylcarnitines). These results show that working nights alters the daily rhythms of the urinary metabolome in rotating shift workers, with the most notable impact observed for acylcarnitines and organic acids, 2 metabolite classes involved in mitochondrial function. Further research is warranted to study how these changes relate to the increased metabolic risks associated with shift work.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10669601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circadian Rhythms in Fear Extinction Recall Depend on the Time of Day of Extinction Recall, Not the Time of Day of Extinction Learning. 恐惧消退记忆的昼夜节律取决于消退记忆的时间,而不是消退学习的时间。
IF 3.5 3区 生物学
Journal of Biological Rhythms Pub Date : 2023-02-01 DOI: 10.1177/07487304221128161
Matthew J Hartsock, Nicholas A Brennan, Robert L Spencer
{"title":"Circadian Rhythms in Fear Extinction Recall Depend on the Time of Day of Extinction Recall, Not the Time of Day of Extinction Learning.","authors":"Matthew J Hartsock,&nbsp;Nicholas A Brennan,&nbsp;Robert L Spencer","doi":"10.1177/07487304221128161","DOIUrl":"https://doi.org/10.1177/07487304221128161","url":null,"abstract":"<p><p>The recall of conditioned fear extinction exhibits a circadian rhythm in humans and rodents, with optimal extinction recall occurring during the early active phase. However, it remains unclear whether this rhythm depends on the circadian modulation of mechanisms supporting memory consolidation versus memory maintenance and retrieval. Here, adult male rats underwent conditioned fear extinction at one of four times throughout the day and then, starting 24 h after extinction, were repeatedly tested for extinction recall over the next 24 h. Rats undergoing extinction learning during the early active phase tended toward accelerated extinction learning compared with rats in other groups, pointing to rhythms in mechanisms that support extinction memory encoding. The next day, the strength of extinction recall followed a 24-h cycle that depended not on the time of day of extinction learning but, instead, on the time of day of extinction recall. This latter finding indicates a rhythm in mechanisms supporting extinction memory maintenance and/or retrieval. Subsequent testing for fear relapse in the conditioning context suggested reduced fear in rats tested during the early active phase. These results lay the groundwork for mechanistic investigations of circadian rhythms in fear extinction memory.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9115311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronotype in Patients With Immune-Mediated Inflammatory Disease: A Systematic Review. 免疫介导炎症性疾病患者的时间型:一项系统综述。
IF 3.5 3区 生物学
Journal of Biological Rhythms Pub Date : 2023-02-01 DOI: 10.1177/07487304221131114
Thomas D Butler, Aala Mohammed Ali, Julie E Gibbs, John T McLaughlin
{"title":"Chronotype in Patients With Immune-Mediated Inflammatory Disease: A Systematic Review.","authors":"Thomas D Butler,&nbsp;Aala Mohammed Ali,&nbsp;Julie E Gibbs,&nbsp;John T McLaughlin","doi":"10.1177/07487304221131114","DOIUrl":"https://doi.org/10.1177/07487304221131114","url":null,"abstract":"<p><p>Immune-mediated inflammatory diseases (IMIDs) such as rheumatoid arthritis, inflammatory bowel disease, and asthma share common pathophysiological pathways characterized by chronic inflammation and subsequent tissue damage involving multiple body sites. Circadian rhythms are 24-h body cycles that regulate immune activity and control the magnitude of immune response based on time of day. Chronotype is a person's individual circadian phase preference, ranging from morningness to eveningness, which is known to influence the risk of cardiometabolic and mental health disease. We systematically reviewed the literature to assess the association of questionnaire-based chronotype and patients with IMID. A comprehensive search of MEDLINE and Embase identified 12 studies meeting the inclusion criteria, conducted in 7 countries and covering 4 IMIDs to include 15,625 IMID patients and 410,783 healthy controls. Results showed that later chronotype may be a risk factor for worse quality of life and increased symptom burden in patients with IMIDs. In addition, chronotype may be a risk factor for IMID incidence, but the direction and magnitude of this effect were not consistent across individual IMIDs. Chronotype assessment could contribute to risk stratification in patients with IMIDs. Cross-disciplinary collaboration to understand the role of circadian rhythms and chronotype in driving common inflammatory pathways could help to improve outcomes for patients with IMIDs.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10850113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Light on Shedding: A Review of Sex and Menstrual Cycle Differences in the Physiological Effects of Light in Humans. 光对脱落的影响:人类光生理效应的性别和月经周期差异综述》。
IF 3.5 3区 生物学
Journal of Biological Rhythms Pub Date : 2023-02-01 Epub Date: 2022-11-11 DOI: 10.1177/07487304221126785
Parisa Vidafar, Manuel Spitschan
{"title":"<i>Light on Shedding</i>: A Review of Sex and Menstrual Cycle Differences in the Physiological Effects of Light in Humans.","authors":"Parisa Vidafar, Manuel Spitschan","doi":"10.1177/07487304221126785","DOIUrl":"10.1177/07487304221126785","url":null,"abstract":"<p><p>The human circadian system responds to light as low as 30 photopic lux. Furthermore, recent evidence shows that there are huge individual differences in light sensitivity, which may help to explain why some people are more susceptible to sleep and circadian disruption than others. The biological mechanisms underlying the differences in light sensitivity remain largely unknown. A key variable of interest in understanding these individual differences in light sensitivity is biological sex. It is possible that in humans, males and females differ in their sensitivity to light, but the evidence is inconclusive. This is in part due to the historic exclusion of women in biomedical research. Hormonal fluctuations across the menstrual cycle in women has often been cited as a confound by researchers. Attitudes, however, are changing with funding and publication agencies advocating for more inclusive research frameworks and mandating that women and minorities participate in scientific research studies. In this article, we distill the existing knowledge regarding the relationship between light and the menstrual cycle. There is some evidence of a relationship between light and the menstrual cycle, but the nature of this relationship seems dependent on the timing of the light source (sunlight, moonlight, and electric light at night). Light sensitivity may be influenced by biological sex and menstrual phase but there might not be any effect at all. To better understand the relationship between light, the circadian system, and the menstrual cycle, future research needs to be designed thoughtfully, conducted rigorously, and reported transparently.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10670056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Association of Time of Day of ChAdOx1 nCoV-19 Vaccine Administration With SARS-CoV-2 Anti-Spike IgG Antibody Levels: An Exploratory Observational Study. ChAdOx1 nCoV-19疫苗接种时间与SARS-CoV-2抗刺突IgG抗体水平的相关性:一项探索性观察研究
IF 3.5 3区 生物学
Journal of Biological Rhythms Pub Date : 2023-02-01 DOI: 10.1177/07487304221132355
Astrid C Erber, Angelika Wagner, Marianna Karachaliou, Maren Jeleff, Polyxeni Kalafatis, Manolis Kogevinas, Beata Pepłońska, Isabel Santonja, Eva Schernhammer, Hannes Stockinger, Kurt Straif, Ursula Wiedermann, Thomas Waldhör, Kyriaki Papantoniou
{"title":"The Association of Time of Day of ChAdOx1 nCoV-19 Vaccine Administration With SARS-CoV-2 Anti-Spike IgG Antibody Levels: An Exploratory Observational Study.","authors":"Astrid C Erber,&nbsp;Angelika Wagner,&nbsp;Marianna Karachaliou,&nbsp;Maren Jeleff,&nbsp;Polyxeni Kalafatis,&nbsp;Manolis Kogevinas,&nbsp;Beata Pepłońska,&nbsp;Isabel Santonja,&nbsp;Eva Schernhammer,&nbsp;Hannes Stockinger,&nbsp;Kurt Straif,&nbsp;Ursula Wiedermann,&nbsp;Thomas Waldhör,&nbsp;Kyriaki Papantoniou","doi":"10.1177/07487304221132355","DOIUrl":"https://doi.org/10.1177/07487304221132355","url":null,"abstract":"<p><p>Data from human and animal studies are highly suggestive of an influence of time of day of vaccine administration on host immune responses. In this population-based study, we aimed to investigate the effect of time of day of administration of a COVID-19 vector vaccine, ChAdOx1 nCoV-19 (AstraZeneca), on SARS-CoV-2 anti-spike S1 immunoglobulin (IgG) levels. Participants were 803 university employees who received their first vaccine dose in March 2021, had serology data at baseline and at 3 weeks, and were seronegative at baseline. Antibody levels were determined in binding antibody units (BAU/mL) using enzyme-linked immunosorbent assay (ELISA). Generalized additive models (GAM) and linear regression were used to evaluate the association of time of day of vaccination continuously and in hourly bins with antibody levels at 3 weeks. Participants had a mean age of 42 years (SD: 12; range: 21-74) and 60% were female. Time of day of vaccination was associated non-linearly (\"reverse J-shape\") with antibody levels. Morning vaccination was associated with the highest (9:00-10:00 h: mean 292.1 BAU/mL; SD: 262.1), early afternoon vaccination with the lowest (12:00-13:00 h: mean 217.3 BAU/mL; SD: 153.6), and late afternoon vaccination with intermediate (14:00-15:00 h: mean 280.7 BAU/mL; SD: 262.4) antibody levels. Antibody levels induced by 12:00-13:00 h vaccination (but not other time intervals) were significantly lower compared to 9:00-10:00 h vaccination after adjusting for potential confounders (beta coefficient = -75.8, 95% confidence interval [CI] = -131.3, -20.4). Our findings show that time of day of vaccination against SARS-CoV-2 has an impact on the magnitude of IgG antibody levels at 3 weeks. Whether this difference persists after booster vaccine doses and whether it influences the level of protection against COVID-19 needs further evaluation.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/05/1d/10.1177_07487304221132355.PMC9659693.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9190439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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