Journal of Biological Rhythms最新文献

{"title":"Malcolm von Schantz.","authors":"Debra J Skene, Simon N Archer, Claudia R C Moreno, Jason Ellis","doi":"10.1177/07487304251414263","DOIUrl":"10.1177/07487304251414263","url":null,"abstract":"","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"299-300"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146041062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stool Dynamics and the Developing Gut Microbiome During Infancy.","authors":"Mohammed Al-Andoli, Sarah Schoch, Andjela Markovic, Christophe Mühlematter, Matthieu Beaugrand, Oskar G Jenni, Rabia Liamlahi, Jean-Claude Walser, Dennis Nielsen, Salome Kurth","doi":"10.1177/07487304251407313","DOIUrl":"10.1177/07487304251407313","url":null,"abstract":"<p><p>The infant gut microbiome is a dynamic ecosystem, and it is key to early development, immune maturation, and overall health. Recent insights reveal that the gut microbiota undergoes changes across the 24-h day, raising the possibility that it may act as a \"zeitgeber,\" supporting the host's sleep-wake organization. Despite its importance, timing factors influencing microbiome composition are poorly understood, limiting its use as a health indicator. This study investigates the relationship between stool dynamics (defecation interval, time of sampling), sleep pressure (interval since last sleep), meal timing, and gut microbial composition. Stool samples from 198 healthy infants, aged 3 to 31 months, were analyzed to assess microbial diversity, richness evenness, and abundance. Our findings reveal that longer intervals between bowel movements are associated with increased microbial diversity, evenness, and richness. Stool timing is associated with shifts in microbial composition, especially in younger infants, indicating diurnal microbial fluctuations to become more stable as infants mature. Longer periods of wakefulness were associated with increased microbial diversity in early infancy, although this effect appeared to diminish with age. Feeding schedules had limited effects on the gut microbiome. Longer fasting before sampling showed no significant associations with most microbial parameters, except for a positive association with microbial richness. At the phylum level, results indicate that infant gut microbial composition is influenced by behavior and physiology. Longer intervals between bowel movements were associated with shifts in bacterial abundance, with <i>Proteobacteria</i> decreasing and <i>Actinobacteria</i> increasing. In addition, later stool sampling times revealed higher <i>Actinobacteria</i> levels, and longer fasting was associated with reduced <i>Bacteroidetes</i>. Sleep pressure showed a trend effect with <i>Firmicutes</i> displaying a slight decrease in infants who had been awake longer. Our findings underscore the importance of time-based factors on infant gut microbiome composition.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"324-343"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evening Activity Termination Timing in <i>Drosophila melanogaster</i>: Effects of Pigment-Dispersing Factor-Containing Large and Small Ventrolateral Neurons.","authors":"Tatsuya Yokosako, Aika Saito, Taishi Yoshii","doi":"10.1177/07487304251388700","DOIUrl":"10.1177/07487304251388700","url":null,"abstract":"<p><p>In animals, the brain contains circadian clock neurons that regulate activity rhythms. The fruit fly <i>Drosophila melanogaster</i> exhibits a bimodal activity pattern characterized by two peaks, in the morning (M) and evening (E), known as the M and E peaks. These activity peaks are orchestrated by a network of approximately 240 clock neurons. The neuropeptide pigment-dispersing factor (PDF) is expressed in two sets of clock neurons, the large ventrolateral neurons (l-LN_v) and the small ventrolateral neurons (s-LN_v). Mutants of <i>Pdf</i>, as well as flies lacking PDF neurons, exhibit a characteristic E activity that is commonly simplified to a phase-advanced pattern under 12 h:12 h light-dark cycles. Previous studies have demonstrated that l-LN_v neurons regulate the phase of the E peak; however, this effect is evident only under long photoperiod conditions. Therefore, the E peak phenotype observed in <i>Pdf</i> mutants remains incompletely explained. In this study, we employed genetic cell ablation and <i>Pdf</i> RNA interference using Gal4 lines specific to l-LN_v neurons in a well-controlled genetic background. Under long photoperiod conditions, flies lacking l-LN_v, s-LN_v, or both neuronal groups exhibited an early termination of E activity prior to lights-off, resulting in a phase-advanced E peak. Similar results were obtained in <i>Pdf</i> knockdown flies. Notably, l-LN_v neurons had a stronger effect on the timing of E activity termination than s-LN_v neurons. These findings demonstrate that LN_v neurons control the phase of E activity by modulating the timing of its offset, providing new insights into the neuronal mechanisms that shape daily activity patterns.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"243-258"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Clocks Go Rogue: Circadian Rhythms and the Rise of Cancer.","authors":"Anestacia S Robinson, Samuel Bennett, Shogo Sato","doi":"10.1177/07487304251391270","DOIUrl":"10.1177/07487304251391270","url":null,"abstract":"<p><p>This review summarizes recent insights into the roles of the circadian clock in regulating cancer hallmarks, with a focus on its impact on the tumor microenvironment, and highlights the translational promise of circadian-informed strategies for cancer therapy. The circadian clock is a 24-hour biological timekeeping system that aligns physiological processes with cyclic environmental cues, such as light-dark cycles. Disruptions of circadian rhythms caused by lifestyle factors, including shift work, irregular sleep patterns, and jet lag, can lead to physiological dysregulation and increased risk of various diseases including cancer, positioning the circadian clock as both a critical driver of tumorigenesis and a potential target for chronotherapies. This review provides a comprehensive overview of circadian regulation in tumorigenesis across diverse cancer types by framing its role according to established cancer hallmarks, with particular emphasis on how the circadian system shapes immune cell dynamics within the tumor microenvironment to modulate tumor progression and immune surveillance. We further discuss recent preclinical and clinical advances in chronotherapy, highlighting how aligning therapeutic interventions with biological rhythms can enhance treatment efficacy, including responses to immunotherapy. By integrating mechanistic insights with translational applications, this review bridges circadian biology and oncology, providing a framework for future chronobiology-based cancer therapies.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"155-177"},"PeriodicalIF":3.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can a Single Night of Sleep Deprivation Unmask Human Sleep and Neurophysiobehavioral Impairments During the Post-Acute Phase of Mild Traumatic Brain Injury?","authors":"Allison Brager, Katie Edwards, Cassie Pattinson, Maria St Pierre-Paul, Antigone Grillakis, Janna Mantua, J Peyer, Thomas J Balkin, Vincent F Capaldi, Jessica Gill, Angela Yarnell","doi":"10.1177/07487304251385057","DOIUrl":"10.1177/07487304251385057","url":null,"abstract":"<p><p>The purpose of this study was twofold: (a) to determine whether, and the extent to which, the challenge of a single night of total sleep deprivation (TSD) unmasks lingering brain health-related deficits in individuals who within the past 3 to 12 months had been diagnosed (yet medically cleared) with a mild traumatic brain injury (mTBI+), and (b) to determine whether mTBI+ results in any neurophysiobehavioral deficits in the ability to recover from TSD. Seven previously concussed (mTBI+) adults (24.5 ± 5.3 years old) and six non-concussed control (mTBI-) adults underwent 24 h TSD preceded by 8 h baseline sleep (BSL) and followed by 8 h recovery sleep (REC). Study measures included the psychomotor vigilance test (PVT) across the entire study and polysomnography during nighttime sleep and daytime nap tests. mTBI+ (vs mTBI-) subjects exhibited more minor lapses on the PVT across all study phases. NREM (N3) sleep and total sleep time (TST) amounts were lower and wake after sleep onset (WASO) was higher in mTBI+ subjects (vs mTBI) at baseline and REC. mTBI+ (vs mTBI-) subjects showed no main effects in maintenance of wakefulness across TSD. Although there is some evidence that TSD may unmask latent performance deficits in mTBI+ subjects, a definitive conclusion was precluded by differences in baseline sleep in mTBI+ (vs mTBI-) subjects, suggesting that they may habitually carry a relatively elevated sleep debt (vs mTBI- controls). Reversal of TSD-induced neurophysiobehavioral deficits following recovery sleep were comparable for both groups, revealing no significant abnormalities in the responsivity of the sleep homeostat in the mTBI+ subjects.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"219-226"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phylogeny of Core Molecular Components of Metazoan Circadian Clocks.","authors":"Olivia M Waldridge, Kaan I Eşkut, Jeramiah J Smith, Vincent M Cassone","doi":"10.1177/07487304251390623","DOIUrl":"10.1177/07487304251390623","url":null,"abstract":"<p><p>The temporal organization of biological activities by circadian clocks is pivotal for the survival of organisms. Significant progress has been made in understanding the molecular foundations of animal circadian clocks through the characterization of key components, such as CLOCK, BMAL1/Cycle (CYC), Period (PER), Timeless, and Cryptochrome (CRY) in several model organisms. To determine the extent of conservation of these elements, we investigated the sequences of these genes and their paralogs across 46 animal species that encompass multiple phyla in the Metazoan kingdom to resolve the relative timing of duplication and loss events that have diversified core clock components. Using analyses of orthology and protein-protein binding predictions, we identified and characterized elements in diverse animal species. Based on these analyses, we propose a circadian molecular mechanism employed by the ancestor of all animals. We also identify derived losses and expansions of circadian elements in smaller animal clades and provide insight into the evolutionary pressures faced by their ancestors to change such an important piece of internal machinery. Our study is the first systematic analysis of the deep phylogeny of nearly all major clades of extant animals.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"227-242"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decline in Circadian Robustness in Lung Cancer Patients During Immunotherapy is Associated With Increased Risk of Disease Progression and Death.","authors":"Louise Strøm, Ali Amidi, Lisa M Wu, Peter Meldgaard, Sonia Ancoli-Israel, Mats Lekander, Daniel Mroczek, Robert Zachariae","doi":"10.1177/07487304251398276","DOIUrl":"10.1177/07487304251398276","url":null,"abstract":"<p><p>Disruptions in sleep and circadian rhythms have been consistently linked to higher mortality rates in the general population. Among cancer patients, these disruptions are not only prevalent but may significantly influence prognosis. Despite this, sleep and circadian trajectories remain unexplored in the context of cancer, particularly related to prognostic outcomes in modern therapies such as immune checkpoint inhibitors (ICIs), which are rapidly transforming oncological care. In this pioneering report, we examined how trajectories of sleep and circadian rhythms relate to prognostic outcomes in patients with non-small cell lung cancer (NSCLC), offering novel insights into their potential role as modifiable biomarkers of clinical outcomes. Forty-nine treatment-naïve NSCLC patients were enrolled in this prospective longitudinal study. Continuous 24-h recordings of circadian function (Circadian Function Index [CFI]) were collected over the first 5 months of treatment, alongside weekly assessments of insomnia severity (Insomnia Severity Index [ISI]) and estimations of total sleep time (TST) derived from sleep diaries every 3 weeks. Follow-up data, time to treatment discontinuation, disease progression, and cancer-related death were obtained from medical records. We estimated hazard ratios (HRs) for these outcomes based on ISI, TST, and CFI, analyzed as continuous variables and median-split. Cox regression analyses indicated that patients with trajectories portraying circadian robustness below the median had a higher risk of earlier progression (HR = 3.75, 95% confidence interval [CI] = [1.475-9.536], <i>p</i> = 0.005) and death (HR = 3.07, 95% CI = [1.128-8.360], <i>p</i> = 0.028). No significant associations were found between insomnia severity, TST, and the prognostic outcomes. Patients with more pronounced declines in circadian robustness demonstrated significantly elevated risks of disease progression and mortality. As the circadian rhythm is modifiable, these findings, if replicated, underscore the need for interventional studies aimed at stabilizing circadian rhythms to further explore potential improvements in patient outcomes and efficacy of cancer therapies.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"178-191"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145819274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Memoriam Sue Binkley (1944-2025).","authors":"Vincent M Cassone, Gregory L Florant","doi":"10.1177/07487304251399311","DOIUrl":"https://doi.org/10.1177/07487304251399311","url":null,"abstract":"<p><p>On 6 January 2025, the field of chronobiology lost a pioneer in Sue Ann Lingenfelter Binkley Tatem, better known as Sue Binkley in scientific circles. Born in Dayton, OH, but moved to Colorado in her high school years, Dr. Binkley received a BS in Biology from the University of Colorado at Boulder, where she met her future husband, Tim Binkley. Sue and Tim had a daughter, Shelley, before moving to Austin, TX, where Sue studied biological rhythms with Michael Menaker at the University of Texas. Sue and Tim separated in 1970 and Sue received her PhD in 1971. Her dissertation research extended the seminal studies in the Menaker Lab showing that surgical removal of the pineal gland of house sparrows, <i>Passer domesticus</i>, abolished free-running circadian locomotor rhythms by demonstrating that circadian patterns of core body temperature were similarly affected. Importantly, her research demonstrated the significance of physiological coupling among oscillators and their multiple outputs.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":"41 2","pages":"292-295"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Who Needs Bright Light and When? Mapping the Interactions of Lighting Environments and Individual Differences in Circadian Light Sensitivity.","authors":"Julia E Stone, Dorothee Steven, Weiqi Cheng, Sean W Cain, Andrew J K Phillips","doi":"10.1177/07487304251391268","DOIUrl":"10.1177/07487304251391268","url":null,"abstract":"<p><p>Light is the primary circadian time cue, but there are large interindividual differences in how sensitive the circadian system is to light. Currently, it is not well understood how individual differences in light sensitivity interact with real-world light environments to determine sleep and circadian timing. We used a validated computational model to simulate sleep and circadian timing (predicted dim light melatonin onset) under realistic assumptions about light and work schedules. Simulations were repeated varying light sensitivity (translated to equivalent ED50 values for interpretability), as well as evening, morning, and daytime illuminances. Brighter evening light led to later predicted circadian and sleep timing, with this effect being amplified by high light sensitivity. Reducing evening light was particularly beneficial for those with high light sensitivity or a long circadian period. Brighter morning light was beneficial for individuals with a long circadian period, or those with both high light sensitivity and high evening light. However, bright morning light could be maladaptive in individuals with a short circadian period or those with low light sensitivity and low evening light. Brighter daytime light attenuated the delaying effects of evening artificial light across conditions, indicating that increasing daytime light was the most universally beneficial lighting intervention. Our results demonstrate how circadian light sensitivity can be used to tailor individual-level solutions that support optimal sleep and circadian timing.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"192-204"},"PeriodicalIF":3.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mitochondrial Function.","authors":"Valentina Sica, Tomoki Sato, Ioannis Tsialtas, Sophia Hernandez, Siwei Chen, Pierre Baldi, Pura Muñoz-Cánoves, Paolo Sassone-Corsi, Kevin B Koronowski, Jacob G Smith","doi":"10.1177/07487304251386926","DOIUrl":"10.1177/07487304251386926","url":null,"abstract":"<p><p>Circadian clocks present throughout the brain and body coordinate diverse physiological processes to support daily homeostasis, yet the specific interorgan signaling axes involved are not well defined. We previously demonstrated that the skeletal muscle clock controls transcript oscillations of genes involved in fatty acid metabolism in the liver, yet the impact of the liver clock on the muscle remained unknown. Here, we use male hepatocyte-specific <i>Bmal1</i> KO mice (Bmal1^hep-/-) to reveal that approximately one-third of transcript rhythms in skeletal muscle are influenced by the liver clock in vivo. Treatment of myotubes with serum harvested from Bmal1^hep-/- mice inhibits expression of genes involved in metabolic pathways, including oxidative phosphorylation. Only small transcriptional changes were induced by liver clock-driven endocrine communication in vitro, leading us to surmise that the liver clock acts to fine-tune metabolic gene expression in muscle. Consistent with functional tuning, treatment of myotubes with serum collected from <i>Bmal1</i>^hep-/- mice during the dark phase lowers mitochondrial ATP production compared with serum from wild-type mice. Overall, our results reveal communication between the liver clock and skeletal muscle, uncovering a bidirectional endocrine communication pathway that may contribute to the metabolic phenotypes of circadian disruption.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"278-291"},"PeriodicalIF":3.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12774450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}