Journal of Biological Rhythms最新文献

{"title":"Direct Temperature Responses of <i>Bmal1</i> and <i>Per2</i> in Reindeer Fibroblasts: Insight Into a Unique Circadian Clock Adaptation to Polar Environments.","authors":"S K Tahajjul Taufique","doi":"10.1177/07487304251327871","DOIUrl":"https://doi.org/10.1177/07487304251327871","url":null,"abstract":"","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"7487304251327871"},"PeriodicalIF":2.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photoperiod-Induced Transcriptional Response in the Suprachiasmatic Nucleus.","authors":"Nemanja Milićević","doi":"10.1177/07487304251328461","DOIUrl":"https://doi.org/10.1177/07487304251328461","url":null,"abstract":"","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"7487304251328461"},"PeriodicalIF":2.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Circadian Phase Tracking: A 5-h DLMO Sampling Protocol Using Wearable Data.","authors":"Dongju Lim, Su Jung Choi, Yun Min Song, Hea Ree Park, Eun Yeon Joo, Jae Kyoung Kim","doi":"10.1177/07487304251317577","DOIUrl":"https://doi.org/10.1177/07487304251317577","url":null,"abstract":"<p><p>Circadian medicine aims to leverage the body's internal clock to develop safer and more effective therapeutics. Traditionally, biological time has been estimated using dim light melatonin onset (DLMO), a method that requires collecting saliva samples over a long period under controlled conditions, to ensure the observation of DLMO, making it time-consuming and labor-intensive. While some studies have mitigated this by reducing the length of the sampling window, they significantly failed to identify the DLMO for shift workers. In this study, we present a framework that reduces the DLMO experiment time for shift workers to just 5 h. This approach combines sleep-wake pattern data from wearable devices with a mathematical model to predict DLMO prospectively. Based on this prediction, we define a targeted 5-h sampling window, from 3 h before to 2 h after the estimated DLMO. Testing this framework with 19 shift workers, we successfully identified the DLMO for all participants, whereas traditional methods failed for more than 40% of participants. This approach significantly reduces the experiment time required for measuring the DLMO of shift workers from 24 h to 5 h, simplifying the circadian phase measurements for shift workers.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"7487304251317577"},"PeriodicalIF":2.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Hidden Markov Models to Identify Behavioral Patterns in Accelerometry Data of Subterranean Rodents in Field Enclosures.","authors":"Milene G Jannetti, Veronica S Valentinuzzi, Gisele A Oda","doi":"10.1177/07487304241313149","DOIUrl":"https://doi.org/10.1177/07487304241313149","url":null,"abstract":"<p><p>Activity rhythms of laboratory rodents are usually measured by running wheels, and although wheel running activity-or-rest data enable straightforward rhythmic analyses, it provides limited behavioral information. In subterranean rodents (tuco-tucos), we used bio-loggers (accelerometers) to measure activity rhythms in both lab and field conditions, detecting diverse movements that compose activity. However, understanding these different accelerometer-detected activity components requires more complex analytical tools. Here we used supervised hidden Markov models (HMMs) as a machine learning analysis, to identify behavioral patterns in accelerometer data of tuco-tucos from field enclosures and characterize their behavioral rhythms in this condition. Activity of tuco-tucos was previously video-recorded in the laboratory with simultaneous accelerometer measurements. Video-obtained behavioral data were used in HMM models to refine (train) the classification of accelerometer recordings into different behavioral states. The classification obtained by HMM matched in 93% the one obtained by the video-observed method. Trained models were then used to automatically extract behavior information from accelerometers attached to 20 unobserved tuco-tucos first maintained in field enclosures and then transferred to the laboratory. Activity bouts associated with digging and locomotion were responsible for the diurnal rhythm in field enclosures and the nocturnal rhythm in the laboratory. Bouts of activity spread throughout day and night (cathemeral) were present in both conditions and were associated with feeding, coprophagy, and grooming. Finally, while rest occurs throughout day and night in the laboratory setting, tuco-tucos restrict rest episodes to nighttime under field enclosures, possibly as a behavioral adjustment to challenging environments. HMM models provide more behavioral information from accelerometry data, expanding the scope of activity pattern studies in small mammals under natural conditions.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"7487304241313149"},"PeriodicalIF":2.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling of Jet Lag and Searching for an Optimal Light Treatment.","authors":"Beatriz Aleixo, Sooyeon Yoon, José F F Mendes, Alexander V Goltsev","doi":"10.1177/07487304241306851","DOIUrl":"10.1177/07487304241306851","url":null,"abstract":"<p><p>The role of the hierarchical organization of the suprachiasmatic nucleus (SCN) in its functioning, jet lag, and the light treatment of jet lag remains poorly understood. Using the core-shell model, we mimic collective behavior of the core and shell populations of the SCN oscillators in transient states after rapid traveling east and west. The existence of a special region of slow dynamical states of the SCN oscillators can explain phenomena such as the east-west asymmetry of jet lag, instances when entrainment to an advance is via delay shifts, and the dynamics of jet lag recovery time. If jet lag brings the SCN state into this region, it will take a long time to leave it and restore synchronization among oscillators. We show that the population of oscillators in the core responds quickly to a rapid phase shift of the light-dark cycle, in contrast to the shell, which responds slowly. A slow recovery of the synchronization among the shell oscillators in transient states may strongly affect reentrainment in peripheral tissues and behavioral rhythms. We discuss the relationship between molecular, electrical, and behavioral rhythms. We also describe how light pulses affect the SCN and analyze the efficiency of the light treatment in facilitating the adaptation of the SCN to a new time zone. Light pulses of a moderate duration and intensity reduce the recovery time after traveling east, but not west. However, long duration and high intensity of light pulses are more detrimental than beneficial for speeding up reentrainment. The results of the core-shell model are compared with experimental data and other biologically motivated models of the SCN.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"36-61"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal Photoperiod Has Long-Term Effects on the Rest-Activity Cycle and Sleep in Male and Female Mice.","authors":"Rick van Dorp, Tom Deboer","doi":"10.1177/07487304241302547","DOIUrl":"10.1177/07487304241302547","url":null,"abstract":"<p><p>Environmental light conditions during development can have long-lasting effects on the physiology and behavior of an animal. Photoperiod, a clear example of environmental light conditions, is detected by and coded in the suprachiasmatic nucleus. It is therefore possible that differences observed in behavior in adulthood after exposure to different perinatal photoperiods are caused by lasting changes in the suprachiasmatic nucleus or alternatively, in other nuclei affected by perinatal photoperiod. It can then be expected that behavior with strong circadian aspects, like rest-activity and sleep, are affected by difference in photoperiod during development as well. To investigate this further, we exposed mice to different photoperiods during their development in the womb until weaning (long: 16 h of light, 8 h of darkness; short: 8 h of light, 16 h of darkness). After weaning, the animals were exposed to a 12 h:12 h light:dark cycle for at least 3 more weeks and some animals were subsequently exposed to constant darkness. We assessed their rest-activity patterns by recording voluntary locomotor activity and used EEG recordings to determine sleep architecture and electroencephalographic spectral density. Perinatal long photoperiod animals showed a shorter duration of locomotor activity than short photoperiod-developed mice in a 12:12 light-dark cycle. This difference disappeared in constant darkness. In the light phase, that is, during the day, perinatal long photoperiod mice spent less time awake and more time in NREM sleep than short photoperiod-developed mice. No effects of perinatal photoperiod were observed in the EEG spectral density or in response to sleep deprivation. We see lasting differences in behavioral locomotor activity and sleep in female and male mice after exposure to different perinatal photoperiods. We conclude that perinatal photoperiod programs a developing mammal for different external conditions and changes brain physiology, which in turn results in long-lasting, possibly even permanent, changes in the sleep and locomotor activity.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"62-75"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Journal Club Commentaries: An Invitation for Chronobiology Trainees to Share Their Ideas.","authors":"Mary E Harrington","doi":"10.1177/07487304251316681","DOIUrl":"10.1177/07487304251316681","url":null,"abstract":"","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"3"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Corrigendum to \"Transcriptomic plasticity of the circadian clock in response to photoperiod: A study in male melatonin-competent mice\"\".","authors":"","doi":"10.1177/07487304241307484","DOIUrl":"10.1177/07487304241307484","url":null,"abstract":"","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"NP2"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Transcriptomic plasticity of the circadian clock in response to photoperiod: A study in male melatonin-competent mice\".","authors":"","doi":"10.1177/07487304241289753","DOIUrl":"10.1177/07487304241289753","url":null,"abstract":"","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"NP1"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in Circadian Timing and Biological Night in Adolescents.","authors":"Armelle Duston, Sydney Holtman, Anne E Bowen, Melanie G Cree, Kristen Nadeau, Kenneth P Wright, Stacey L Simon, Cecilia G Diniz Behn","doi":"10.1177/07487304241309165","DOIUrl":"10.1177/07487304241309165","url":null,"abstract":"<p><p>Circadian rhythms, intrinsic 24-h cycles that drive rhythmic changes in behavior and physiology, are important for normal physiology and health. Previous work in adults has identified sex differences in circadian rhythms of melatonin, temperature, and the intrinsic period of the human circadian timing system. However, less is known about sex differences in circadian rhythms at other developmental stages. To address this gap, we considered a secondary analysis of sleep and circadian data from two studies involving adolescent participants during the academic year: (<i>n</i> = 32, 15 females). We collected 1 week of in-home actigraphy data to calculate sleep-wake parameters and in-laboratory salivary melatonin data collection in dim-light conditions was used to compute dim-light melatonin onset (DLMO) and offset (DLMOff) using a threshold of 4 pg/mL. We found that DLMO was an average of 96 min earlier, the time between DLMO and bedtime was an average of 56 min greater, and the biological night (time between DLMO and DLMOff) was 60 min longer in females compared to males, even though bedtimes and waketimes were not statistically different between the groups. In addition, after accounting for differences in bedtime, sex was still a significant predictor of DLMO. Conversely, no evidence was found indicating a difference in DLMOff or the phase angle between DLMOff and waketime by sex. These findings suggest that sex differences in circadian rhythms are present in adolescents and may have implications for circadian health during this important developmental period.</p>","PeriodicalId":15056,"journal":{"name":"Journal of Biological Rhythms","volume":" ","pages":"7-18"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}