Journal of Antivirals & Antiretrovirals最新文献_第6页

Note on Antivirals and Antiretrovirals 关于抗病毒药物和抗逆转录病毒药物的说明

Journal of Antivirals & Antiretrovirals Pub Date : 2020-01-01 DOI: 10.35248/1948-5964.20.12.E196

Shan Jheng

引用次数: 0

Hand Washing Practices among Health Care Workers in Jugal Hospital, Harar, Ethiopia, 2020: In the Era of Corona Virus: Observational Study 埃塞俄比亚哈拉尔Jugal医院医护人员的洗手习惯，2020:在冠状病毒时代:观察性研究

Journal of Antivirals & Antiretrovirals Pub Date : 2020-01-01 DOI: 10.35248/1948-5964.20.12.197

East Ethiopia

{"title":"Hand Washing Practices among Health Care Workers in Jugal Hospital, Harar, Ethiopia, 2020: In the Era of Corona Virus: Observational Study","authors":"East Ethiopia","doi":"10.35248/1948-5964.20.12.197","DOIUrl":"https://doi.org/10.35248/1948-5964.20.12.197","url":null,"abstract":"Introduction: the current burden of the spreading coronavirus (Covid-19) implied an action to review our basic strategies in hand hygiene practice. This calls for effective infection control measures in health care settings, in particular hand hygiene. Hence, hand hygiene practice will continue to be a concern and are essential to explore to bridge the theory practice gap. Methodology: Cross sectional observational study was conducted from February to March 2020 at Jugal hospital, Harar, Ethiopia, which is found 525 km to East of Addis Ababa. Ethical clearance was obtained from Harar Health Science College institutional review board (IRB) (Ref.no.HHSC-27/2020). Consent was obtained from both administrative body and respondent. SPSS version 20 was used for data analysis. Result: Majority 99 (59.64%) said that they use Soap bar followed by 57(34.34%) only water and 10(6.02%) alcohol base sanitizer, whereas there is no any one answered Chlorhexidine solution and Liquid hand wash use for hand washing. Only 7 (4.22%) washed their hands when switching from one patient to the second patient. Only twenty seven (16.27%) followed correct sequence in hand washing. Shared ward towels drying was the preferred method of hand drying after washing which was seen in 111 (66.87%) of the participants. Lack of water and soap were the major constraints against washing hands which was seen among 122 (73.49%) Conclusion: Very poor practice with Hand washing practices among studied Health Care Workers is calling for urgent intervention. Implementing five movements of hand hygiene are the best method for preventing healthcare associated infections. Therefore, the health care provider should be followed this principle to fight healthcare associated infections.","PeriodicalId":15020,"journal":{"name":"Journal of Antivirals & Antiretrovirals","volume":"93 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73232079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Scientific Advances in HIV 艾滋病毒的科学进展

Journal of Antivirals & Antiretrovirals Pub Date : 2020-01-01 DOI: 10.35248/1948-5964.20.S14.E001

J. Bebawy

引用次数: 0

Cellular Immune Response (CD8+CD38+) in Relation to Hepatitis B Virus DNA Level and HBsAg Quantification in Hepatitis B Patients 乙型肝炎患者细胞免疫应答(CD8+CD38+)与乙型肝炎病毒DNA水平和HBsAg定量的关系

Journal of Antivirals & Antiretrovirals Pub Date : 2020-01-01 DOI: 10.35248/1948

G. Shiha, E. Toson, A. Elbeeh, H. Abdellatif

{"title":"Cellular Immune Response (CD8+CD38+) in Relation to Hepatitis B Virus DNA Level and HBsAg Quantification in Hepatitis B Patients","authors":"G. Shiha, E. Toson, A. Elbeeh, H. Abdellatif","doi":"10.35248/1948","DOIUrl":"https://doi.org/10.35248/1948","url":null,"abstract":"Introduction: Hepatitis B Virus (HBV) infection is a global public health concern. The immune response in HBV represents a key factor in patient outcome. However, the relationship between viral replication and host immune reactivity remains a matter of investigation. Aim: The aim of our study was to investigate whether the cellular immune response of recently diagnosed and treatment naive chronic hepatitis B(CHB) patients may be influenced by the replicative status of HBV. Towards this aim, the correlation between HBV viral load, HBsAg quantification and peripheral T-cell subpopulations CD8+CD38+. Methods: Proportions and absolute counts of CD8 CD38 T cells were determined using three-color flow cytometry in chronic hepatitis B patients (n=50) and healthy controls (n=35). Chronic hepatitis B patients were regularly followed for 48 weeks, during which period the T cell subsets, serum viral load and HBsAg quantitation were measured every 24 months. Results: There was a high level of CD8+CD38+% during the pretreatment stage (Mean 32.4514, standard deviation (SD) 16.8007) compared to the control group (Mean 19.4628, SD 9.75555), p=0.000. Significant decreases in CD8 count were detected 12 months after treatment initiation of HBV therapy (Mean 1359.44, SD 724.362) compared to the control group (Mean 1944.13, SD 948.931), p=0.001. There is a significant correlation between CD8+CD38+ count and serum HBV DNA. A Positive correlation was found between CD8+CD38+ count and HBsAg quantitation. Conclusion: There was a positive correlation between CD8+CD38+ T cells and HBsAg quantitation. The combined use of CD8+CD38+ T cells, HBsAg quantitation and HBV DNA assessment in patients with CHB may guide the clinicians as they guage the likelihood of treatment response.","PeriodicalId":15020,"journal":{"name":"Journal of Antivirals & Antiretrovirals","volume":"118 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89448179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antivirus Therapy: Using Annihilating Inside Liposomes as a Bait for SARS-CoV2 抗病毒治疗:利用脂质体内湮灭作为SARS-CoV2的诱饵

Journal of Antivirals & Antiretrovirals Pub Date : 2020-01-01 DOI: 10.35248/1948-5964.20.S6.001

Dimitris Labrou

引用次数: 0

Corona Virus Effects over the Human Body 冠状病毒对人体的影响

Journal of Antivirals & Antiretrovirals Pub Date : 2020-01-01 DOI: 10.35248/1948-5964.20.S6.E003

R. Sane

引用次数: 1

Drug Delivery in HIV HIV中的药物递送

Journal of Antivirals & Antiretrovirals Pub Date : 2020-01-01 DOI: 10.35248/1948-5964.20.S14.E002

Sri Ch, Ra

引用次数: 0

Sequencing Analysis of Hepatitis 肝炎病毒序列分析

Journal of Antivirals & Antiretrovirals Pub Date : 2020-01-01 DOI: 10.35248/1948-5964.20.S8.E002

J. Varela

引用次数: 0

In Vitro Search for Antiviral Activity against Human Cytomegalovirus from Medicinal Mushrooms Pleurotus sp. and Lentinus sp. 药用蘑菇平菇和香菇体外抗人巨细胞病毒活性的研究。

Journal of Antivirals & Antiretrovirals Pub Date : 2020-01-01 DOI: 10.35248/1948-5964.20.12.201

Debsopan Roy, S. Ansari, Aroni Chatterjee, A. Luganini, S. Ghosh, N. Chakraborty

{"title":"In Vitro Search for Antiviral Activity against Human Cytomegalovirus from Medicinal Mushrooms Pleurotus sp. and Lentinus sp.","authors":"Debsopan Roy, S. Ansari, Aroni Chatterjee, A. Luganini, S. Ghosh, N. Chakraborty","doi":"10.35248/1948-5964.20.12.201","DOIUrl":"https://doi.org/10.35248/1948-5964.20.12.201","url":null,"abstract":"Human Cytomegalovirus is a ubiquitous opportunist pathogen capable of infecting newborns, immune compromised and immunosuppressed patients. Till date only a limited number of clinically approved drugs are available for treatment. All these drugs prove to be very effective against active HCMV infection but with their respective share of drawbacks. Anti-viral agents derived from natural compounds are the need of the hour. They have potent anti-viral property but lack the cytotoxic effect associated with their synthetic counterparts. In this regard the medicinal mushrooms have proven to be quite an interesting candidate of choice. We collected and isolated extracts from four different edible mushroom species and used them on in vitro cultured MRC5 and 1B4 cell lines. Cytotoxicity and anti-viral response for each mushroom was tested in a dose dependent and time dependent fashion. Among the four mushroom types, only Pleurotus sp. and Lentinus sp. were found to have potent anti-viral response with minimum cytotoxicity against human cytomegalovirus. Their crude extracts showed 100% inhibition of HCMV replication at 180 μg/ml and 160 μg/ml respectively. Our study highlights that extracts from both of these mushrooms can be used as alternative HCMV therapeutic strategy.","PeriodicalId":15020,"journal":{"name":"Journal of Antivirals & Antiretrovirals","volume":"39 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90496072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Insights of Antivirals: A New Drug Delivery Systems 抗病毒药物的见解:一种新的药物输送系统

Journal of Antivirals & Antiretrovirals Pub Date : 2020-01-01 DOI: 10.35248/1948-5964.20.S7.E001

Tahseen Asa Azad

引用次数: 0