Biological Markers and Guided Therapy最新文献

{"title":"Cellular care and extracellular vesicles therapies of heart failure","authors":"A. Berezin, A. Berezin","doi":"10.12988/bmgt.2019.9510","DOIUrl":"https://doi.org/10.12988/bmgt.2019.9510","url":null,"abstract":"Heart failure (HF) is a major factor contributing to premature death in patients with established cardiovascular (CV) disease. Current cell therapies of HF based on at least two different approaches, in which stem cell transplantation and extracellular vesicles (EV) received from pre-treated cells, were used. Although in HF restoring cardiac function aimed improve survival is target of cell therapy, it is not yet yielded whether isolated EVs from circulating progenitor cells, induced pluripotent stem cells (iPSCs), human embryonic stem cells-derived CV progenitors (hESC-Pg) would be effective translators of reparative signals for cardiac repair. The short communication is depicted the role of different cell strategies in HF. It has emphasized lack of strong evidence of clinical advantages implanted EVs to human cells to iPSCs in HF requires comparison in large clinical trials.","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122763934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial function among patients with hypertension stage II with varying degrees of arterial hypertension","authors":"O. M. Bayduzha","doi":"10.12988/bmgt.2019.936","DOIUrl":"https://doi.org/10.12988/bmgt.2019.936","url":null,"abstract":"Aim of the study was to determine the levels of endothelial cell biomarkers in patients with stage II of hypertension with varying degrees of arterial hypertension. Methods: In order to carry out the study, a comprehensive examination of 224 patients with HT was conducted, including 126 patients with stage II HT of the 1-3 AH degree and 98 ones with stage I HT of the 1-3 AH degree, who were treated at PI \"Zaporizhzhya city clinical hospital No 10\" of Zaporizhzhya city Council. Practically healthy individuals were examined on an outpatient basis. To participate in the study, patients had to sign “Voluntary informed consent of the patient to participate in the study” form. Results: The synthesis of endothelin-1 is triggered by vasoactive hormones, hypoxia, active oxygen forms, increased content of low-density lipoproteins, shear stress on the endothelium. Abnormalities of NO-dependent relaxation of arteries in patients with hypertension may be caused due to the following mechanisms: decrease in NO production, its accelerated degradation, the changes in cytoarchitectonics of blood vessels. But the greatest importance in the reduction of endothelium-dependent vasodilation is attached to intracellular oxidative stress: free radical oxidation significantly reduces the production of NO by endothelial cells","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":"312 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124429163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The pathogenetic role of pro- and anti- inflammatory cytokines in developing of diabetic myopathy in children","authors":"O. Pashkova, N. Chudova","doi":"10.12988/BMGT.2019.948","DOIUrl":"https://doi.org/10.12988/BMGT.2019.948","url":null,"abstract":"The level of interleukin-6 and interleukin-13 was analysed in the blood serum of children with diabetes type 1 from 11 to 17 years old. They divided into three groups: the duration of diabetes less than 1 year (1st group), the duration of diabetes from 1 to 5 years (2nd group) and over 5 years (3rd group). The group of control includes conventionally healthy children. All kids have gone through the detailed clinical examination wich included functional tests to determine the condition of skeletal muscles, such as skeletal muscle strength, muscular tissue loss, functional capability and estimation of the muscular mass. Pathogeneticic mechanism of diabetic myopathy is a result of dysbalance between proand anti-inflammatory interleukins. The first manifestations of diabetic myopathy in children occur after the 5 year of diabetes, but subclinical signs develop over the first years of disease. It appears of muscle strength decrease and violation of its functional capability.","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123711369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-22 level and vascular remodeling in patients with hypertension in associated with abdominal obesity","authors":"K. Kysylenko, O. Kovalyova","doi":"10.12988/bmgt.2019.947","DOIUrl":"https://doi.org/10.12988/bmgt.2019.947","url":null,"abstract":"The purpose of the study was to estimate the interleukin-22 (IL-22) level in the blood serum of hypertensive patients with abdominal obesity (AO), depending on common carotid arteries (CCA) remodeling presence. Ninety-five subjects: 83 hypertensive patients and 12 healthy controls were examined. The patients were divided into two groups, depending on the presence of AO followed by the division of patients into subgroups depending on the intima-media thickness (IMT). For all patients, the following anthropometric parameters were measured: weight, height, waist circumstances (WC), hip circumstances (HC); the body mass index (BMI) and the waist-to-hip ratio (WC/HC) were calculated. The serum IL-22 level was determined in the patients by means of the Bender Medsystems® Human IL-22 Platinum ELISA kit by immunoassay method. Additionally, the patients underwent an ultrasound examination of carotid arteries. The study revealed that the CCA IMT in hypertensive patients with and without AO compared to the control group were significant differences. Serum IL-22 levels in hypertensive patients with AO having IMT ≥ 0.9 mm was statistically higher as compared with patients having IMT < 0.9 mm. 64 Kateryna Kysylenko and Olga Kovalyova The IL-22 levels in hypertensive patients without AO having IMT < 0.9 mm and having IMT ≥ 0.9 mm were significantly exceeds cytokine level in the control group. The obtained results may indicate that the blood serum IL-22 level is associated with a greater degree of vascular wall damage in hyprtensive patient both with and without AO. Higher IL-22 levels in the groups of hypertensive patients both with and without AO, with normal IMT compared with the control group, probably indicate that elevated blood serum IL-22 content can promote an early affection of the vascular endothelium.","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125815699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining biomarkers and TIMI score for prediction of left ventricular systolic dysfunction among patients with STEMI","authors":"E. Sid","doi":"10.12988/bmgt.2021.91024","DOIUrl":"https://doi.org/10.12988/bmgt.2021.91024","url":null,"abstract":"","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121409932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of markers of bone resorption in oral fluid in patients with generalized parodontitis during its treatment","authors":"A. Y. Lukash, O. Fastovets, S. Pavlov","doi":"10.12988/bmgt.2019.914","DOIUrl":"https://doi.org/10.12988/bmgt.2019.914","url":null,"abstract":"One of the promising courses in the clinical dentistry is the use of molecular biological markers in patients with periodontal disease. First of all, this is due to the rising trend in the prevalence and risk factors of the disease, which makes relevant finding effective methods for early detection and preventive treatment. 30 patients diagnosed with generalized periodontitis of the I and II degree of severity were selected for the research. In the experimental groups of patients, an immunoassay was used to determine the marker level of bone marrow metabolism (MMP-8) in the oral fluid, in the dynamics of treatment. During the study, the content of this enzyme was found to be indicative of the transformation of the inflammatory process in the gums into the destruction of the alveolar bone. 20 A. Yu. Lukash et al. The obtained values of the concentration of MMP-8 in the oral fluid, as well as their dynamics, proved this marker to be indicative of the course of the inflammatory-destructive process in periodontal tissues, and therefore the possibility of its application for the diagnosis and monitoring of the results of treatment of generalized periodontitis","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127589334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial progenitor cell dysfunction in diabetes mellitus: new target for risk stratification and therapies?","authors":"A. Berezin, A. Berezin","doi":"10.12988/bmgt.2019.915","DOIUrl":"https://doi.org/10.12988/bmgt.2019.915","url":null,"abstract":"","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129239262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of the heat shock protein HSP70 modulators on the energy metabolism of the rats brain in acute cerebral ischemia","authors":"I. Belenichev, Y. Bila","doi":"10.12988/BMGT.2019.949","DOIUrl":"https://doi.org/10.12988/BMGT.2019.949","url":null,"abstract":"","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":"25 19","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113984371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relation of the atherosclerotic process with the manifestation of oxidative stress in arterial hypertension patients combined with rheumatoid arthritis","authors":"N. G. Ryndina","doi":"10.12988/bmgt.2019.91012","DOIUrl":"https://doi.org/10.12988/bmgt.2019.91012","url":null,"abstract":"Introduction. When arterial hypertension (AH) is combined with rheumatoid arthritis (RA), there are significant imbalances between the production of lipid peroxidation (LP) derivatives and the ability to neutralize these reactive substances. Aim of the study: To investigate the lipid profile, the thickness of the intimamedia complex (TIMC) of common carotid arteries in patients with rheumatoid arthritis in combination with arterial hypertension, and to correlate these indicators with the manifestations of oxidative stress, and the antioxidant system. Materials and methods: The results of the study are based on a comprehensive survey of 96 patients with stage 2 hypertension in combination with RA, 45 patients with stage 2 hypertension and 31 healthy volunteers. Research results. The stage of hypertension significantly influenced the manifestations of atherosclerotic process and oxidative stress, average TIMC indexes of the right CCA 1.28 (1.08; 1.30) mm and left CCA 1.29 (1.06; 1.30) mm in patients with RA in combination with stage 2 AH were significantly higher by 24.2% and 24%, respectively, against rates of RA patients in combination with grade 1 AH (p <0.01). The detection rate of atherosclerotic plaques in the subgroup of RA patients 102 Nataly G. Ryndina in combination with grade 2 AH was significantly higher 10 times, compared to the subgroup of RA patients in combination with stage 1 AH (p <0.01). Significant relation between LP products indices and manifestations of atherosclerotic process in patients with hypertension in combination with RA, direct linear correlation of medium strength between indices of malonic aldehyde and LDL R = + 0,57, TG R = + 0,56, TIMC R = + 0.55, respectively (p <0.05), diene ketones and TG R = + 0.52, TG R = + 0.55, respectively (p <0.05). Conclusions. The highest predictive value for the detection of atheromatous plaques in the CCA system had malonic aldehyde (AUC 0.870, 95% CI AUC 0.784 to 0.931) at the optimum distribution point > 5.25 nmol/ml, sensitivity 88.73%, and specificity 90.43%, and diene ketones (AUC 0.869, 95% CI AUC 0.784 to 0.930) sensitivity 90.36% and specificity 88.87% at the optimum distribution point > 5 c.un./ml.","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133436832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The study of antiarrhythmic activity of some derivatives of 7-alkyl-8-piperazine-3-methylxanthine","authors":"I. Samura, L. Grigorieva, M. Romanenko","doi":"10.12988/bmgt.2019.913","DOIUrl":"https://doi.org/10.12988/bmgt.2019.913","url":null,"abstract":"Some of appropriate 7-alkyl-8-piperazine derivatives of 3-methylxanthine were tested for their effect oncirculatory system, protection against adrenaline-, strophanthin-, and calcium chloride-induced arrhythmias, as wellascatecholamine metabolism in the heart of experimental animals. The most prominent antiarrhythmicactivity in this row was demonstrated by7-isopropyl-8-piperazine-3methylxanthine (compound 3) that in a conditional therapeutic dose of 13.7mg/kg prevented or decreased the incidence of adrenaline, strophanthine and calcium chloride evoked arrhythmias. In adrenaline and calcium-evoked model of arrhythmia compound 3decreased or delayed the incidence of arrhythmias by 37% and 55.7% respectively, as well as episodes and severity of extrasystoles by 37%, efficiently prevented bigeminy (70%, p < 0.01) and diminished (42.8%, p<0.05) mortality of animals. Some of investigated compounds (2-5) decreased heart rate by 10-18%, prolonged P-Q section, QRS complex and Q-T interval. 34 Iryna B. Samura et al. The most potent and significant negative chronotropic effect and markedly prolonged duration of P-Q section was demonstrated by compound 3. Theinfluence of investigated compounds on ECG components suggests that activity of compound 3 is similar to class 1A antiarrhythmic agents according to VoughanWilliams classification of antiarrhythmic drugs, because of prolongation of P-Q and Q-T intervals and extension of QRS complex. Compounds 3in a dose of 13.7 mg/kg within 0.5 h after intraperitoneal administration showed to protect against CaCl2-induced abnormalities in the metabolism of catecholamines–decarboxylation of 3,4-dihydroxyphenylalanine (DOPA) and methylation of norepinephrine. The mechanism of antiarrhythmic action of compound 3is most likely to include blockade of sodium channels of the conducting system of the heart, consequent indirect suppression of potassium ion exit from the cell as well as normalization of heart tissue catecholamines and their precursors content, along with the interference in the activity of the enzyme systems participating in the biotransformation of catecholamines.","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124315153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}