Biological Markers and Guided Therapy最新文献_第2页

Experimental assessment of the specific activity of a new dosage form of angiolin in cataract modeling 一种新剂型血管素在白内障建模中的比活性实验评价

Biological Markers and Guided Therapy Pub Date : 1900-01-01 DOI: 10.12988/bmgt.2019.91013

I. Belenichev, L. Kucherenko, I. Mazur, R. Akopyan, E. A. Portnaya

{"title":"Experimental assessment of the specific activity of a new dosage form of angiolin in cataract modeling","authors":"I. Belenichev, L. Kucherenko, I. Mazur, R. Akopyan, E. A. Portnaya","doi":"10.12988/bmgt.2019.91013","DOIUrl":"https://doi.org/10.12988/bmgt.2019.91013","url":null,"abstract":"Age-related cataract is currently the leading cause of incurable blindness in the world and the most common eye disease in people over 60 years. Among all ophthalmic diseases, cataract is about 65%. The following medicines are used to treat cataracts: Oftan Catachrom (Santen AO, Finland), Taufon (Farmak, OAO, Kiev, Ukraine.), Quinax (Alcon -Couvreur, Belgium), Vita-Iodurol (Excelvision AG for Novartis Pharma AG, France/Switzerland), Potassium iodide (OOO “UNIMED PHARMA”, Slovak Republic). Based on the foregoing, it is clear that the range of drugs for the treatment of cataracts is limited, and mainly consists of imported drugs. All of the above opens up new prospects for the creation of new ophthalmic medicines for expanding the range of domestic drugs, namely eye drops with wound healing, reparative, anti-inflammatory effects. Therefore, the aim of our work is to create a new ophthalmic drug based on the original substance Angiolin, which will exhibit anti-inflammatory, wound healing, reparative properties. cataract was reproduced on both eyes of 10 animals (20 eyes) by chemical induction of free radical oxidation of biopolymers of eye tissues according to the D.K. Buyan method, for which 30 μl of a sterile solution of dibromide diquat at a dose of 600 nmol was injected once into the vitreous body. Treatment began from 7 days, when the initial opacity of the lens was formed, and was carried out by instillation of drugs into the conjunctival cavity of the eyes 3 times a day. Results: the course administration of 1% Angiolin eye drops had a significant therapeutic effect in the conditions of chemical cataracts. The use of Angiolin drops reduced the lens opacity of the eye of experimental animals by 43,5%. Findings: 1% Angiolin eye drops ((S) -2,6-diaminohexanoic acid 3-methyl-1,2,4-triazolyl-5-thioacetate) as an active ingredient, exhibit significant anti-inflammatory, wound healing, reparative properties, and also have a high therapeutic effect in the treatment of cataracts.","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":"132 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128303933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating vascular endothelial growth factor in ST-segment elevation myocardial infarction: from bench to bedside 循环血管内皮生长因子在st段抬高型心肌梗死中的作用:从实验室到床边

Biological Markers and Guided Therapy Pub Date : 1900-01-01 DOI: 10.12988/BMGT.2019.912

A. Berezin, A. Berezin

{"title":"Circulating vascular endothelial growth factor in ST-segment elevation myocardial infarction: from bench to bedside","authors":"A. Berezin, A. Berezin","doi":"10.12988/BMGT.2019.912","DOIUrl":"https://doi.org/10.12988/BMGT.2019.912","url":null,"abstract":"The aim of the mini review is discuss the controversial role of vascular endothelial growth factor (VEGF) family members in prediction of clinical outcomes in acute ST segment elevation myocardial infarction (STEMI) patients. Recent studies have shown that high levels of circulating VEGF in STEMI may characterize patients with extensive intracoronary thrombosis, as well as it could associate with favorable clinical outcomes. Although VEGF-A mediated angiogenesis and vasodilation, it was able to promote expression of cell adhesion molecules, such as E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in surface of endothelial cells, and up-regulated permeability, pro-coagulant activity and inflammation of microvasculature. Yet, exon 8 of VEGF-A gene is involved in the alternate splicing that determines whether the VEGF-A proteins are pro-angiogenic isoform or antiangiogenic isoform of VEGF-A. Moreover, anti-angiogenic potency of VEGF-A165b isoform can influence on developing of adverse cardiac remodeling and plaque rupture. In the review is reported that predictive value of VEGF family member predominantly 10 Alexander E. Berezin and Alexander A. Berezin VEGF-A needs to be investigated in future, because there are several controversial in interpretation of changes in VEGF levels in STEMI","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123884481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of insufficiency of vitamin D on activity of endogenous antimicrobic peptides at children of early age with acute bacterial diseases of the respiratory system 维生素D不足对早期急性呼吸系统细菌性疾病患儿内源性抗菌肽活性的影响

Biological Markers and Guided Therapy Pub Date : 1900-01-01 DOI: 10.12988/bmgt.2019.9511

G. Lezhenko, H. V. Kraynya

引用次数: 0

The use of biomarkers in planning prosthetic rehabilitation in patients with periodontium tissues disorders 生物标志物在牙周组织紊乱患者假肢康复计划中的应用

Biological Markers and Guided Therapy Pub Date : 1900-01-01 DOI: 10.12988/BMGT.2019.911

V. Romaniuk, S. Pavlov, A. V. Vozniy

{"title":"The use of biomarkers in planning prosthetic rehabilitation in patients with periodontium tissues disorders","authors":"V. Romaniuk, S. Pavlov, A. V. Vozniy","doi":"10.12988/BMGT.2019.911","DOIUrl":"https://doi.org/10.12988/BMGT.2019.911","url":null,"abstract":"The research is devoted to the current issue of medicine using of molecular-biological markers in implantation and prosthtetic rehabilitation of dental patients with dental defects and periodontal tissue diseases. Values of such biomarkers as MMP-8, cathelicidin and lactoferrin were estimated in the oral cavity fluid with the employment of enzyme multiplied immunoassay. 40 patients were selected for the present study. Among them, 10 healthy patients comprised observational group, and 30 patients with periodontium tissues diseases formed treatment group. There were 10 patients with first-degree periodontitis, 10 patients with second-degree periodontitis and 10 patients with third-degree periodontitis and defects of dental arches. Level of MMP-8 in oral cavity fluid increased directly depending on periodontitis degree. Values of LL-37 were estimated in inversed relation to MMP-8, i.e. they decreased according to periodontitis degree. Values of lactoferrin increased directly depending on periodontitis degree. Received findings indicates the destruction of connective tissue that points at the intensity of inflammation processes of oral cavity mucous membranes, decreasing of antimicrobial activity and decreasing of tissue immunity in the oral cavity. 2 V.N. Romaniuk et al.","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123825191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Influence of different resveratrol dosage forms оn indicators of endogenous neuroprotection in experimental hypoestrogenic state 不同白藜芦醇剂型对实验性低雌激素状态下内源性神经保护指标的影响

Biological Markers and Guided Therapy Pub Date : 1900-01-01 DOI: 10.12988/BMGT.2021.91022

G. Zaychenko, O. Stryga, I. Belenichev, K. Sorokopud, Ігор Федорович Бєленічев

引用次数: 0