The use of biomarkers in planning prosthetic rehabilitation in patients with periodontium tissues disorders

The research is devoted to the current issue of medicine using of molecular-biological markers in implantation and prosthtetic rehabilitation of dental patients with dental defects and periodontal tissue diseases. Values of such biomarkers as MMP-8, cathelicidin and lactoferrin were estimated in the oral cavity fluid with the employment of enzyme multiplied immunoassay. 40 patients were selected for the present study. Among them, 10 healthy patients comprised observational group, and 30 patients with periodontium tissues diseases formed treatment group. There were 10 patients with first-degree periodontitis, 10 patients with second-degree periodontitis and 10 patients with third-degree periodontitis and defects of dental arches. Level of MMP-8 in oral cavity fluid increased directly depending on periodontitis degree. Values of LL-37 were estimated in inversed relation to MMP-8, i.e. they decreased according to periodontitis degree. Values of lactoferrin increased directly depending on periodontitis degree. Received findings indicates the destruction of connective tissue that points at the intensity of inflammation processes of oral cavity mucous membranes, decreasing of antimicrobial activity and decreasing of tissue immunity in the oral cavity. 2 V.N. Romaniuk et al.