The influence of insufficiency of vitamin D on activity of endogenous antimicrobic peptides at children of early age with acute bacterial diseases of the respiratory system

G. Lezhenko, H. V. Kraynya
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Abstract

Determination of content of vitamin D and antimicrobic peptides (cathelicidin, β1defensins, lactoferrin and hBPI) in blood serum of 67 children with acute bacterial diseases of a respiratory system aged from 1 month up to 3 years taking into account the level of providing with vitamin D is carried out. The research showed that decrease in maintenance of a number of antimicrobial peptides in blood serum against the background of deficiency of vitamin D acts as risk factor of development of acute bacterial diseases of a respiratory system of children of early age.
维生素D不足对早期急性呼吸系统细菌性疾病患儿内源性抗菌肽活性的影响
本文对67例1个月~ 3岁急性呼吸道细菌性疾病患儿血清中维生素D和抗菌肽(抗菌肽、β1防御素、乳铁蛋白和hBPI)含量进行了测定,并考虑了维生素D的提供水平。研究表明,在维生素D缺乏的背景下,血清中一些抗菌肽的维持减少是早期儿童呼吸系统急性细菌性疾病发展的危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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