Endothelial function among patients with hypertension stage II with varying degrees of arterial hypertension

Abstract

Aim of the study was to determine the levels of endothelial cell biomarkers in patients with stage II of hypertension with varying degrees of arterial hypertension. Methods: In order to carry out the study, a comprehensive examination of 224 patients with HT was conducted, including 126 patients with stage II HT of the 1-3 AH degree and 98 ones with stage I HT of the 1-3 AH degree, who were treated at PI "Zaporizhzhya city clinical hospital No 10" of Zaporizhzhya city Council. Practically healthy individuals were examined on an outpatient basis. To participate in the study, patients had to sign “Voluntary informed consent of the patient to participate in the study” form. Results: The synthesis of endothelin-1 is triggered by vasoactive hormones, hypoxia, active oxygen forms, increased content of low-density lipoproteins, shear stress on the endothelium. Abnormalities of NO-dependent relaxation of arteries in patients with hypertension may be caused due to the following mechanisms: decrease in NO production, its accelerated degradation, the changes in cytoarchitectonics of blood vessels. But the greatest importance in the reduction of endothelium-dependent vasodilation is attached to intracellular oxidative stress: free radical oxidation significantly reduces the production of NO by endothelial cells