Journal of Antimicrobial Chemotherapy最新文献

{"title":"Antibiotic resistance and population structure of Staphylococcus epidermidis from prosthetic joint infections in Sweden and France.","authors":"Sofie M Edslev, Frederic Laurent, Emeli Månsson, Thor Bech Johannesen, Mia Aarris, Ute Wolff Sönksen, Camille Kolenda, Bo Söderquist, Marc Stegger","doi":"10.1093/jac/dkaf166","DOIUrl":"https://doi.org/10.1093/jac/dkaf166","url":null,"abstract":"<p><strong>Background and objectives: </strong>Staphylococcus epidermidis is a major cause of prosthetic joint infections (PJIs). Multidrug resistant (MDR), hospital-adapted clones constitute most cases globally, though regional differences in lineage dissemination likely exist. The aim was to explore the population structure of S. epidermidis from PJIs in Sweden and France, with a focus on the presence of antimicrobial resistance (AMR).</p><p><strong>Methods: </strong>This study included genome sequence data from 191 clinical S. epidermidis isolates collected from patients with PJI in central Sweden (2007-16; n = 138) and the Lyon region in France (2015-20; n = 53).</p><p><strong>Results: </strong>Hospital-adapted lineages with a high burden of AMR dominated the cases in both countries. However, the ST2 lineage was significantly more prevalent in Sweden (43% versus 11% in France), while ST5 and ST87 were more common in France (55% versus 10% in Sweden). ST215 was only present in Sweden (25%). A significantly higher prevalence of streptogramin resistance genes [vat(B), vga(A), vga(B)] was found in French (26%) versus Swedish (2%) isolates. These genes were present in all ST87 isolates and in 20% of the French ST5 isolates. The erm(C) gene (resistance to streptogramin A, macrolides and lincosamides) was also more common in the French isolates (77% versus 55% of Swedish isolates), and so was the fusidic acid resistance gene fusB (France: 66%, Sweden: 39%).</p><p><strong>Conclusions: </strong>This study highlights significant regional differences in S. epidermidis variants causing PJI. Despite similar MDR levels, certain AMR genes, particularly those related to streptogramin resistance, were significantly more prevalent among French isolates. This suggests that S. epidermidis undergoes local adaptation to region-specific antibiotic usage.</p>","PeriodicalId":14969,"journal":{"name":"Journal of Antimicrobial Chemotherapy","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population pharmacokinetics of weight-based compared with fixed dosing of CAP256V2LS, a broadly neutralizing antibody for HIV prevention in women.","authors":"Sharana Mahomed, Martin Beliveau, Roberto Heredia-Ortiz, Farzana Osman, Marothi Letsoalo, Nigel Garrett, Tanuja N Gengiah, Derseree Archary, Jennifer Wang, Sandeep Narpala, Mike Castro, Leonid Serebryannyy, Kevin Carlton, Richard A Koup, Penny L Moore, Lynn Morris, Quarraisha Abdool Karim, Salim S Abdool Karim","doi":"10.1093/jac/dkaf181","DOIUrl":"https://doi.org/10.1093/jac/dkaf181","url":null,"abstract":"<p><strong>Introduction: </strong>In the development of broadly neutralizing monoclonal antibodies (bNAb) for HIV prevention, there is a need for simpler dosing strategies. This study assessed whether fixed dosing achieves comparable systemic bNAb concentrations to weight-based dosing across a range of weights.</p><p><strong>Methods: </strong>The CAPRISA 012B trial was a first-in-human, Phase 1 dose-escalation study conducted in young, HIV-negative women (median age 25 years; IQR: 22-29) in South Africa, evaluating the subcutaneous administration of CAP256V2LS alone and in combination with VRC07-523LS. Weight-based dosing between 5 and 20 mg/kg was assessed. A fixed 1200 mg dose of CAP256V2LS and VRC07-523LS, administered alone or in combination, was evaluated in women weighing from 59.5 kg to 93.2 kg, with a median weight of 78.3 kg (IQR: 67.2-81.5). A population pharmacokinetic model was developed to describe and predict the concentration-time profiles of CAP256V2LS in participants. Model-based simulations then extended this analysis across a broader hypothetical weight range (34.2-119 kg).</p><p><strong>Results: </strong>Model-based simulations revealed comparable exposure between the 1200 mg fixed-dose and the 20 mg/kg weight-based dosing regimens. Inter-individual variability in bioavailability and clearance was 0.212 and 0.019, respectively, and was consistent across both fixed-dose and weight-based dosing, regardless of the route of administration. Weight-based dosing of CAP256V2LS led to a mean wastage of 265.8 mg for the 5 mg/kg dose, 433.4 mg for the 10 mg/kg dose, and 324.2 mg for the 20 mg/kg dose.</p><p><strong>Conclusions: </strong>For women weighing 60-93 kg, a fixed-dose of 1200 mg of CAP256V2LS produced similar adverse events and pharmacokinetic profiles as weight-based dosing. The fixed dose reduced variability in the plasma concentrations and product wastage compared with weight-based dosing.</p>","PeriodicalId":14969,"journal":{"name":"Journal of Antimicrobial Chemotherapy","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel methicillin-resistant Staphylococcus aureus lineage (ST4174) with an uncharacterized SCCmec variant identified in Korean pigs.","authors":"Hyeonwoo Cho, Kun Taek Park","doi":"10.1093/jac/dkaf178","DOIUrl":"https://doi.org/10.1093/jac/dkaf178","url":null,"abstract":"","PeriodicalId":14969,"journal":{"name":"Journal of Antimicrobial Chemotherapy","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversal of phenotypic resistance in multi-drug resistant carbapenemase-producing K. pneumoniae clinical isolates due to in vitro synergistic interactions between bacteriophages and antibiotics at clinically achievable concentrations.","authors":"Paschalis Paranos, Maria Siopi, Eleni Papanikolaou, Sophia Vourli, Panagoula Kolia, Spyros Pournaras, Joseph Meletiadis","doi":"10.1093/jac/dkaf163","DOIUrl":"https://doi.org/10.1093/jac/dkaf163","url":null,"abstract":"<p><strong>Background: </strong>Therapeutic options for MDR carbapenemase-producing Klebsiella pneumoniae (CRKP) are limited. We therefore assessed the in vitro activity of five antibiotics from different classes in combination with lytic bacteriophages (phages) against MDR CRKP isolates.</p><p><strong>Material and methods: </strong>A total of 15 non-repetitive, well-characterized MDR CRKP isolates and four phages belonging to the Podoviridae family were used in chequerboard assays with amikacin, meropenem, ciprofloxacin, colistin and ceftazidime/avibactam. The spectrophotometrically determined MIC of drugs and phages alone and in combination were used to calculate the fractional inhibitory concentration index (FICi). The clinical relevance was assessed based on the MIC reductions at clinically achievable concentrations and below the corresponding susceptibility breakpoints. Emergence of resistance was studied in growth curves and time-kill experiments.</p><p><strong>Results: </strong>Synergy was found for ciprofloxacin in 6/15 (40%) isolates, meropenem in 10/15 (67%), ceftazidime/avibactam in 11/15 (73%), colistin in 8/15 (53%) and amikacin in 9/15 (60%) with all four phages against host bacteria. The synergistic interactions were strong as the FICi were 0.01-0.35 reducing the MICs (>90% growth inhibition) to clinically achievable concentrations for 87%-100% of strains, except ciprofloxacin. Reversal of phenotypic resistance was observed for amikacin, meropenem, colistin and ceftazidime/avibactam in 100%, 53%, 89% and 80% of isolates, respectively. No emergence of resistance was found for isolates with low level resistance to amikacin (MΙC 64 mg/L).</p><p><strong>Conclusions: </strong>The phage-antibiotic combinations were synergistic against more than half of the isolates for all antibiotics except ciprofloxacin reversing resistance in most strains particularly with amikacin.</p>","PeriodicalId":14969,"journal":{"name":"Journal of Antimicrobial Chemotherapy","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of hypoalbuminemia on patients receiving ertapenem combination therapy for methicillin-susceptible Staphylococcus aureus bacteraemia.","authors":"Sunish Shah, Lloyd G Clarke, G K Balasubramani, Lingyi Peng, Brandon J Smith, Ryan K Shields","doi":"10.1093/jac/dkaf134","DOIUrl":"https://doi.org/10.1093/jac/dkaf134","url":null,"abstract":"<p><strong>Background: </strong>Ertapenem combination therapy has been associated with a faster time to blood culture sterilization in patients with MSSA bacteraemia. However, guidance documents advise avoiding ertapenem in patients with a serum albumin level of <2.5 g/dL for Gram negative infections given that ertapenem is highly protein bound and patients with hypoalbuminemia may experience suboptimal ertapenem exposures.</p><p><strong>Patients and methods: </strong>This study was a retrospective, multicenter study of consecutive adult patients with MSSA bacteraemia for >48 h who were treated with cefazolin, oxacillin, or nafcillin in combination with ertapenem. Patients with hypoalbuminemia, defined as a serum albumin level of <2.5 g/dL, were compared to those with normal albumin levels. Patients received ertapenem 1 g every 24 h or 500 mg every 24 h if they had a creatinine clearance below 30 mL/min. The primary outcome was time from ertapenem administration to negative blood cultures.</p><p><strong>Results: </strong>Among the 109 patients who received ertapenem for MSSA bacteraemia, 100 met the inclusion criteria. Thirty-eight percent were patients who inject drugs and 52% had definitive endocarditis. After propensity score weighting, patients with hypoalbuminemia had a significantly longer time to negative blood cultures compared to patients with normal albumin levels (HR=0.45, 95% CI: 0.27-0.72, P = 0.001).</p><p><strong>Conclusions: </strong>Among patients with persistent MSSA bacteraemia who were treated with ertapenem combination therapy, patients with hypoalbuminemia had a significantly longer time to negative blood cultures. Pharmacokinetic studies are warranted to confirm if these findings are due to drug exposures or the underlying condition of patients with hypoalbuminemia.</p>","PeriodicalId":14969,"journal":{"name":"Journal of Antimicrobial Chemotherapy","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-time FT-IR typing of Klebsiella pneumoniae: a flexible and rapid approach for outbreak detection and infection control.","authors":"Ana Beatriz Gonçalves, Valquíria Alves, Isabel Neves, Antónia Read, Natália Pinheiro, Anna E Henius, Henrik Hasman, Luísa Peixe, Ângela Novais","doi":"10.1093/jac/dkaf170","DOIUrl":"https://doi.org/10.1093/jac/dkaf170","url":null,"abstract":"<p><strong>Background: </strong>Expansion of carbapenemase-producing Klebsiella pneumoniae (CP-Kp) is driven by within-hospital transmission, requiring timely typing data for effective infection control.</p><p><strong>Objectives: </strong>We evaluated real-time performance and flexibility of our previously developed Fourier-transform infrared (FT-IR) spectroscopy workflow (spectra acquisition and analysis by machine-learning model).</p><p><strong>Methods: </strong>All CP-Kp infection isolates (n = 136) identified at a northern Portuguese hospital (April 2022-March 2023) were tested from Columbia agar with 5% sheep blood, identified by FT-IR (KL-type/sublineage) and confirmed by reference methods (wzi sequencing, MLST and/or WGS).</p><p><strong>Results: </strong>FT-IR typing from Columbia agar with 5% sheep blood showed 73% sensitivity, 79% specificity and 74% accuracy. Our method correctly identified 94% of typeable isolates, 87% of which were communicated in <24 h. Non-typeable isolates belonged to new KL-types to the model (40%) or non-recognized KL-types (60%), most of which (66%) were correctly predicted when retested from Mueller-Hinton agar. Accuracy was then higher (88%) when results from both culture media were considered, and the model retrained to incorporate new sublineages. Three K. pneumoniae sublineages (ST147-KL64, ST15-KL19, ST268-KL20) were predominant and 86% of the isolates were correctly identified. During the study, an outbreak by ST268-KL20 in the neonatal ICU was quickly recognized, and solved in 23 days. Most isolates (98%) produced KPC-3.</p><p><strong>Conclusions: </strong>We demonstrate that FT-IR spectroscopy meets high performance standards in real-time and adaptability to clonal dynamics, and we provide practical guidance for integrating FT-IR into daily microbiology practices. The unique time to response (same day as bacterial identification) enables early and effective infection control interventions.</p>","PeriodicalId":14969,"journal":{"name":"Journal of Antimicrobial Chemotherapy","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An ex vivo model to determine transmembrane clearance of antimicrobials during continuous renal replacement therapy.","authors":"Cole McGrath, Christina Koenig, Hanna F Roenfanz, Yuwei Shen, David P Nicolau, Joseph L Kuti","doi":"10.1093/jac/dkaf177","DOIUrl":"https://doi.org/10.1093/jac/dkaf177","url":null,"abstract":"<p><strong>Background: </strong>The extracorporeal removal of antibiotics in patients requiring continuous renal replacement therapy (CRRT) can be impacted by both individual drug properties as well as factors related to the dialysis prescription. Herein, we describe the detailed methodology for setting up an ex vivo CRRT model to determine the adsorption and transmembrane clearance (CLTM) of cefepime, meropenem, levofloxacin and micafungin across various haemofilters, modes and effluent flow rates.</p><p><strong>Methods: </strong>Two methods to determine CLTM were evaluated to derive optimal dosing regimens and method development: CLSC/SA was calculated by the sieving coefficient (SC) for continuous veno-venous haemofiltration and saturation coefficient (SA) for continuous veno-venous haemodialysis. An alternative calculation CLNCM, was derived from non-compartmental analysis of concentrations from the central reservoir.</p><p><strong>Results: </strong>The average SC/SA of cefepime, meropenem, levofloxacin and micafungin were 1.01, 1.04, 0.87 and <0.01, respectively, which was concordant with their protein-binding profiles. Effluent rate was the primary driver of CLTM for all drugs except micafungin and could be used to guide proposed dosing regimens. CLSC/SA and CLNCM resulted in similar values for cefepime, meropenem and levofloxacin across the effluent rate range but were discordant for micafungin due to filter adsorption; thereby suggesting both methods could be utilized to evaluate CLTM provided negligible filter adsorption is observed.</p><p><strong>Conclusions: </strong>These ex vivo methods can be combined with patient pharmacokinetic data to determine optimal drug dosing regimens for CRRT during new drug development.</p>","PeriodicalId":14969,"journal":{"name":"Journal of Antimicrobial Chemotherapy","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment and validation of downsized hollow-fibre infection model and pharmacokinetics/pharmacodynamics analysis of VAN on Enterococcus faecium.","authors":"Yukitaka Hayashi, Mishu Takahashi, Moe Sasaki, Kenta Suzuki, Yuki Mizukami, Xiaoxi Liu, Yuki Enoki, Kazuaki Taguchi, Tetsuo Yamaguchi, Kazuhiro Tateda, Kazuaki Matsumoto","doi":"10.1093/jac/dkaf175","DOIUrl":"https://doi.org/10.1093/jac/dkaf175","url":null,"abstract":"<p><strong>Objectives: </strong>This study clarified the target values of VAN against Enterococcus faecium using pharmacokinetics/pharmacodynamics (PK/PD) analysis and compared a downsized hollow fibre infection model (HFIM) with a conventional HFIM.</p><p><strong>Methods: </strong>VAN was administered subcutaneously and blood concentrations were measured to calculate the PK parameters. PD studies were performed in an infected mouse model by administering VAN at doses ranging from 25 to 400 mg/kg based on PK parameters. PK/PD parameters correlated with antimicrobial efficacy were determined, and a target value of 2 log10 kills was calculated. The efficacy of VAN against E. faecium was evaluated by reproducing the VAN PK in the plasma at doses that achieved the target value using conventional and novel downsized HFIMs.</p><p><strong>Results: </strong>PK/PD analysis showed that fAUC/minimum inhibitory concentration (MIC) demonstrated the most relevant index, with a target value of 249 to achieve a 2 log10 kill. Blood concentrations of 750 mg VAN every 12 h (equivalent to 260 fAUC/MIC) were simulated well with both HFIMs. Changes in E. faecium caused by continuous exposure to VAN resulted in a reduction in bacterial counts by ∼6.0 log10 kill 168 h after the start of treatment in both models. Downsizing reduced the extracapillary space volume, circulating medium, amount of drugs used and infectious waste. The total cost of the downsized cartridge system was approximately half that of the conventional model system.</p><p><strong>Conclusions: </strong>We established a downsized HFIM and demonstrated its viability as a cost-effective and environmentally sustainable in vitro PK/PD. The findings highlighted its potential as a future PK/PD analysis standard.</p>","PeriodicalId":14969,"journal":{"name":"Journal of Antimicrobial Chemotherapy","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic stress affects the secretion and physicochemical features of extracellular vesicles produced by Helicobacter pylori.","authors":"Paweł Krzyżek, Agnieszka Opalińska, Paweł Migdał, Kaja Tusiewicz, Paweł Szpot, Marcin Zawadzki, Barbara Krzyżanowska, Michał Jerzy Kulus, Marzenna Podhorska-Okołów, Beata Sobieszczańska","doi":"10.1093/jac/dkaf172","DOIUrl":"https://doi.org/10.1093/jac/dkaf172","url":null,"abstract":"<p><strong>Background: </strong>Bacterial extracellular vesicles (EVs) may reduce the effectiveness of various antimicrobials; however, the impact of antibiotics on the secretion and properties of EVs produced by Helicobacter pylori has not been established.</p><p><strong>Methods: </strong>Using clinical H. pylori strains and culture in EV-depleted media, the influence of ¼ × MIC of clarithromycin, metronidazole and levofloxacin on EV features was determined. Physicochemical properties of EVs were measured using nanoparticle tracking analysis and dynamic light scattering. Determination of fatty acid profiles of EVs and bacterial cells was performed with GC triple-quadrupole tandem MS. Bacteria and EVs were observed by scanning and transmission electron microscopy, respectively.</p><p><strong>Results: </strong>Antibiotic stress induced in H. pylori affects the secretion intensity and physicochemical features of EVs secreted by this bacterium in a strain- and antibiotic-dependent manner. Exposure to ¼ × MIC of metronidazole or levofloxacin increased the secretion of EVs and contributed to significant changes in their fatty acid profile, whereas treatment with ¼ × MIC of clarithromycin did not induce such changes. Regardless of the culture conditions and the strain analysed, the existence of a conservative process of selective packaging of C17:0 fatty acids into EVs and a substantial limitation of this phenomenon for C14:0, C18:1 and C19c:0 was demonstrated.</p><p><strong>Conclusion: </strong>This is the first study showing the modulatory effect of antibiotic stress on the secretion and physicochemical features of EVs produced by H. pylori, as well as the first to suggest the involvement of EVs in maintaining the appropriate membrane fatty acid composition of this bacterium.</p>","PeriodicalId":14969,"journal":{"name":"Journal of Antimicrobial Chemotherapy","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posaconazole dosing of enteral formulations in infants and young children to achieve therapeutic concentrations.","authors":"Jeffrey Harrington, Gianni Scappaticci, Julia Brown, Madeleine King","doi":"10.1093/jac/dkaf151","DOIUrl":"https://doi.org/10.1093/jac/dkaf151","url":null,"abstract":"","PeriodicalId":14969,"journal":{"name":"Journal of Antimicrobial Chemotherapy","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}