Journal of Analytical Oncology最新文献_第7页

An Inquiry on the Social and Education Status of Women from Northern Cameroon Suffering Cervical Cancer and the State of Knowledge of their Disease 关于喀麦隆北部患宫颈癌妇女的社会和教育状况以及对其疾病的了解状况的调查

Journal of Analytical Oncology Pub Date : 2017-12-14 DOI: 10.6000/1927-7229.2017.06.04.1

A. H. N. Kamdje, G. Kalgong, R. S. Tagne, J. M. Amvene, C. Nangue

{"title":"An Inquiry on the Social and Education Status of Women from Northern Cameroon Suffering Cervical Cancer and the State of Knowledge of their Disease","authors":"A. H. N. Kamdje, G. Kalgong, R. S. Tagne, J. M. Amvene, C. Nangue","doi":"10.6000/1927-7229.2017.06.04.1","DOIUrl":"https://doi.org/10.6000/1927-7229.2017.06.04.1","url":null,"abstract":"Abstract: Background : Cervical cancer is a major cause of women death worldwide. The reduction of the mortality and morbidity of this pathology depends on the early detection based on powerful suitable screening methods, that will lead to optimal treatment strategies. However in some rural region of developing countries, it is very difficult to get access to standard screening methods, alternative screening methods, cheaper and easy to handle are then useful. Objective : The aim of this work was to test the sensitivity and specificity of VIA (Visual inspection with acetic acid) and VILI (Visual inspection with lugol iodine) as screening test of cervical cancer compared to the Pap Smear, evaluating the feasibility in health formation in the North Cameroon region, of implementing epidemiological surveillance of cervical cancer based on early diagnosis using the VIA-VILI association Method : 309 women age 20 to 62 years were recruited in this study, 307 were included in the statistical analyzes. Each woman was screened for cervical cancer by a conventional Smear and visual inspection with acetic acid 5% and the lugol solution. Results : We found in our study a prevalence of precancerous lesions of cervix at 12.70%. The risks factors of cervical cancer identified are age, matrimonial status, age of first sexual intercourse and parity. The association of VIA and VILI showed a sensitivity, specificity, positive and negative predictive value respectively about 93.58%; 97.01%; 82.01%, 99.04%. Conclusion : Compared to PAP Smear, VIA or VILI could be used as an alternative screening methods for cervical cancer in developing countries. However, histology test was recommended to use a « Gold Standard » to evaluate the test accuracy of VIA/VILI because it can be used to diagnose cancer, while PAP smear cannot.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84452265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Molecular Subtypes and Survival in Patients with Breast Cancer 乳腺癌患者分子亚型与生存的关系

Journal of Analytical Oncology Pub Date : 2017-09-06 DOI: 10.6000/1927-7229.2017.06.03.3

M. Eren, A. Eren, B. Yücel, Seher Bahar, A. Çinkaya, R. Matsuno, N. Beşe

{"title":"Association between Molecular Subtypes and Survival in Patients with Breast Cancer","authors":"M. Eren, A. Eren, B. Yücel, Seher Bahar, A. Çinkaya, R. Matsuno, N. Beşe","doi":"10.6000/1927-7229.2017.06.03.3","DOIUrl":"https://doi.org/10.6000/1927-7229.2017.06.03.3","url":null,"abstract":"Background : Aim of this study is to classify intrinsic subtypes and evaluate the differences in clinical/pathological characteristics and survival outcomes among the molecular types. Patients and Methods : Breast cancer subtypes were classified according to the 2013 St. Gallen Consensus. Five molecular subtypes were determined, Luminal A, Luminal B-like HER2 negative, Luminal B-like HER2 positive, HER2 positive, and triple negative. Data was obtained from the records of patients with invasive breast cancer retrospectively. The differences in clinical/pathological parameters, overall survival and disease-free survival among the molecular subtypes were analyzed. The Kaplan-Meier method, log-rank test and Cox regression tests were used to compare groups. Results : The median follow-up period is 48 months. The Luminal B-HER2 negative was the most prevalent type (26.6%). Patient demographics, tumor characteristics and survival data were analyzed. The Luminal A and Luminal B-HER2 negative subtypes had significantly higher overall survival and disease-free survival rates. Multivariate Cox analysis revealed that tumor stage, more than 3 positive axillary lymph node involvement, and breast cancer subtype as significant factors for overall survival and disease-free survival ( p<0.05 ). Triple Negative subtype had a higher relative hazard of local recurrence and distant metastasis (HR=2.69, 95% CI=1.47; 4.95). Conclusions : Breast cancer subtype has significant impact on overall survival and disease-free survival rates. While Luminal A and luminal B HER2 negative subtypes have better outcome, triple negative and HER2- subtypes remain poor.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81133901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge and Behavior of Women on Cervical Cancer in the Northern Region of Cameroon 喀麦隆北部地区妇女对子宫颈癌的知识和行为

Journal of Analytical Oncology Pub Date : 2017-09-06 DOI: 10.6000/1927-7229.2017.06.03.1

A. H. N. Kamdje, G. Kalgong, P. T. Kamga, R. S. Tagne, J. M. Amvene, C. Nangue

{"title":"Knowledge and Behavior of Women on Cervical Cancer in the Northern Region of Cameroon","authors":"A. H. N. Kamdje, G. Kalgong, P. T. Kamga, R. S. Tagne, J. M. Amvene, C. Nangue","doi":"10.6000/1927-7229.2017.06.03.1","DOIUrl":"https://doi.org/10.6000/1927-7229.2017.06.03.1","url":null,"abstract":"Background : Cervical cancer is a major cause of women death worldwide. The reduction of the mortality and morbidity of this pathology depends on the early detection based on powerful suitable screening methods, that will lead to optimal treatment strategies. However in some rural region of developing countries, it is very difficult to get access to standard screening methods, alternative screening methods, cheaper and easy to handle are then useful. Objective : The aim of this work was to test the sensitivity and specificity of VIA (Visual inspection with acetic acid) and VILI (Visual inspection with lugol iodine) as a diagnostic test of cervical cancer compared to the Pap Smear, evaluating the feasibility in health formation in the North Cameroon region, of implementing epidemiological surveillance of cervical cancer based on early diagnosis using the VIA-VILI association Method : 309 women age 20 to 62 years were recruited in this study, 307 were included in the statistical analyzes. Each woman was screened for cervical cancer by a conventional Smear and visual inspection with acetic acid 5% and the lugol solution. Results : We found in our study a prevalence of precancerous lesions of cervix at 12.70%. The risks factors of cervical cancer identified are age, matrimonial status, age of first sexual intercourse and parity. The association of VIA and VILI showed a sensitivity, specificity, positive and negative predictive value respectively about 93.58%; 97.01%; 82.01%, 99.04%. Conclusion : Compared to PAP Smear, VIA or VILI could be used as an alternative screening methods for cervical cancer in developing countries, where it is difficult to access to more accurate test such as colposcopy and biopsy.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88773164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Prevalence of precancerous lesions among positive HIV women in the hospital complex and University of Yaounde (Cameroun) 雅温得综合医院和大学(喀麦隆)艾滋病毒阳性妇女癌前病变发生率

Journal of Analytical Oncology Pub Date : 2017-04-25 DOI: 10.6000/1927-7229.2017.06.02.3

Dominique Vanessa Sob Djuendje, A. H. N. Kamdje, B. Nkégoum

{"title":"Prevalence of precancerous lesions among positive HIV women in the hospital complex and University of Yaounde (Cameroun)","authors":"Dominique Vanessa Sob Djuendje, A. H. N. Kamdje, B. Nkégoum","doi":"10.6000/1927-7229.2017.06.02.3","DOIUrl":"https://doi.org/10.6000/1927-7229.2017.06.02.3","url":null,"abstract":"In the year 2000, a wide campaign of screening and treatment of the dysplastic lesions of the cervix was initiated in Cameroun. The precancerous lesions of the cervix are the most important demonstration of gynecological infection by the AIDS. As these lesions remain little documented in Cameroun, we carried out a study which the goal was to determine the prevalence of the precancerous lesions among positive AIDS women. It is about a descriptive study with a retrospective collection of data carried out between 2010 and 2016 among 253 positive AIDS women having carried out a consultation in the Hospital complex and University of Yaounde aged from 18 to 80 years. The analysis of the data was essentially carried on: the age, clinical Factors data of risk of the precancerous lesions, anatomo-pathological search of precancerous lesion. AIDS status and/or the catch the antiretroviral one. The Software SPSS was used for the analysis of data. The test of Chi2 for the comparison of the variables. A variable was considered significant if P<0,05. 53 women presented precancerous lesions i.e. 20,94%. The lesions were in 92% of the squamous lesions with intra epithelial of low rank and in 8% of the squamous lesions with intra epithelial of high rank. 22 women (38%) were aged between 36 and 45 years; 22 women (40%) were housewives; 18 women (31%) were single people; 36 women (67%) were multipares; 45 women (85%) did not smoke; 33 women (62%) had a peak of CD4 located between 500-1000/mm3;14 women (26%) did not have opportunist diseases 10 women (19%) had the zona, 8 women (15%) of tuberculosis and 9 women (17%) suffered from HTA. Because of the high potential risk of precancerous lesions in our population of study, we recommend a regular clinical follow-up of the patients presenting high factors of risk, and a widened access to antiretroviral.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75792254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In silico Meta-Analysis of Circulatory microRNAs in Prostate Cancer 前列腺癌中循环小rna的计算机meta分析

Journal of Analytical Oncology Pub Date : 2017-04-25 DOI: 10.6000/1927-7229.2017.06.02.4

A. Singh, Neeti Sharma

{"title":"In silico Meta-Analysis of Circulatory microRNAs in Prostate Cancer","authors":"A. Singh, Neeti Sharma","doi":"10.6000/1927-7229.2017.06.02.4","DOIUrl":"https://doi.org/10.6000/1927-7229.2017.06.02.4","url":null,"abstract":"Circulatory microRNAs (miRNAs) have emerged as a new class of non coding RNA molecules which regulate many crucial molecular and biological processes. We have aimed to shed light on the roles of circulatory miRNAs in Prostate Cancer (PCa) using an integrative in silico bioinformatics approach. We have described a new protocol for target prediction and functional analysis which was applied to 40 highly differentially dysregulated circulatory miRNAs in PCa. This framework comprises: (i) evidence of involvement of these circulatory miRNAs from previous literature and microarray analysis (ii) overlap of prediction results by target prediction tools, including miRTarBase, miRDB, DIANA- microT 4.0 and TargetScan (combining computational learning, alignment, interaction energy and statistical tests for minimization of false positives), (iii) gene ontology (GO) along with pathway enrichment analysis of the miRNA targets and their pathways and (iv) linking these pathways to oncogenesis and cancer hallmarks. More than 200 target genes and 40 regulatory pathways were retrieved and analysed which was followed by associating their roles with cancer hallmark processes. Wnt signalling, Cell cycle, MAPK signalling, Cadherin signalling, Integrin signalling and Ras pathways were some of the identified regulatory pathways during bioinformatics analysis. These signalling and developmental pathways crosstalk and regulate stem cell renewal thus indicating a definite role of circulatory miRNAs in PCa development. Our study identified miR-181, miR-9, Let-7 family, miR-26b circulatory miRNAs, to be contributing majorly in the oncogenic pathways, thus proposing their role as potential biomarkers in PCa initiation and progression.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79742601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Breast Cancer Treatment Protocols: Systematic Review of the Last 35 Years 乳腺癌治疗方案:近35年的系统回顾

Journal of Analytical Oncology Pub Date : 2017-04-25 DOI: 10.6000/1927-7229.2017.06.02.2

R. Santos-Oliveira, Thaís Ligiéro Braga, Filipe Leal Portilho

引用次数: 1

Differences between 66 Chemical Element Contents in Normal and Cancerous Prostate 正常前列腺与癌前列腺中66种化学元素含量的差异

Journal of Analytical Oncology Pub Date : 2017-04-25 DOI: 10.6000/1927-7229.2017.06.02.1

V. Zaichick

引用次数: 20

Prevalence of Malnutrition among Cancer Patients in a Nigerian Institution 尼日利亚一家机构中癌症患者营养不良的发生率

Journal of Analytical Oncology Pub Date : 2017-04-25 DOI: 10.6000/1927-7229.2017.06.02.5

A. Ntekim, O. Folasire, A. Folasire

{"title":"Prevalence of Malnutrition among Cancer Patients in a Nigerian Institution","authors":"A. Ntekim, O. Folasire, A. Folasire","doi":"10.6000/1927-7229.2017.06.02.5","DOIUrl":"https://doi.org/10.6000/1927-7229.2017.06.02.5","url":null,"abstract":"Background : Cancer is a major health problem. Successful management includes adequate supportive care. Nutritional problems are common among cancer patients and these are not routinely addressed by oncologists during oncology care leading to suboptimal outcome even in developed countries. In Nigeria and other low and medium income countries, the situation is worse as nutritional screening and assessment of cancer patients are not routinely carried out. Objectives : To determine the proportion of cancer patients at risk of malnutrition and compare convergence of risk assessment using SGA and MUST tools. Methods : This was a prospective study carried out among cancer patients who presented for cancer care in the Department of Radiation Oncology, University College Hospital Ibadan, Nigeria. Nutritional assessment tools which included Malnutrition Universal Scoring Tool (MUST) and Subjective Global Assessment (SGA) were used to assess the nutritional status of the participants. Results : A total of 89 patients aged between 18 and 85 years participated in the study. The number of males were 13 (15%) while females were 76(85%). In our study 54 (60.8%) of our patients were at risk of malnutrition using the malnutrition universal scoring tool (MUST) scale while 53(60%) were malnourished using the subjective global assessment (SGA) scale. The reliability for the classifications using the MUST and SGA scales was positive (moderate) [Kappa = 0.584 (p<0.0005), 95% CI (0.410, 0.758)]. Conclusion : There is a high proportion of clinical malnutrition among cancer patients in the study population. According to this study, there was similarity between the classifications of nutritional risk, using the MUST and SGA tools.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81302446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brachytherapy in Head and Neck Cancer: A Forgotten Art or a Skill to be Remembered!! 近距离治疗头颈癌:被遗忘的艺术还是被记住的技能!!

Journal of Analytical Oncology Pub Date : 2017-01-26 DOI: 10.6000/1927-7229.2017.06.01.3

A. S. K. Koushik, R. Alva

引用次数: 1

Comparison of Analytical Characteristics of Commercial and in-House Methods for DNA Isolation from Paraffin Histology Blocks 从石蜡组织块中分离DNA的商业和内部方法的分析特性比较

Journal of Analytical Oncology Pub Date : 2017-01-26 DOI: 10.6000/1927-7229.2017.06.01.1

N. A. Os’kina, A. Avdalyan, D. Subbotin, A. Lazarev, A. Kel, N. Kushlinskii, M. Filipenko

引用次数: 0