雅温得综合医院和大学(喀麦隆)艾滋病毒阳性妇女癌前病变发生率

Dominique Vanessa Sob Djuendje, A. H. N. Kamdje, B. Nkégoum
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摘要

2000年,喀麦隆开展了一项广泛的筛查和治疗宫颈发育不良病变的运动。宫颈癌前病变是艾滋病感染妇科最重要的表现。由于这些病变在喀麦隆几乎没有记录,我们进行了一项研究,目的是确定艾滋病阳性妇女中癌前病变的患病率。这是一项描述性研究,对2010年至2016年期间在雅温得医院和雅温得大学进行会诊的253名18至80岁艾滋病阳性妇女进行了回顾性数据收集。主要对资料进行分析:年龄、癌前病变危险的临床因素资料、癌前病变的解剖病理搜索。艾滋病状况和/或抗逆转录病毒感染者。采用SPSS软件对数据进行分析。测试用Chi2进行变量的比较。如果P< 0.05,则变量被认为是显著的。53名妇女出现癌前病变,占20.94%。92%的低级别上皮内鳞状病变出现病变,8%的高级别上皮内鳞状病变出现病变。22名女性(38%)年龄在36至45岁之间;22名妇女(40%)是家庭主妇;18名女性(31%)是单身人士;36名女性(67%)为多胎;45名女性(85%)不吸烟;33名妇女(62%)的CD4峰值位于500-1000/mm3之间;14名妇女(26%)没有机会性疾病,10名妇女(19%)患有带状疱疹,8名妇女(15%)患有结核病,9名妇女(17%)患有HTA。由于我们的研究人群中癌前病变的潜在风险很高,我们建议对呈现高风险因素的患者进行定期临床随访,并扩大抗逆转录病毒治疗的范围。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence of precancerous lesions among positive HIV women in the hospital complex and University of Yaounde (Cameroun)
In the year 2000, a wide campaign of screening and treatment of the dysplastic lesions of the cervix was initiated in Cameroun. The precancerous lesions of the cervix are the most important demonstration of gynecological infection by the AIDS. As these lesions remain little documented in Cameroun, we carried out a study which the goal was to determine the prevalence of the precancerous lesions among positive AIDS women. It is about a descriptive study with a retrospective collection of data carried out between 2010 and 2016 among 253 positive AIDS women having carried out a consultation in the Hospital complex and University of Yaounde aged from 18 to 80 years. The analysis of the data was essentially carried on: the age, clinical Factors data of risk of the precancerous lesions, anatomo-pathological search of precancerous lesion. AIDS status and/or the catch the antiretroviral one. The Software SPSS was used for the analysis of data. The test of Chi2 for the comparison of the variables. A variable was considered significant if P<0,05. 53 women presented precancerous lesions i.e. 20,94%. The lesions were in 92% of the squamous lesions with intra epithelial of low rank and in 8% of the squamous lesions with intra epithelial of high rank. 22 women (38%) were aged between 36 and 45 years; 22 women (40%) were housewives; 18 women (31%) were single people; 36 women (67%) were multipares; 45 women (85%) did not smoke; 33 women (62%) had a peak of CD4 located between 500-1000/mm3;14 women (26%) did not have opportunist diseases 10 women (19%) had the zona, 8 women (15%) of tuberculosis and 9 women (17%) suffered from HTA. Because of the high potential risk of precancerous lesions in our population of study, we recommend a regular clinical follow-up of the patients presenting high factors of risk, and a widened access to antiretroviral.
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