Journal of Analytical Oncology最新文献_第8页

Distribution of Breast Cancer Biomarkers by Age in Iran 伊朗乳腺癌生物标志物的年龄分布

Journal of Analytical Oncology Pub Date : 2017-01-26 DOI: 10.6000/1927-7229.2017.06.01.2

H. Akbari, Farzad Taghizadeh Hesary, L. R. Nikoukar

{"title":"Distribution of Breast Cancer Biomarkers by Age in Iran","authors":"H. Akbari, Farzad Taghizadeh Hesary, L. R. Nikoukar","doi":"10.6000/1927-7229.2017.06.01.2","DOIUrl":"https://doi.org/10.6000/1927-7229.2017.06.01.2","url":null,"abstract":"Background and Objectives : Breast cancer is the leading cause of cancer related death globally and presents as the most common female malignancy in Iran. Multiple factors are associated with an increased risk of developing breast cancer; for example first degree family history of breast cancer, BRCA1, 2 mutation and history of atypical hyperplasia on biopsy are the most important risk factors for developing breast cancer. Some prognostic factors are classically used that it would help us to either choosing recommended optimal treatment or recognizing the prognosis. In several studies it is shown that these factors have different patterns in age groups or histopathologic types. The aim of this study was to determine the age distribution of hormone receptors and biomarkers and determine their relation to the histopathologic types. Methods : Data were gathered from the medical records of Baqiyatallah hospital, Tehran, Iran. Breast cancer patients whose disease was confirmed by pathologic studies and had immunohistochemical profile, were included. Estrogen receptor (ER), Progesterone receptors (PR), HER2/neu and p53 were selected as biomarkers of this study. Results : Mean age of patients was 49.47Â±12.50 years (range 20 to 86). The most common histopathologic type was invasive ductal carcinoma. Distribution of ER and PR against age detected similar; ER positivity increased with age and it peaked in fifth decade of life, and PR positivity showed more regular pattern and it also peaked in fifth decade of life (p 0.05). Conclusions : Our breast cancer patients were generally younger than patients round the world. The different distribution pattern of biomarkers in our studies in comparison with similar studies, may suggest different biologic behavior of breast cancer in our patients. Further studies will help illuminate this point.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82658197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Angular Variation of Applicators in LDR-ICBT LDR-ICBT应用器角度变化研究

Journal of Analytical Oncology Pub Date : 2017-01-26 DOI: 10.6000/1927-7229.2017.06.01.4

A. S. K. Koushik, R. Alva, M. Janaki, A. Ponni

引用次数: 0

Local Staging of Prostate Cancer Using Three Dimensional (3D) Transrectal Ultrasound Assisted with Power Doppler Capability 三维经直肠超声辅助功率多普勒诊断前列腺癌局部分期

Journal of Analytical Oncology Pub Date : 2017-01-26 DOI: 10.6000/1927-7229.2017.06.01.5

A. Youssef

{"title":"Local Staging of Prostate Cancer Using Three Dimensional (3D) Transrectal Ultrasound Assisted with Power Doppler Capability","authors":"A. Youssef","doi":"10.6000/1927-7229.2017.06.01.5","DOIUrl":"https://doi.org/10.6000/1927-7229.2017.06.01.5","url":null,"abstract":"Introduction : The ability to differentiate between carcinoma confined to the prostate and the extra-capsular extension (ECE) of the tumor is the key point for management. ECE of prostate cancer can lead to failure of radical prostatectomy and every attempt should be made to localize the tumor and assess its extensions preoperatively. The study aimed to evaluate the value of three dimensional (3D) Transrectal ultrasound (TRUS) assisted with power Doppler in local staging of prostate cancer. Methodology : -3D TRUS assisted with the power Doppler capability was performed for 120 patients were complaining of burning urination, difficult urination or blood in urine, among them 95 patients were subjected to 3D TRUS guided biopsies. Results : 33 patients showed prostatic carcinomas, 2 patients showed prostatic sarcoma. In patients with proven prostate cancer 3D TRUS showed an estimated sensitivity 85.7% and specificity 90% with a positive predictive value 83.3%, negative predictive value 91.5% and total accuracy 90.9%. 77% of our cancer patients (27/35) showed hypervascularity by power Doppler ultrasonography while 8 patients (23%) showed no abnormal high vascularity. Power Doppler increased the sensitivity of 3D TRUS in the detection of prostate cancer from 85.7% to 88.5% 3D TRUS clearly identified the extra-prostatic spread in 15 out of 18 patients of an estimated sensitivity (83%). Conclusion : 3D TRUS aided with power Doppler is a valuable tool in local staging of prostate cancer .The expected benefits in local staging of prostate cancer from the combination of 3D TRUS, power Doppler and 3D TRUS guided biopsy as one sitting exam, will be highly promising .","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76326915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viability of Whole Tissue Microbiopsy (WTM) for the Study and Management of Oral Leukoplakia 全组织显微活检(WTM)在口腔白斑研究和治疗中的可行性

Journal of Analytical Oncology Pub Date : 2016-11-21 DOI: 10.6000/1927-7229.2016.05.04.1

A. C. Torres, Ãngel MartÃnez Sahuquillo MÃ¡rquez, I. G. Castillo, M. J. C. Fuentes, JosÃ© RamÃ³n Armas PadrÃ³n

{"title":"Viability of Whole Tissue Microbiopsy (WTM) for the Study and Management of Oral Leukoplakia","authors":"A. C. Torres, Ãngel MartÃnez Sahuquillo MÃ¡rquez, I. G. Castillo, M. J. C. Fuentes, JosÃ© RamÃ³n Armas PadrÃ³n","doi":"10.6000/1927-7229.2016.05.04.1","DOIUrl":"https://doi.org/10.6000/1927-7229.2016.05.04.1","url":null,"abstract":"Introduction : Leukoplakia is the most frequent potentially malignant disorder. Management and diagnosis requires clinical and histopathogical monitorization. Conventional biopsy generates patient morbidity and is considered a complex procedure for general dentists, which can delay initial diagnosis. To solve these problems, we have proposed a novel procedure denominated Whole Tissue Microbiopsy (WTM). The aim of this study is to evaluate the samples obtained with the WTM procedure and to test their viability; to check if they are applicable in all anatomic locations and compare the results with those obtained with conventional biopsy. Methods : We studied 41 clinically compatible lesions with oral leukoplakia. A tissue sample was taken using the WTM technique, after which, a conventional biopsy was performed on the same location. Both samples were studied and compared in terms of viability and concordance. Results : 100% of the samples obtained using the WTM procedure were viable. 95% of the samples were useful to detect dysplasia, and in 85% of cases the basal membrane was retained. Coincidence with conventional biopsy as to detect cancer-dysplasia was 78% and showed a 53.8% sensitivity regarding the detection of dysplasia-Cancer. Discussion and Conclusion : The samples obtained by the WTM are viable for study. Conservation of all epithelial layers in the sample and the basement membrane in particular is not influenced by the anatomical area or by the clinical appearance of the lesion. The results that did not coincide with the conventional biopsy were due to the difference in size and not the quality of it.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79692170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased Incidence of Breast Cancer Due to Long Exposure of Light 长时间暴露在光线下会增加乳腺癌的发病率

Journal of Analytical Oncology Pub Date : 2016-11-21 DOI: 10.6000/1927-7229.2016.05.04.3

K. Pushkala, Gupta Pd

{"title":"Increased Incidence of Breast Cancer Due to Long Exposure of Light","authors":"K. Pushkala, Gupta Pd","doi":"10.6000/1927-7229.2016.05.04.3","DOIUrl":"https://doi.org/10.6000/1927-7229.2016.05.04.3","url":null,"abstract":"The disturbed circadian rhythm due to long exposure to varied photo periods or to artificial light during night time (LAN) results in hormonal imbalance. The epidemiological survey indicates a clear difference in the incidence of breast cancer (BC) in countries closer to the poles and to the equator. Long-term exposure to LAN during sleep cycle is found to be the root cause of many health problems. Light dependent conversion of melatonin from serotonin plays a major role in cancer development. In rat model it is shown that levels of melatonin are always inversely proportional to oestradiol in the blood. Melatonin decreases the formation of oestrogens (mitogenic hormone) from androgens via aromatise inhibition. In a pilot study we have shown that in menopausal blind (risk age for BC) women the prevalence of BC is very low (1:169; Risk Rate (RR); Cumulative Risk (CR)35-64 age), compared to sighted women (1:78; CR, 35 - 64 age). Data was collected from a total of 2060 blind subjects (18.8% being <40 years of age and 81.2% above 40 years). Partially blind subjects have 11% greater risk of developing BC than those who are totally blind (RR=1.106; 95% CI=.352 to 3.472). Other established risk factors for BC are ineffective in blind. The blind women model (proposed in this study) suggests that dark hours are essential in our daily routine. By management of proper circadian rhythms better management of various endocrine diseases including hormone dependent cancers can be achieved.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78958698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Incidence of Breast Cancer in Iran: A Systematic Review and Meta-Analysis 伊朗乳腺癌发病率:一项系统回顾和荟萃分析

Journal of Analytical Oncology Pub Date : 2016-11-21 DOI: 10.6000/1927-7229.2016.05.04.2

A. Rezaianzadeh, Soheil Hassanipour, A. Mokhtari, A. Maghsoudi, M. Nazarzadeh, S. Dehghani, Salar Rahimi Kazerooni

{"title":"The Incidence of Breast Cancer in Iran: A Systematic Review and Meta-Analysis","authors":"A. Rezaianzadeh, Soheil Hassanipour, A. Mokhtari, A. Maghsoudi, M. Nazarzadeh, S. Dehghani, Salar Rahimi Kazerooni","doi":"10.6000/1927-7229.2016.05.04.2","DOIUrl":"https://doi.org/10.6000/1927-7229.2016.05.04.2","url":null,"abstract":"Background : Breast cancer is the most common invasive cancer among women globally. Its incidence greatly varies around the world the globe. There are several estimates of breast cancer incidence from different geographical areas in Iran. In addition, no systematic reviews are available pertaining to the incidence rate of breast cancer in Iran. Therefore, the present systematic review aimed to address this epidemiological gap. Method : This systematic review was carried out based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) in January 2016. In doing so, the researchers searched Medline/PubMed, Scopus, Sciencedirect, and Google scholar for international papers and four Iranian databases (Scientific Information Database, MagIran, Iran Medex, and Iran Doc) for Persian articles. Result : A total of 427 titles were retrieved in the initial search of the databases. Further refinement and screening of the retrieved studies produced a total of 18 researches. Based on the random effect model, the Age-Standardized Rate (ASR) of breast cancer was 26.4, 95% CI (20.1 to 31.7). However, the results of Cochranâ€™s test showed the heterogeneity of the studies (Q=1788.2, df=17, I 2 =99%, p<0.001). Conclusion : The incidence of breast cancer was lower in Iran compared to other parts of the world. However, establishing cancer registries covering a broader perspective of the population and carrying out further studies are needed to map out the exact incidence rate and trend of breast cancer in Iran.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91247795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Depth-Sensitive Raman Spectroscopy of Intact Formalin-Fixed and Paraffin-Embedded Tissue Blocks for Objective Diagnosis of Cancer- An Exploratory Study 完整的福尔马林固定和石蜡包埋组织块的深度敏感拉曼光谱客观诊断癌症-一项探索性研究

Journal of Analytical Oncology Pub Date : 2016-11-21 DOI: 10.6000/1927-7229.2016.05.04.4

K. M. Khan, Hemant Krishna, C. V. Kulkarni, S. Majumder

{"title":"Depth-Sensitive Raman Spectroscopy of Intact Formalin-Fixed and Paraffin-Embedded Tissue Blocks for Objective Diagnosis of Cancer- An Exploratory Study","authors":"K. M. Khan, Hemant Krishna, C. V. Kulkarni, S. Majumder","doi":"10.6000/1927-7229.2016.05.04.4","DOIUrl":"https://doi.org/10.6000/1927-7229.2016.05.04.4","url":null,"abstract":"Histopathology, the current “gold standard”, is prone to human errors as it depends on expert interpretation of the microscopically derived cellular and sub-cellular information for tissue diagnosis. Further, this light microscope based approach requires preparation of appropriately stained specimens of micro-thin tissue sections from the formalin-fixed and paraffin-embedded (FFPE) blocks of tissue samples. We report a method that provides quantitative feedback about tissue diagnosis by measuring depth-sensitive Raman spectra from the intact FFPE tissue blocks without requiring preparation of any thin tissue sections or any other processing. The FFPE blocks of pathologically certified cancerous and normal breast tissues were used for validating the approach. The measured depth-sensitive Raman spectra were mathematically de-paraffinized for retrieving the characteristic tissue Raman signatures using scaled-subtraction. A multivariate analysis of the scaled-subtracted, depth-sensitive Raman spectra employing a probability-based diagnostic algorithm developed using the framework of sparse multinomial logistic regression (SMLR) provided a sensitivity and specificity of up to 100% towards cancer based on leave-one-block-out cross validation. The results of this exploratory study suggest that depth-sensitive Raman spectroscopy along with a multivariate statistical algorithm can provide a valuable alternate diagnostic modality in clinical pathology setting for discriminating cancerous from normal FFPE tissue blocks.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75279485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Intracellular Zinc Excess as One of the Main Factors in the Etiology of Prostate Cancer 细胞内锌过量是前列腺癌病因的主要因素之一

Journal of Analytical Oncology Pub Date : 2016-08-15 DOI: 10.6000/1927-7229.2016.05.03.5

V. Zaichick, S. Zaichick, S. Wynchank

{"title":"Intracellular Zinc Excess as One of the Main Factors in the Etiology of Prostate Cancer","authors":"V. Zaichick, S. Zaichick, S. Wynchank","doi":"10.6000/1927-7229.2016.05.03.5","DOIUrl":"https://doi.org/10.6000/1927-7229.2016.05.03.5","url":null,"abstract":"Numerous studies show that prevalence of prostate cancer (PCa) drastically increases with age, these malignant tumours are mainly formed in the peripheral zone of the prostate gland, and a high intake of red meat is associated with a statistically significant elevation in risk of PCa. The factors which cause all these well-specified features of the PCa are currently unclear. Here we describe one factor which can play an important role in etiology of malignant transformation of the prostate and is connected with the above-mentioned features of PCa. It is hypothesized that the prostatic intracellular Zn concentrations are probably one of the most important factors in the etiology of PCa. For an endorsement of our standpoint the estimation of changes of intracellular Zn concentrations over malesâ€™ lifespan was obtained using morphometric and Zn content data for the peripheral zone of prostate tissue, as well as Zn concentration in prostatic fluid. It was shown that the Zn concentrations in prostatic cells for men aged over 45 years are 10-fold higher than in those aged 18 to 30 years and this excessive accumulation of Zn may disturb the cellsâ€™ functions, resulting in cellular degeneration, death or malignant transformation. We hypothesize this excessive intracellular Zn concentration in cells of the prostate gland periphery has previously unrecognized and most important consequences, associated with PCa.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77577433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Tobacco Consumption Induced Changes in the Healthy Oral Mucosa and its Effect on Differential Diagnosis of Oral Lesions – A Clinical In Vivo Raman Spectroscopic Study 烟草消费引起的健康口腔黏膜变化及其对口腔病变鉴别诊断的影响——临床体内拉曼光谱研究

Journal of Analytical Oncology Pub Date : 2016-08-10 DOI: 10.6000/1927-7229.2016.05.03.4

Hemant Krishna, S. Muttagi, Pranav D Ingole, P. Chaturvedi, S. Majumder

{"title":"Tobacco Consumption Induced Changes in the Healthy Oral Mucosa and its Effect on Differential Diagnosis of Oral Lesions – A Clinical In Vivo Raman Spectroscopic Study","authors":"Hemant Krishna, S. Muttagi, Pranav D Ingole, P. Chaturvedi, S. Majumder","doi":"10.6000/1927-7229.2016.05.03.4","DOIUrl":"https://doi.org/10.6000/1927-7229.2016.05.03.4","url":null,"abstract":"Objective : To investigate tobacco consumption induced changes in the in vivo Raman spectra of oral mucosa of healthy volunteers and to study its effect on the differential diagnosis of oral lesions. Materials and Methods : The clinical in vivo study involved 28 healthy volunteers and 171 patients having malignant and potentially malignant lesions of the oral cavity. Twenty of the healthy volunteers had habits of either smoking and/or of chewing tobacco while the rest did not have any tobacco consumption habits. The in vivo Raman spectra were measured using a compact and portable near-infrared Raman spectroscopic system. A probability based multi-class diagnostic algorithm, developed for supervised classification, was employed to classify the whole set of measured tissue Raman spectra into various categories. Results : It was found that the Raman spectra of healthy volunteers with tobacco consumption habits could be separated from the spectra of those without any habit of tobacco consumption with an accuracy of over 95%. Further, it was found that exclusion of the spectral data of the oral cavity of the healthy volunteers from the reference normal database considerably improved the overall classification accuracy (92.3% as against 86%) of the algorithm in separing the oral lesions from the normal oral mucosa. Conclusion : The results of the clinical study demonstrate the potential of Raman spectroscopy in screening tobacco users who are at an increased risk of developing dysplasia or malignancy. Further, the results also show that for accurate discrimination of oral lesions based on their Raman spectra, the reference normal database should exclude spectral data of tobacco using healthy subjects.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81569839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Influence of Pigment Transfer on the Risk of Developing Melanoma: The Significance of the Melanocyte ‘Amputation Cycle’ 色素转移对黑色素瘤发生风险的影响:黑色素细胞“截肢周期”的意义

Journal of Analytical Oncology Pub Date : 2016-08-10 DOI: 10.6000/1927-7229.2016.05.03.1

P. Riley

引用次数: 1